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The map label for this gene is xanP [H]

Identifier: 157373104

GI number: 157373104

Start: 5397825

End: 5399225

Strand: Direct

Name: xanP [H]

Synonym: Spro_4873

Alternate gene names: 157373104

Gene position: 5397825-5399225 (Clockwise)

Preceding gene: 157373102

Following gene: 157373105

Centisome position: 99.06

GC content: 58.03

Gene sequence:

>1401_bases
ATGACCCTGCCATCCGCCGAGCTCGATGCCGCGCAAAAAACCTCTGCCACACCCCGTAACAGCGAGCTGATTTATCGCCT
GGAAGACCGCCCACCTCTGCCGCAAACGCTGTTTGCCGCCGGTCAGCACCTGTTGGCAATGTTTGTTGCGGTGATCACCC
CGGCGCTGTTGATTTGTCAGGCGTTAGGGTTACCGGCACAAGATACTCAGCACATTATCAGCATGTCGCTGTTTGCCTCC
GGTCTGGCCTCTATCCTGCAAATTAAAACCTGGGGACCGGTCGGTTCTGGCCTGCTGTCCATTCAGGGCACCAGCTTTAA
CTTTGTCTCGCCGCTGATTATGGGCGGTCTGGCGCTGAAAAACGGCGGTGCCGACGTGCCGACCATGATGGCAGCGCTAT
TTGGCACGCTAATGGTCGCCTCCTGCACCGAAATCCTGTTGTCGCGCGTCCTTCACCTGGCACGCCGTATTATCACCCCG
CTGGTCTCCGGCATTGTGGTGATGATTATCGGTTTATCGCTGATCCAGGTCGGGCTGACCTCCATCGGCGGCGGTTATGC
TGCGATGAACGGGGGCAGCTTCGGCGCCCCTAAAAACCTGCTGCTGGCCGGTGCGGTATTATTGGTTATCATTCTGCTTA
ACCGTCAGCGCAACCCCTACCTGCGCGTTGCCTCACTGGTGATTGCCATGGCGGTCGGCTATCTGCTGGCCTGGGCCATG
GATATGTTGCCGCAAAGCCAACCGGCTCTCGAGACGGCAGCCATAGTCATCCCAACGCCGCTCTATTACGGTCTGGGCTT
TGACTGGAACCTGCTGTTACCTCTGATGTTGATCTTTATGGTCACCTCACTGGAAACCATCGGCGATATCACCGCCACCT
CGGACGTGTCGGAACAGCCGGTCAGCGGTCCGCTGTATATGAAGCGCCTGAAGGGCGGTGTGTTGGCTAACGGCCTGAAC
TCGATGTTGTCGGCAGTATTCAACACCTTCCCCAACTCCTGCTTTGGTCAGAACAATGGCGTGATCCAACTGACCGGTGT
TGCCAGCCGCTATGTAGGTTTCGTGGTGGCGCTGATGCTGATCGTACTGGGGCTATTCCCGGCGGTGGCCGGTTTCGTAC
AACATATTCCCGAGCCGGTCCTGGGCGGTGCAACCCTGGTGATGTTCGGCACCATCGCCGCATCTGGCGTGCGTATCGTG
TCTCGCGAACGACTGAATCGCCGCGCAATCATGATTATGGCGCTGTCTCTGGCGGTGGGTATGGGCGTGTCGCAACAGCC
GCTGATCCTGCAGTTCGCGCCGGACTGGCTGAAAACCCTGCTTTCCTCCGGTATTGCTGCCGGTGGCATCACCGCTATCG
TGTTGAACCTGGTGTTCCCACACGAACACGAAAAGCCATAA

Upstream 100 bases:

>100_bases
ACCCGGCGATAAAGCTAACATAACTTTAACGCGCAACCGTTTGCTTTTGTGGGTCAAATCATTAAAATGCCTGCTTTGCC
GTTTCTGGAAATGCCACACC

Downstream 100 bases:

>100_bases
TCGGCCACGCTGACAGTCAAACGGCCGCTCGCGGCCGTTTTTTTATTGCCTATCAGACCATTGCACTTGAGATGCCCGGC
CAATTGCGGCATAAACAGGG

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTLPSAELDAAQKTSATPRNSELIYRLEDRPPLPQTLFAAGQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFAS
GLASILQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADVPTMMAALFGTLMVASCTEILLSRVLHLARRIITP
LVSGIVVMIIGLSLIQVGLTSIGGGYAAMNGGSFGAPKNLLLAGAVLLVIILLNRQRNPYLRVASLVIAMAVGYLLAWAM
DMLPQSQPALETAAIVIPTPLYYGLGFDWNLLLPLMLIFMVTSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLN
SMLSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIV
SRERLNRRAIMIMALSLAVGMGVSQQPLILQFAPDWLKTLLSSGIAAGGITAIVLNLVFPHEHEKP

Sequences:

>Translated_466_residues
MTLPSAELDAAQKTSATPRNSELIYRLEDRPPLPQTLFAAGQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFAS
GLASILQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADVPTMMAALFGTLMVASCTEILLSRVLHLARRIITP
LVSGIVVMIIGLSLIQVGLTSIGGGYAAMNGGSFGAPKNLLLAGAVLLVIILLNRQRNPYLRVASLVIAMAVGYLLAWAM
DMLPQSQPALETAAIVIPTPLYYGLGFDWNLLLPLMLIFMVTSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLN
SMLSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIV
SRERLNRRAIMIMALSLAVGMGVSQQPLILQFAPDWLKTLLSSGIAAGGITAIVLNLVFPHEHEKP
>Mature_465_residues
TLPSAELDAAQKTSATPRNSELIYRLEDRPPLPQTLFAAGQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASG
LASILQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADVPTMMAALFGTLMVASCTEILLSRVLHLARRIITPL
VSGIVVMIIGLSLIQVGLTSIGGGYAAMNGGSFGAPKNLLLAGAVLLVIILLNRQRNPYLRVASLVIAMAVGYLLAWAMD
MLPQSQPALETAAIVIPTPLYYGLGFDWNLLLPLMLIFMVTSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNS
MLSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVS
RERLNRRAIMIMALSLAVGMGVSQQPLILQFAPDWLKTLLSSGIAAGGITAIVLNLVFPHEHEKP

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=518, Percent_Identity=23.1660231660232, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI40316845, Length=518, Percent_Identity=23.1660231660232, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1790087, Length=464, Percent_Identity=85.7758620689655, Blast_Score=776, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=445, Percent_Identity=44.9438202247191, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI87082181, Length=443, Percent_Identity=31.8284424379233, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1788843, Length=408, Percent_Identity=26.4705882352941, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081818, Length=402, Percent_Identity=24.6268656716418, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=505, Percent_Identity=23.5643564356436, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356175, Length=520, Percent_Identity=22.3076923076923, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 49118; Mature: 48987

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPSAELDAAQKTSATPRNSELIYRLEDRPPLPQTLFAAGQHLLAMFVAVITPALLICQ
CCCCCCHHCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGLPAQDTQHIISMSLFASGLASILQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALK
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCCHHCC
NGGADVPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLVSGIVVMIIGLSLIQVGLT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIGGGYAAMNGGSFGAPKNLLLAGAVLLVIILLNRQRNPYLRVASLVIAMAVGYLLAWAM
HCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
DMLPQSQPALETAAIVIPTPLYYGLGFDWNLLLPLMLIFMVTSLETIGDITATSDVSEQP
HHCCCCCCCHHHEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VSGPLYMKRLKGGVLANGLNSMLSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALML
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHH
IVLGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRERLNRRAIMIMALSLAVG
HHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MGVSQQPLILQFAPDWLKTLLSSGIAAGGITAIVLNLVFPHEHEKP
CCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TLPSAELDAAQKTSATPRNSELIYRLEDRPPLPQTLFAAGQHLLAMFVAVITPALLICQ
CCCCCHHCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGLPAQDTQHIISMSLFASGLASILQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALK
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCCHHCC
NGGADVPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLVSGIVVMIIGLSLIQVGLT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIGGGYAAMNGGSFGAPKNLLLAGAVLLVIILLNRQRNPYLRVASLVIAMAVGYLLAWAM
HCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
DMLPQSQPALETAAIVIPTPLYYGLGFDWNLLLPLMLIFMVTSLETIGDITATSDVSEQP
HHCCCCCCCHHHEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VSGPLYMKRLKGGVLANGLNSMLSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALML
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHH
IVLGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRERLNRRAIMIMALSLAVG
HHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MGVSQQPLILQFAPDWLKTLLSSGIAAGGITAIVLNLVFPHEHEKP
CCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]