Click here to switch to the map view.

The map label for this gene is pth [H]

Identifier: 157962951

GI number: 157962951

Start: 3838700

End: 3839326

Strand: Reverse

Name: pth [H]

Synonym: Spea_3134

Alternate gene names: 157962951

Gene position: 3839326-3838700 (Counterclockwise)

Preceding gene: 157962952

Following gene: 157962950

Centisome position: 74.2

GC content: 46.09

Gene sequence:

>627_bases
TTGGCGGCAAAACTTAAGTTAGGCAATAACAGACTAGGTACTATGAGCAATATTAAACTGATAGTTGGGCTTGCAAACCC
CGGCGCGCAGTATGAACGGACTCGTCATAATGCTGGCGCGTGGTACGTTGAAGAACTCGCTAGAGTCTGTGGTGCCACAT
TAACACTAGACAGTAAATACTTTGGCATGACAGCGAGAGTGACGCTGCATGGTAAAGATGTACGTCTACTTATACCGACG
ACCTTTATGAATTTAAGCGGAAAGTCGGTAGGGGCGTTAGCGAACTTTTTTCGCATCGCCCCAGAAGAGATTTTAGTAGC
GCACGATGAGCTAGATATGCCACCGGGTGTTGCAAAGTTTAAGTTGGGCGGTGGTCACGGTGGTCATAACGGTCTTAAAG
ATATCATTGCAAAATTAGCGAATGATAAAGGCTTCTACCGATTACGCATCGGCATAGGCCATCCTGGTGATAAGAGTCAG
GTGAGCAATTATGTGCTGAGTAAGGCCTCCCCAACAGATCAAGAACTGATGGACGCTGCGATTGATGAAGCGGTACGTTC
GACAGAAGTCTTGTTCAACCAAGATATGGCAAAGGCGATGCATAGACTGCATTCTTTTAAAGCATAA

Upstream 100 bases:

>100_bases
GGTTACAAATTAAAATAATGGAAATTTGCGTATAATTTGTTGGCAGGCTATTTGAGTGCTAAAATGTCGCGTTTTTAATT
TTGCTGCTGGGTTATTTTGC

Downstream 100 bases:

>100_bases
ACAAGTGCTTGGAGCAAAGCTTCAAGTCATTCATTGATATTAAAGGTAACAATATGGGTTTCAAATGTGGCATCGTAGGC
CTGCCAAACGTTGGTAAATC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MAAKLKLGNNRLGTMSNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKYFGMTARVTLHGKDVRLLIPT
TFMNLSGKSVGALANFFRIAPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKGFYRLRIGIGHPGDKSQ
VSNYVLSKASPTDQELMDAAIDEAVRSTEVLFNQDMAKAMHRLHSFKA

Sequences:

>Translated_208_residues
MAAKLKLGNNRLGTMSNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKYFGMTARVTLHGKDVRLLIPT
TFMNLSGKSVGALANFFRIAPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKGFYRLRIGIGHPGDKSQ
VSNYVLSKASPTDQELMDAAIDEAVRSTEVLFNQDMAKAMHRLHSFKA
>Mature_207_residues
AAKLKLGNNRLGTMSNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKYFGMTARVTLHGKDVRLLIPTT
FMNLSGKSVGALANFFRIAPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKGFYRLRIGIGHPGDKSQV
SNYVLSKASPTDQELMDAAIDEAVRSTEVLFNQDMAKAMHRLHSFKA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=177, Percent_Identity=36.7231638418079, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=68.2291666666667, Blast_Score=251, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22602; Mature: 22471

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKLKLGNNRLGTMSNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKY
CCCEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHCCCEEEECCCC
FGMTARVTLHGKDVRLLIPTTFMNLSGKSVGALANFFRIAPEEILVAHDELDMPPGVAKF
CCEEEEEEEECCCEEEEECEEEECCCCCHHHHHHHHHHCCCHHHEEECCCCCCCCCCEEE
KLGGGHGGHNGLKDIIAKLANDKGFYRLRIGIGHPGDKSQVSNYVLSKASPTDQELMDAA
EECCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHH
IDEAVRSTEVLFNQDMAKAMHRLHSFKA
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAKLKLGNNRLGTMSNIKLIVGLANPGAQYERTRHNAGAWYVEELARVCGATLTLDSKY
CCEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHCCCEEEECCCC
FGMTARVTLHGKDVRLLIPTTFMNLSGKSVGALANFFRIAPEEILVAHDELDMPPGVAKF
CCEEEEEEEECCCEEEEECEEEECCCCCHHHHHHHHHHCCCHHHEEECCCCCCCCCCEEE
KLGGGHGGHNGLKDIIAKLANDKGFYRLRIGIGHPGDKSQVSNYVLSKASPTDQELMDAA
EECCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHH
IDEAVRSTEVLFNQDMAKAMHRLHSFKA
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA