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The map label for this gene is typA [H]

Identifier: 157963726

GI number: 157963726

Start: 4762221

End: 4764050

Strand: Reverse

Name: typA [H]

Synonym: Spea_3915

Alternate gene names: 157963726

Gene position: 4764050-4762221 (Counterclockwise)

Preceding gene: 157963731

Following gene: 157963725

Centisome position: 92.07

GC content: 45.79

Gene sequence:

>1830_bases
ATGGTAAGAGGTTTAGCCGTGTTAGAGAATTTACGTAACATCGCCATTATTGCACACGTTGACCATGGTAAGACTACCTT
GGTTGATAAGTTGCTGGCGCAGTCAGGAACCCTTGAGTCTCGAGGAGAAGCCACTGAGCGGGTGATGGATTCAAATGATC
TTGAAAAGGAACGTGGTATCACGATTCTGGCCAAGAACACTGCCATCAAGTGGAACGATTACCGTATCAACATCGTTGAT
ACCCCTGGTCACGCCGATTTCGGTGGTGAGGTAGAGCGTGTTCTATCTATGGTTGACTCAGTATTACTACTAGTTGACGC
AGTTGATGGTCCAATGCCACAGACTCGCTTCGTGACTAAGAAAGCTTTCGCTCAAGGTCTAAAGCCAATCGTTGTTATCA
ACAAGATTGACCGTCCAGGCGCACGTCCAGATTGGGTTATTGACCAAGTATTTGACTTGTTCGACAACCTAGGCGCTACC
GATGAGCAACTAGATTTCCCAATCGTTTATGCTTCTGCGCTAAACGGTTTTGCTACATTAGATCCAGACGAAGTTAGCGC
TGACATGACGCCGCTATTCGAAACGATCGTTGAAAAAGTTTCTTCACCAGATGCTGATGCTGAAGGTGATTTCCAGATGC
AAATTTCGCAAATCGACTACAACTCATACGTGGGTGTTATCGGTATTGGCCGCATCAAGCGTGGTAGTGTTAAAACTAAC
CAACAAGTGACTATTCTTGGCGCTGACGGCAAGAAGCGTAACGGTAAAATCGGTCAAGTATTAGGTTACATGGGCCTTGA
GCGTCATGAAGTTTCTGATGCAACTGCTGGTGACATCGTTGCGATTACTGGTCTTGGCCAGTTGCTAATTTCTGACACTG
TTTGTGCAACTACTAACGTAGAAGCGCTACCTCCATTGTCTGTTGATGAGCCAACACTAACCATGACTTTCCAGGTGAAC
ACTTCTCCGTTCGCTGGTAAAGAAGGTAAGTACGTGACTTCACGTAATATCCTTGAGCGTCTACAGCAAGAACTAGTACA
CAACGTAGCATTGCGCGTTGAAGAAACTGACAGCCCAGATCGTTTCCGCGTATCAGGCCGTGGTGAACTTCACCTTTCAA
TCTTGATTGAAAACATGCGTCGTGAAGGTTACGAGCTAGCTGTATCTCGTCCAGAAGTTATCGTTAAAGAGATCGATGGC
GAGATGTGTGAGCCGTTCGAAACACTAACTGTTGACGTTCAAGAAGAACATCAAGGTGCAGTGATCGAGAAGCTTGGTAT
CCGTAAGGGTGACATGAAGGACATGCAGTTAGACGGTAAGGGTCGTGTACGTATCGATTTCGTTATCCCTAGCCGTGGTC
TAATCGGTTTCCAAACTGAGTTCATGACAGCGACTTCTGGTACTGGTCTAATTTACCATTCATTCGACCATTACGGTCCA
TTGAAAGGTGGTGACATTGGTCAACGTGCTCGTGGCGTATTGATCTCTAACGCTACTGGTAAAGCACTAACATTCGCACT
ATTCGGTCTACAAGAGCGTGGTCGTCTGTTTATTACTCACGCTACAGAAGTATACGAAGGCCAAGTAGTTGGTCTTCACG
CACGTGCTAACGACCTAACAGTTAACTGTTTGAAAGGTAAGCAGCTAACTAACATGCGTGCATCTGGTACTGACGAAGCT
CAAGTACTAACTCCGCATATCGAAATGACACTTGAGCAAGCTCTTGAGTTCATCGATGATGACGAATTAGTAGAAGTAAC
GCCACTGAACATCCGTGTTCGTAAGCGTTTCTTGACTGAAAACGAGCGTAAGCGTCATAACCGTAAGTAA

Upstream 100 bases:

>100_bases
AGATACCGCCGAGCTAGAGTAGAATGTCACGCTTTTTATTGCAACTACTATACTAGATTGGTTTTAGTCGTTGTCAGTAA
CCCCCCTATATTTTATACCG

Downstream 100 bases:

>100_bases
TGACCGCGTTTAGCTTCAACCCTTAATGGGTTAAGTATTAAAAAGGCCCTGAACATGTAAGTGTTCAGGGCCTTTTTGTT
ATATAGCTTGTGGGTGTTTT

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MVRGLAVLENLRNIAIIAHVDHGKTTLVDKLLAQSGTLESRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVD
TPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGAT
DEQLDFPIVYASALNGFATLDPDEVSADMTPLFETIVEKVSSPDADAEGDFQMQISQIDYNSYVGVIGIGRIKRGSVKTN
QQVTILGADGKKRNGKIGQVLGYMGLERHEVSDATAGDIVAITGLGQLLISDTVCATTNVEALPPLSVDEPTLTMTFQVN
TSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFRVSGRGELHLSILIENMRREGYELAVSRPEVIVKEIDG
EMCEPFETLTVDVQEEHQGAVIEKLGIRKGDMKDMQLDGKGRVRIDFVIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGP
LKGGDIGQRARGVLISNATGKALTFALFGLQERGRLFITHATEVYEGQVVGLHARANDLTVNCLKGKQLTNMRASGTDEA
QVLTPHIEMTLEQALEFIDDDELVEVTPLNIRVRKRFLTENERKRHNRK

Sequences:

>Translated_609_residues
MVRGLAVLENLRNIAIIAHVDHGKTTLVDKLLAQSGTLESRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVD
TPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGAT
DEQLDFPIVYASALNGFATLDPDEVSADMTPLFETIVEKVSSPDADAEGDFQMQISQIDYNSYVGVIGIGRIKRGSVKTN
QQVTILGADGKKRNGKIGQVLGYMGLERHEVSDATAGDIVAITGLGQLLISDTVCATTNVEALPPLSVDEPTLTMTFQVN
TSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFRVSGRGELHLSILIENMRREGYELAVSRPEVIVKEIDG
EMCEPFETLTVDVQEEHQGAVIEKLGIRKGDMKDMQLDGKGRVRIDFVIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGP
LKGGDIGQRARGVLISNATGKALTFALFGLQERGRLFITHATEVYEGQVVGLHARANDLTVNCLKGKQLTNMRASGTDEA
QVLTPHIEMTLEQALEFIDDDELVEVTPLNIRVRKRFLTENERKRHNRK
>Mature_609_residues
MVRGLAVLENLRNIAIIAHVDHGKTTLVDKLLAQSGTLESRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVD
TPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGAT
DEQLDFPIVYASALNGFATLDPDEVSADMTPLFETIVEKVSSPDADAEGDFQMQISQIDYNSYVGVIGIGRIKRGSVKTN
QQVTILGADGKKRNGKIGQVLGYMGLERHEVSDATAGDIVAITGLGQLLISDTVCATTNVEALPPLSVDEPTLTMTFQVN
TSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFRVSGRGELHLSILIENMRREGYELAVSRPEVIVKEIDG
EMCEPFETLTVDVQEEHQGAVIEKLGIRKGDMKDMQLDGKGRVRIDFVIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGP
LKGGDIGQRARGVLISNATGKALTFALFGLQERGRLFITHATEVYEGQVVGLHARANDLTVNCLKGKQLTNMRASGTDEA
QVLTPHIEMTLEQALEFIDDDELVEVTPLNIRVRKRFLTENERKRHNRK

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=510, Percent_Identity=26.4705882352941, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=43.609022556391, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=41.4965986394558, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=40.1360544217687, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI25306287, Length=171, Percent_Identity=35.0877192982456, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI19923640, Length=171, Percent_Identity=35.0877192982456, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI25306283, Length=171, Percent_Identity=35.0877192982456, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=40.5405405405405, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=40.5405405405405, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=40.5405405405405, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI34147630, Length=267, Percent_Identity=29.2134831460674, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI217272892, Length=137, Percent_Identity=37.2262773722628, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI217272894, Length=137, Percent_Identity=37.2262773722628, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=31.0077519379845, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI4503471, Length=280, Percent_Identity=26.7857142857143, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI48994988, Length=602, Percent_Identity=76.4119601328904, Blast_Score=959, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=502, Percent_Identity=28.6852589641434, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=39.1891891891892, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790835, Length=212, Percent_Identity=30.188679245283, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789737, Length=245, Percent_Identity=30.6122448979592, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790412, Length=245, Percent_Identity=30.6122448979592, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789559, Length=137, Percent_Identity=35.7664233576642, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=273, Percent_Identity=33.6996336996337, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17556745, Length=440, Percent_Identity=27.7272727272727, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17533571, Length=185, Percent_Identity=37.2972972972973, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=40.7692307692308, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=40.7692307692308, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17506493, Length=159, Percent_Identity=36.4779874213836, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17552882, Length=179, Percent_Identity=34.0782122905028, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17556456, Length=284, Percent_Identity=28.8732394366197, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115532067, Length=268, Percent_Identity=25.7462686567164, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532065, Length=268, Percent_Identity=25.7462686567164, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=590, Percent_Identity=27.1186440677966, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324707, Length=147, Percent_Identity=40.1360544217687, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=147, Percent_Identity=40.1360544217687, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=179, Percent_Identity=37.9888268156425, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322359, Length=151, Percent_Identity=39.0728476821192, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324761, Length=273, Percent_Identity=29.3040293040293, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=38.0281690140845, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324550, Length=125, Percent_Identity=35.2, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI78706572, Length=558, Percent_Identity=27.5985663082437, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24582462, Length=178, Percent_Identity=38.7640449438202, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=40.2877697841727, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585709, Length=160, Percent_Identity=37.5, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=37.7483443708609, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=37.7483443708609, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221458488, Length=160, Percent_Identity=39.375, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21357743, Length=190, Percent_Identity=34.2105263157895, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363316, Length=317, Percent_Identity=27.1293375394322, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17864358, Length=317, Percent_Identity=27.1293375394322, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19921738, Length=281, Percent_Identity=27.7580071174377, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28572034, Length=129, Percent_Identity=37.984496124031, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67205; Mature: 67205

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRGLAVLENLRNIAIIAHVDHGKTTLVDKLLAQSGTLESRGEATERVMDSNDLEKERGI
CCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCHHHCCE
TILAKNTAIKWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTK
EEEEECCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDFPIVYASALNGFATL
HHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEC
DPDEVSADMTPLFETIVEKVSSPDADAEGDFQMQISQIDYNSYVGVIGIGRIKRGSVKTN
CHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEEECCEECCCCCCC
QQVTILGADGKKRNGKIGQVLGYMGLERHEVSDATAGDIVAITGLGQLLISDTVCATTNV
CEEEEEECCCCCCCCCHHHHHHHCCCCHHCCCCCCCCCEEEEECCCHHHHCCCEEECCCC
EALPPLSVDEPTLTMTFQVNTSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPD
CCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHEEEEECCCCCC
RFRVSGRGELHLSILIENMRREGYELAVSRPEVIVKEIDGEMCEPFETLTVDVQEEHQGA
EEEECCCCCEEEEEEEHHHHCCCEEEEECCCHHHHHHCCCCCCCCCEEEEEEECCCCCCH
VIEKLGIRKGDMKDMQLDGKGRVRIDFVIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGP
HHHHHCCCCCCCCCEEECCCCCEEEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCCCC
LKGGDIGQRARGVLISNATGKALTFALFGLQERGRLFITHATEVYEGQVVGLHARANDLT
CCCCCCCCHHCEEEEECCCCCEEEEEEECCCCCCCEEEEECCEEECCEEEEEEECCCCEE
VNCLKGKQLTNMRASGTDEAQVLTPHIEMTLEQALEFIDDDELVEVTPLNIRVRKRFLTE
EEEECCCEECCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCCEEEEECCCEEEHHHHHCC
NERKRHNRK
CHHHHCCCC
>Mature Secondary Structure
MVRGLAVLENLRNIAIIAHVDHGKTTLVDKLLAQSGTLESRGEATERVMDSNDLEKERGI
CCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCHHHCCE
TILAKNTAIKWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTK
EEEEECCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDFPIVYASALNGFATL
HHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEC
DPDEVSADMTPLFETIVEKVSSPDADAEGDFQMQISQIDYNSYVGVIGIGRIKRGSVKTN
CHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEEECCEECCCCCCC
QQVTILGADGKKRNGKIGQVLGYMGLERHEVSDATAGDIVAITGLGQLLISDTVCATTNV
CEEEEEECCCCCCCCCHHHHHHHCCCCHHCCCCCCCCCEEEEECCCHHHHCCCEEECCCC
EALPPLSVDEPTLTMTFQVNTSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPD
CCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHEEEEECCCCCC
RFRVSGRGELHLSILIENMRREGYELAVSRPEVIVKEIDGEMCEPFETLTVDVQEEHQGA
EEEECCCCCEEEEEEEHHHHCCCEEEEECCCHHHHHHCCCCCCCCCEEEEEEECCCCCCH
VIEKLGIRKGDMKDMQLDGKGRVRIDFVIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGP
HHHHHCCCCCCCCCEEECCCCCEEEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCCCC
LKGGDIGQRARGVLISNATGKALTFALFGLQERGRLFITHATEVYEGQVVGLHARANDLT
CCCCCCCCHHCEEEEECCCCCEEEEEEECCCCCCCEEEEECCEEECCEEEEEEECCCCEE
VNCLKGKQLTNMRASGTDEAQVLTPHIEMTLEQALEFIDDDELVEVTPLNIRVRKRFLTE
EEEECCCEECCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCCEEEEECCCEEEHHHHHCC
NERKRHNRK
CHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]