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The map label for this gene is fimB [H]

Identifier: 157372468

GI number: 157372468

Start: 4699316

End: 4699777

Strand: Direct

Name: fimB [H]

Synonym: Spro_4235

Alternate gene names: 157372468

Gene position: 4699316-4699777 (Clockwise)

Preceding gene: 157372466

Following gene: 157372469

Centisome position: 86.24

GC content: 47.19

Gene sequence:

>462_bases
ATGATCAGCATGTGTTTTATTCACGGCTTGCGTGCCAGTGAGCTGGGAGGGTTGACATTGGATAATATCGAGCTGGATGC
AAAGAGGATCTACATCCCTCGCTTGAAGAATGGCCTGTCCGTGCAACACCCTTTACATGATAATGAAATAATCATGCTGA
ATCATTGGTTGGAAATAAGAAAAAGCTGGCGCTATGCCGATCAGCCCTGGCTGTTTCTTTCACGAAAAGGCGGGCCAATA
ACCCGCCAGCAAATTTATCGTCTGATCCGTGATTACGGTAAAAATGCCAACATCCAGGTTCCGACACATCCTCATATGTT
ACGCCATGCCTGTGGCTACTTTCTGGCAAACCTGGGCATGGACACCCGTTTGATTCAGGACTACCTTGGGCATCGAAACA
TTCACCACACCGTACTCTATACCGCCAGTAATGCCATGCGATTTCAGGCTATTGAATTCTGA

Upstream 100 bases:

>100_bases
CTGTGTGAAACCGAACATCAGAAAATATCTGGATGAGTCAGAAATAAACAGCATGATCGAGAATATTAAAAAAGGCCTGA
ATGCCTGGCGTGACAGATGC

Downstream 100 bases:

>100_bases
TTCATTTCCCCAAGAAATAATAACAACGCTTCACAAATAGAAATAAAGTATATTTCCAAATTGAACTATTAATAACTAAA
GTGACTAGAAACACATTACT

Product: integrase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MISMCFIHGLRASELGGLTLDNIELDAKRIYIPRLKNGLSVQHPLHDNEIIMLNHWLEIRKSWRYADQPWLFLSRKGGPI
TRQQIYRLIRDYGKNANIQVPTHPHMLRHACGYFLANLGMDTRLIQDYLGHRNIHHTVLYTASNAMRFQAIEF

Sequences:

>Translated_153_residues
MISMCFIHGLRASELGGLTLDNIELDAKRIYIPRLKNGLSVQHPLHDNEIIMLNHWLEIRKSWRYADQPWLFLSRKGGPI
TRQQIYRLIRDYGKNANIQVPTHPHMLRHACGYFLANLGMDTRLIQDYLGHRNIHHTVLYTASNAMRFQAIEF
>Mature_153_residues
MISMCFIHGLRASELGGLTLDNIELDAKRIYIPRLKNGLSVQHPLHDNEIIMLNHWLEIRKSWRYADQPWLFLSRKGGPI
TRQQIYRLIRDYGKNANIQVPTHPHMLRHACGYFLANLGMDTRLIQDYLGHRNIHHTVLYTASNAMRFQAIEF

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=148, Percent_Identity=59.4594594594595, Blast_Score=187, Evalue=2e-49,
Organism=Escherichia coli, GI1790768, Length=152, Percent_Identity=53.2894736842105, Blast_Score=161, Evalue=1e-41,
Organism=Escherichia coli, GI1790244, Length=141, Percent_Identity=29.0780141843972, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1789261, Length=154, Percent_Identity=31.1688311688312, Blast_Score=64, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 17933; Mature: 17933

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISMCFIHGLRASELGGLTLDNIELDAKRIYIPRLKNGLSVQHPLHDNEIIMLNHWLEIR
CCEEEEEECCCCCCCCCEEECCEEECCEEEECCCCCCCCCEECCCCCCCEEEEHHHHHHH
KSWRYADQPWLFLSRKGGPITRQQIYRLIRDYGKNANIQVPTHPHMLRHACGYFLANLGM
HHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCC
DTRLIQDYLGHRNIHHTVLYTASNAMRFQAIEF
CHHHHHHHHCCCCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MISMCFIHGLRASELGGLTLDNIELDAKRIYIPRLKNGLSVQHPLHDNEIIMLNHWLEIR
CCEEEEEECCCCCCCCCEEECCEEECCEEEECCCCCCCCCEECCCCCCCEEEEHHHHHHH
KSWRYADQPWLFLSRKGGPITRQQIYRLIRDYGKNANIQVPTHPHMLRHACGYFLANLGM
HHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCC
DTRLIQDYLGHRNIHHTVLYTASNAMRFQAIEF
CHHHHHHHHCCCCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]