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The map label for this gene is mutH [H]

Identifier: 157960848

GI number: 157960848

Start: 1242845

End: 1243516

Strand: Reverse

Name: mutH [H]

Synonym: Spea_1020

Alternate gene names: 157960848

Gene position: 1243516-1242845 (Counterclockwise)

Preceding gene: 157960858

Following gene: 157960847

Centisome position: 24.03

GC content: 45.83

Gene sequence:

>672_bases
ATGAAGAAATCACTCCACTCTCCAAATAGCATCGAAGAGTTGATGCAACGCGCTGAATCCATGGCAGGTTTAACCTTAGG
CCAACTTGCGCATTATCATGGCATTGAGATGCCAAAAGATTTAAAACGTCATAAAGGCTGGGTTGGTCAACTAATAGAGC
TGGAACTCGGCGCCTTGGCAGGTTCAAAGCCAGAACAAGATTTTGCACATTTGGGTGTAGAGCTGAAGACGATTCCAATC
AACCGCCTAGGTAAAGTATTGGAAACGACCTACGTGACCGTCGCTCCGCTTACCAATATTCAAGGGTTGACCTGGGAAGA
GAGTGTTGTTTGCCATAAGCTACAACAGGTTCTGTGGATCCCTGTACAAGGCGATCGGGAGCTCCCCTTAAGCGAGCGCC
AAATTGGTTCACCTATCCTATGGCAGCCATCAGTTGAAGAAAGCGAACTGCTTAAGCAGGATTGGGAAGAGATAATGGAG
TTTATCTCGATGGGACAGGTCGATAGGGTCACCGCTCGCCATGGTGAAGTGTTGCAACTAAGGCCGAAGGCTGCAAATAG
TCAAGTACTAACAGATAGCATTGGACGAGATGGAGAGCTTACCCGAACTAACCCCAGAGGTTTTTATTTAAAAACCCAAT
TTACCCAAAAAATACTTTCACAGTTATTTTAA

Upstream 100 bases:

>100_bases
AAACTTAGGCGATGCTTTTCTACTTATCCTCAACAAAGTGAATACCTGTTCATTTTTCATCCTGTTTGATTAACTCCGCC
ACTCAGGTAAAATTACCCAC

Downstream 100 bases:

>100_bases
GCTGTTTTTGTTCCAAAACTCACACTCATTTGACTTAGATCACAAATACTACTGGTAAAAGTAGGGGGATATTCTATAAA
ATGGCGCCTCCTAAAATTAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKKSLHSPNSIEELMQRAESMAGLTLGQLAHYHGIEMPKDLKRHKGWVGQLIELELGALAGSKPEQDFAHLGVELKTIPI
NRLGKVLETTYVTVAPLTNIQGLTWEESVVCHKLQQVLWIPVQGDRELPLSERQIGSPILWQPSVEESELLKQDWEEIME
FISMGQVDRVTARHGEVLQLRPKAANSQVLTDSIGRDGELTRTNPRGFYLKTQFTQKILSQLF

Sequences:

>Translated_223_residues
MKKSLHSPNSIEELMQRAESMAGLTLGQLAHYHGIEMPKDLKRHKGWVGQLIELELGALAGSKPEQDFAHLGVELKTIPI
NRLGKVLETTYVTVAPLTNIQGLTWEESVVCHKLQQVLWIPVQGDRELPLSERQIGSPILWQPSVEESELLKQDWEEIME
FISMGQVDRVTARHGEVLQLRPKAANSQVLTDSIGRDGELTRTNPRGFYLKTQFTQKILSQLF
>Mature_223_residues
MKKSLHSPNSIEELMQRAESMAGLTLGQLAHYHGIEMPKDLKRHKGWVGQLIELELGALAGSKPEQDFAHLGVELKTIPI
NRLGKVLETTYVTVAPLTNIQGLTWEESVVCHKLQQVLWIPVQGDRELPLSERQIGSPILWQPSVEESELLKQDWEEIME
FISMGQVDRVTARHGEVLQLRPKAANSQVLTDSIGRDGELTRTNPRGFYLKTQFTQKILSQLF

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=219, Percent_Identity=57.9908675799087, Blast_Score=269, Evalue=9e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 25211; Mature: 25211

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSLHSPNSIEELMQRAESMAGLTLGQLAHYHGIEMPKDLKRHKGWVGQLIELELGALA
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHC
GSKPEQDFAHLGVELKTIPINRLGKVLETTYVTVAPLTNIQGLTWEESVVCHKLQQVLWI
CCCCHHHHHHCCCEEEECCHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHEEE
PVQGDRELPLSERQIGSPILWQPSVEESELLKQDWEEIMEFISMGQVDRVTARHGEVLQL
CCCCCCCCCCCHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEE
RPKAANSQVLTDSIGRDGELTRTNPRGFYLKTQFTQKILSQLF
CCCCCCCCHHHHHCCCCCCCEECCCCCEEEEHHHHHHHHHHHC
>Mature Secondary Structure
MKKSLHSPNSIEELMQRAESMAGLTLGQLAHYHGIEMPKDLKRHKGWVGQLIELELGALA
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHC
GSKPEQDFAHLGVELKTIPINRLGKVLETTYVTVAPLTNIQGLTWEESVVCHKLQQVLWI
CCCCHHHHHHCCCEEEECCHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHEEE
PVQGDRELPLSERQIGSPILWQPSVEESELLKQDWEEIMEFISMGQVDRVTARHGEVLQL
CCCCCCCCCCCHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEE
RPKAANSQVLTDSIGRDGELTRTNPRGFYLKTQFTQKILSQLF
CCCCCCCCHHHHHCCCCCCCEECCCCCEEEEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA