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The map label for this gene is lldD [H]

Identifier: 157372090

GI number: 157372090

Start: 4267073

End: 4268215

Strand: Direct

Name: lldD [H]

Synonym: Spro_3855

Alternate gene names: 157372090

Gene position: 4267073-4268215 (Clockwise)

Preceding gene: 157372089

Following gene: 157372092

Centisome position: 78.31

GC content: 62.2

Gene sequence:

>1143_bases
ATGATTATCTCCGCTTCAACCGATTACCGGGCCGCAGCACAGGCTAAGCTCCCGCCTTTTCTGTTTCACTATATTGACGG
CGGGGCCTACGCGGAACACACGCTACGACGCAACACGGAAGACCTGGCGGGCATCGCGCTGCGCCAGCGCATACTGCGCA
ATATGTCCGACCTCAGCCTGGAAACCAGCCTGTTCGGTGAAAAACTGGCGATGCCGGTGATCCTCGGCCCGGTCGGGTTA
ACCGGTATGTACGCCCGACGCGGTGAAGTCCAGGCAGCCAAAGCCGCCGCGCAGAAAGGCATTCCTTTTACCCTGTCGAC
GGTCTCGGTTTGCCCGATTGAAGAAGTGGCACCGGCAATCGATCGGCCGATGTGGTTCCAGCTGTACGTATTGAAAGACC
GGGGCTTTATGCGCAATGCGCTGGAGCGCGCCAAAGCGGCCGGGGTGAAAACCCTGGTATTCACCGTCGATATGCCGGTG
CCCGGTGCGCGTTACCGTGACGCCCACTCCGGCATGAGTGGCCCCAATGCCGCCGTGCGCCGCATGTTGCAGGCGGTGAC
CCATCCGCAGTGGGCCTGGGACGTCGGGCTGTGCGGCAAGCCGCACGATCTGGGCAACGTCTCGGCCTATCGCGGCAAAC
CCACCAGCCTGGAAGACTATATCGGCTGGCTGGGCACCAACTTCGATCCCTCGATTTCCTGGAAGGATCTGGACTGGATC
CGCGAGTTCTGGCAAGGCCCGATGATCATCAAAGGCATTTTGGATCCCGAAGACGCCAAAGATGCGGTGCGCTTTGGTGC
CGACGGTATTGTGGTATCCAACCACGGCGGCCGCCAGCTCGACGGCGTGTTGTCCACTGCCCATGCGCTGCCGGCGATTG
CCGAGGCGGTAAAAGGCGATATCACCCTGCTGGCCGACTCTGGCATTCGCAGCGGGCTGGACGTGGTGCGCATGATTGCT
CTGGGCGCCGACGGCGTGCTGCTGGGGCGCGCCTTTGCCTATGCGCTGGCCGCCGCCGGGCAGGCCGGAGTCGCCAACCT
GCTCGAACTGATCGATAAAGAAATGCGCGTTGCCATGACGCTGATCGGCGCGAAAACCATTGCGGACATCAGCGCCGACT
CACTGGTCCAGGGGCTGCGTTAA

Upstream 100 bases:

>100_bases
ACCGTATTGCCCATGTTGGTGTACGGGGGGATCGCCGCTGTGATGGCGCAGGCAATGATCCTCTGAGCGTAAAAGCCCAT
TATCGAAATAAGGTATAAAT

Downstream 100 bases:

>100_bases
TCACATTGTTCTTATAATTAGCGTTACCATTGCGCCAGCCTTGGAGGGGGGTAACGCGGGCAATTCAGCACCCGGCAGAC
GAAAACCCCTCGGCAAAGGC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MIISASTDYRAAAQAKLPPFLFHYIDGGAYAEHTLRRNTEDLAGIALRQRILRNMSDLSLETSLFGEKLAMPVILGPVGL
TGMYARRGEVQAAKAAAQKGIPFTLSTVSVCPIEEVAPAIDRPMWFQLYVLKDRGFMRNALERAKAAGVKTLVFTVDMPV
PGARYRDAHSGMSGPNAAVRRMLQAVTHPQWAWDVGLCGKPHDLGNVSAYRGKPTSLEDYIGWLGTNFDPSISWKDLDWI
REFWQGPMIIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSTAHALPAIAEAVKGDITLLADSGIRSGLDVVRMIA
LGADGVLLGRAFAYALAAAGQAGVANLLELIDKEMRVAMTLIGAKTIADISADSLVQGLR

Sequences:

>Translated_380_residues
MIISASTDYRAAAQAKLPPFLFHYIDGGAYAEHTLRRNTEDLAGIALRQRILRNMSDLSLETSLFGEKLAMPVILGPVGL
TGMYARRGEVQAAKAAAQKGIPFTLSTVSVCPIEEVAPAIDRPMWFQLYVLKDRGFMRNALERAKAAGVKTLVFTVDMPV
PGARYRDAHSGMSGPNAAVRRMLQAVTHPQWAWDVGLCGKPHDLGNVSAYRGKPTSLEDYIGWLGTNFDPSISWKDLDWI
REFWQGPMIIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSTAHALPAIAEAVKGDITLLADSGIRSGLDVVRMIA
LGADGVLLGRAFAYALAAAGQAGVANLLELIDKEMRVAMTLIGAKTIADISADSLVQGLR
>Mature_380_residues
MIISASTDYRAAAQAKLPPFLFHYIDGGAYAEHTLRRNTEDLAGIALRQRILRNMSDLSLETSLFGEKLAMPVILGPVGL
TGMYARRGEVQAAKAAAQKGIPFTLSTVSVCPIEEVAPAIDRPMWFQLYVLKDRGFMRNALERAKAAGVKTLVFTVDMPV
PGARYRDAHSGMSGPNAAVRRMLQAVTHPQWAWDVGLCGKPHDLGNVSAYRGKPTSLEDYIGWLGTNFDPSISWKDLDWI
REFWQGPMIIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSTAHALPAIAEAVKGDITLLADSGIRSGLDVVRMIA
LGADGVLLGRAFAYALAAAGQAGVANLLELIDKEMRVAMTLIGAKTIADISADSLVQGLR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=365, Percent_Identity=35.0684931506849, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI54234014, Length=381, Percent_Identity=34.1207349081365, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI7705393, Length=381, Percent_Identity=34.1207349081365, Blast_Score=212, Evalue=4e-55,
Organism=Escherichia coli, GI1790033, Length=379, Percent_Identity=84.9604221635884, Blast_Score=669, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=371, Percent_Identity=33.9622641509434, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=33.0985915492958, Blast_Score=150, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323587, Length=379, Percent_Identity=29.5514511873351, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281363140, Length=378, Percent_Identity=34.3915343915344, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI78707190, Length=378, Percent_Identity=34.3915343915344, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI78707188, Length=378, Percent_Identity=34.3915343915344, Blast_Score=211, Evalue=9e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 40878; Mature: 40878

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISASTDYRAAAQAKLPPFLFHYIDGGAYAEHTLRRNTEDLAGIALRQRILRNMSDLSL
CEECCCCCCHHHHHCCCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETSLFGEKLAMPVILGPVGLTGMYARRGEVQAAKAAAQKGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHCCCEEECCCCCCHHHHCCCCHHHHHHHHHCCCCEEECCEEECCHHHHHHHH
DRPMWFQLYVLKDRGFMRNALERAKAAGVKTLVFTVDMPVPGARYRDAHSGMSGPNAAVR
CCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RMLQAVTHPQWAWDVGLCGKPHDLGNVSAYRGKPTSLEDYIGWLGTNFDPSISWKDLDWI
HHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHH
REFWQGPMIIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSTAHALPAIAEAVKGD
HHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
ITLLADSGIRSGLDVVRMIALGADGVLLGRAFAYALAAAGQAGVANLLELIDKEMRVAMT
EEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LIGAKTIADISADSLVQGLR
HHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure
MIISASTDYRAAAQAKLPPFLFHYIDGGAYAEHTLRRNTEDLAGIALRQRILRNMSDLSL
CEECCCCCCHHHHHCCCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETSLFGEKLAMPVILGPVGLTGMYARRGEVQAAKAAAQKGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHCCCEEECCCCCCHHHHCCCCHHHHHHHHHCCCCEEECCEEECCHHHHHHHH
DRPMWFQLYVLKDRGFMRNALERAKAAGVKTLVFTVDMPVPGARYRDAHSGMSGPNAAVR
CCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RMLQAVTHPQWAWDVGLCGKPHDLGNVSAYRGKPTSLEDYIGWLGTNFDPSISWKDLDWI
HHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHH
REFWQGPMIIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSTAHALPAIAEAVKGD
HHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
ITLLADSGIRSGLDVVRMIALGADGVLLGRAFAYALAAAGQAGVANLLELIDKEMRVAMT
EEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LIGAKTIADISADSLVQGLR
HHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA