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The map label for this gene is proC [H]

Identifier: 157960954

GI number: 157960954

Start: 1363642

End: 1364460

Strand: Reverse

Name: proC [H]

Synonym: Spea_1126

Alternate gene names: 157960954

Gene position: 1364460-1363642 (Counterclockwise)

Preceding gene: 157960955

Following gene: 157960953

Centisome position: 26.37

GC content: 48.23

Gene sequence:

>819_bases
ATGACACAAAAGAAAGTATGCTTTATCGGCGCAGGCAATATGACCCGCAGTATCGTCAGTGGCTTAGTCAAAAGTGGCTA
TAGCCCTGAGCTAATCCAAGCCACGAATCCAAGCCAACCTAAGCTCGATGCTATGGTGGCAGACTTTGGCATTAAGGTAT
CGAATAACAACCTAGATGCGGCGCAAGCGGCCGATGTTATCGTGCTTGGCGTAAAGCCACACCTGATGCAAGTCGTCGGC
GAAGAGCTAAGCGGTCTGGACCTTTCTAATAAACTGATTATCACCATAGCCGCAGGCGTAACAGCCAAGCGTTATAGTGA
TTATTTTAAGCAAGAGATCAAACTAATTCGCACTATGCCTAATACTCCCACCCAAATAGGTGTAGGCTTGACAGGGCTCT
ATGCGGGCGATGACATATCGGCTGAGCAAAAAGCCATTTGCGAAACCTTAATGGCAACTGGCGGCGAAGTCGTCTGGGTC
AGTAAGGAAGATGAATTAAACCAAGTGATCGCACTTGCGGGTAGCTCTCCAGCATATTTCTTCCTATTTTTAGAATCTAT
GGTAGAAAGTGCAGTGAAAGGTGGCATGTCTGAACTTGCCGCAAGAGAGATGGCGCAGCAAGCAGCACTTGGCGCGGCCT
TGATGGTCAAACAAAACCCAGATGTGAGTCTTGCTCAGCTTAGAGCGAACGTAACATCAAAAGGCGGCACAACGGCGCAG
GCGGTTGAGACGTTTGAAAAAGGTGATTTAAGAGGTTTGGTCGATAATGCAATGAACAATTGTATCGCCCGCGCCGAAGA
GATGGCCAAGCAGTACTAG

Upstream 100 bases:

>100_bases
TGAAATAGTCTTTAGTAAAATAGCCCTTAATTAAATAATCTTTTTCCTTGTAAGTGCAAAAGATGTTCGGTGCAGCTAAC
TAAAACAAAAAGAGATCTCC

Downstream 100 bases:

>100_bases
TTTTTAAATTTAACTTGAACAAGTAGAGTAAACAGATGAATGCATTTAGTTTTCTGATAAGCACGGTATTCGATCTATAC
CTGATGGTCGTGGTGTTACG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTQKKVCFIGAGNMTRSIVSGLVKSGYSPELIQATNPSQPKLDAMVADFGIKVSNNNLDAAQAADVIVLGVKPHLMQVVG
EELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMPNTPTQIGVGLTGLYAGDDISAEQKAICETLMATGGEVVWV
SKEDELNQVIALAGSSPAYFFLFLESMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQ
AVETFEKGDLRGLVDNAMNNCIARAEEMAKQY

Sequences:

>Translated_272_residues
MTQKKVCFIGAGNMTRSIVSGLVKSGYSPELIQATNPSQPKLDAMVADFGIKVSNNNLDAAQAADVIVLGVKPHLMQVVG
EELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMPNTPTQIGVGLTGLYAGDDISAEQKAICETLMATGGEVVWV
SKEDELNQVIALAGSSPAYFFLFLESMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQ
AVETFEKGDLRGLVDNAMNNCIARAEEMAKQY
>Mature_271_residues
TQKKVCFIGAGNMTRSIVSGLVKSGYSPELIQATNPSQPKLDAMVADFGIKVSNNNLDAAQAADVIVLGVKPHLMQVVGE
ELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMPNTPTQIGVGLTGLYAGDDISAEQKAICETLMATGGEVVWVS
KEDELNQVIALAGSSPAYFFLFLESMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQA
VETFEKGDLRGLVDNAMNNCIARAEEMAKQY

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=32, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=32, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI21361454, Length=272, Percent_Identity=31.9852941176471, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI198041662, Length=274, Percent_Identity=27.3722627737226, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=36.6666666666667, Blast_Score=159, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=30.2238805970149, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=30.3571428571429, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320861, Length=274, Percent_Identity=30.2919708029197, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24648116, Length=282, Percent_Identity=31.2056737588652, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=29.2134831460674, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=30.4093567251462, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28885; Mature: 28753

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKKVCFIGAGNMTRSIVSGLVKSGYSPELIQATNPSQPKLDAMVADFGIKVSNNNLDA
CCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHCCEEEECCCCCH
AQAADVIVLGVKPHLMQVVGEELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMP
HHHCCEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCC
NTPTQIGVGLTGLYAGDDISAEQKAICETLMATGGEVVWVSKEDELNQVIALAGSSPAYF
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHEEEECCCCCHHH
FLFLESMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQ
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCHHH
AVETFEKGDLRGLVDNAMNNCIARAEEMAKQY
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQKKVCFIGAGNMTRSIVSGLVKSGYSPELIQATNPSQPKLDAMVADFGIKVSNNNLDA
CCCEEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHCCEEEECCCCCH
AQAADVIVLGVKPHLMQVVGEELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMP
HHHCCEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCC
NTPTQIGVGLTGLYAGDDISAEQKAICETLMATGGEVVWVSKEDELNQVIALAGSSPAYF
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHEEEECCCCCHHH
FLFLESMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQ
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCHHH
AVETFEKGDLRGLVDNAMNNCIARAEEMAKQY
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]