Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 157825211

GI number: 157825211

Start: 72124

End: 72546

Strand: Direct

Name: ndk [H]

Synonym: A1C_00450

Alternate gene names: 157825211

Gene position: 72124-72546 (Clockwise)

Preceding gene: 157825210

Following gene: 157825212

Centisome position: 5.86

GC content: 32.39

Gene sequence:

>423_bases
ATGACAATACAATATACTTTTTCAATGATTAAGCCTGATGCTATCAAGAGGAATAAAATAGGACAAGTTAATGCTTATTT
AGAAAATGGAGGCTTAAAGATAGTGGCTCAGAAAATGAGATTTTTAACTAAATATGAAGCTGAGTGTTTCTACGATGAAC
ATAGAGCAAGAACGTTTTTTAATAGCTTAGTTGAATATATTACTTCAGGAGCGGTAGTACTTCAAGTTCTTAAGGGAGAA
GATGCTATAATTTTAAACCGTACCATTATGGGTGCAACTAATCCTGCTGAAGCTGAAGCAGGAACTATTAGAAAAGATTT
AGGCGAATCAATTGAGGCTAATAGTATTCATGGTTCAGATAGTGAAAACAGTGCGAAAAGAGAAATCGCATTTTTCTTTA
ACAAATCTGAAATTATAGAATAA

Upstream 100 bases:

>100_bases
ATTTTTCAGTATTTCTGCTCTTTTAGGAGGAGGGTTGTTTGCTTTAACATGGAATCGTTCAGCTAAAAAATAAATTTAAT
CATTATATAAAGGTTACAAA

Downstream 100 bases:

>100_bases
TTAATGCTAAAATATGACGTAATAGTTATAGGTGGCGGACATGCAGGCGTGGAAGCAGCAGCAGCTTCTGCACGTCTTGG
AGTTTCTACTCTCTTAATTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MTIQYTFSMIKPDAIKRNKIGQVNAYLENGGLKIVAQKMRFLTKYEAECFYDEHRARTFFNSLVEYITSGAVVLQVLKGE
DAIILNRTIMGATNPAEAEAGTIRKDLGESIEANSIHGSDSENSAKREIAFFFNKSEIIE

Sequences:

>Translated_140_residues
MTIQYTFSMIKPDAIKRNKIGQVNAYLENGGLKIVAQKMRFLTKYEAECFYDEHRARTFFNSLVEYITSGAVVLQVLKGE
DAIILNRTIMGATNPAEAEAGTIRKDLGESIEANSIHGSDSENSAKREIAFFFNKSEIIE
>Mature_139_residues
TIQYTFSMIKPDAIKRNKIGQVNAYLENGGLKIVAQKMRFLTKYEAECFYDEHRARTFFNSLVEYITSGAVVLQVLKGED
AIILNRTIMGATNPAEAEAGTIRKDLGESIEANSIHGSDSENSAKREIAFFFNKSEIIE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=134, Percent_Identity=41.7910447761194, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI66392203, Length=138, Percent_Identity=36.231884057971, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI66392227, Length=138, Percent_Identity=36.231884057971, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI66392205, Length=138, Percent_Identity=36.231884057971, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI4505409, Length=138, Percent_Identity=36.231884057971, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI66392192, Length=138, Percent_Identity=36.231884057971, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=36.2962962962963, Blast_Score=99, Evalue=8e-22,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=36.2962962962963, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=35.2517985611511, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=35.9712230215827, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=35.9712230215827, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=37.7777777777778, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=50.7246376811594, Blast_Score=145, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17506807, Length=133, Percent_Identity=42.1052631578947, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=39.2592592592593, Blast_Score=108, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45549037, Length=134, Percent_Identity=41.7910447761194, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.8358208955224, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15704; Mature: 15573

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQYTFSMIKPDAIKRNKIGQVNAYLENGGLKIVAQKMRFLTKYEAECFYDEHRARTFF
CEEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSLVEYITSGAVVLQVLKGEDAIILNRTIMGATNPAEAEAGTIRKDLGESIEANSIHGSD
HHHHHHHHCCHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
SENSAKREIAFFFNKSEIIE
CCCCHHHHEEEEECCHHHCC
>Mature Secondary Structure 
TIQYTFSMIKPDAIKRNKIGQVNAYLENGGLKIVAQKMRFLTKYEAECFYDEHRARTFF
EEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSLVEYITSGAVVLQVLKGEDAIILNRTIMGATNPAEAEAGTIRKDLGESIEANSIHGSD
HHHHHHHHCCHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
SENSAKREIAFFFNKSEIIE
CCCCHHHHEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA