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The map label for this gene is lldP [C]

Identifier: 157372089

GI number: 157372089

Start: 4265458

End: 4267038

Strand: Direct

Name: lldP [C]

Synonym: Spro_3854

Alternate gene names: 157372089

Gene position: 4265458-4267038 (Clockwise)

Preceding gene: 157372088

Following gene: 157372090

Centisome position: 78.28

GC content: 55.72

Gene sequence:

>1581_bases
ATGTCCCTGTTTTTCAGTATTGCGCCGATCGTCCTGCTGATTTGGATGATGACCAAAAAGAACGGTGTGCCCTCTTATAT
CGCGCTGCCCTTAACGGCCGCTGCCGTGTATGGCGTGCAAATGTTTTGGTTCGACAGTCTGCCCCTGCTGCTGCACGCCA
ATATCATTACCGCACTGGTGTCGGTTTTCACCCCGATAACCATTATTGCCGGCGCGATTTTGCTGAATAAGCTGATGCAA
ATCAGCGGTGCGGAAAATGTGGTTCGTCGTTGGCTGGAAAATATCAGCCCCAATCCGGTTGCTCAGTTGATGATTATCGG
TTGGGCATTCGCCTTTATGATTGAAGGTGCCAGCGGATTCGGCACGCCAGCCGCCATTGCCGCCCCCATTCTGGTCGGGC
TAGGTTTTAACCCCCTGCGCGTTGCGCTGCTGACGCTGGTCATGAACTCGGTTCCCGTCTCATTCGGTGCCGTCGGCACG
CCCACCTGGTTCGGGTTTGCCAATTTGGGGTTATCCGATGCCAGCCTGCTGGAAATTGGCCGTCAGACCGCGTTGATCCA
CTTTGTCGCCGGATTTGTTATCCCATTGCTGGCGCTGCGTTTTATCGTTTCCTGGCGTGAAATTCGCTATAACCTGCCGT
TTATTTTACTTAGCGTCTTGAGTTGCACGGTGCCTTACCTGCTGCTGGCACAGGTTAACTATGAATTCCCGGCTCTGGTG
GGCGGCGCCATTGGCCTGATGTTGTCGGTGCTGTTGGCGCGTGCCGGCATCGGCCTGACCCGCTGCGAAGGCAAAACATC
TCCCCAGGCCGTGCCATTCGTTCAGGTCATCAAGGCAATGACCCCGACCCTGCTGCTGATTGCTATTCTGATAGTGACCC
GTATCCACCAGTTGGGCATTAAAGCGCTGCTCAACAGCAGCGCACTGCTGTGGCAAGGGAGCCTCGGCAACCTGGGTGAG
CTACGCGTCAGCAATGCCCTGATCATTGAATTGCAGCAGGTATTCGGCACTTCTGCCGCCGCCAGCTACAAAACGCTGTA
TGTACCCGCACTGATCCCTTTCTTGCTGGTGGTCGTGCTGTGTATTCCCCTGTTCCGGCTGAACTGCAGGCAGGTAAAAC
AGATGTTCGCAGAAACCGGTGGGCGCGTGGCTAAACCCTTTATCGCCCTGTTTGGTGCGCTGGTGATGGTCAACCTGATG
ATGCTGGGCGGCGACAATGCGCCGGTGATCCTCATCGGCAAGGCGTTGGCGGCATTGACGGGGGAAAGCTGGCTGCTGTT
CTCTTCTTTCCTTGGGGCGCTGGGTTCGTTTTTCTCCGGTTCCAATACCGTTTCCAACCTGACGTTCGGCGGCATCCAGC
AGTCAATCGCCCTGAGCAGCGGGCTAAACGTCAACCTGACGCTGGCACTGCAATCCGTCGGGGGAGCGATGGGCAACATG
ATATGCCTGAACAATATTATCGCCGTTTGCTCAATCCTCGGGATCGGCAATGCCGAAGGCAAAATTATCAAAAAGACCGT
ATTGCCCATGTTGGTGTACGGGGGGATCGCCGCTGTGATGGCGCAGGCAATGATCCTCTGA

Upstream 100 bases:

>100_bases
TAGAACATCAGCCAGCGTTGTGATTAGAATGAAAATGTTGCGGTAATTAACCTTCCGGCTACATACCTCTACAAATAACA
ATAATAACGCTGAGGCTCTT

Downstream 100 bases:

>100_bases
GCGTAAAAGCCCATTATCGAAATAAGGTATAAATATGATTATCTCCGCTTCAACCGATTACCGGGCCGCAGCACAGGCTA
AGCTCCCGCCTTTTCTGTTT

Product: L-lactate transport

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSLFFSIAPIVLLIWMMTKKNGVPSYIALPLTAAAVYGVQMFWFDSLPLLLHANIITALVSVFTPITIIAGAILLNKLMQ
ISGAENVVRRWLENISPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILVGLGFNPLRVALLTLVMNSVPVSFGAVGT
PTWFGFANLGLSDASLLEIGRQTALIHFVAGFVIPLLALRFIVSWREIRYNLPFILLSVLSCTVPYLLLAQVNYEFPALV
GGAIGLMLSVLLARAGIGLTRCEGKTSPQAVPFVQVIKAMTPTLLLIAILIVTRIHQLGIKALLNSSALLWQGSLGNLGE
LRVSNALIIELQQVFGTSAAASYKTLYVPALIPFLLVVVLCIPLFRLNCRQVKQMFAETGGRVAKPFIALFGALVMVNLM
MLGGDNAPVILIGKALAALTGESWLLFSSFLGALGSFFSGSNTVSNLTFGGIQQSIALSSGLNVNLTLALQSVGGAMGNM
ICLNNIIAVCSILGIGNAEGKIIKKTVLPMLVYGGIAAVMAQAMIL

Sequences:

>Translated_526_residues
MSLFFSIAPIVLLIWMMTKKNGVPSYIALPLTAAAVYGVQMFWFDSLPLLLHANIITALVSVFTPITIIAGAILLNKLMQ
ISGAENVVRRWLENISPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILVGLGFNPLRVALLTLVMNSVPVSFGAVGT
PTWFGFANLGLSDASLLEIGRQTALIHFVAGFVIPLLALRFIVSWREIRYNLPFILLSVLSCTVPYLLLAQVNYEFPALV
GGAIGLMLSVLLARAGIGLTRCEGKTSPQAVPFVQVIKAMTPTLLLIAILIVTRIHQLGIKALLNSSALLWQGSLGNLGE
LRVSNALIIELQQVFGTSAAASYKTLYVPALIPFLLVVVLCIPLFRLNCRQVKQMFAETGGRVAKPFIALFGALVMVNLM
MLGGDNAPVILIGKALAALTGESWLLFSSFLGALGSFFSGSNTVSNLTFGGIQQSIALSSGLNVNLTLALQSVGGAMGNM
ICLNNIIAVCSILGIGNAEGKIIKKTVLPMLVYGGIAAVMAQAMIL
>Mature_525_residues
SLFFSIAPIVLLIWMMTKKNGVPSYIALPLTAAAVYGVQMFWFDSLPLLLHANIITALVSVFTPITIIAGAILLNKLMQI
SGAENVVRRWLENISPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILVGLGFNPLRVALLTLVMNSVPVSFGAVGTP
TWFGFANLGLSDASLLEIGRQTALIHFVAGFVIPLLALRFIVSWREIRYNLPFILLSVLSCTVPYLLLAQVNYEFPALVG
GAIGLMLSVLLARAGIGLTRCEGKTSPQAVPFVQVIKAMTPTLLLIAILIVTRIHQLGIKALLNSSALLWQGSLGNLGEL
RVSNALIIELQQVFGTSAAASYKTLYVPALIPFLLVVVLCIPLFRLNCRQVKQMFAETGGRVAKPFIALFGALVMVNLMM
LGGDNAPVILIGKALAALTGESWLLFSSFLGALGSFFSGSNTVSNLTFGGIQQSIALSSGLNVNLTLALQSVGGAMGNMI
CLNNIIAVCSILGIGNAEGKIIKKTVLPMLVYGGIAAVMAQAMIL

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=540, Percent_Identity=27.7777777777778, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789347, Length=485, Percent_Identity=25.5670103092783, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 55771; Mature: 55640

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFFSIAPIVLLIWMMTKKNGVPSYIALPLTAAAVYGVQMFWFDSLPLLLHANIITALV
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SVFTPITIIAGAILLNKLMQISGAENVVRRWLENISPNPVAQLMIIGWAFAFMIEGASGF
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
GTPAAIAAPILVGLGFNPLRVALLTLVMNSVPVSFGAVGTPTWFGFANLGLSDASLLEIG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHH
RQTALIHFVAGFVIPLLALRFIVSWREIRYNLPFILLSVLSCTVPYLLLAQVNYEFPALV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
GGAIGLMLSVLLARAGIGLTRCEGKTSPQAVPFVQVIKAMTPTLLLIAILIVTRIHQLGI
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALLNSSALLWQGSLGNLGELRVSNALIIELQQVFGTSAAASYKTLYVPALIPFLLVVVL
HHHHCCCCEEEECCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
CIPLFRLNCRQVKQMFAETGGRVAKPFIALFGALVMVNLMMLGGDNAPVILIGKALAALT
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHC
GESWLLFSSFLGALGSFFSGSNTVSNLTFGGIQQSIALSSGLNVNLTLALQSVGGAMGNM
CCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHCCHHHHH
ICLNNIIAVCSILGIGNAEGKIIKKTVLPMLVYGGIAAVMAQAMIL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLFFSIAPIVLLIWMMTKKNGVPSYIALPLTAAAVYGVQMFWFDSLPLLLHANIITALV
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SVFTPITIIAGAILLNKLMQISGAENVVRRWLENISPNPVAQLMIIGWAFAFMIEGASGF
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
GTPAAIAAPILVGLGFNPLRVALLTLVMNSVPVSFGAVGTPTWFGFANLGLSDASLLEIG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHH
RQTALIHFVAGFVIPLLALRFIVSWREIRYNLPFILLSVLSCTVPYLLLAQVNYEFPALV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
GGAIGLMLSVLLARAGIGLTRCEGKTSPQAVPFVQVIKAMTPTLLLIAILIVTRIHQLGI
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALLNSSALLWQGSLGNLGELRVSNALIIELQQVFGTSAAASYKTLYVPALIPFLLVVVL
HHHHCCCCEEEECCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
CIPLFRLNCRQVKQMFAETGGRVAKPFIALFGALVMVNLMMLGGDNAPVILIGKALAALT
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHC
GESWLLFSSFLGALGSFFSGSNTVSNLTFGGIQQSIALSSGLNVNLTLALQSVGGAMGNM
CCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHCCHHHHH
ICLNNIIAVCSILGIGNAEGKIIKKTVLPMLVYGGIAAVMAQAMIL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]