Click here to switch to the map view.

The map label for this gene is pdhR [H]

Identifier: 157960247

GI number: 157960247

Start: 511158

End: 511910

Strand: Direct

Name: pdhR [H]

Synonym: Spea_0418

Alternate gene names: 157960247

Gene position: 511158-511910 (Clockwise)

Preceding gene: 157960246

Following gene: 157960248

Centisome position: 9.88

GC content: 45.68

Gene sequence:

>753_bases
ATGGCTTATAGCAAAATAAACCAGCCAAAAATATCCGATGTCATTATGGGACAGTTGGAGCAGATGATTCTGGAAGGCAG
TATTCAACCAGGACAAAAGCTACCACCTGAACGTGAACTGGCATTGCAATTTGAAGTTTCGCGCCCTTCTTTACGTGAAG
CGATTCAAAAATTAGAAGCAAAGGGCTTGTTGATGCGTCGTCAAGGCGGCGGAACCTATGTAAAAGAGCAACTCTGGCAA
AGTCTTGCCGACCCAATTGTTGAACTCATGCATTCAGATTCAGAAAGTCAGTACGACTTACTGGAGTTTCGTCATGCCAC
TGAAGGCATGATGGCGTATTTTGCAGCGCTTCGTGGTAACGACGCCGATATGCAAAATATTAAGCGTACGATTCTGGAAG
TTGAGTCAGCTAATTTAATTGAAGATCAAGCTAATGCGATTGTGCGTTTTTACCGCGCAGTTGCCGAAGCGTCACACAAT
GTGGCTATGCTTCACCTTGTATTAAGTTTATCTCCAGTGCTGCATAAAAACGTGGCACAAAACTTAGAGCTTTTAAGCCG
ACGCGAAGAAGCCTCTACAACGGCTAATGATCACAGACGAGCGCTGCTTGCTGCAATTATTCGCCGCGACCCAGAAGCTG
CACGCGAAGCCTCCAATGAACACTTAAGTTACATTGAAGAGGTGATGCTGTCAGTAAGGGAAGAAGACAGCCGATTGCAG
CGTAGCCTGCGTCGTTTAAAGAGTGGTGTATAG

Upstream 100 bases:

>100_bases
TGATGTAGATCACTAACTGGACATCCAAAGTGTGATTTGATAAAGTGCGCTCAGTCAATTAAATTGGTAAGACCAATTTA
CAATAGGAGCTGAGGCCCAC

Downstream 100 bases:

>100_bases
GCTAACCCTTAAACGAGTTACCCCTGTTGCCAAACAATATTTCAAAATTTAAATACACTAATCACTGCAGTAGTGACTTA
GGTATTACGTATAGGAAAGG

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MAYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SLADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGNDADMQNIKRTILEVESANLIEDQANAIVRFYRAVAEASHN
VAMLHLVLSLSPVLHKNVAQNLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGV

Sequences:

>Translated_250_residues
MAYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SLADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGNDADMQNIKRTILEVESANLIEDQANAIVRFYRAVAEASHN
VAMLHLVLSLSPVLHKNVAQNLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGV
>Mature_249_residues
AYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQS
LADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGNDADMQNIKRTILEVESANLIEDQANAIVRFYRAVAEASHNV
AMLHLVLSLSPVLHKNVAQNLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQR
SLRRLKSGV

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=57.0815450643777, Blast_Score=264, Evalue=3e-72,
Organism=Escherichia coli, GI1790032, Length=242, Percent_Identity=33.8842975206612, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1789353, Length=239, Percent_Identity=27.1966527196653, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790780, Length=225, Percent_Identity=30.2222222222222, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994955, Length=217, Percent_Identity=29.4930875576037, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87082208, Length=236, Percent_Identity=26.6949152542373, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789621, Length=243, Percent_Identity=27.9835390946502, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28328; Mature: 28197

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSLADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGN
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DADMQNIKRTILEVESANLIEDQANAIVRFYRAVAEASHNVAMLHLVLSLSPVLHKNVAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGV
HHHHHHHCCC
>Mature Secondary Structure 
AYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSLADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGN
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DADMQNIKRTILEVESANLIEDQANAIVRFYRAVAEASHNVAMLHLVLSLSPVLHKNVAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGV
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]