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The map label for this gene is dsbC [H]

Identifier: 157960634

GI number: 157960634

Start: 999232

End: 999957

Strand: Direct

Name: dsbC [H]

Synonym: Spea_0806

Alternate gene names: 157960634

Gene position: 999232-999957 (Clockwise)

Preceding gene: 157960633

Following gene: 157960635

Centisome position: 19.31

GC content: 45.73

Gene sequence:

>726_bases
ATGAAGTTCACTCGAACATTTTCTTTGATTGCTGCGATGATGATAGCACCAGCAGCCCTAGCTGCATCGAATAGCAGCGA
CGATACTGCCGCGTTAAAACAAAAGCTAAGTGACGCATTAAGCGTTGAAGTGATCTCAATTAAGCCTTCACCCGTTGCAG
AGTTATATGAAGCCTACACAGATCGCGGCGTGCTTTATATTTCTAGAGATGGTTCAAAGCTATTTCACGGTAGCCTTTAT
GACTTAGATAAAGGTATGAAGAACCTTACTGAAGCCGCTATGGCCGGTCCTCGTTTGGACATGTTGAAGCCACTTGAAGA
CAACATGTTGGTTTACAAGGCCAAGAATGAAAAGCATGTAGTGACTATCTTTACCGATGTCAGCTGCGGTTATTGCCGTA
AGTTGCACAACGAAATGGACGGTTATAACGATCTAGGTATTACAGTGCGTTACCTTGCCTTCCCGCGTGCTGGTGTGCCA
TCGGCTAATGCCGACGAGATGGAGTCTGTATGGTGTGCAGCCGATCCGCTAAAGGCGATGGGCCAAGCTAAAAATGGTAA
AGCGATTAAGCAAGCTAAGTGTGACGCTAAGATTGCTGAGCAATATAATGTAGGTCAAGCTATTGGTATTAACGGTACAC
CGGCAATCATTCTTGAAGACGGTACTTTGATCCCTGGCTACCAGCCACCTAAGGCACTGTTACGTACACTCGAGTCAGTA
CAGTAA

Upstream 100 bases:

>100_bases
AATTTGCTTTAACTGAGTTGAGTCTGTAACTTTTCAGCTCCAGACAAGGTCTAATCTTTTATATCCATCAGTCTGCCCCT
TACATAGAGTAGGAAAACTA

Downstream 100 bases:

>100_bases
TCTTTAGGCCGATATAAGACCAACATAAGACAAAACACTGTCTTATGAAGTACAGTCTTATAAAGTAATCGCTAAAAAGG
TGAGCCTAGGCTCACCTTTT

Product: thiol:disulfide interchange protein DsbC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MKFTRTFSLIAAMMIAPAALAASNSSDDTAALKQKLSDALSVEVISIKPSPVAELYEAYTDRGVLYISRDGSKLFHGSLY
DLDKGMKNLTEAAMAGPRLDMLKPLEDNMLVYKAKNEKHVVTIFTDVSCGYCRKLHNEMDGYNDLGITVRYLAFPRAGVP
SANADEMESVWCAADPLKAMGQAKNGKAIKQAKCDAKIAEQYNVGQAIGINGTPAIILEDGTLIPGYQPPKALLRTLESV
Q

Sequences:

>Translated_241_residues
MKFTRTFSLIAAMMIAPAALAASNSSDDTAALKQKLSDALSVEVISIKPSPVAELYEAYTDRGVLYISRDGSKLFHGSLY
DLDKGMKNLTEAAMAGPRLDMLKPLEDNMLVYKAKNEKHVVTIFTDVSCGYCRKLHNEMDGYNDLGITVRYLAFPRAGVP
SANADEMESVWCAADPLKAMGQAKNGKAIKQAKCDAKIAEQYNVGQAIGINGTPAIILEDGTLIPGYQPPKALLRTLESV
Q
>Mature_241_residues
MKFTRTFSLIAAMMIAPAALAASNSSDDTAALKQKLSDALSVEVISIKPSPVAELYEAYTDRGVLYISRDGSKLFHGSLY
DLDKGMKNLTEAAMAGPRLDMLKPLEDNMLVYKAKNEKHVVTIFTDVSCGYCRKLHNEMDGYNDLGITVRYLAFPRAGVP
SANADEMESVWCAADPLKAMGQAKNGKAIKQAKCDAKIAEQYNVGQAIGINGTPAIILEDGTLIPGYQPPKALLRTLESV
Q

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=225, Percent_Identity=45.3333333333333, Blast_Score=205, Evalue=2e-54,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 26110; Mature: 26110

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTRTFSLIAAMMIAPAALAASNSSDDTAALKQKLSDALSVEVISIKPSPVAELYEAYT
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHH
DRGVLYISRDGSKLFHGSLYDLDKGMKNLTEAAMAGPRLDMLKPLEDNMLVYKAKNEKHV
CCCEEEEECCCCEECCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCEE
VTIFTDVSCGYCRKLHNEMDGYNDLGITVRYLAFPRAGVPSANADEMESVWCAADPLKAM
EEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHH
GQAKNGKAIKQAKCDAKIAEQYNVGQAIGINGTPAIILEDGTLIPGYQPPKALLRTLESV
CCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCEEEEECCEECCCCCCHHHHHHHHHHC
Q
C
>Mature Secondary Structure
MKFTRTFSLIAAMMIAPAALAASNSSDDTAALKQKLSDALSVEVISIKPSPVAELYEAYT
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHH
DRGVLYISRDGSKLFHGSLYDLDKGMKNLTEAAMAGPRLDMLKPLEDNMLVYKAKNEKHV
CCCEEEEECCCCEECCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCEE
VTIFTDVSCGYCRKLHNEMDGYNDLGITVRYLAFPRAGVPSANADEMESVWCAADPLKAM
EEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHH
GQAKNGKAIKQAKCDAKIAEQYNVGQAIGINGTPAIILEDGTLIPGYQPPKALLRTLESV
CCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCEEEEECCEECCCCCCHHHHHHHHHHC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8168497 [H]