Click here to switch to the map view.

The map label for this gene is fadE [H]

Identifier: 157962159

GI number: 157962159

Start: 2848256

End: 2850538

Strand: Reverse

Name: fadE [H]

Synonym: Spea_2338

Alternate gene names: 157962159

Gene position: 2850538-2848256 (Counterclockwise)

Preceding gene: 157962160

Following gene: 157962156

Centisome position: 55.09

GC content: 45.73

Gene sequence:

>2283_bases
ATGGCTACGACATTATTAGTACTGTTGCTTATCGCAATAGTCGTTGTATTCAGCGTTAAAAACATCAGGATGCAGTTAAT
TACGCGTCCTGTATTTAGTTTTTTCAAAAAAGTATTGCCACCACTTTCTGTTACTGAGAAAGAAGCGATGGAAGCGGGCG
ATGTATGGTGGGAAGGCGAGCTATTTAAAGGCAAACCTAACTGGCAGTTACTTCACAGTTACGGTAAACCGACGCTGACA
TCAGAAGAGCAAGACTTTATCGATAATCAAGTCATGACAGCATTAACTATGATCGATGATTACGACATAGTGAATAACAG
AAAAGACTTACCGCCAGAACTTTGGCAATACTTCAAGAAAGAAGGCTTCTTTGCGTTAATCATTCCAAAAAAATATGGTG
GTAAGGCGTTTTCGGCTTACGCAAACTCGACTATCGTCAGTAAGATTGCCAGCCGTAGCGTTAGCGCGGCAGTAACCGTT
ATGGTACCTAACTCATTAGGTCCTGGAGAGCTATTGACCCATTATGGTACTAGCGAACAGAAAGATTATTGGTTACCCCA
ACTTGCCGATGGCAGTGCCATTCCTTGTTTTGCCTTAACGGGTCCAGACGCGGGCAGTGATGCTGGTGCAATTCCTGACA
CTGGTATCGTTTGTCGCCAAGAGTTTAATGGGGAAGAAGTACTCGGCCTAAAACTGAATTGGGATAAACGATATATAACC
CTTGCTCCTGTAGCTGATGTGCTCGGTCTTGCATTTCAGATGTCCGATCCAGATGGCTTGTTAGGTGACACAAAACATAT
CGGCATCACCTGTGCGTTAATTCCAACTGATCATGAAGGCGTCGAGATTGGTAGTCGTCATAATCCGCTCAATATGGCGT
TTATGAATGGTACGACCCGAGGTAAAGATGTGTTTATTCCATTGGATTGGATCATCGGTGGCCCTCAATATGCGGGACGC
GGCTGGAGAATGCTAGTTGAGTGTTTGTCGGCTGGTCGTGGCATTTCACTACCCGCTTTATCAACCGCTTCAGGCCATAT
GGCTACCAAGACGACGACGGCCTACAGCGCAGTGCGTCAGCAGTTTGGTCTGGATATTGGTCAATTTGAAGGGGTGCAAG
AGGCACTTGCTCGTGTGATTGCCAATACGTATCAACTTGAAGCCGCAAGACGTTTAACCACCACCGGCATCGACTTAAAG
GTTAAGCCGTCAGTTGTGACCGCAATTGCTAAATATCATATGACTGAGCTTGGTCGAAAGGTGATTGATGATGCGATGGA
CATTCAGTCGGGTAAGGGCATTCAGCTTGGACCTAAGAATTATCTAGGCCATGGTTATATGGCGCTGCCAATCTCTATCA
CGGTAGAAGGGGCAAATATTCTAACCAGAAGTTTGATGATTTTCGGCCAAGGGGCAACACGTTGTCACCCTTATGTGCTA
GCTGAGATGGAAGCGGCGGGAATGCAAGACACCAGTGAAGGCCTTGAGCGTTTCGATGACTTGTTACTGGGACATATTGG
CTATGCGACTCGTAATGCCTTTAGCGCGTTAGGTAATGCCTTGACTGGCAGCCGTTTTGCTCAATCACCAGTGAGTGGTG
AAACCAAGCAGTATTATAAAGACATGACGCGTTTATCTGCTGGCTTAGCCTTGATGACAGATGTTTCTATGCTTATTCTT
GGCGGCGATCTGAAACGTAAAGAGATGCTAAGTGCACGTATGGGCGATGTGTTAAGTCAGCTATATCTTGGTTCTGCGAC
CTTAAAACTTTTTGAAGATAATGGTCGTCAGTTTGATGACTTACCAGCGGTACGCCACGTTATGGCTACCCGTCTTCACT
TAGCGGCAAAAGCGTTAGATGAAGCGATTCGTAACTTCCCAAATCGCGGGGTTGCATTGCTGCTGCGTGCATTAATCTTC
CCGCTTGGTAACCGATTTAAAGATGCGAGTGATAAGCTATCGATTGATTTGGCCAATGCGATGAATAAGCAAGGTCCAGC
TCGTGACAGGTTAACTTTCTTGTGCCCAAGTTTTGATGGGGATACAAGTGGTATTACCGAAGTTGAAAATGCCTTTATTG
CTAAACATGGGTGCAAAGGGCTGTATAAGAAGCTTAAGCAAGCACAGAAAGAGGGCAGCTTACCGAAGAAGTTGCCAGCA
GTGGCATTGTTTGGCGCTGCATTGGAGATCTCGTTAATCTCAGAGCAAGAGCACCAAAACTTGATTAAAGCTGATGAGCT
GCGCTTAGCTGCTATCGCTGTTGACGAGTTCGATAAACTTTAA

Upstream 100 bases:

>100_bases
TTGGGGAGCAAAATGATATTGAAGCTGTTATCAGAAAAGTCATTCCGTATTTGTCTGCCGGAGTGTCCGTTCCACTTACT
AAGGATGTAATGTAAAAATT

Downstream 100 bases:

>100_bases
CCCGTTTATTGAGTATAAAAAAAGGTACGCAATGCGTACCTTTTTTATTGACTAAATCCCTAATGATTTAAGGGGGAGTA
TGGTTTAAACAACAACAACC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MATTLLVLLLIAIVVVFSVKNIRMQLITRPVFSFFKKVLPPLSVTEKEAMEAGDVWWEGELFKGKPNWQLLHSYGKPTLT
SEEQDFIDNQVMTALTMIDDYDIVNNRKDLPPELWQYFKKEGFFALIIPKKYGGKAFSAYANSTIVSKIASRSVSAAVTV
MVPNSLGPGELLTHYGTSEQKDYWLPQLADGSAIPCFALTGPDAGSDAGAIPDTGIVCRQEFNGEEVLGLKLNWDKRYIT
LAPVADVLGLAFQMSDPDGLLGDTKHIGITCALIPTDHEGVEIGSRHNPLNMAFMNGTTRGKDVFIPLDWIIGGPQYAGR
GWRMLVECLSAGRGISLPALSTASGHMATKTTTAYSAVRQQFGLDIGQFEGVQEALARVIANTYQLEAARRLTTTGIDLK
VKPSVVTAIAKYHMTELGRKVIDDAMDIQSGKGIQLGPKNYLGHGYMALPISITVEGANILTRSLMIFGQGATRCHPYVL
AEMEAAGMQDTSEGLERFDDLLLGHIGYATRNAFSALGNALTGSRFAQSPVSGETKQYYKDMTRLSAGLALMTDVSMLIL
GGDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQFDDLPAVRHVMATRLHLAAKALDEAIRNFPNRGVALLLRALIF
PLGNRFKDASDKLSIDLANAMNKQGPARDRLTFLCPSFDGDTSGITEVENAFIAKHGCKGLYKKLKQAQKEGSLPKKLPA
VALFGAALEISLISEQEHQNLIKADELRLAAIAVDEFDKL

Sequences:

>Translated_760_residues
MATTLLVLLLIAIVVVFSVKNIRMQLITRPVFSFFKKVLPPLSVTEKEAMEAGDVWWEGELFKGKPNWQLLHSYGKPTLT
SEEQDFIDNQVMTALTMIDDYDIVNNRKDLPPELWQYFKKEGFFALIIPKKYGGKAFSAYANSTIVSKIASRSVSAAVTV
MVPNSLGPGELLTHYGTSEQKDYWLPQLADGSAIPCFALTGPDAGSDAGAIPDTGIVCRQEFNGEEVLGLKLNWDKRYIT
LAPVADVLGLAFQMSDPDGLLGDTKHIGITCALIPTDHEGVEIGSRHNPLNMAFMNGTTRGKDVFIPLDWIIGGPQYAGR
GWRMLVECLSAGRGISLPALSTASGHMATKTTTAYSAVRQQFGLDIGQFEGVQEALARVIANTYQLEAARRLTTTGIDLK
VKPSVVTAIAKYHMTELGRKVIDDAMDIQSGKGIQLGPKNYLGHGYMALPISITVEGANILTRSLMIFGQGATRCHPYVL
AEMEAAGMQDTSEGLERFDDLLLGHIGYATRNAFSALGNALTGSRFAQSPVSGETKQYYKDMTRLSAGLALMTDVSMLIL
GGDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQFDDLPAVRHVMATRLHLAAKALDEAIRNFPNRGVALLLRALIF
PLGNRFKDASDKLSIDLANAMNKQGPARDRLTFLCPSFDGDTSGITEVENAFIAKHGCKGLYKKLKQAQKEGSLPKKLPA
VALFGAALEISLISEQEHQNLIKADELRLAAIAVDEFDKL
>Mature_759_residues
ATTLLVLLLIAIVVVFSVKNIRMQLITRPVFSFFKKVLPPLSVTEKEAMEAGDVWWEGELFKGKPNWQLLHSYGKPTLTS
EEQDFIDNQVMTALTMIDDYDIVNNRKDLPPELWQYFKKEGFFALIIPKKYGGKAFSAYANSTIVSKIASRSVSAAVTVM
VPNSLGPGELLTHYGTSEQKDYWLPQLADGSAIPCFALTGPDAGSDAGAIPDTGIVCRQEFNGEEVLGLKLNWDKRYITL
APVADVLGLAFQMSDPDGLLGDTKHIGITCALIPTDHEGVEIGSRHNPLNMAFMNGTTRGKDVFIPLDWIIGGPQYAGRG
WRMLVECLSAGRGISLPALSTASGHMATKTTTAYSAVRQQFGLDIGQFEGVQEALARVIANTYQLEAARRLTTTGIDLKV
KPSVVTAIAKYHMTELGRKVIDDAMDIQSGKGIQLGPKNYLGHGYMALPISITVEGANILTRSLMIFGQGATRCHPYVLA
EMEAAGMQDTSEGLERFDDLLLGHIGYATRNAFSALGNALTGSRFAQSPVSGETKQYYKDMTRLSAGLALMTDVSMLILG
GDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQFDDLPAVRHVMATRLHLAAKALDEAIRNFPNRGVALLLRALIFP
LGNRFKDASDKLSIDLANAMNKQGPARDRLTFLCPSFDGDTSGITEVENAFIAKHGCKGLYKKLKQAQKEGSLPKKLPAV
ALFGAALEISLISEQEHQNLIKADELRLAAIAVDEFDKL

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=383, Percent_Identity=27.154046997389, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI4557235, Length=408, Percent_Identity=25, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=25.7731958762887, Blast_Score=97, Evalue=8e-20,
Organism=Homo sapiens, GI4557233, Length=382, Percent_Identity=28.0104712041885, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4501859, Length=368, Percent_Identity=28.5326086956522, Blast_Score=91, Evalue=6e-18,
Organism=Escherichia coli, GI87081702, Length=759, Percent_Identity=52.3056653491436, Blast_Score=776, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=439, Percent_Identity=25.5125284738041, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=283, Percent_Identity=30.7420494699647, Blast_Score=96, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71985192, Length=351, Percent_Identity=25.3561253561254, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=292, Percent_Identity=27.7397260273973, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=27.2108843537415, Blast_Score=83, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17570075, Length=330, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17533517, Length=367, Percent_Identity=25.0681198910082, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17569725, Length=335, Percent_Identity=25.9701492537313, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71982178, Length=239, Percent_Identity=28.8702928870293, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534899, Length=338, Percent_Identity=25.7396449704142, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356377, Length=359, Percent_Identity=27.5766016713092, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281363737, Length=355, Percent_Identity=25.9154929577465, Blast_Score=90, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24666513, Length=330, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355753, Length=341, Percent_Identity=24.9266862170088, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 82907; Mature: 82775

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTLLVLLLIAIVVVFSVKNIRMQLITRPVFSFFKKVLPPLSVTEKEAMEAGDVWWEGE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEECCE
LFKGKPNWQLLHSYGKPTLTSEEQDFIDNQVMTALTMIDDYDIVNNRKDLPPELWQYFKK
EECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHH
EGFFALIIPKKYGGKAFSAYANSTIVSKIASRSVSAAVTVMVPNSLGPGELLTHYGTSEQ
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCC
KDYWLPQLADGSAIPCFALTGPDAGSDAGAIPDTGIVCRQEFNGEEVLGLKLNWDKRYIT
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCEEEE
LAPVADVLGLAFQMSDPDGLLGDTKHIGITCALIPTDHEGVEIGSRHNPLNMAFMNGTTR
ECCHHHHHHHEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCC
GKDVFIPLDWIIGGPQYAGRGWRMLVECLSAGRGISLPALSTASGHMATKTTTAYSAVRQ
CCEEEEEHHEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHH
QFGLDIGQFEGVQEALARVIANTYQLEAARRLTTTGIDLKVKPSVVTAIAKYHMTELGRK
HHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEECHHHHHHHHHHHHHHHHHH
VIDDAMDIQSGKGIQLGPKNYLGHGYMALPISITVEGANILTRSLMIFGQGATRCHPYVL
HHHHHHHCCCCCCCEECCCCCCCCCEEEEEEEEEECCHHHHHHHHHEECCCCCCCCCCEE
AEMEAAGMQDTSEGLERFDDLLLGHIGYATRNAFSALGNALTGSRFAQSPVSGETKQYYK
EEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHH
DMTRLSAGLALMTDVSMLILGGDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQFDD
HHHHHHHCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHH
LPAVRHVMATRLHLAAKALDEAIRNFPNRGVALLLRALIFPLGNRFKDASDKLSIDLANA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEHHHH
MNKQGPARDRLTFLCPSFDGDTSGITEVENAFIAKHGCKGLYKKLKQAQKEGSLPKKLPA
HCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCH
VALFGAALEISLISEQEHQNLIKADELRLAAIAVDEFDKL
HHHHHHHEEEEEECCHHHHHHHHHHCEEEEEEEHHHHCCC
>Mature Secondary Structure 
ATTLLVLLLIAIVVVFSVKNIRMQLITRPVFSFFKKVLPPLSVTEKEAMEAGDVWWEGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEECCE
LFKGKPNWQLLHSYGKPTLTSEEQDFIDNQVMTALTMIDDYDIVNNRKDLPPELWQYFKK
EECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHH
EGFFALIIPKKYGGKAFSAYANSTIVSKIASRSVSAAVTVMVPNSLGPGELLTHYGTSEQ
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCC
KDYWLPQLADGSAIPCFALTGPDAGSDAGAIPDTGIVCRQEFNGEEVLGLKLNWDKRYIT
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCEEEE
LAPVADVLGLAFQMSDPDGLLGDTKHIGITCALIPTDHEGVEIGSRHNPLNMAFMNGTTR
ECCHHHHHHHEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCC
GKDVFIPLDWIIGGPQYAGRGWRMLVECLSAGRGISLPALSTASGHMATKTTTAYSAVRQ
CCEEEEEHHEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHH
QFGLDIGQFEGVQEALARVIANTYQLEAARRLTTTGIDLKVKPSVVTAIAKYHMTELGRK
HHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEECHHHHHHHHHHHHHHHHHH
VIDDAMDIQSGKGIQLGPKNYLGHGYMALPISITVEGANILTRSLMIFGQGATRCHPYVL
HHHHHHHCCCCCCCEECCCCCCCCCEEEEEEEEEECCHHHHHHHHHEECCCCCCCCCCEE
AEMEAAGMQDTSEGLERFDDLLLGHIGYATRNAFSALGNALTGSRFAQSPVSGETKQYYK
EEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHH
DMTRLSAGLALMTDVSMLILGGDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQFDD
HHHHHHHCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHH
LPAVRHVMATRLHLAAKALDEAIRNFPNRGVALLLRALIFPLGNRFKDASDKLSIDLANA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEHHHH
MNKQGPARDRLTFLCPSFDGDTSGITEVENAFIAKHGCKGLYKKLKQAQKEGSLPKKLPA
HCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCH
VALFGAALEISLISEQEHQNLIKADELRLAAIAVDEFDKL
HHHHHHHEEEEEECCHHHHHHHHHHCEEEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]