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The map label for this gene is hutH [H]

Identifier: 157963979

GI number: 157963979

Start: 5059501

End: 5061033

Strand: Reverse

Name: hutH [H]

Synonym: Spea_4168

Alternate gene names: 157963979

Gene position: 5061033-5059501 (Counterclockwise)

Preceding gene: 157963980

Following gene: 157963978

Centisome position: 97.81

GC content: 52.9

Gene sequence:

>1533_bases
ATGAGCCATTTAGTATTAACTCCGGGTACCTTAACCCTAGCGCAAATCCGTGAAATCAGCCGTGGCAAGGTCACTTTAGA
GCTGGCCGAAAGTGCTATCGCAGATATCAACACTAGCGCAGGCCTAGTGCAGCAAGTATTGGATGAAGGCCGCACTGTTT
ACGGTATCAACACAGGTTTTGGGTTGCTCGCTAACACTAAGATTGCCGCCGACGATCTGCAATTGTTGCAGCGCTCAATC
GTACTGTCTCATGCAGCGGGTACCGGCCAATATATGCAAGACGCCACCGTGCGTTTGATGATGGTATTGAAGATCAACTC
CCTAAGCCGTGGTTTCTCGGGCATTCGTTTAGAGGTGATCAACTTCCTTATCGCCTTGGTTAACGCGGGTGTTTATCCAT
GTGTACCAGAGAAAGGCTCTGTAGGGGCTTCGGGTGACCTCGCGCCGCTATCACACATGTGTTTGCCGCTGCTTGGCGAA
GGCGAGATGAGCTATCAAGGTCAGCTCATCAGCGCGGCTGAGGGCCTCGAAATTGCAGGCCTTAAGCCTATCGAATTGGC
CGCGAAAGAAGGTCTAGCGCTACTTAACGGCACGCAAGCGTCAACGGCTTTAGCCCTTGAAGGCCTATTTAACGCAGAAG
ATCTGTTTGCCGCAAGCTCGGTAATCGGTGCCATGAGCGTTGAAGCGGCCATGGGCAGTCGTAGCCCGTTTGACCCACGT
ATTCACGCGGCTCGCGGGCAAAAAGGTCAAATCGATTCGGCAGCGGTGTTCCGTCATTTACTGGGTGGTGAGTCTGAGAT
TAGCCTAGATCACGTCAACTGTGAAAAGGTGCAAGATCCATATTCACTGCGCTGTCAGCCACAGGTGCTCGGCGCATGTT
TGACTCAAATTCGTCATGCGGCCGAAGTGCTAGGCACAGAAGCAAACGGCGTTACCGATAATCCATTAGTGTTCCAAGAC
ACGGGCGACATTATCTCGGGCGGTAACTTTCACGCCGAACCTGTTGCCATGGCGGCTGATAACTTGGCGATTGCCATTGC
AGAATTGGGCTCGATTGCAGAACGTCGTATTGCGCTGCTTATCGACTCTAACCTGTCTAAGCTACCGCCATTCTTGGTGG
AAAACGGCGGGGTAAACTCAGGCTTTATGATTGCCCAGGTAACAGCGGCGGCATTGGCCTCTGAGAACAAGACCTACGCC
CACCCAGCCTCGGTAGATAGTTTGCCAACATCGGCTAACCAAGAAGATCACGTGTCTATGGCGACCTTCGCGGCGCGTCG
TTTACGCGATATGTCTGAAAACACCCGTGGGGTTTTAGCGGTTGAGCTATTGGCTGCGGCGCAGGGGTTAGATTTCCGTG
CGCCACTACAACCTAGCAAGGCTGTGGCACAGGCCAAAGGCGAGTTACGTGAGCTAGTGAGTTACTACGATAAGGACCGT
TTCTTCGGCCCAGATATCGAAGCGGCGACTGACCTACTGCTAACGGCAAGCTATAACGCTTACCTGCCAGCAGAGATCTT
GCCAAGCCTATAG

Upstream 100 bases:

>100_bases
TCATGCTGACGCGGGTTACGATATCGCTAAAAATTGTGCAAAAGAGCAGGGTCTAGACCTGCCGATGCTAGAGAAAGCCA
CAACAGAGGGTAAGTAGAAC

Downstream 100 bases:

>100_bases
GTTTAGTCAGTAGTGAGTAAAAAGGGCCTGAGGGCATAATACTGATAAGATAAGCTCCAACTTGATTAATAAGTAAAAAA
CTAAGAACCCTGCATATGTA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGFGLLANTKIAADDLQLLQRSI
VLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLIALVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGE
GEMSYQGQLISAAEGLEIAGLKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDPR
IHAARGQKGQIDSAAVFRHLLGGESEISLDHVNCEKVQDPYSLRCQPQVLGACLTQIRHAAEVLGTEANGVTDNPLVFQD
TGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYA
HPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPSKAVAQAKGELRELVSYYDKDR
FFGPDIEAATDLLLTASYNAYLPAEILPSL

Sequences:

>Translated_510_residues
MSHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGFGLLANTKIAADDLQLLQRSI
VLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLIALVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGE
GEMSYQGQLISAAEGLEIAGLKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDPR
IHAARGQKGQIDSAAVFRHLLGGESEISLDHVNCEKVQDPYSLRCQPQVLGACLTQIRHAAEVLGTEANGVTDNPLVFQD
TGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYA
HPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPSKAVAQAKGELRELVSYYDKDR
FFGPDIEAATDLLLTASYNAYLPAEILPSL
>Mature_509_residues
SHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGFGLLANTKIAADDLQLLQRSIV
LSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLIALVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGEG
EMSYQGQLISAAEGLEIAGLKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDPRI
HAARGQKGQIDSAAVFRHLLGGESEISLDHVNCEKVQDPYSLRCQPQVLGACLTQIRHAAEVLGTEANGVTDNPLVFQDT
GDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYAH
PASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPSKAVAQAKGELRELVSYYDKDRF
FGPDIEAATDLLLTASYNAYLPAEILPSL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=488, Percent_Identity=46.5163934426229, Blast_Score=420, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567831, Length=505, Percent_Identity=41.7821782178218, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53713; Mature: 53582

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGF
CCCEEECCCCHHHHHHHHHHCCEEEEEEHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCC
GLLANTKIAADDLQLLQRSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVI
CEEECCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEEHHHHHCCCCCHHHHHH
NFLIALVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGEGEMSYQGQLISAAEGLEIAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEHHCCCCEECC
LKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDPR
CCHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IHAARGQKGQIDSAAVFRHLLGGESEISLDHVNCEKVQDPYSLRCQPQVLGACLTQIRHA
EECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHH
AEVLGTEANGVTDNPLVFQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALL
HHHHCCCCCCCCCCCEEEECCCCEECCCCCCCCCHHEECCCCEEEHHHHHHHHHHEEEEE
IDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYAHPASVDSLPTSANQEDHVSM
EECCHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
ATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPSKAVAQAKGELRELVSYYDKDR
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
FFGPDIEAATDLLLTASYNAYLPAEILPSL
CCCCCHHHHHHEEEEECCCCCCCHHHCCCC
>Mature Secondary Structure 
SHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGF
CCEEECCCCHHHHHHHHHHCCEEEEEEHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCC
GLLANTKIAADDLQLLQRSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVI
CEEECCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEEHHHHHCCCCCHHHHHH
NFLIALVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGEGEMSYQGQLISAAEGLEIAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEHHCCCCEECC
LKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDPR
CCHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IHAARGQKGQIDSAAVFRHLLGGESEISLDHVNCEKVQDPYSLRCQPQVLGACLTQIRHA
EECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHH
AEVLGTEANGVTDNPLVFQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALL
HHHHCCCCCCCCCCCEEEECCCCEECCCCCCCCCHHEECCCCEEEHHHHHHHHHHEEEEE
IDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYAHPASVDSLPTSANQEDHVSM
EECCHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
ATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPSKAVAQAKGELRELVSYYDKDR
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
FFGPDIEAATDLLLTASYNAYLPAEILPSL
CCCCCHHHHHHEEEEECCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA