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The map label for this gene is ffh [H]

Identifier: 157825358

GI number: 157825358

Start: 230546

End: 231895

Strand: Direct

Name: ffh [H]

Synonym: A1C_01230

Alternate gene names: 157825358

Gene position: 230546-231895 (Clockwise)

Preceding gene: 157825357

Following gene: 157825359

Centisome position: 18.73

GC content: 34.44

Gene sequence:

>1350_bases
ATGTTTAAAACTTTAACACAAAATTTAACGAAGATTTTTGATAAATTAGCCAGTTCAGGCATTTTAACGGAAGCTCAAAT
AGATAACGCTATGCGTGATATCAGAGTGGCTCTTTTAGAGTCGGATGTTGCATTACCGGTGATAAAAGATTTTATAGCAG
AAGTTAAAAAGAACGCTTTAGGGCATGAGGTTATTAAATCCGTTTCACCGGGGCAGATGATAATTAAAATTATTCATGAA
GAGATGATAAATCTCTTAGCTTCAAGTGAAAGTGAGACAAAGCTAAATTTAAATTCAAAGCCGCCCATAAATTTCCTAAT
GGTAGGGCTGCAAGGGAGCGGTAAAACTACCGCAAGTGGCAAGCTTGCTCTGCGACTTAAAAATCAAAATAAAAAAGTTT
TACTTGTTTCTTTGGATACTTACAGACCGGCCGCCCAAGAGCAACTTGCTATACTGGCAAACTCAGTACAGATTAATTCA
TTACCTATTGTGCAAGGTGAGCAACCTCTTGATATTGTCACAAGAGCTATTGCCGAGGCTAAAATTTCTGCTTATGACGT
TGTAATTTATGATACGGCAGGTCGTACACAAATTGATCAAGAGATGATGGAGGAAGCGCTTGCAATAAAAAATATAGTGG
AGCCTACAGAAACTTTGCTAGTAATTGATAGTATGACAGGGCAGGATGCGGTAGTTACGGCAAGCAACTTTAATAAAAAG
TTAGAAATTTCAGGATTAATTTTATCTAGAATTGACGGCGATTCTAAAGGCGGTGCAGCACTTAGTGTAAAATATATTAC
TAAAAAGCCGATTAAATTTTTAAGTAGCGGTGAAAAACTAACTGATTTAGAAGAATTCAATGCTGAACGTTTAGCTTCTC
GAATACTTGATATGGGCGATATTATATCTTTTGTTGAAAAAGCAGCTAGTATCGTTGATAGAGAAGAAGCTGAAAAAACT
GCAGCTAAATTAAAAAAAGGTAAGTTTGATTTAAATGATTATCTTCAGCAAATGAGAAGTATAAAAAAAATGGGAGGTTT
TGGAAGTATACTTAGTATGTTACCGGGTAGCGGTAAAATTATGGATCAAATAGATCAATCAAAATTAAATAGTAAAATAA
TTGAACATCAAGAAGCAATGATTTTATCTATGACTCTGAAAGAACGTAAGAATCCGGATATAATTAATGCATCTCGTAGA
AAACGTATAGCTGCTGGAGCAGGGACTACAGTACAAAAAGTCAATATTTTGCTAAAGCAATATAAGCAAATAAGTGAGAT
GATGAAAAAAGCCAGTAAAATGAATCCTAAAAATCTATTACGTAGCGGAATTGGAAAATTGTTTTCATAA

Upstream 100 bases:

>100_bases
TCGATTCATGCAACAACGCCTACATAAAACCATAAAATATTATTGTTGCTAAAACATATTGGGCAAAATATATTAGAACT
TTATAAATTAAATTACTTAC

Downstream 100 bases:

>100_bases
AACGGCATTATTGCCTGGAGTGGTAAAATCCACTGTGTCACCCCGTGGCTTGACAAAGGTGAAATTAATCCACACGGGCA
ATGCACACGTGAAGTAAAAT

Product: Signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFKTLTQNLTKIFDKLASSGILTEAQIDNAMRDIRVALLESDVALPVIKDFIAEVKKNALGHEVIKSVSPGQMIIKIIHE
EMINLLASSESETKLNLNSKPPINFLMVGLQGSGKTTASGKLALRLKNQNKKVLLVSLDTYRPAAQEQLAILANSVQINS
LPIVQGEQPLDIVTRAIAEAKISAYDVVIYDTAGRTQIDQEMMEEALAIKNIVEPTETLLVIDSMTGQDAVVTASNFNKK
LEISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGEKLTDLEEFNAERLASRILDMGDIISFVEKAASIVDREEAEKT
AAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAMILSMTLKERKNPDIINASRR
KRIAAGAGTTVQKVNILLKQYKQISEMMKKASKMNPKNLLRSGIGKLFS

Sequences:

>Translated_449_residues
MFKTLTQNLTKIFDKLASSGILTEAQIDNAMRDIRVALLESDVALPVIKDFIAEVKKNALGHEVIKSVSPGQMIIKIIHE
EMINLLASSESETKLNLNSKPPINFLMVGLQGSGKTTASGKLALRLKNQNKKVLLVSLDTYRPAAQEQLAILANSVQINS
LPIVQGEQPLDIVTRAIAEAKISAYDVVIYDTAGRTQIDQEMMEEALAIKNIVEPTETLLVIDSMTGQDAVVTASNFNKK
LEISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGEKLTDLEEFNAERLASRILDMGDIISFVEKAASIVDREEAEKT
AAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAMILSMTLKERKNPDIINASRR
KRIAAGAGTTVQKVNILLKQYKQISEMMKKASKMNPKNLLRSGIGKLFS
>Mature_449_residues
MFKTLTQNLTKIFDKLASSGILTEAQIDNAMRDIRVALLESDVALPVIKDFIAEVKKNALGHEVIKSVSPGQMIIKIIHE
EMINLLASSESETKLNLNSKPPINFLMVGLQGSGKTTASGKLALRLKNQNKKVLLVSLDTYRPAAQEQLAILANSVQINS
LPIVQGEQPLDIVTRAIAEAKISAYDVVIYDTAGRTQIDQEMMEEALAIKNIVEPTETLLVIDSMTGQDAVVTASNFNKK
LEISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGEKLTDLEEFNAERLASRILDMGDIISFVEKAASIVDREEAEKT
AAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAMILSMTLKERKNPDIINASRR
KRIAAGAGTTVQKVNILLKQYKQISEMMKKASKMNPKNLLRSGIGKLFS

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=461, Percent_Identity=30.1518438177874, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI226371618, Length=403, Percent_Identity=31.0173697270471, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=33.125, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI295424842, Length=219, Percent_Identity=30.5936073059361, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI23308697, Length=219, Percent_Identity=30.5936073059361, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788963, Length=423, Percent_Identity=50.354609929078, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1789874, Length=233, Percent_Identity=36.480686695279, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=29.8206278026906, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=214, Percent_Identity=31.7757009345794, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=419, Percent_Identity=31.980906921241, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=211, Percent_Identity=30.8056872037915, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647949, Length=445, Percent_Identity=28.9887640449438, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24641198, Length=273, Percent_Identity=28.9377289377289, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49317; Mature: 49317

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTLTQNLTKIFDKLASSGILTEAQIDNAMRDIRVALLESDVALPVIKDFIAEVKKNAL
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GHEVIKSVSPGQMIIKIIHEEMINLLASSESETKLNLNSKPPINFLMVGLQGSGKTTASG
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCC
KLALRLKNQNKKVLLVSLDTYRPAAQEQLAILANSVQINSLPIVQGEQPLDIVTRAIAEA
EEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHH
KISAYDVVIYDTAGRTQIDQEMMEEALAIKNIVEPTETLLVIDSMTGQDAVVTASNFNKK
HHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCE
LEISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGEKLTDLEEFNAERLASRILDMGD
EEEHHEEEEECCCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHCHHH
IISFVEKAASIVDREEAEKTAAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHH
MDQIDQSKLNSKIIEHQEAMILSMTLKERKNPDIINASRRKRIAAGAGTTVQKVNILLKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHH
YKQISEMMKKASKMNPKNLLRSGIGKLFS
HHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFKTLTQNLTKIFDKLASSGILTEAQIDNAMRDIRVALLESDVALPVIKDFIAEVKKNAL
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GHEVIKSVSPGQMIIKIIHEEMINLLASSESETKLNLNSKPPINFLMVGLQGSGKTTASG
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCC
KLALRLKNQNKKVLLVSLDTYRPAAQEQLAILANSVQINSLPIVQGEQPLDIVTRAIAEA
EEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHH
KISAYDVVIYDTAGRTQIDQEMMEEALAIKNIVEPTETLLVIDSMTGQDAVVTASNFNKK
HHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCE
LEISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGEKLTDLEEFNAERLASRILDMGD
EEEHHEEEEECCCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHCHHH
IISFVEKAASIVDREEAEKTAAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHH
MDQIDQSKLNSKIIEHQEAMILSMTLKERKNPDIINASRRKRIAAGAGTTVQKVNILLKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHH
YKQISEMMKKASKMNPKNLLRSGIGKLFS
HHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]