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The map label for this gene is holB [H]

Identifier: 157825357

GI number: 157825357

Start: 229385

End: 230263

Strand: Direct

Name: holB [H]

Synonym: A1C_01225

Alternate gene names: 157825357

Gene position: 229385-230263 (Clockwise)

Preceding gene: 157825356

Following gene: 157825358

Centisome position: 18.63

GC content: 27.53

Gene sequence:

>879_bases
GTGATACTAGAAAAACCGGCTCATGCAACAATGCTCTGCAAAAGCCGGAATGATATAGAACAATTCTTAACGATATTACA
ACCATTGATAATTGAACGCCTAAAGTTTAACTTAAAGCATAATAAGCTATATCATAGTTGGCTTATCGAAGCTGAAAATA
TAGAGCAAGCTTTAAAAGATTTAGAAGATTTCGTATATAGTACGCTTTTTAAGAATAGCATTCCGCTTGAAAACAATCCT
GATTATCATTTTATCTCTAGAGAAACTTCATATACATCTAATGCTAAAAATATTTCTATTGAACAAATAAGAAAATTACA
AGACTTCTTAAGTAAAACTTCTGCAATCTCAGGTTATAAAGTTGTAGTAATTTATGCGGCAGATCTTATGAATTTGAATG
CAGCGAATTCATGTTTAAAAATTCTTGAAGATGCACCAAAGAATAGTTACATTTTTTTAATTACTTCAAGAGCTGCAAGT
ATTATATCTACGATTAGATCAAGATGTTTTAAAGTTAATATTAGATCTACTCTACCTCATGCTCGAAATGACTTATATCT
TCAGTTTATTCAACCGATAGCAGATAATGAAACATTAGATTTTATTCATCGTTTTACTAATAAAGACCGAGAATTATGGC
TAGATTTTATTGACAATTTATTATTATTAATGAATAGAATGCTTAAAAAAGCTGCTAACGTTAATATTGAACTGCTAGAT
TTAGAAAATAAGATTTTTAATAAATTATCAAATAAGCATCCTTCCTATTTACTACAAAAATTTACCGGTATAAAAAAGTT
AATATATAATACCATTGATTATGATTTGGACTTAAAAACAAGTTATATATTAGTGGTGAATGAGTTTACTAGTAATTAA

Upstream 100 bases:

>100_bases
CCTACTTTTAGAGCTGGAAGAAAAATGAAAGAAGCTTGTAATTAAAAAAGTAACTTATTACAGTACTGATAGTTTCCAAA
CCACGTTATAAGTTTGCAGG

Downstream 100 bases:

>100_bases
CACGACATCACTACGTTCCTTTCAATGTTATTCATAAAAGGCGTTATTGTATGGATAGGTAAAATCAGTTGTGTCACCCT
GTGGCTCGACCACTTTGTCC

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MILEKPAHATMLCKSRNDIEQFLTILQPLIIERLKFNLKHNKLYHSWLIEAENIEQALKDLEDFVYSTLFKNSIPLENNP
DYHFISRETSYTSNAKNISIEQIRKLQDFLSKTSAISGYKVVVIYAADLMNLNAANSCLKILEDAPKNSYIFLITSRAAS
IISTIRSRCFKVNIRSTLPHARNDLYLQFIQPIADNETLDFIHRFTNKDRELWLDFIDNLLLLMNRMLKKAANVNIELLD
LENKIFNKLSNKHPSYLLQKFTGIKKLIYNTIDYDLDLKTSYILVVNEFTSN

Sequences:

>Translated_292_residues
MILEKPAHATMLCKSRNDIEQFLTILQPLIIERLKFNLKHNKLYHSWLIEAENIEQALKDLEDFVYSTLFKNSIPLENNP
DYHFISRETSYTSNAKNISIEQIRKLQDFLSKTSAISGYKVVVIYAADLMNLNAANSCLKILEDAPKNSYIFLITSRAAS
IISTIRSRCFKVNIRSTLPHARNDLYLQFIQPIADNETLDFIHRFTNKDRELWLDFIDNLLLLMNRMLKKAANVNIELLD
LENKIFNKLSNKHPSYLLQKFTGIKKLIYNTIDYDLDLKTSYILVVNEFTSN
>Mature_292_residues
MILEKPAHATMLCKSRNDIEQFLTILQPLIIERLKFNLKHNKLYHSWLIEAENIEQALKDLEDFVYSTLFKNSIPLENNP
DYHFISRETSYTSNAKNISIEQIRKLQDFLSKTSAISGYKVVVIYAADLMNLNAANSCLKILEDAPKNSYIFLITSRAAS
IISTIRSRCFKVNIRSTLPHARNDLYLQFIQPIADNETLDFIHRFTNKDRELWLDFIDNLLLLMNRMLKKAANVNIELLD
LENKIFNKLSNKHPSYLLQKFTGIKKLIYNTIDYDLDLKTSYILVVNEFTSN

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 34033; Mature: 34033

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILEKPAHATMLCKSRNDIEQFLTILQPLIIERLKFNLKHNKLYHSWLIEAENIEQALKD
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LEDFVYSTLFKNSIPLENNPDYHFISRETSYTSNAKNISIEQIRKLQDFLSKTSAISGYK
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCE
VVVIYAADLMNLNAANSCLKILEDAPKNSYIFLITSRAASIISTIRSRCFKVNIRSTLPH
EEEEEEEHHHCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHEEEEHHHHCCC
ARNDLYLQFIQPIADNETLDFIHRFTNKDRELWLDFIDNLLLLMNRMLKKAANVNIELLD
CCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
LENKIFNKLSNKHPSYLLQKFTGIKKLIYNTIDYDLDLKTSYILVVNEFTSN
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEECCCCC
>Mature Secondary Structure
MILEKPAHATMLCKSRNDIEQFLTILQPLIIERLKFNLKHNKLYHSWLIEAENIEQALKD
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LEDFVYSTLFKNSIPLENNPDYHFISRETSYTSNAKNISIEQIRKLQDFLSKTSAISGYK
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCE
VVVIYAADLMNLNAANSCLKILEDAPKNSYIFLITSRAASIISTIRSRCFKVNIRSTLPH
EEEEEEEHHHCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHEEEEHHHHCCC
ARNDLYLQFIQPIADNETLDFIHRFTNKDRELWLDFIDNLLLLMNRMLKKAANVNIELLD
CCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
LENKIFNKLSNKHPSYLLQKFTGIKKLIYNTIDYDLDLKTSYILVVNEFTSN
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]