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The map label for this gene is mutL

Identifier: 157963356

GI number: 157963356

Start: 4324926

End: 4326812

Strand: Reverse

Name: mutL

Synonym: Spea_3542

Alternate gene names: 157963356

Gene position: 4326812-4324926 (Counterclockwise)

Preceding gene: 157963357

Following gene: 157963355

Centisome position: 83.62

GC content: 47.59

Gene sequence:

>1887_bases
ATGGCAATAGAAAAATTACCGCCACAATTAGCTAATCAGATCGCCGCAGGTGAGGTGGTCGAACGTCCTGCATCTGTGAT
TAAAGAGCTGGTTGAAAACAGTCTCGATGCAGGGGCTACACGCGTCGATATCGAGATTGAAAAAGGCGGCGCTAAACTTA
TTCGGATCCGCGATAATGGCTCAGGGATCCCAAAAGAAGATCTGAGTCTAGCTTTGTCTCGACATGCCACGTCCAAGCTT
AAATCGCTGGATGATTTAGAGGCTATTTTGAGCTTTGGTTTTCGCGGCGAAGCGTTAGCGAGTATTAGCTCTGTTTCGCG
GCTTATCTTAACCTCACGAACAGCCGAGCAAACAGAGGCCTGGCAAGCGCACGCCGAGGGTACCGAGATGGCCGTTAAGG
TATTACCAGCGGCTCATCCTGTCGGTTCAACTGTCGAAGCTGTGGATTTGTTTTTTAATACCCCAGCAAGGCGTCGTTTC
TTAAAGAGTGATAAGACAGAGTTCACCCATATTGATGAGTGGCTCAAGCGTATAGCTTTGGCTAGGCGTGATATCCATTT
CACCTTAAAACACAACGGTAAGACGGTACGCAATTACCGTCCTGCGAATACCGAGATTCAGTATATTCAGCGCTTGGGGC
AAATCTGCGGTAAAGCATTCGCAGAAACCTGCCTGCGTATAGAGTGTGAGCATAATGACTTAAAACTAAGTGGTTACTTA
CAATCACCTAGTGCTGCTAGCGGCTACAGTGAGACCCAGTATTTCTATGTGAATGGTCGCCTAGTAAAAGACAGACTGGT
TAATCACGCCGTTCGTCAGGCGTTTTCGCAATATGCCGAGGGTATTTCTCCTGGTTACGTGCTGATGCTAGAGCTTGACC
CGCATCAAGTGGATGTGAACGTACATCCGGCAAAACATGAGGTACGTTTTCATCAGAGTCGTTACGTACACGACTATATT
TTACAAGCCCTGCAGTCGGCGATGGCGCAATCGACTCAACTTAGTGTTGATATAGAACCAGAGTCCGAACAGACTACTGC
ATGGCAAACAAGCCCGACGCGAGGAGCTGTAGCACCGTCTCACTACGTTGACGAATCGAAGAGTAAGCCATCGGCAGTGT
TCGATGTACGTGAAAGACACTCAAGCGCCAGTCAAGCGGGTTACTCAGGGGGCGGGGGGAGTTATAGGAGTCAACTTAAA
CCAGCTTCTAGAAACTCCGAGGTAAGTTTACCCTCTCAGACGAGTATTCGTGCATATGGTGAGCTCTTGAGTACTGACTC
TGTTCAGACTCAAAGCACGAATGTGCCTCTACGTCCAGCAGCTCATCAAGCCGGCATGATGTCTACCTCTCATGGGGCGG
CGAGTATGCCGCCAGTCATAGCGGGCCAATACTGGGTGCTAGTTAAAGAGGATAAAATATCTCTGCTGGATATTGCCATG
GTAGCAAAGGCGGCATTGAAAGCAGAAATAGCAGCCAAGCTTGCACAAGGTATAATTGGCCAACCTTTATTGATGCCTGT
AGCGATTAGTGTTGATGATGATTGGCCTGAGATTATCGATAATCGTGAGCAGTTATTACGAAAGTTGGGAATAGAGCTCT
CTATTCGTCTCGGGCAGTTGATTATTAAGAAAGTGCCCCCATATCTAAGAGATAGTCAACTGGCAGCCTTAATCCCTGAA
TTACTAGAGTGGATTAGATTAGAATTACCAAGCGATGCCGCTGTTATAAAGTGGCTTGCAGAGCAAGCAGCAAACCGATT
TACTTCGGCCAGTGAGGCATGGTTTGCCTTCAGTGCATTGCCGGATGATGTGCAGTGTGAGCTTTATAATCACTCCCAAG
AGTTACCTTGGGAGCAATGGATGAAAGAAAATCAGAGTGACCGATAA

Upstream 100 bases:

>100_bases
ATAAGCCGTTTGAAGAAGGCAAACAACCTTAAATCAAATAACCTACGAATTGGTCAGAAATTAAAGATTCCGAGTGCGTA
AGGGCTTTTGAGAGTACACA

Downstream 100 bases:

>100_bases
AAAATCACAGAAAGTTATTACCTTGATGGGGCCTACAGCCTCAGGTAAAACCGCATTAGCGATTGAGCTTGTTAAGCAGT
ATGACTGTGAGATCATCTCT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MAIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGAKLIRIRDNGSGIPKEDLSLALSRHATSKL
KSLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQTEAWQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALARRDIHFTLKHNGKTVRNYRPANTEIQYIQRLGQICGKAFAETCLRIECEHNDLKLSGYL
QSPSAASGYSETQYFYVNGRLVKDRLVNHAVRQAFSQYAEGISPGYVLMLELDPHQVDVNVHPAKHEVRFHQSRYVHDYI
LQALQSAMAQSTQLSVDIEPESEQTTAWQTSPTRGAVAPSHYVDESKSKPSAVFDVRERHSSASQAGYSGGGGSYRSQLK
PASRNSEVSLPSQTSIRAYGELLSTDSVQTQSTNVPLRPAAHQAGMMSTSHGAASMPPVIAGQYWVLVKEDKISLLDIAM
VAKAALKAEIAAKLAQGIIGQPLLMPVAISVDDDWPEIIDNREQLLRKLGIELSIRLGQLIIKKVPPYLRDSQLAALIPE
LLEWIRLELPSDAAVIKWLAEQAANRFTSASEAWFAFSALPDDVQCELYNHSQELPWEQWMKENQSDR

Sequences:

>Translated_628_residues
MAIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGAKLIRIRDNGSGIPKEDLSLALSRHATSKL
KSLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQTEAWQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALARRDIHFTLKHNGKTVRNYRPANTEIQYIQRLGQICGKAFAETCLRIECEHNDLKLSGYL
QSPSAASGYSETQYFYVNGRLVKDRLVNHAVRQAFSQYAEGISPGYVLMLELDPHQVDVNVHPAKHEVRFHQSRYVHDYI
LQALQSAMAQSTQLSVDIEPESEQTTAWQTSPTRGAVAPSHYVDESKSKPSAVFDVRERHSSASQAGYSGGGGSYRSQLK
PASRNSEVSLPSQTSIRAYGELLSTDSVQTQSTNVPLRPAAHQAGMMSTSHGAASMPPVIAGQYWVLVKEDKISLLDIAM
VAKAALKAEIAAKLAQGIIGQPLLMPVAISVDDDWPEIIDNREQLLRKLGIELSIRLGQLIIKKVPPYLRDSQLAALIPE
LLEWIRLELPSDAAVIKWLAEQAANRFTSASEAWFAFSALPDDVQCELYNHSQELPWEQWMKENQSDR
>Mature_627_residues
AIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGAKLIRIRDNGSGIPKEDLSLALSRHATSKLK
SLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQTEAWQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRFL
KSDKTEFTHIDEWLKRIALARRDIHFTLKHNGKTVRNYRPANTEIQYIQRLGQICGKAFAETCLRIECEHNDLKLSGYLQ
SPSAASGYSETQYFYVNGRLVKDRLVNHAVRQAFSQYAEGISPGYVLMLELDPHQVDVNVHPAKHEVRFHQSRYVHDYIL
QALQSAMAQSTQLSVDIEPESEQTTAWQTSPTRGAVAPSHYVDESKSKPSAVFDVRERHSSASQAGYSGGGGSYRSQLKP
ASRNSEVSLPSQTSIRAYGELLSTDSVQTQSTNVPLRPAAHQAGMMSTSHGAASMPPVIAGQYWVLVKEDKISLLDIAMV
AKAALKAEIAAKLAQGIIGQPLLMPVAISVDDDWPEIIDNREQLLRKLGIELSIRLGQLIIKKVPPYLRDSQLAALIPEL
LEWIRLELPSDAAVIKWLAEQAANRFTSASEAWFAFSALPDDVQCELYNHSQELPWEQWMKENQSDR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=339, Percent_Identity=36.5781710914454, Blast_Score=216, Evalue=6e-56,
Organism=Homo sapiens, GI4505911, Length=340, Percent_Identity=29.4117647058824, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI189458898, Length=340, Percent_Identity=29.4117647058824, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI189458896, Length=339, Percent_Identity=28.9085545722714, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI4505913, Length=341, Percent_Identity=26.6862170087977, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI310128478, Length=341, Percent_Identity=26.6862170087977, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI263191589, Length=244, Percent_Identity=30.7377049180328, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI91992162, Length=341, Percent_Identity=24.9266862170088, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI91992160, Length=341, Percent_Identity=24.9266862170088, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310128480, Length=293, Percent_Identity=23.8907849829352, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=570, Percent_Identity=48.7719298245614, Blast_Score=494, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71991825, Length=325, Percent_Identity=35.3846153846154, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17562796, Length=345, Percent_Identity=26.6666666666667, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=320, Percent_Identity=39.0625, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324247, Length=342, Percent_Identity=26.3157894736842, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6325093, Length=307, Percent_Identity=26.3843648208469, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=357, Percent_Identity=24.3697478991597, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136968, Length=341, Percent_Identity=35.4838709677419, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.0504201680672, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_SHEPA (A8H8G8)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001503390.1
- ProteinModelPortal:   A8H8G8
- STRING:   A8H8G8
- GeneID:   5663928
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_3542
- NMPDR:   fig|398579.3.peg.3056
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FTHIDEW
- ProtClustDB:   PRK00095
- BioCyc:   SPEA398579:SPEA_3542-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 69497; Mature: 69366

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGAKLIRIRDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
SGIPKEDLSLALSRHATSKLKSLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQTEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
WQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHCCCHHEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
ARRDIHFTLKHNGKTVRNYRPANTEIQYIQRLGQICGKAFAETCLRIECEHNDLKLSGYL
HHCCEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEE
QSPSAASGYSETQYFYVNGRLVKDRLVNHAVRQAFSQYAEGISPGYVLMLELDPHQVDVN
CCCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEE
VHPAKHEVRFHQSRYVHDYILQALQSAMAQSTQLSVDIEPESEQTTAWQTSPTRGAVAPS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCCCCCCH
HYVDESKSKPSAVFDVRERHSSASQAGYSGGGGSYRSQLKPASRNSEVSLPSQTSIRAYG
HHCCCCCCCCCHHHHHHHHHCHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHH
ELLSTDSVQTQSTNVPLRPAAHQAGMMSTSHGAASMPPVIAGQYWVLVKEDKISLLDIAM
HHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEECCCEEEEEECCCCHHHHHHH
VAKAALKAEIAAKLAQGIIGQPLLMPVAISVDDDWPEIIDNREQLLRKLGIELSIRLGQL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCHHHHHHHHCCEEEEHHHHH
IIKKVPPYLRDSQLAALIPELLEWIRLELPSDAAVIKWLAEQAANRFTSASEAWFAFSAL
HHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHEEEECC
PDDVQCELYNHSQELPWEQWMKENQSDR
CCCCEEEEECCCCCCCHHHHHHCCCCCC
>Mature Secondary Structure 
AIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGAKLIRIRDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
SGIPKEDLSLALSRHATSKLKSLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQTEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
WQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHCCCHHEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
ARRDIHFTLKHNGKTVRNYRPANTEIQYIQRLGQICGKAFAETCLRIECEHNDLKLSGYL
HHCCEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEE
QSPSAASGYSETQYFYVNGRLVKDRLVNHAVRQAFSQYAEGISPGYVLMLELDPHQVDVN
CCCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEE
VHPAKHEVRFHQSRYVHDYILQALQSAMAQSTQLSVDIEPESEQTTAWQTSPTRGAVAPS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCCCCCCH
HYVDESKSKPSAVFDVRERHSSASQAGYSGGGGSYRSQLKPASRNSEVSLPSQTSIRAYG
HHCCCCCCCCCHHHHHHHHHCHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHH
ELLSTDSVQTQSTNVPLRPAAHQAGMMSTSHGAASMPPVIAGQYWVLVKEDKISLLDIAM
HHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEECCCEEEEEECCCCHHHHHHH
VAKAALKAEIAAKLAQGIIGQPLLMPVAISVDDDWPEIIDNREQLLRKLGIELSIRLGQL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCHHHHHHHHCCEEEEHHHHH
IIKKVPPYLRDSQLAALIPELLEWIRLELPSDAAVIKWLAEQAANRFTSASEAWFAFSAL
HHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHEEEECC
PDDVQCELYNHSQELPWEQWMKENQSDR
CCCCEEEEECCCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA