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The map label for this gene is hemB [H]

Identifier: 157825860

GI number: 157825860

Start: 715867

End: 716859

Strand: Reverse

Name: hemB [H]

Synonym: A1C_03995

Alternate gene names: 157825860

Gene position: 716859-715867 (Counterclockwise)

Preceding gene: 157825861

Following gene: 157825859

Centisome position: 58.23

GC content: 35.65

Gene sequence:

>993_bases
ATGTACCCCCATATTAGACTTAGAAGAAATAGAAAAGCTTTTTGGCTTAGAGAGTTAATAGCCGAAAGTAATTTATCGGT
TAGTGATTTAGTGTTACCTTTATTTGTTGTTGAAGGACATAATGAAAGACAAGCAATTAAGACTATGCCCGATATATATC
GTTTATCGATCGATCAAATAGTAGAAACGGCAAAAGAAGCAGCAGAGCTTGGTATTAATGCTATTGCATTATTTCCGAGT
ATTGATCAAGGTCTAAAAAATGACAATGCCGACGAGGCTTATAATTTAGATAATTTAATATGTAGAACTATTAGAAGCAT
AAAGAACGCTAATATCGATATCGGTATAATATGTGATGTAGCACTTGATCCGTACACTATAAGCGGTCATGACGGTATTG
TGCATCACGTGGAAGTTGATAATGATAGATCGGTAAGAGCTTTATGTAATCAAGCATTAGTGCTAGCAAAAGCCGGGGTA
GATATTGTTGCACCTTCAGATATGATGGATGGAAGAATCGGGGCTATAAGGGAATATCTTGACAAAGAGGGATTTATAAA
TGTTGGAATTCTTGCTTATGCCGCTAAATATGCTTCAAGCTTTTACGGTCCGTTTCGTGATGCTGTTAAGAGTAATAAAA
AGAATTATTTAGATAAATCAAGCTATCAAATGGATGTACGTAATGTTAAGGAAGCAATGCTTGAGATTAAGCATGATATA
GCAGAGGGAGCCGATATGGTAATGGTTAAACCGGGTATGATGTTTTTGGATGTTATTCGTGAAGCGGCAAATAATTTTAA
TGCTAAACTTTTTGCATATCAGGTTAGCGGAGAATATGCAATGTTAAAATTGGCAGCAGCAGCAGGAGTAATTGATTGGG
AGAGAGCTTTGATGGAGTCATTAATTAGTTTTAAACGTGCCGGTGCAACAGGTATATTTACCTATGCTGCTCTTGAAGTA
GCTGAAATATTAAAGAACAATAAAATTAAGTAG

Upstream 100 bases:

>100_bases
AATTTCTTTTTGGAATACAATATTTTTACTATAAGATAGTTAAGTTATATATTTTCTACATTAGAATCCAAGTTATTAAC
TAAAATGAGATATGAATTTT

Downstream 100 bases:

>100_bases
AAAACGGCTTCTATCCTTGATATAAAATAAATAATATGTTTTATTATTATATAAAAATTATCAATTTTATGTAAATCATT
ATAAAGAGGTGAGGATGACT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MYPHIRLRRNRKAFWLRELIAESNLSVSDLVLPLFVVEGHNERQAIKTMPDIYRLSIDQIVETAKEAAELGINAIALFPS
IDQGLKNDNADEAYNLDNLICRTIRSIKNANIDIGIICDVALDPYTISGHDGIVHHVEVDNDRSVRALCNQALVLAKAGV
DIVAPSDMMDGRIGAIREYLDKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNVKEAMLEIKHDI
AEGADMVMVKPGMMFLDVIREAANNFNAKLFAYQVSGEYAMLKLAAAAGVIDWERALMESLISFKRAGATGIFTYAALEV
AEILKNNKIK

Sequences:

>Translated_330_residues
MYPHIRLRRNRKAFWLRELIAESNLSVSDLVLPLFVVEGHNERQAIKTMPDIYRLSIDQIVETAKEAAELGINAIALFPS
IDQGLKNDNADEAYNLDNLICRTIRSIKNANIDIGIICDVALDPYTISGHDGIVHHVEVDNDRSVRALCNQALVLAKAGV
DIVAPSDMMDGRIGAIREYLDKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNVKEAMLEIKHDI
AEGADMVMVKPGMMFLDVIREAANNFNAKLFAYQVSGEYAMLKLAAAAGVIDWERALMESLISFKRAGATGIFTYAALEV
AEILKNNKIK
>Mature_330_residues
MYPHIRLRRNRKAFWLRELIAESNLSVSDLVLPLFVVEGHNERQAIKTMPDIYRLSIDQIVETAKEAAELGINAIALFPS
IDQGLKNDNADEAYNLDNLICRTIRSIKNANIDIGIICDVALDPYTISGHDGIVHHVEVDNDRSVRALCNQALVLAKAGV
DIVAPSDMMDGRIGAIREYLDKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNVKEAMLEIKHDI
AEGADMVMVKPGMMFLDVIREAANNFNAKLFAYQVSGEYAMLKLAAAAGVIDWERALMESLISFKRAGATGIFTYAALEV
AEILKNNKIK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. Required for nodule development [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=310, Percent_Identity=36.4516129032258, Blast_Score=202, Evalue=4e-52,
Organism=Escherichia coli, GI87081728, Length=317, Percent_Identity=42.2712933753943, Blast_Score=231, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=36.3636363636364, Blast_Score=175, Evalue=9e-45,
Organism=Drosophila melanogaster, GI21358291, Length=303, Percent_Identity=38.6138613861386, Blast_Score=217, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36725; Mature: 36725

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPHIRLRRNRKAFWLRELIAESNLSVSDLVLPLFVVEGHNERQAIKTMPDIYRLSIDQI
CCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHEECCCCHHHHHHHCHHHHHHHHHHH
VETAKEAAELGINAIALFPSIDQGLKNDNADEAYNLDNLICRTIRSIKNANIDIGIICDV
HHHHHHHHHCCCCEEEECCCHHHHCCCCCCCHHCCHHHHHHHHHHHHHCCCCEEEEEEEE
ALDPYTISGHDGIVHHVEVDNDRSVRALCNQALVLAKAGVDIVAPSDMMDGRIGAIREYL
CCCCEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEECCCHHHCCHHHHHHHHH
DKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNVKEAMLEIKHDI
CCCCCEEHHHHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AEGADMVMVKPGMMFLDVIREAANNFNAKLFAYQVSGEYAMLKLAAAAGVIDWERALMES
HCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHH
LISFKRAGATGIFTYAALEVAEILKNNKIK
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYPHIRLRRNRKAFWLRELIAESNLSVSDLVLPLFVVEGHNERQAIKTMPDIYRLSIDQI
CCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHEECCCCHHHHHHHCHHHHHHHHHHH
VETAKEAAELGINAIALFPSIDQGLKNDNADEAYNLDNLICRTIRSIKNANIDIGIICDV
HHHHHHHHHCCCCEEEECCCHHHHCCCCCCCHHCCHHHHHHHHHHHHHCCCCEEEEEEEE
ALDPYTISGHDGIVHHVEVDNDRSVRALCNQALVLAKAGVDIVAPSDMMDGRIGAIREYL
CCCCEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEECCCHHHCCHHHHHHHHH
DKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNVKEAMLEIKHDI
CCCCCEEHHHHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AEGADMVMVKPGMMFLDVIREAANNFNAKLFAYQVSGEYAMLKLAAAAGVIDWERALMES
HCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHH
LISFKRAGATGIFTYAALEVAEILKNNKIK
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226669; 12597275 [H]