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The map label for this gene is selA [H]

Identifier: 157960271

GI number: 157960271

Start: 549258

End: 550748

Strand: Direct

Name: selA [H]

Synonym: Spea_0442

Alternate gene names: 157960271

Gene position: 549258-550748 (Clockwise)

Preceding gene: 157960270

Following gene: 157960272

Centisome position: 10.61

GC content: 50.1

Gene sequence:

>1491_bases
ATGACTCAAGCTATCAATTCCACTCAAGCCCTTTACCGTTGTTTACCTGCAATGGACAGCTTGCTGCTGATACCTCAAGT
GATAAGTTTTATCGACCAGCAAGGCAAGCCCTGGATTAAATCGTTACTGGCGCAAATGCTTCAAGATGCACGCCAACATA
TTGCCGAGCAGCAAAGCTTGCCAAGCTGGTGCTTAGATTTAAGCAATATCATTACCGAGTTAGCCCGCCGTATTGCCAAA
GCCCAGCGCCCAAGCATGACCCCAGTAATTAACCTTACCGGCACCATATTGCATACCAATCTTGGTCGCTCGCAGATGTG
TGAGGCCGCTATCGATGCTGTTACCCAAGTGATGCGCAGCCCAGTGCCACTTGAGTTTGATATGGGCCAAGGTAAACGCG
GTCACCGCGATAGCGCAATCTCTGCATTGATTCATGAGCTAACTGGCGCTGACACTTGTTGCATCGTCAATAACAACGCC
GCCGCCGTTTTGCTAATGCTTGCTGCCACCGCTGCGGGTAAAGAGGTGATTGTGTCTCGCGGTGAGCTGGTGGAAATTGG
CGGCGCGTTTCGTATTCCCGACATTATGGCGCAGGCGGGTTGCAAGCTGGTGGAAGTCGGCTGCACCAACCGAACTCACC
TTAAAGATTACGCCGCGGCGATAACTGAAGACACCGCTGCGATTATGAAGGTGCACACCAGTAATTATCATATTAGTGGT
TTTACTAAGGTCACCGAAGAAGCTGAATTAGCTGCCTTGTGTAAAGAACGCGGCATCGCACTGATTTCCGATCTGGGCAG
TGGTGCGCTGACGGATCTGTCGCGCTTTGGTTTGTCAAAAGAGCCGATGCCACAGCAGATGCTTAAAGATGGCGTCAACC
TAGTGAGCTTTTCAGGTGATAAATTGCTCGGCGGGCCGCAAGCAGGCTTAGTGGTGGGTGATGCCGAGCTAATTGCTAAG
CTGCAAGCGCACCCGCTAAAGCGCGCACTGCGCTGTGACAAGATGACCTTGGCAGCGCTCGAAGCCACGCTTATGCAGTA
TCGTAATCCCACAAGTCTCGATACTCAATTGCCTATTTTTAGAAAACTCTCCCGTCCATTAGCAGAGCTTGAAACGCTGG
CGCAGCAACTCACTACGGTATGTAGCCCGGTACAAACACAGTTTAATGTGACAATAAAACCTTGCCAAACTCAGGTGGGC
AGTGGCTCACAGCCAGATGTGTTGCTGGACTCTATCGCGCTGTGCTTCTCTGTAAATGCCAATGCCGTCAAAGAGCACAA
CTCGCTAAGTGTGTTGCAACTAGATAAGTTTTTTAAAGCCGCAAGTTTGCCGATTATTGGCCGCATTACAGCTAACCAGC
TTTGGCTCGATCTGCGTGGTACTGACAACGATACCCAGCTTATCGAAGTCCTGACAAAAACCTTAATCGAGTTTGAGCAA
GCTCATATCAACACGCTTTCCGTATTACCAAGAGTAGAGGCTCAGTCATGA

Upstream 100 bases:

>100_bases
AGCCGCTTTTAAGCTAATTAGTAAGCAAGAGCCGCATCTCGGTGCGGCTCTTTTATTAACCCAAATCTTTAAAATCATTG
AACTAACTAGACGAAGACCT

Downstream 100 bases:

>100_bases
TTGTTGTTACTTCAGGCCATGTGGACCACGGTAAAACCAGCCTGATTCAAGCGCTAACTGGCACCGATGCCGACCGCTTA
CCGGAAGAAAAACAGCGTGG

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTQAINSTQALYRCLPAMDSLLLIPQVISFIDQQGKPWIKSLLAQMLQDARQHIAEQQSLPSWCLDLSNIITELARRIAK
AQRPSMTPVINLTGTILHTNLGRSQMCEAAIDAVTQVMRSPVPLEFDMGQGKRGHRDSAISALIHELTGADTCCIVNNNA
AAVLLMLAATAAGKEVIVSRGELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITEDTAAIMKVHTSNYHISG
FTKVTEEAELAALCKERGIALISDLGSGALTDLSRFGLSKEPMPQQMLKDGVNLVSFSGDKLLGGPQAGLVVGDAELIAK
LQAHPLKRALRCDKMTLAALEATLMQYRNPTSLDTQLPIFRKLSRPLAELETLAQQLTTVCSPVQTQFNVTIKPCQTQVG
SGSQPDVLLDSIALCFSVNANAVKEHNSLSVLQLDKFFKAASLPIIGRITANQLWLDLRGTDNDTQLIEVLTKTLIEFEQ
AHINTLSVLPRVEAQS

Sequences:

>Translated_496_residues
MTQAINSTQALYRCLPAMDSLLLIPQVISFIDQQGKPWIKSLLAQMLQDARQHIAEQQSLPSWCLDLSNIITELARRIAK
AQRPSMTPVINLTGTILHTNLGRSQMCEAAIDAVTQVMRSPVPLEFDMGQGKRGHRDSAISALIHELTGADTCCIVNNNA
AAVLLMLAATAAGKEVIVSRGELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITEDTAAIMKVHTSNYHISG
FTKVTEEAELAALCKERGIALISDLGSGALTDLSRFGLSKEPMPQQMLKDGVNLVSFSGDKLLGGPQAGLVVGDAELIAK
LQAHPLKRALRCDKMTLAALEATLMQYRNPTSLDTQLPIFRKLSRPLAELETLAQQLTTVCSPVQTQFNVTIKPCQTQVG
SGSQPDVLLDSIALCFSVNANAVKEHNSLSVLQLDKFFKAASLPIIGRITANQLWLDLRGTDNDTQLIEVLTKTLIEFEQ
AHINTLSVLPRVEAQS
>Mature_495_residues
TQAINSTQALYRCLPAMDSLLLIPQVISFIDQQGKPWIKSLLAQMLQDARQHIAEQQSLPSWCLDLSNIITELARRIAKA
QRPSMTPVINLTGTILHTNLGRSQMCEAAIDAVTQVMRSPVPLEFDMGQGKRGHRDSAISALIHELTGADTCCIVNNNAA
AVLLMLAATAAGKEVIVSRGELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITEDTAAIMKVHTSNYHISGF
TKVTEEAELAALCKERGIALISDLGSGALTDLSRFGLSKEPMPQQMLKDGVNLVSFSGDKLLGGPQAGLVVGDAELIAKL
QAHPLKRALRCDKMTLAALEATLMQYRNPTSLDTQLPIFRKLSRPLAELETLAQQLTTVCSPVQTQFNVTIKPCQTQVGS
GSQPDVLLDSIALCFSVNANAVKEHNSLSVLQLDKFFKAASLPIIGRITANQLWLDLRGTDNDTQLIEVLTKTLIEFEQA
HINTLSVLPRVEAQS

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis [H]

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family [H]

Homologues:

Organism=Escherichia coli, GI2367248, Length=467, Percent_Identity=53.9614561027837, Blast_Score=452, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534 [H]

Pfam domain/function: PF03841 SelA [H]

EC number: =2.9.1.1 [H]

Molecular weight: Translated: 53735; Mature: 53604

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAINSTQALYRCLPAMDSLLLIPQVISFIDQQGKPWIKSLLAQMLQDARQHIAEQQSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PSWCLDLSNIITELARRIAKAQRPSMTPVINLTGTILHTNLGRSQMCEAAIDAVTQVMRS
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECEEEEECCCCHHHHHHHHHHHHHHHHCC
PVPLEFDMGQGKRGHRDSAISALIHELTGADTCCIVNNNAAAVLLMLAATAAGKEVIVSR
CCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHCC
GELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITEDTAAIMKVHTSNYHISG
CCEEEECCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCEEECC
FTKVTEEAELAALCKERGIALISDLGSGALTDLSRFGLSKEPMPQQMLKDGVNLVSFSGD
HHHHHHHHHHHHHHHHCCCEEEHHCCCCHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCC
KLLGGPQAGLVVGDAELIAKLQAHPLKRALRCDKMTLAALEATLMQYRNPTSLDTQLPIF
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
RKLSRPLAELETLAQQLTTVCSPVQTQFNVTIKPCQTQVGSGSQPDVLLDSIALCFSVNA
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
NAVKEHNSLSVLQLDKFFKAASLPIIGRITANQLWLDLRGTDNDTQLIEVLTKTLIEFEQ
HHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHH
AHINTLSVLPRVEAQS
HHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQAINSTQALYRCLPAMDSLLLIPQVISFIDQQGKPWIKSLLAQMLQDARQHIAEQQSL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PSWCLDLSNIITELARRIAKAQRPSMTPVINLTGTILHTNLGRSQMCEAAIDAVTQVMRS
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECEEEEECCCCHHHHHHHHHHHHHHHHCC
PVPLEFDMGQGKRGHRDSAISALIHELTGADTCCIVNNNAAAVLLMLAATAAGKEVIVSR
CCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHCC
GELVEIGGAFRIPDIMAQAGCKLVEVGCTNRTHLKDYAAAITEDTAAIMKVHTSNYHISG
CCEEEECCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCEEECC
FTKVTEEAELAALCKERGIALISDLGSGALTDLSRFGLSKEPMPQQMLKDGVNLVSFSGD
HHHHHHHHHHHHHHHHCCCEEEHHCCCCHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCC
KLLGGPQAGLVVGDAELIAKLQAHPLKRALRCDKMTLAALEATLMQYRNPTSLDTQLPIF
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
RKLSRPLAELETLAQQLTTVCSPVQTQFNVTIKPCQTQVGSGSQPDVLLDSIALCFSVNA
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
NAVKEHNSLSVLQLDKFFKAASLPIIGRITANQLWLDLRGTDNDTQLIEVLTKTLIEFEQ
HHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHH
AHINTLSVLPRVEAQS
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]