Click here to switch to the map view.

The map label for this gene is hutC [H]

Identifier: 157963981

GI number: 157963981

Start: 5062857

End: 5063561

Strand: Reverse

Name: hutC [H]

Synonym: Spea_4170

Alternate gene names: 157963981

Gene position: 5063561-5062857 (Counterclockwise)

Preceding gene: 157963983

Following gene: 157963980

Centisome position: 97.85

GC content: 48.51

Gene sequence:

>705_bases
ATGGCAACGCCAAAGTTTGAAGAGATTAAGCAATATATTTTAGCGCAAATTGAGTCTGGCGAATGGGCGGAAGATAGCCG
CGTACCGTCTGAAAATCAGTTGGCGGAACTATTTAATTGTAGCCGTATGACGGCGCGTCGAGCGTTAACTGAGTTAACCG
AATCGGGCGTTTTAGAGCGTTCACAAGGCTTAGGTACCTTCGTTGCTGGCTTAAAATCGCAGTCTTCAATGATGGCGATC
CGTAATATTGCCGATGAGATAAAAGACCGTGGCCATGGTTATAGTGTGCAACAAGTGTTGCTCACGCAAACGGTAGCAAC
TGGCGCGATTGCGATTGCGCTTGGGCTGGAAGAAGGCAGTACGGTTTACCAGTCGGTATTAGTACATTGCGAGCAGGGTA
CGCCGCTGCAGCTAGAAGATCGCTTCGTTAATCCTAAACTGGTGCCTGAGTATTTATCCCAAGATTTTACTAAACAAACT
CCCCATGAATATTTATCGATGGTGGCACCGCTTACCGAAGCTAAGCACACCATCGAAGCCAAAATGGCCGATGTGACGCA
GTTAGCGCTACTTGAAATCGCCGCCACTGAGCCCTGTTTACAGATCACTCGCCGCACTTGGTCACGCCAAGGTGTGGTGA
GTTTTGCACGTTTAGTGCACCCAGGAAGTCGATTTAGACTCGGTGGCCACCTGACTTTTAGTTAA

Upstream 100 bases:

>100_bases
GAGCTAGCTTGTGTTTACTTGTATATACAAGCTAGGATTGTAGCCGAGTTTTTAAGCAAGTAAATAGTCGGTGAGTAGTT
TAGCGGTAACGGGACGGTTA

Downstream 100 bases:

>100_bases
GCCAGTTAAGTTACAGCATGAGCAGTAAAACGATTTACCAAATGATTTACAAAATAAATAGACAGTAAATATAAAGCTTA
AAAATAAGCGAATAAGAAAA

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRALTELTESGVLERSQGLGTFVAGLKSQSSMMAI
RNIADEIKDRGHGYSVQQVLLTQTVATGAIAIALGLEEGSTVYQSVLVHCEQGTPLQLEDRFVNPKLVPEYLSQDFTKQT
PHEYLSMVAPLTEAKHTIEAKMADVTQLALLEIAATEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS

Sequences:

>Translated_234_residues
MATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRALTELTESGVLERSQGLGTFVAGLKSQSSMMAI
RNIADEIKDRGHGYSVQQVLLTQTVATGAIAIALGLEEGSTVYQSVLVHCEQGTPLQLEDRFVNPKLVPEYLSQDFTKQT
PHEYLSMVAPLTEAKHTIEAKMADVTQLALLEIAATEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS
>Mature_233_residues
ATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRALTELTESGVLERSQGLGTFVAGLKSQSSMMAIR
NIADEIKDRGHGYSVQQVLLTQTVATGAIAIALGLEEGSTVYQSVLVHCEQGTPLQLEDRFVNPKLVPEYLSQDFTKQTP
HEYLSMVAPLTEAKHTIEAKMADVTQLALLEIAATEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790118, Length=229, Percent_Identity=24.4541484716157, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082252, Length=203, Percent_Identity=24.6305418719212, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790540, Length=178, Percent_Identity=29.2134831460674, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 25908; Mature: 25777

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRALTELTESGVLER
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQGLGTFVAGLKSQSSMMAIRNIADEIKDRGHGYSVQQVLLTQTVATGAIAIALGLEEGS
HCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCCH
TVYQSVLVHCEQGTPLQLEDRFVNPKLVPEYLSQDFTKQTPHEYLSMVAPLTEAKHTIEA
HHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KMADVTQLALLEIAATEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECC
>Mature Secondary Structure 
ATPKFEEIKQYILAQIESGEWAEDSRVPSENQLAELFNCSRMTARRALTELTESGVLER
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQGLGTFVAGLKSQSSMMAIRNIADEIKDRGHGYSVQQVLLTQTVATGAIAIALGLEEGS
HCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCCH
TVYQSVLVHCEQGTPLQLEDRFVNPKLVPEYLSQDFTKQTPHEYLSMVAPLTEAKHTIEA
HHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KMADVTQLALLEIAATEPCLQITRRTWSRQGVVSFARLVHPGSRFRLGGHLTFS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]