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The map label for this gene is fkpA [H]

Identifier: 157960655

GI number: 157960655

Start: 1026670

End: 1027437

Strand: Direct

Name: fkpA [H]

Synonym: Spea_0827

Alternate gene names: 157960655

Gene position: 1026670-1027437 (Clockwise)

Preceding gene: 157960649

Following gene: 157960656

Centisome position: 19.84

GC content: 45.96

Gene sequence:

>768_bases
ATGAAATCGATTTATAAATATTCACTAGTGGCTTTGGCCGTAGTTGGTCTTACGGCGTGTAACCAAGAGCAAGCCGTTGC
TGTCGACGCCCCTGTAGAATTAAAAACTGAAGCACAAAAAGAAGCTTACAGCGTGGGCGCATCAATCGGTACTTATATGG
CAGGCCATATTAAGGAACAAGAAGAGCTTGGTCTTAACGTTGATAGAAGCTTGATTGTGACGGGTTTCAGCGAAGGCCTA
AACAGTGAGCTAAAACTGACTCAAGAAGAGATGCAAACAATTTTGCAAACTCTTGACGAGAAGCTAAATGAAAAGCGTCA
GGCACAGGCTTTAGCATTGGCAGAGAAGAGCCTAGCCGAAAGTAAGGCTTTCCTAGAGACGAACAAGGCGAAAGAAGGCG
TTGTGACTACAGACTCTGGCCTACAGTATGAAGTCATCACCGAAGGTACTGGTGAAAAGCCTGTGGCTGAAGACACAGTT
AAAGTGCATTACGTTGGTACATTAACTGATGGTACTGAGTTTGATAGCTCAGTTGCACGTGGCGAGCCAGCGACTTTCCC
ACTAAATCGTGTTATTGCTGGTTGGACTGAAGGTGTTCAGTTGATGTCTGTTGGTTCTAAGTACAAGTTTGTTATCCCTG
CAGATCTTGCTTATGGCGACCGTGACACTGGCACTATCCCTGCAAACTCGACGCTAGTATTTGAAGTCGAGCTGCTGGAT
ATCCAAAAGGCTGAAGCGCCTACTGCAGATGCAGCGCACGCACATTAA

Upstream 100 bases:

>100_bases
ACCGATCTGATTGGAATAACCAATTTAACTAGTATAGAGTGGTTCGCCTAAATAAAAATAAAGGTTAGTTTAACCACGTG
TAAATGCTGAGGAAGCTTTA

Downstream 100 bases:

>100_bases
TCGATAATCATGGCTTCATCACTCTATACAGTGGTGCTAGCGAAGAGAATTGATAGCTTAAAAAAGGACGCATTCAGCGT
CCTTTTTTGCGTTAGGTCAT

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MKSIYKYSLVALAVVGLTACNQEQAVAVDAPVELKTEAQKEAYSVGASIGTYMAGHIKEQEELGLNVDRSLIVTGFSEGL
NSELKLTQEEMQTILQTLDEKLNEKRQAQALALAEKSLAESKAFLETNKAKEGVVTTDSGLQYEVITEGTGEKPVAEDTV
KVHYVGTLTDGTEFDSSVARGEPATFPLNRVIAGWTEGVQLMSVGSKYKFVIPADLAYGDRDTGTIPANSTLVFEVELLD
IQKAEAPTADAAHAH

Sequences:

>Translated_255_residues
MKSIYKYSLVALAVVGLTACNQEQAVAVDAPVELKTEAQKEAYSVGASIGTYMAGHIKEQEELGLNVDRSLIVTGFSEGL
NSELKLTQEEMQTILQTLDEKLNEKRQAQALALAEKSLAESKAFLETNKAKEGVVTTDSGLQYEVITEGTGEKPVAEDTV
KVHYVGTLTDGTEFDSSVARGEPATFPLNRVIAGWTEGVQLMSVGSKYKFVIPADLAYGDRDTGTIPANSTLVFEVELLD
IQKAEAPTADAAHAH
>Mature_255_residues
MKSIYKYSLVALAVVGLTACNQEQAVAVDAPVELKTEAQKEAYSVGASIGTYMAGHIKEQEELGLNVDRSLIVTGFSEGL
NSELKLTQEEMQTILQTLDEKLNEKRQAQALALAEKSLAESKAFLETNKAKEGVVTTDSGLQYEVITEGTGEKPVAEDTV
KVHYVGTLTDGTEFDSSVARGEPATFPLNRVIAGWTEGVQLMSVGSKYKFVIPADLAYGDRDTGTIPANSTLVFEVELLD
IQKAEAPTADAAHAH

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=89, Percent_Identity=49.438202247191, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI17149844, Length=89, Percent_Identity=49.438202247191, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI17149842, Length=89, Percent_Identity=49.438202247191, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=47.6635514018692, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=47.6635514018692, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=41.1214953271028, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4503729, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI224809329, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI224809327, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4758384, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI224809331, Length=109, Percent_Identity=41.2844036697248, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI33469985, Length=144, Percent_Identity=29.8611111111111, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789745, Length=258, Percent_Identity=41.4728682170543, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI87082390, Length=148, Percent_Identity=54.0540540540541, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=48.5981308411215, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17561782, Length=107, Percent_Identity=47.6635514018692, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17540882, Length=89, Percent_Identity=48.314606741573, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320727, Length=96, Percent_Identity=52.0833333333333, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324194, Length=106, Percent_Identity=45.2830188679245, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323566, Length=130, Percent_Identity=36.1538461538462, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323482, Length=97, Percent_Identity=42.2680412371134, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=47.6635514018692, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363946, Length=116, Percent_Identity=44.8275862068966, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17352457, Length=116, Percent_Identity=44.8275862068966, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24583150, Length=109, Percent_Identity=41.2844036697248, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21356629, Length=89, Percent_Identity=48.314606741573, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 27400; Mature: 27400

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIYKYSLVALAVVGLTACNQEQAVAVDAPVELKTEAQKEAYSVGASIGTYMAGHIKEQ
CCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
EELGLNVDRSLIVTGFSEGLNSELKLTQEEMQTILQTLDEKLNEKRQAQALALAEKSLAE
HHCCCCCCCEEEEEECCCCCCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAFLETNKAKEGVVTTDSGLQYEVITEGTGEKPVAEDTVKVHYVGTLTDGTEFDSSVAR
HHHHHHCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHC
GEPATFPLNRVIAGWTEGVQLMSVGSKYKFVIPADLAYGDRDTGTIPANSTLVFEVELLD
CCCCCCCHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEE
IQKAEAPTADAAHAH
EECCCCCCCCCCCCC
>Mature Secondary Structure
MKSIYKYSLVALAVVGLTACNQEQAVAVDAPVELKTEAQKEAYSVGASIGTYMAGHIKEQ
CCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
EELGLNVDRSLIVTGFSEGLNSELKLTQEEMQTILQTLDEKLNEKRQAQALALAEKSLAE
HHCCCCCCCEEEEEECCCCCCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAFLETNKAKEGVVTTDSGLQYEVITEGTGEKPVAEDTVKVHYVGTLTDGTEFDSSVAR
HHHHHHCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHC
GEPATFPLNRVIAGWTEGVQLMSVGSKYKFVIPADLAYGDRDTGTIPANSTLVFEVELLD
CCCCCCCHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEE
IQKAEAPTADAAHAH
EECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]