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The map label for this gene is fadA [H]

Identifier: 157961991

GI number: 157961991

Start: 2626720

End: 2627925

Strand: Direct

Name: fadA [H]

Synonym: Spea_2170

Alternate gene names: 157961991

Gene position: 2626720-2627925 (Clockwise)

Preceding gene: 157961990

Following gene: 157961992

Centisome position: 50.76

GC content: 48.42

Gene sequence:

>1206_bases
ATGACAGAAGCAGTGATCGTCTCCGTTGCACGTACCGCATTAAGCAAATCTTTTCGTGGCGCATTTAATGATACTGAAGC
CCCGGTTCTTGGTGGCCATGTTGTCAAGTCTGTCGTTGAGCGTGCTGGTATTGACCCTAAGTCTATCGATGATGTGATTA
TGGGCGCAGCAGCCCAGCAGGGGACCCAATCCTACAACATTGGCAGACTCTCAGCTTATACCGCTGGCCTACCCGATACC
GTATCAGGCATGGCACTAGACCGTATGTGCGCATCGGGTTTAATGAGTATTGGTGTTGCAGCAAAATCGATTATGACTGA
CGAGATGAGCACCGTTGTTGCCGGTGGCGTTGAGTCGTTATCGTTAACCCAAAATAAATATAAGAATACTTATCGAGCAC
AGTCTCAAGCGGCAATTGCTGCAATGCCTAGTGCTTACATTCAAATGATCGAAACTGCCGAAATTGTCGCAGAGCGCTAC
GGCATCAGTCGTCAGGCTCAAGATGAATACTCGCTGCTAAGTCAGCAACGCACCGCTAGCGCCCAGCAAGCGGGTTACTT
TAATGATGAAATTGTACCGATTACTGTTCAGCAACTGACCTTTGATGAAAACCGCCAACCAGCAGGCCATAAAGAAACGA
TTGCGTTACAAGACGATTGTAATAGACCGCAAACAACGCTAGACAGTTTGTCTAATCTTGCTCCTGTTTGGAAAGGTGGC
GAGTGGACTGGCGAAGGCCGCAATGTTACCGCGGGCAATGCATCACAGTTTGCCGATGGCGCAGCGGCAAGTTTATTAAT
GAGTAAAACCCAAGCAGCAAGCCTTGGTATTGCCCCCTTAGGAACTTACAAAGGTATTGCCGTAGCAGGTTGTGCCCCAG
AAGAGATGGGAATAGGTCCGGTGCTCGCTATCCCCAAACTGTTAAAGCGTTTTGGTCTGACCATTGATGATATAGGTCTG
TGGGAGATCAATGAAGCCTTTGCAAGCCAAGTTGTTTATTGCCAACACAAGTTAGAGATCCCCGCCGATAGATTAAATGT
AAATGGCGGCGCTATTTCTATTGGGCACCCATTTGGTATGTCTGGCGCTCGTATGGTGGGTCATGCACTGATTGAAGGCA
GGCGTCGAGGCGTTAAATACGTTGTTGTAGCAATGTGTATTGGCGGTGGTATGGGCGCAGCAGGACTCTTTGAAGTCAAT
CAGTAA

Upstream 100 bases:

>100_bases
GATCCAAGGTTCTGACCGCCCAGCCTGTGTGGTTGACACCATCAGTTGCTACACCTTTGATACGCCAACGACAAACTCTA
ATAACTAAAGGAATTATAAG

Downstream 100 bases:

>100_bases
TAAAGGAGTGATTCATGTCAGTAATTTTAGAAAAAGCACAGAAACTATTCTTGTCAGACAATGACGCAAATGTACTCACA
GGCCATCAATTTGAAACGGT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPKSIDDVIMGAAAQQGTQSYNIGRLSAYTAGLPDT
VSGMALDRMCASGLMSIGVAAKSIMTDEMSTVVAGGVESLSLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERY
GISRQAQDEYSLLSQQRTASAQQAGYFNDEIVPITVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGG
EWTGEGRNVTAGNASQFADGAAASLLMSKTQAASLGIAPLGTYKGIAVAGCAPEEMGIGPVLAIPKLLKRFGLTIDDIGL
WEINEAFASQVVYCQHKLEIPADRLNVNGGAISIGHPFGMSGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVN
Q

Sequences:

>Translated_401_residues
MTEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPKSIDDVIMGAAAQQGTQSYNIGRLSAYTAGLPDT
VSGMALDRMCASGLMSIGVAAKSIMTDEMSTVVAGGVESLSLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERY
GISRQAQDEYSLLSQQRTASAQQAGYFNDEIVPITVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGG
EWTGEGRNVTAGNASQFADGAAASLLMSKTQAASLGIAPLGTYKGIAVAGCAPEEMGIGPVLAIPKLLKRFGLTIDDIGL
WEINEAFASQVVYCQHKLEIPADRLNVNGGAISIGHPFGMSGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVN
Q
>Mature_400_residues
TEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPKSIDDVIMGAAAQQGTQSYNIGRLSAYTAGLPDTV
SGMALDRMCASGLMSIGVAAKSIMTDEMSTVVAGGVESLSLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERYG
ISRQAQDEYSLLSQQRTASAQQAGYFNDEIVPITVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGGE
WTGEGRNVTAGNASQFADGAAASLLMSKTQAASLGIAPLGTYKGIAVAGCAPEEMGIGPVLAIPKLLKRFGLTIDDIGLW
EINEAFASQVVYCQHKLEIPADRLNVNGGAISIGHPFGMSGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVNQ

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=40.5, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=35.9801488833747, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI148539872, Length=404, Percent_Identity=35.3960396039604, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=33.743842364532, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4504327, Length=406, Percent_Identity=27.5862068965517, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI194353979, Length=282, Percent_Identity=28.3687943262411, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1787663, Length=419, Percent_Identity=37.4701670644391, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI48994986, Length=406, Percent_Identity=34.9753694581281, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1788554, Length=411, Percent_Identity=37.712895377129, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87082165, Length=416, Percent_Identity=35.8173076923077, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=28.8461538461538, Blast_Score=141, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=403, Percent_Identity=34.7394540942928, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI25147385, Length=403, Percent_Identity=30.5210918114144, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17535921, Length=415, Percent_Identity=31.0843373493976, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17551802, Length=442, Percent_Identity=28.5067873303167, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=27.363184079602, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=36.3861386138614, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=31.2655086848635, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=35.9801488833747, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=34.9753694581281, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17648125, Length=404, Percent_Identity=35.3960396039604, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI17137578, Length=414, Percent_Identity=31.4009661835749, Blast_Score=158, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42212; Mature: 42080

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPKSIDDVIMGAAAQQ
CCCHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GTQSYNIGRLSAYTAGLPDTVSGMALDRMCASGLMSIGVAAKSIMTDEMSTVVAGGVESL
CCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERYGISRQAQDEYSLLSQQRTAS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AQQAGYFNDEIVPITVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGG
HHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCC
EWTGEGRNVTAGNASQFADGAAASLLMSKTQAASLGIAPLGTYKGIAVAGCAPEEMGIGP
CCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHCCCCH
VLAIPKLLKRFGLTIDDIGLWEINEAFASQVVYCQHKLEIPADRLNVNGGAISIGHPFGM
HHHHHHHHHHHCCCEECCCCEEHHHHHHHHHHHHHHHCCCCHHHEECCCCEEEECCCCCC
SGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVNQ
CHHHHHHHHHHHHHHCCHHHEEEEHHHCCCCCCCCEEEECC
>Mature Secondary Structure 
TEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPKSIDDVIMGAAAQQ
CCHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GTQSYNIGRLSAYTAGLPDTVSGMALDRMCASGLMSIGVAAKSIMTDEMSTVVAGGVESL
CCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERYGISRQAQDEYSLLSQQRTAS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AQQAGYFNDEIVPITVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGG
HHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCC
EWTGEGRNVTAGNASQFADGAAASLLMSKTQAASLGIAPLGTYKGIAVAGCAPEEMGIGP
CCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHCCCCH
VLAIPKLLKRFGLTIDDIGLWEINEAFASQVVYCQHKLEIPADRLNVNGGAISIGHPFGM
HHHHHHHHHHHCCCEECCCCEEHHHHHHHHHHHHHHHCCCCHHHEECCCCEEEECCCCCC
SGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVNQ
CHHHHHHHHHHHHHHCCHHHEEEEHHHCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]