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The map label for this gene is gudP [H]

Identifier: 157372196

GI number: 157372196

Start: 4390581

End: 4391843

Strand: Reverse

Name: gudP [H]

Synonym: Spro_3962

Alternate gene names: 157372196

Gene position: 4391843-4390581 (Counterclockwise)

Preceding gene: 157372197

Following gene: 157372195

Centisome position: 80.6

GC content: 59.14

Gene sequence:

>1263_bases
ATGACTACGCAAGATATTGACGCCCGCGCTGGACGGGTGGGGGAAACCGTTGCCGAAAATCCGCAGCAGCGGGTGCGCTG
GTCGGTGCCGATTGCGCTGTTTGCCTGCGTGCTGTTGGCGTTTTTCGACAAGATCAGCATCGCGGCACTGTTTTCCGATA
GCGAATTCCAGCAGGCGCTGGGCATCAGTTTTGACCCGGCGCGACTGGGCTTGCTGATGAGCGCATTTTTGTTCTCGTAC
GGCATTTCTTCGATGCTGCTCAGCGGCATTGGCGACCGGCTGAATCCGGTAAAAGTGTTGATCGGCATGATGGTAGTGTG
GGGCGTATTGATGGTGCTGATGGGCCTGGCCCGTTCGTATCACACCATGATGACGCTGCGCATTTTGCTCGGCATTGCCG
AAGGCCCGCTGCTGCCGATGGCCTACGCCATTATCCGCCAGGCCTTCCCGCAGCGGCTGCAGGCGCGTGCCACCATGCTG
TGGCTACTCGGCACCCCACTGGGGGCGGCGCTCGGTTTCCCGGTCACGCTATATATCCTCAACACTTTTGACTGGCAGAC
CACCTTCTTCTTTATGGCGTTTCTGACGCTGCCGGTAATGCTGTTAGTGCTGTTCGGTATGCGTCATCTGAATGTGTCAC
GCCCGGCCGCCGCTACCGTTTCAAAACCGGCCATCGCCGAACGCAAACAGCATCGCCTTGAGCTGCTGCGCAACCCGCAT
TTCTGGATGATTTGCCTGTTTAACATCGCCTTCCTGACCTACCTGTGGGGCATGAACGGCTGGCTGCCCAGCTACCTGAT
CAAGGGCAAAGGTATTCACCTGGAACACGCCGGGTACCTGTCATCGCTGCCGTTTATCGCCATGCTGCTGGGTGAAGTGC
TCGGGGCCTGGCTGTCGGACAAACTGGATCGTCGTGCGCTGGCCTGCTTTATCTCGCTGTGCGGTGCCGGGCTGGGGCTG
GCCGCGGTGCTGCATATGCAGGGCACCTACAGCGTGATCGCCGCCATGGCCTTCAGCACCTTTATGTGGGGGGCCGGTGC
GCCGAACATTTTTGCCCTGCTGGCGAAGGCCACCAGTAGCAAGGTTAGTGCCACCGCCGGCGGTATTTTTAACGGATTGG
GTAATTTTGCCGGTGCGCTGGCGCCGGTGCTGATGGGGGCGCTGATCGCCGCCACCGGCAACATGGATAACGGCTTGCTG
TTCCTGGTGGTAATGGCCTTTATCGGCTGCATCATTCTGCTGCCGTTGCTGAAGAAATATTGA

Upstream 100 bases:

>100_bases
CTGGCTGGCCAGTGGGCGAGTGTTGGAGCCACAGCAGTTGGCGGACGCGGAGTTTTCTTTGATGGCGTTGAAATAACGCC
CGTAACCTCGGGAGCGTTTC

Downstream 100 bases:

>100_bases
TATCCCATTGATTGAAAAGAGGAGTACCAACATGTCCCAGGTTGAGAAACAAGCCGGCGTCAAGCCGCAGGATCAGTCGA
TAGAGCATTGGGTGGAATCC

Product: major facilitator transporter

Products: NA

Alternate protein names: D-glucarate permease [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTTQDIDARAGRVGETVAENPQQRVRWSVPIALFACVLLAFFDKISIAALFSDSEFQQALGISFDPARLGLLMSAFLFSY
GISSMLLSGIGDRLNPVKVLIGMMVVWGVLMVLMGLARSYHTMMTLRILLGIAEGPLLPMAYAIIRQAFPQRLQARATML
WLLGTPLGAALGFPVTLYILNTFDWQTTFFFMAFLTLPVMLLVLFGMRHLNVSRPAAATVSKPAIAERKQHRLELLRNPH
FWMICLFNIAFLTYLWGMNGWLPSYLIKGKGIHLEHAGYLSSLPFIAMLLGEVLGAWLSDKLDRRALACFISLCGAGLGL
AAVLHMQGTYSVIAAMAFSTFMWGAGAPNIFALLAKATSSKVSATAGGIFNGLGNFAGALAPVLMGALIAATGNMDNGLL
FLVVMAFIGCIILLPLLKKY

Sequences:

>Translated_420_residues
MTTQDIDARAGRVGETVAENPQQRVRWSVPIALFACVLLAFFDKISIAALFSDSEFQQALGISFDPARLGLLMSAFLFSY
GISSMLLSGIGDRLNPVKVLIGMMVVWGVLMVLMGLARSYHTMMTLRILLGIAEGPLLPMAYAIIRQAFPQRLQARATML
WLLGTPLGAALGFPVTLYILNTFDWQTTFFFMAFLTLPVMLLVLFGMRHLNVSRPAAATVSKPAIAERKQHRLELLRNPH
FWMICLFNIAFLTYLWGMNGWLPSYLIKGKGIHLEHAGYLSSLPFIAMLLGEVLGAWLSDKLDRRALACFISLCGAGLGL
AAVLHMQGTYSVIAAMAFSTFMWGAGAPNIFALLAKATSSKVSATAGGIFNGLGNFAGALAPVLMGALIAATGNMDNGLL
FLVVMAFIGCIILLPLLKKY
>Mature_419_residues
TTQDIDARAGRVGETVAENPQQRVRWSVPIALFACVLLAFFDKISIAALFSDSEFQQALGISFDPARLGLLMSAFLFSYG
ISSMLLSGIGDRLNPVKVLIGMMVVWGVLMVLMGLARSYHTMMTLRILLGIAEGPLLPMAYAIIRQAFPQRLQARATMLW
LLGTPLGAALGFPVTLYILNTFDWQTTFFFMAFLTLPVMLLVLFGMRHLNVSRPAAATVSKPAIAERKQHRLELLRNPHF
WMICLFNIAFLTYLWGMNGWLPSYLIKGKGIHLEHAGYLSSLPFIAMLLGEVLGAWLSDKLDRRALACFISLCGAGLGLA
AVLHMQGTYSVIAAMAFSTFMWGAGAPNIFALLAKATSSKVSATAGGIFNGLGNFAGALAPVLMGALIAATGNMDNGLLF
LVVMAFIGCIILLPLLKKY

Specific function: Uptake of D-glucarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=351, Percent_Identity=23.6467236467236, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1789152, Length=436, Percent_Identity=23.394495412844, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87082320, Length=426, Percent_Identity=23.4741784037559, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI2367379, Length=411, Percent_Identity=21.4111922141119, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789515, Length=437, Percent_Identity=21.7391304347826, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082071, Length=422, Percent_Identity=25.8293838862559, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24654037, Length=312, Percent_Identity=24.0384615384615, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24654041, Length=312, Percent_Identity=24.0384615384615, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45640; Mature: 45509

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure 
TTQDIDARAGRVGETVAENPQQRVRWSVPIALFACVLLAFFDKISIAALFSDSEFQQAL
CCCCCCHHCCCCCCHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GISFDPARLGLLMSAFLFSYGISSMLLSGIGDRLNPVKVLIGMMVVWGVLMVLMGLARSY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HTMMTLRILLGIAEGPLLPMAYAIIRQAFPQRLQARATMLWLLGTPLGAALGFPVTLYIL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEE
NTFDWQTTFFFMAFLTLPVMLLVLFGMRHLNVSRPAAATVSKPAIAERKQHRLELLRNPH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCC
FWMICLFNIAFLTYLWGMNGWLPSYLIKGKGIHLEHAGYLSSLPFIAMLLGEVLGAWLSD
HHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
KLDRRALACFISLCGAGLGLAAVLHMQGTYSVIAAMAFSTFMWGAGAPNIFALLAKATSS
HHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
KVSATAGGIFNGLGNFAGALAPVLMGALIAATGNMDNGLLFLVVMAFIGCIILLPLLKKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9772162; 10762278 [H]