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The map label for this gene is ilvC [H]

Identifier: 157960173

GI number: 157960173

Start: 389278

End: 390759

Strand: Direct

Name: ilvC [H]

Synonym: Spea_0344

Alternate gene names: 157960173

Gene position: 389278-390759 (Clockwise)

Preceding gene: 157960171

Following gene: 157960174

Centisome position: 7.52

GC content: 48.72

Gene sequence:

>1482_bases
ATGGCTAACTATTTTAACTCTCTGAATTTGCGTCAACAATTGGAACAGCTGGCTCAATGCCGCTTCATGGATCGTAGCGA
GTTCAGCGAAGGCTGCAACTTCATTAAAGGCTGGAACATCGTCATTCTTGGCTGTGGCGCTCAAGGCCTTAACCAAGGCT
TGAATATGCGTGACTCAGGTCTAAATATCTCTTTCGCATTGCGTGAACAGGCGATTAGCGAAAAACGTGATTCGTACCAG
AAAGCAACCGGTAACGGTTTCCGCGTTGGCACTATCGAAGAGCTTATCCCAGATGCGGATCTCGTGCTTAACCTAACGCC
AGACAAGCAACACACTAATGCTGTTAACACGGTTATGCCGTTAATGAAGCAAGGTGCAACGCTGTCTTACTCGCACGGTT
TCAATATCGTTGAAGAGGGCATGCAAGTTCGCCCAGATATCACGGTTATCATGGTAGCGCCTAAGTGTCCGGGTACTGAA
GTACGTGAAGAGTACAAGCGTGGTTTCGGCGTGCCGACACTGATCGCGGTTCACCCAGAGAATGACCCTAAGGGTGACGG
TTTCGATATCGCTAAGGCTTACGCAAGTGCTACCGGTGGCGATCGCGCTGGTGTATTGCATTCATCTTTCATTGCCGAAG
TGAAGTCAGATCTAATGGGCGAGCAGACTATCCTTTGCGGCATGCTGCAAACGGGTGCGATCCTAGGTTACGAGAAGCTA
GTAGCCGACGGTGTTGAGCCAGGTTACGCGGCTAAGCTCATTCAGCAAGGCTGGGAGACAACGACTGAAGCACTGAAGCA
TGGCGGCATCACTCATATGATGGATCGACTATCAAACCCTGCCAAGATCAAAGCATTTGATATGGCTGAAGAGTTGAAAG
TTATCCTTAAGCCACTGTTTGAAAAGCATATGGACGACATCATAGGTGGTGAGTTCTCTAAGACCATGATGGCCGATTGG
GCTAACGATGACGCGAATCTACTTAAGTGGCGCAGCGAAACTAACGACACGGGTTTTGAAAATGCACCGGGTTGTGAAGA
GCATATCGACGAGCAAGCTTATTTCGATAAAGGCATCTTCTTAGTGGCAATGATCAAGGCCGGTGTTGAGCTTGCTTTCG
ATACCATGGTTGCCGCTGGCATCATCGAAGAGTCGGCTTACTACGAGTCACTGCATGAGACGCCACTTATCGCTAACACC
ATTGCACGTAAGCGTTTGTACGAGATGAACGTGGTGATTTCTGATACCGCAGAATACGGCTGTTACCTATTCAACCATGC
GGCGCTGCCACTACTGAAAGATTACGTGGCGAACATGTCTGCAGAGTACCTAGGCGGTGGCTTACAAGATGCCAGCAACG
GTGTCGATAACGTACGTTTAATCGAGGTTAACGCAGCAATTCGTGGTACTGCAGTTGAAGAAATTGGTGCAGAGCTACGT
GGCTACATGACAGAAATGAAGCGTATCGTAGAAGAGAAGTAA

Upstream 100 bases:

>100_bases
ATTTTAAGCAATGAAAAGCTTGCGCTATAGTGATTACATCACAGCGTGACTCGAGCAAGAGTCAGCCTTATAACAATCCA
GAATCAAGGTGGTATATCAG

Downstream 100 bases:

>100_bases
TTTTGCTTCTATTTTAGTCGGGTCTAAACAGGTTTTTGTTTAGACCTAGGCTAGATGATTTGGAACTTGAGAGCGTCACG
ATTTTAGATAACTCATTAAC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MANYFNSLNLRQQLEQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSGLNISFALREQAISEKRDSYQ
KATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMPLMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGDGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKL
VADGVEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLFEKHMDDIIGGEFSKTMMADW
ANDDANLLKWRSETNDTGFENAPGCEEHIDEQAYFDKGIFLVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAALPLLKDYVANMSAEYLGGGLQDASNGVDNVRLIEVNAAIRGTAVEEIGAELR
GYMTEMKRIVEEK

Sequences:

>Translated_493_residues
MANYFNSLNLRQQLEQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSGLNISFALREQAISEKRDSYQ
KATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMPLMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGDGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKL
VADGVEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLFEKHMDDIIGGEFSKTMMADW
ANDDANLLKWRSETNDTGFENAPGCEEHIDEQAYFDKGIFLVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAALPLLKDYVANMSAEYLGGGLQDASNGVDNVRLIEVNAAIRGTAVEEIGAELR
GYMTEMKRIVEEK
>Mature_492_residues
ANYFNSLNLRQQLEQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSGLNISFALREQAISEKRDSYQK
ATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMPLMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPKGDGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKLV
ADGVEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLFEKHMDDIIGGEFSKTMMADWA
NDDANLLKWRSETNDTGFENAPGCEEHIDEQAYFDKGIFLVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANTI
ARKRLYEMNVVISDTAEYGCYLFNHAALPLLKDYVANMSAEYLGGGLQDASNGVDNVRLIEVNAAIRGTAVEEIGAELRG
YMTEMKRIVEEK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=489, Percent_Identity=71.3701431492842, Blast_Score=721, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=269, Percent_Identity=30.8550185873606, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54259; Mature: 54128

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNSLNLRQQLEQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSG
CCCCHHCCCHHHHHHHHHHHHCCCHHHHHHCCCEECCCCEEEEECCCHHHHCCCCCCCCC
LNISFALREQAISEKRDSYQKATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMP
CCEEHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHCCCEECCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGDGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKL
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHH
VADGVEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
EKHMDDIIGGEFSKTMMADWANDDANLLKWRSETNDTGFENAPGCEEHIDEQAYFDKGIF
HHHHHHHHCCCHHHHHHHHCCCCCHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHH
LVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCHHHH
CYLFNHAALPLLKDYVANMSAEYLGGGLQDASNGVDNVRLIEVNAAIRGTAVEEIGAELR
HHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHH
GYMTEMKRIVEEK
HHHHHHHHHHHCC
>Mature Secondary Structure 
ANYFNSLNLRQQLEQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSG
CCCHHCCCHHHHHHHHHHHHCCCHHHHHHCCCEECCCCEEEEECCCHHHHCCCCCCCCC
LNISFALREQAISEKRDSYQKATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMP
CCEEHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHCCCEECCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGDGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKL
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHH
VADGVEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
EKHMDDIIGGEFSKTMMADWANDDANLLKWRSETNDTGFENAPGCEEHIDEQAYFDKGIF
HHHHHHHHCCCHHHHHHHHCCCCCHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHH
LVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCHHHH
CYLFNHAALPLLKDYVANMSAEYLGGGLQDASNGVDNVRLIEVNAAIRGTAVEEIGAELR
HHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHH
GYMTEMKRIVEEK
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA