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The map label for this gene is aceE [H]

Identifier: 157960248

GI number: 157960248

Start: 512019

End: 514679

Strand: Direct

Name: aceE [H]

Synonym: Spea_0419

Alternate gene names: 157960248

Gene position: 512019-514679 (Clockwise)

Preceding gene: 157960247

Following gene: 157960249

Centisome position: 9.89

GC content: 44.87

Gene sequence:

>2661_bases
ATGTCTGAACATATGCTAAATGACATCGATCCACTAGAAACTAATGAGTGGTTGTCTGCTCTAGAATCAGTTGTACGCGA
AGAAGGCGTTGAGCGCGCTCAATACCTACTTGAGCAAGTACTTGATAAGGCTCGTCTAGACGGTGTCGATATGGCAACGG
GGATTACGACCAACTATATCAACACCATTCCTACGAGCCAAGAGCCAGCATATCCTGGTAATACAACTATTGAGCGCCGT
ATTCGTTCAATTATTCGTTGGAACGCAATCATGATCGTCCTACGTGCATCTAAGAAAGACTTAGATCTCGGTGGTCATAT
GGCGTCTTACCAATCTGCTGCATCATTTTATGAAATGTGTTTTAACCATTTCTTCCGTGCACCAAACGAAGTAGATGGTG
GTGATTTAGTTTACTATCAGGGTCATATATCTCCAGGTATCTACTCGCGCGCATTTCTTGAAGGTCGTTTAACTGCCGAT
CAGTTAGATAACTTCCGTCAAGAAGTTGATGGTAAAGGTATTCCTTCATACCCACATCCAAAGTTAATGCCTGAGTTCTG
GCAGTTCCCGACTGTATCTATGGGTCTAGGCCCAATGTCTGCTATTTACCAAGCCCGTTTCCTTAAGTACCTAGATGGCC
GTGGTCTAAAAGATACCTCTGCACAGCGAGTATACGCCTTCTTAGGTGACGGTGAGATGGATGAGCCAGAATCTCGCGGT
GCTATCTCTTTCGCATCACGTGAAAAGCTAGATAACCTATGTTTCTTGATTAACTGTAACCTACAGCGTCTTGATGGCCC
AGTTATGGGTAACGGTAAGATCATTCAAGAGCTTGAAGGTCTATTTAGAGGCGCTGGCTGGAACGTAGTTAAAGTGATCT
GGGGCAATAACTGGGATGCACTGATTGCCAAAGATACTACTGGTAAGCTGCTACAGCTTATGAACGAAACCATTGACGGT
GACTACCAGACATTTAAGTCCAAAGATGGCGCTTATGTACGTGAGCACTTCTTTGGTAAGTACCCAGAAACAGCTGCACT
TGTATCTGATATGACAGATGCAGAGATCTTCGCGCTTAAGCGCGGTGGTCATGAGCCTTCTAAATTGTTTGCAGCATTTA
AAAATGCGCAAGAAACTAAAGGCAAGCCAACAGTTATCTTAGCTAAAACTGTAAAAGGTTATGGCATGGGCGATGCTGCT
GAAGGCAAGAACATCGCTCACGGCGTGAAGAAGATGGATATGACCCATGTACTTCAGTTGCGTAACCGTCTTGGTCTTGG
CGACTTGCTTAGCGATGAAAAAGTGTCAGAGTTGCCTTACCTAACGCTTGAAGAAGGTTCTGAAGAGTACAAGTATTTGC
ACGCTCGTCGTGATGCGCTACATGGTTATACACCACAGCGTCTACCTAACTTTACTCAGCCACTTGAACTACCAGTTGTT
GAAGAGTTCAGTTCTTTGCTTGTTGAGCAAAAGCGTGAAATCTCAACCACTATGGCATTTGTTCGTACCCTGAACATCCT
GCTTAAGAACAAAGGCATTGGTAAGAACATCGTTCCTATTATTGCTGACGAAGCACGTACTTTCGGTATGGAAGGTCTGT
TCCGTCAAATTGGTATTTACAACCCGCATGGTCAGGAATACACGCCTGAAGATCGCAGTGTTGTGTCGTACTATAAAGAA
GCGACTTCTGGTCAAGTATTGCAGGAAGGTATCAACGAGTTAGGTGCTATGTCTTCATGGGTTGCTGCGGCAACGTCATA
CAGCACTAACGATCTACCTATGATCCCGTTCTACATCTACTACTCTATGTTTGGTTTCCAACGTGTTGGCGACATGGCAT
GGATGGCGGGTGATCAGCAAGCACGTGGTTTCCTATTAGGTGCTACTGCTGGTCGTACAACGCTAAACGGTGAAGGTCTG
CAGCACGAAGATGGCCACAGCCATGTTCAAGCTAACACGATTCCAAACTGTATCTCTTACGACCCAACATTCGCGTACGA
GCTAGCGGTTATCATGCAAGACGGTATCCGTCGTATGTATGGCGAGCAAGAGAACGTGTTCTATTACTTGACGCTAATGA
ATGAAAACTACGCAATGCCTGCAATGCCAGAAGGCAGCGAAGAAGGTATCCGTAAGGGTATTTATAAGCTTGAGTCGTAC
AAAGGTAGCAACAAGGTTCAGTTAATGAGCTCTGGTACTATCATGAACGAAGTGCGTAAAGCTGCGCAAATTCTAAGTGA
AGAGTACGACGTTGCATCAGATGTTTACTCTGTGACTTCATTCAACGAGCTAACTCGTGAAGGTCAAGATGTTGAGCGTT
TCAACATGCTGCACCCAGAAGCAGAGCAAAAGACTGCGTACATTACTCAAGTAATGGGCACTGAACCTGCAATTGCTGCA
ACCGATTACATGAAGAACTATGCTGAACAAGTTCGTGCATTTATGCCTTCTGAATCATTCAAAGTGCTAGGTACAGACGG
TTTTGGTCGTTCAGACAGCCGTGAAAATCTACGTCGTCACTTTGAAGTAAATGCTGGTTACGTTGTAGTAGCTGCACTAA
ACGAACTCGCAAAACGTGGCGATATTGAAAAGTCAGTGGTTGCAGCAGCAATTACTAAATTCAACATCGACGCTGACAAG
ACAAACCCGCTATACGCGTAA

Upstream 100 bases:

>100_bases
TTAAACGAGTTACCCCTGTTGCCAAACAATATTTCAAAATTTAAATACACTAATCACTGCAGTAGTGACTTAGGTATTAC
GTATAGGAAAGGACTGCAAC

Downstream 100 bases:

>100_bases
GAGGCAATACAAAATGACAATCGAAATTAATGTACCAGATATCGGTGCGGATGAGGTTGAAGTAACAGAGATCCTTGTTA
GCGTAGGCGACAAGGTTGAA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 886; Mature: 885

Protein sequence:

>886_residues
MSEHMLNDIDPLETNEWLSALESVVREEGVERAQYLLEQVLDKARLDGVDMATGITTNYINTIPTSQEPAYPGNTTIERR
IRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAASFYEMCFNHFFRAPNEVDGGDLVYYQGHISPGIYSRAFLEGRLTAD
QLDNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPMSAIYQARFLKYLDGRGLKDTSAQRVYAFLGDGEMDEPESRG
AISFASREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFRGAGWNVVKVIWGNNWDALIAKDTTGKLLQLMNETIDG
DYQTFKSKDGAYVREHFFGKYPETAALVSDMTDAEIFALKRGGHEPSKLFAAFKNAQETKGKPTVILAKTVKGYGMGDAA
EGKNIAHGVKKMDMTHVLQLRNRLGLGDLLSDEKVSELPYLTLEEGSEEYKYLHARRDALHGYTPQRLPNFTQPLELPVV
EEFSSLLVEQKREISTTMAFVRTLNILLKNKGIGKNIVPIIADEARTFGMEGLFRQIGIYNPHGQEYTPEDRSVVSYYKE
ATSGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIYYSMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGL
QHEDGHSHVQANTIPNCISYDPTFAYELAVIMQDGIRRMYGEQENVFYYLTLMNENYAMPAMPEGSEEGIRKGIYKLESY
KGSNKVQLMSSGTIMNEVRKAAQILSEEYDVASDVYSVTSFNELTREGQDVERFNMLHPEAEQKTAYITQVMGTEPAIAA
TDYMKNYAEQVRAFMPSESFKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALNELAKRGDIEKSVVAAAITKFNIDADK
TNPLYA

Sequences:

>Translated_886_residues
MSEHMLNDIDPLETNEWLSALESVVREEGVERAQYLLEQVLDKARLDGVDMATGITTNYINTIPTSQEPAYPGNTTIERR
IRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAASFYEMCFNHFFRAPNEVDGGDLVYYQGHISPGIYSRAFLEGRLTAD
QLDNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPMSAIYQARFLKYLDGRGLKDTSAQRVYAFLGDGEMDEPESRG
AISFASREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFRGAGWNVVKVIWGNNWDALIAKDTTGKLLQLMNETIDG
DYQTFKSKDGAYVREHFFGKYPETAALVSDMTDAEIFALKRGGHEPSKLFAAFKNAQETKGKPTVILAKTVKGYGMGDAA
EGKNIAHGVKKMDMTHVLQLRNRLGLGDLLSDEKVSELPYLTLEEGSEEYKYLHARRDALHGYTPQRLPNFTQPLELPVV
EEFSSLLVEQKREISTTMAFVRTLNILLKNKGIGKNIVPIIADEARTFGMEGLFRQIGIYNPHGQEYTPEDRSVVSYYKE
ATSGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIYYSMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGL
QHEDGHSHVQANTIPNCISYDPTFAYELAVIMQDGIRRMYGEQENVFYYLTLMNENYAMPAMPEGSEEGIRKGIYKLESY
KGSNKVQLMSSGTIMNEVRKAAQILSEEYDVASDVYSVTSFNELTREGQDVERFNMLHPEAEQKTAYITQVMGTEPAIAA
TDYMKNYAEQVRAFMPSESFKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALNELAKRGDIEKSVVAAAITKFNIDADK
TNPLYA
>Mature_885_residues
SEHMLNDIDPLETNEWLSALESVVREEGVERAQYLLEQVLDKARLDGVDMATGITTNYINTIPTSQEPAYPGNTTIERRI
RSIIRWNAIMIVLRASKKDLDLGGHMASYQSAASFYEMCFNHFFRAPNEVDGGDLVYYQGHISPGIYSRAFLEGRLTADQ
LDNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPMSAIYQARFLKYLDGRGLKDTSAQRVYAFLGDGEMDEPESRGA
ISFASREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFRGAGWNVVKVIWGNNWDALIAKDTTGKLLQLMNETIDGD
YQTFKSKDGAYVREHFFGKYPETAALVSDMTDAEIFALKRGGHEPSKLFAAFKNAQETKGKPTVILAKTVKGYGMGDAAE
GKNIAHGVKKMDMTHVLQLRNRLGLGDLLSDEKVSELPYLTLEEGSEEYKYLHARRDALHGYTPQRLPNFTQPLELPVVE
EFSSLLVEQKREISTTMAFVRTLNILLKNKGIGKNIVPIIADEARTFGMEGLFRQIGIYNPHGQEYTPEDRSVVSYYKEA
TSGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIYYSMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGLQ
HEDGHSHVQANTIPNCISYDPTFAYELAVIMQDGIRRMYGEQENVFYYLTLMNENYAMPAMPEGSEEGIRKGIYKLESYK
GSNKVQLMSSGTIMNEVRKAAQILSEEYDVASDVYSVTSFNELTREGQDVERFNMLHPEAEQKTAYITQVMGTEPAIAAT
DYMKNYAEQVRAFMPSESFKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALNELAKRGDIEKSVVAAAITKFNIDADKT
NPLYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=889, Percent_Identity=73.0033745781777, Blast_Score=1390, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=228, Percent_Identity=29.3859649122807, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99245; Mature: 99113

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHMLNDIDPLETNEWLSALESVVREEGVERAQYLLEQVLDKARLDGVDMATGITTNYI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHH
NTIPTSQEPAYPGNTTIERRIRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAASFYEMC
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
FNHFFRAPNEVDGGDLVYYQGHISPGIYSRAFLEGRLTADQLDNFRQEVDGKGIPSYPHP
HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPEFWQFPTVSMGLGPMSAIYQARFLKYLDGRGLKDTSAQRVYAFLGDGEMDEPESRG
CCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCCCCCCCCC
AISFASREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFRGAGWNVVKVIWGNNWDA
CEEHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCE
LIAKDTTGKLLQLMNETIDGDYQTFKSKDGAYVREHFFGKYPETAALVSDMTDAEIFALK
EEEECCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHHHCCCCHHEEEEC
RGGHEPSKLFAAFKNAQETKGKPTVILAKTVKGYGMGDAAEGKNIAHGVKKMDMTHVLQL
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RNRLGLGDLLSDEKVSELPYLTLEEGSEEYKYLHARRDALHGYTPQRLPNFTQPLELPVV
HHHCCCCHHCCCCHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHH
EEFSSLLVEQKREISTTMAFVRTLNILLKNKGIGKNIVPIIADEARTFGMEGLFRQIGIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHCHHHHHHHHCCC
NPHGQEYTPEDRSVVSYYKEATSGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIY
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
YSMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGLQHEDGHSHVQANTIPNCISY
HHHHHHHHHCCHHHHCCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCC
DPTFAYELAVIMQDGIRRMYGEQENVFYYLTLMNENYAMPAMPEGSEEGIRKGIYKLESY
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
KGSNKVQLMSSGTIMNEVRKAAQILSEEYDVASDVYSVTSFNELTREGQDVERFNMLHPE
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
AEQKTAYITQVMGTEPAIAATDYMKNYAEQVRAFMPSESFKVLGTDGFGRSDSRENLRRH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHH
FEVNAGYVVVAALNELAKRGDIEKSVVAAAITKFNIDADKTNPLYA
EECCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SEHMLNDIDPLETNEWLSALESVVREEGVERAQYLLEQVLDKARLDGVDMATGITTNYI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHH
NTIPTSQEPAYPGNTTIERRIRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAASFYEMC
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
FNHFFRAPNEVDGGDLVYYQGHISPGIYSRAFLEGRLTADQLDNFRQEVDGKGIPSYPHP
HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPEFWQFPTVSMGLGPMSAIYQARFLKYLDGRGLKDTSAQRVYAFLGDGEMDEPESRG
CCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCCCCCCCCC
AISFASREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFRGAGWNVVKVIWGNNWDA
CEEHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCE
LIAKDTTGKLLQLMNETIDGDYQTFKSKDGAYVREHFFGKYPETAALVSDMTDAEIFALK
EEEECCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHHHCCCCHHEEEEC
RGGHEPSKLFAAFKNAQETKGKPTVILAKTVKGYGMGDAAEGKNIAHGVKKMDMTHVLQL
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RNRLGLGDLLSDEKVSELPYLTLEEGSEEYKYLHARRDALHGYTPQRLPNFTQPLELPVV
HHHCCCCHHCCCCHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHH
EEFSSLLVEQKREISTTMAFVRTLNILLKNKGIGKNIVPIIADEARTFGMEGLFRQIGIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHCHHHHHHHHCCC
NPHGQEYTPEDRSVVSYYKEATSGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIY
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
YSMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGLQHEDGHSHVQANTIPNCISY
HHHHHHHHHCCHHHHCCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCC
DPTFAYELAVIMQDGIRRMYGEQENVFYYLTLMNENYAMPAMPEGSEEGIRKGIYKLESY
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
KGSNKVQLMSSGTIMNEVRKAAQILSEEYDVASDVYSVTSFNELTREGQDVERFNMLHPE
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
AEQKTAYITQVMGTEPAIAATDYMKNYAEQVRAFMPSESFKVLGTDGFGRSDSRENLRRH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHH
FEVNAGYVVVAALNELAKRGDIEKSVVAAAITKFNIDADKTNPLYA
EECCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]