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The map label for this gene is zwf [H]

Identifier: 157962156

GI number: 157962156

Start: 2843908

End: 2845404

Strand: Reverse

Name: zwf [H]

Synonym: Spea_2335

Alternate gene names: 157962156

Gene position: 2845404-2843908 (Counterclockwise)

Preceding gene: 157962159

Following gene: 157962155

Centisome position: 54.99

GC content: 45.16

Gene sequence:

>1497_bases
GTGTCAAAAGGAGATATTGAAGCGATGGGCATTACGACACCTAAAGCCAAAGCTTGTGATTTTGTTCTATTTGGTACCAA
GGGAGATCTTGCGAAGCGTAAGTTACTTCCTTCTTTATACCAACTCGATAAAGCCAATTTGCTGAATGTCGATACTAAAA
TCCTCGGCGTCGCAAAGGATGAATTTAGTCAAGAAGAATACCGCGAGCTGGTGGTAAACGCCTTAACGACTTTTGTAAAA
GACGAGCTTTGTGAAGAGACGGTGAACCGTTTCTTAGACCGTTGTCATTATGTAGGCACCAACTTCACAGAGTCTGATGG
CTATCAAGCTTTCCACGATATTCTCGAGCCAGAAAAACGCGTCATGGTGAGTTACTTCGCCACTCCTCCTGCTATTTTTG
GCGATATCTGTCGTTGCCTTCACGAACAAAAACTTATTTTCCCTGACTCTCGCGTCGTTCTAGAAAAACCAATCGGTTCC
GATCTCGCAAGTTCTCGCATCATTAACGACCAAGTCTCAGCCTATTTCGAAGAAACCCAAGTTTATCGTATCGACCATTA
CTTAGGTAAAGAGACGGTGCAAAACTTACTTGCATTGCGTTTTGCCAACTCTCTTTTCGCTTCTAAGTGGGATAACCGTA
CTATCGATCATGTACAGCTAACTGTTGCTGAAGAGGTGGGTATCGAAGGCCGTTGGGGTTATTTCGACAAAGCGGGCCAG
ATGCGCGACATGATCCAAAATCATCTATTACAGGTATTAACCTTAGTGGCGATGGATCCACCAGTTAACTTAGATGCTGA
CAATATTCGTGACGAAAAAGTAAAAGTGCTTAAGTCACTGCGACCAATCAATGCTGATAACATCTATGAGAATACGGTTC
GTGGTCAATATAGCTCTGGTTTCTTAAAAGGCGCTCCGGTTCCAGGTTACTTAGAGGAAGAGGGCGCGAATGTTCAGTCT
AAAGCTGAAACCTTTGTAGCACTTCGCGTAGACATCGATAACTGGCGCTGGGCTGGCGTGCCATTCTACCTTCGTAGTGG
CAAGCGTATGCCGTTTAAGAGTTCAGAAATCGTGGTGTATTTTAAAAATCCACCGCACAACCTATACAGTTCAAATTATC
GTAATCTGCCACCGAATAAACTGACAATACGATTACAGCCTCATGAAGGGGTTGAAATCCAGATGTTGAATAAGGTGCCG
GGTCTAGGTGAAAAGCAGCGTCTACAAACCACCAAACTCGATTTAAGTTTCTCTGAAACATTCAAGAGTGAACGAATTGC
CGATGCATACGAGCGTTTATTGCTTGAAGCCATGTTAGGCAATCAGGCGCTGTTTGTACGCCGAGATGAAGTCGAGCAGG
CGTGGAGCTGGGTCGATGGTATTATTCAAGCGTGGGAAGAAACAGACGAAACGCCAAAGCCTTACCCTGCTGGCACATGG
GGCCCAGTCGCCTCTGTTGCGCTTATCACTAAAGATGGCCGTTCTTGGGACGAGTAA

Upstream 100 bases:

>100_bases
AGCTAACTTGAAGTTTATTATAAAATTTAGATGCAATTAGCTATTTCTGTTGTTATATTACAACAAACGTGTGAATTCTC
ATCAAAAATGATGGGGCACA

Downstream 100 bases:

>100_bases
GGGGAAGACAATGATTAAAGAAACTGTTTTCAAATCGTTCGATAATAAAGAGGCGTTAGAAGCGCAACTGGCCGAGCGTA
TTGCTAATCAACTGCAAGAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSKGDIEAMGITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKDEFSQEEYRELVVNALTTFVK
DELCEETVNRFLDRCHYVGTNFTESDGYQAFHDILEPEKRVMVSYFATPPAIFGDICRCLHEQKLIFPDSRVVLEKPIGS
DLASSRIINDQVSAYFEETQVYRIDHYLGKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQ
MRDMIQNHLLQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSGFLKGAPVPGYLEEEGANVQS
KAETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVP
GLGEKQRLQTTKLDLSFSETFKSERIADAYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDETPKPYPAGTW
GPVASVALITKDGRSWDE

Sequences:

>Translated_498_residues
MSKGDIEAMGITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKDEFSQEEYRELVVNALTTFVK
DELCEETVNRFLDRCHYVGTNFTESDGYQAFHDILEPEKRVMVSYFATPPAIFGDICRCLHEQKLIFPDSRVVLEKPIGS
DLASSRIINDQVSAYFEETQVYRIDHYLGKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQ
MRDMIQNHLLQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSGFLKGAPVPGYLEEEGANVQS
KAETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVP
GLGEKQRLQTTKLDLSFSETFKSERIADAYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDETPKPYPAGTW
GPVASVALITKDGRSWDE
>Mature_497_residues
SKGDIEAMGITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKDEFSQEEYRELVVNALTTFVKD
ELCEETVNRFLDRCHYVGTNFTESDGYQAFHDILEPEKRVMVSYFATPPAIFGDICRCLHEQKLIFPDSRVVLEKPIGSD
LASSRIINDQVSAYFEETQVYRIDHYLGKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQM
RDMIQNHLLQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSGFLKGAPVPGYLEEEGANVQSK
AETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVPG
LGEKQRLQTTKLDLSFSETFKSERIADAYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDETPKPYPAGTWG
PVASVALITKDGRSWDE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=35.1966873706004, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=35.1966873706004, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI52145310, Length=509, Percent_Identity=27.7013752455796, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1788158, Length=486, Percent_Identity=64.40329218107, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=484, Percent_Identity=37.603305785124, Blast_Score=323, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6324088, Length=473, Percent_Identity=36.7864693446089, Blast_Score=303, Evalue=4e-83,
Organism=Drosophila melanogaster, GI24643352, Length=470, Percent_Identity=36.1702127659575, Blast_Score=298, Evalue=8e-81,
Organism=Drosophila melanogaster, GI24643350, Length=470, Percent_Identity=36.1702127659575, Blast_Score=298, Evalue=8e-81,
Organism=Drosophila melanogaster, GI221513548, Length=481, Percent_Identity=26.8191268191268, Blast_Score=183, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56679; Mature: 56548

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGDIEAMGITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKD
CCCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEECCHHEEEECHH
EFSQEEYRELVVNALTTFVKDELCEETVNRFLDRCHYVGTNFTESDGYQAFHDILEPEKR
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHH
VMVSYFATPPAIFGDICRCLHEQKLIFPDSRVVLEKPIGSDLASSRIINDQVSAYFEETQ
EEEHHHCCCHHHHHHHHHHHHHCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VYRIDHYLGKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQ
EEEHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCHH
MRDMIQNHLLQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
FLKGAPVPGYLEEEGANVQSKAETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVY
CCCCCCCCCCHHCCCCCCHHCCCEEEEEEEECCCCEECCCCCEECCCCCCCCCCCCEEEE
FKNPPHNLYSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVPGLGEKQRLQTTKLDLSFSET
ECCCCCCHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHEECCCHHHH
FKSERIADAYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDETPKPYPAGTW
HHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GPVASVALITKDGRSWDE
CCHHEEEEEEECCCCCCC
>Mature Secondary Structure 
SKGDIEAMGITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKD
CCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEECCHHEEEECHH
EFSQEEYRELVVNALTTFVKDELCEETVNRFLDRCHYVGTNFTESDGYQAFHDILEPEKR
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHH
VMVSYFATPPAIFGDICRCLHEQKLIFPDSRVVLEKPIGSDLASSRIINDQVSAYFEETQ
EEEHHHCCCHHHHHHHHHHHHHCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VYRIDHYLGKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQ
EEEHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCHH
MRDMIQNHLLQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
FLKGAPVPGYLEEEGANVQSKAETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVY
CCCCCCCCCCHHCCCCCCHHCCCEEEEEEEECCCCEECCCCCEECCCCCCCCCCCCEEEE
FKNPPHNLYSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVPGLGEKQRLQTTKLDLSFSET
ECCCCCCHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHEECCCHHHH
FKSERIADAYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDETPKPYPAGTW
HHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GPVASVALITKDGRSWDE
CCHHEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]