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The map label for this gene is aqpZ [H]

Identifier: 157960816

GI number: 157960816

Start: 1200210

End: 1200917

Strand: Reverse

Name: aqpZ [H]

Synonym: Spea_0988

Alternate gene names: 157960816

Gene position: 1200917-1200210 (Counterclockwise)

Preceding gene: 157960817

Following gene: 157960815

Centisome position: 23.21

GC content: 50.28

Gene sequence:

>708_bases
ATGAATATGAACCAAAAAATGACCGCCGAGTTTATCGGTACACTTTGGCTTGTCTTAGGTGGTTGTGGTAGCGCCGTCTT
AGCCGCGGCTTTTCCAGAGCTTGGCATAGGCTTTCTCGGGGTGGCATTTGCGTTCGGTTTGACCGTCCTCACCATGGCAT
TTGCCATAGGACATATCTCCGGATGCCATTTAAACCCCGCGGTTTCAATTGGTCTATGGGCGGGCGGACGTTTTCCTGCC
TCTGAATTACTGCCCTATATTATCGCTCAGGTAGCAGGCGGTATCGCTGGCGCCAGCATTTTATATCTTATCGCCTCGGG
GCAAGATGGTTTTAGCCTCTCGGCAGGCTTTGCCTCAAACGGCTATGGAGAACACTCCCCCGGAAGTTATAGCTTAACGG
CGGCACTGATTTGTGAAATCGTGATGACTCTGTTCTTCTTGCTTATCATTCTTGGCGCTACCGATTCACGCACTCCGAAA
GGCTTTGCCCCTATCGCCATTGGTTTAGGGCTTACATTAATCCACCTAATCAGCATTCCTGTAACCAATACTTCGGTCAA
TCCGGCTCGCAGCACGGGGCCAGCACTGTTTGTCGGCGACTGGGCTATCTCTCAGCTTTGGCTATTTTGGCTTGCGCCAA
TTATTGGTGCGATTCTCGCGGGCTTGATTTATAGAGTCTTCGACACTAAAGGTGAATCGTCTATATAG

Upstream 100 bases:

>100_bases
AAATTTCATTTTGGAACTGTTTACTTCGTAATTTAGCAAAACATAAAGTACAGTCGACAGTTACTGCCAATGGAATGATG
CAAACTCAAGGAACTGTTTT

Downstream 100 bases:

>100_bases
ATAAACAGAGCCTAAAGCGGCTCTGTTTTCTTTTTCATTGGCCTGCTAGGTGCTATTATCCGTCTAAATCGGCGCGCTTT
CCTTGTTTCAAGGCTCGCCT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MNMNQKMTAEFIGTLWLVLGGCGSAVLAAAFPELGIGFLGVAFAFGLTVLTMAFAIGHISGCHLNPAVSIGLWAGGRFPA
SELLPYIIAQVAGGIAGASILYLIASGQDGFSLSAGFASNGYGEHSPGSYSLTAALICEIVMTLFFLLIILGATDSRTPK
GFAPIAIGLGLTLIHLISIPVTNTSVNPARSTGPALFVGDWAISQLWLFWLAPIIGAILAGLIYRVFDTKGESSI

Sequences:

>Translated_235_residues
MNMNQKMTAEFIGTLWLVLGGCGSAVLAAAFPELGIGFLGVAFAFGLTVLTMAFAIGHISGCHLNPAVSIGLWAGGRFPA
SELLPYIIAQVAGGIAGASILYLIASGQDGFSLSAGFASNGYGEHSPGSYSLTAALICEIVMTLFFLLIILGATDSRTPK
GFAPIAIGLGLTLIHLISIPVTNTSVNPARSTGPALFVGDWAISQLWLFWLAPIIGAILAGLIYRVFDTKGESSI
>Mature_235_residues
MNMNQKMTAEFIGTLWLVLGGCGSAVLAAAFPELGIGFLGVAFAFGLTVLTMAFAIGHISGCHLNPAVSIGLWAGGRFPA
SELLPYIIAQVAGGIAGASILYLIASGQDGFSLSAGFASNGYGEHSPGSYSLTAALICEIVMTLFFLLIILGATDSRTPK
GFAPIAIGLGLTLIHLISIPVTNTSVNPARSTGPALFVGDWAISQLWLFWLAPIIGAILAGLIYRVFDTKGESSI

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=223, Percent_Identity=37.6681614349776, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI37694062, Length=227, Percent_Identity=38.3259911894273, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI4755125, Length=228, Percent_Identity=34.2105263157895, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI4502181, Length=228, Percent_Identity=34.2105263157895, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4502179, Length=223, Percent_Identity=35.4260089686099, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI6912506, Length=222, Percent_Identity=34.6846846846847, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI86792455, Length=232, Percent_Identity=33.1896551724138, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI45446752, Length=232, Percent_Identity=31.4655172413793, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI157266307, Length=244, Percent_Identity=30.327868852459, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4826645, Length=253, Percent_Identity=28.8537549407115, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI297307120, Length=88, Percent_Identity=45.4545454545455, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI297307116, Length=110, Percent_Identity=41.8181818181818, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI297307118, Length=110, Percent_Identity=41.8181818181818, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787101, Length=231, Percent_Identity=70.1298701298701, Blast_Score=300, Evalue=4e-83,
Organism=Escherichia coli, GI1790362, Length=253, Percent_Identity=27.6679841897233, Blast_Score=78, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71993722, Length=235, Percent_Identity=34.8936170212766, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17558372, Length=236, Percent_Identity=30.9322033898305, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71992966, Length=247, Percent_Identity=26.7206477732794, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17531431, Length=232, Percent_Identity=27.1551724137931, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531429, Length=232, Percent_Identity=27.1551724137931, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24652747, Length=224, Percent_Identity=35.7142857142857, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45551084, Length=224, Percent_Identity=35.7142857142857, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24652751, Length=231, Percent_Identity=33.7662337662338, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922038, Length=235, Percent_Identity=33.1914893617021, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136672, Length=204, Percent_Identity=29.9019607843137, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762342, Length=199, Percent_Identity=30.1507537688442, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45550503, Length=238, Percent_Identity=26.890756302521, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24762346, Length=219, Percent_Identity=30.1369863013699, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24762348, Length=219, Percent_Identity=30.1369863013699, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20130305, Length=219, Percent_Identity=30.1369863013699, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24762344, Length=219, Percent_Identity=30.1369863013699, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24294; Mature: 24294

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMNQKMTAEFIGTLWLVLGGCGSAVLAAAFPELGIGFLGVAFAFGLTVLTMAFAIGHIS
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSIGLWAGGRFPASELLPYIIAQVAGGIAGASILYLIASGQDGFSLSAGFASN
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCCEEECCCCCC
GYGEHSPGSYSLTAALICEIVMTLFFLLIILGATDSRTPKGFAPIAIGLGLTLIHLISIP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
VTNTSVNPARSTGPALFVGDWAISQLWLFWLAPIIGAILAGLIYRVFDTKGESSI
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNMNQKMTAEFIGTLWLVLGGCGSAVLAAAFPELGIGFLGVAFAFGLTVLTMAFAIGHIS
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSIGLWAGGRFPASELLPYIIAQVAGGIAGASILYLIASGQDGFSLSAGFASN
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCCEEECCCCCC
GYGEHSPGSYSLTAALICEIVMTLFFLLIILGATDSRTPKGFAPIAIGLGLTLIHLISIP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
VTNTSVNPARSTGPALFVGDWAISQLWLFWLAPIIGAILAGLIYRVFDTKGESSI
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]