Click here to switch to the map view.

The map label for this gene is ung

Identifier: 157371918

GI number: 157371918

Start: 4075891

End: 4076574

Strand: Direct

Name: ung

Synonym: Spro_3683

Alternate gene names: 157371918

Gene position: 4075891-4076574 (Clockwise)

Preceding gene: 157371914

Following gene: 157371920

Centisome position: 74.8

GC content: 57.89

Gene sequence:

>684_bases
ATGTCCACCTCCCTCACCTGGCATGATGTCATTGGCAAGGAGAAAGAGCAGCCCTATTTTCATGAAACGCTTGCCTTTGT
TGCCGCTGAACGTCAGGCCGGTAAGACCATTTACCCACCGCAAAAAGACGTGTTCAACGCCTTTCGCTATACCGAACTGG
CAGACGTGAAGGTGGTGATCCTCGGTCAGGATCCGTACCACGGCCCGAATCAGGCCCATGGCCTGTCTTTCTCGGTGCTG
CCCGGCGTGCCTGCTCCCCCTTCGCTGGTGAATATGTATAAAGAGCTGGCGACGGATATCCCGGGTTTTGAACGCCCTAG
CCACGGCTGTCTGCAAAGTTGGGCGGAACAAGGCGTGCTGCTGCTTAACACGGTGTTGACGGTGGAAGGTGGCCAGGCGC
ATTCACACGCCAAACTGGGCTGGGAAACCTTTACCGACAAGGTGATTGCCGCGCTGAATGAAAACCGCGAAGGCGTGGTG
TTTCTGCTGTGGGGCGCTCACGCCCAGAAGAAAGGCAATTTTATCGACAGCAACCGCCACCACGTGCTGAAAGCGCCGCA
CCCTTCACCGCTTTCCGCCCACCGGGGTTTCCTCGGCTGCCGCCACTTCTCGCAGGCTAATCAGTTGCTGGTGCAACAGG
GGTTGCAACCTATCGACTGGCTGCCGCAACTGCCGCAGAGCTGA

Upstream 100 bases:

>100_bases
TAAAACGAAAAGACGCCAGGATAAAAGCGGGTTTCACTGAGTGAAGCTAAACGGTAAGCTATGCCCAGTGAATTGTTAAC
GAAAACAAAGGAGAGCGTTT

Downstream 100 bases:

>100_bases
TTCAGACGTAAAAAAGGCACCCTAAGGTGCCTTTTCTTTACTTAATTCGCTTAAGCCTTGGCTTTGGAAACCGCGACCAT
CGCCGGGCGCAGCAGGCGGC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MSTSLTWHDVIGKEKEQPYFHETLAFVAAERQAGKTIYPPQKDVFNAFRYTELADVKVVILGQDPYHGPNQAHGLSFSVL
PGVPAPPSLVNMYKELATDIPGFERPSHGCLQSWAEQGVLLLNTVLTVEGGQAHSHAKLGWETFTDKVIAALNENREGVV
FLLWGAHAQKKGNFIDSNRHHVLKAPHPSPLSAHRGFLGCRHFSQANQLLVQQGLQPIDWLPQLPQS

Sequences:

>Translated_227_residues
MSTSLTWHDVIGKEKEQPYFHETLAFVAAERQAGKTIYPPQKDVFNAFRYTELADVKVVILGQDPYHGPNQAHGLSFSVL
PGVPAPPSLVNMYKELATDIPGFERPSHGCLQSWAEQGVLLLNTVLTVEGGQAHSHAKLGWETFTDKVIAALNENREGVV
FLLWGAHAQKKGNFIDSNRHHVLKAPHPSPLSAHRGFLGCRHFSQANQLLVQQGLQPIDWLPQLPQS
>Mature_226_residues
STSLTWHDVIGKEKEQPYFHETLAFVAAERQAGKTIYPPQKDVFNAFRYTELADVKVVILGQDPYHGPNQAHGLSFSVLP
GVPAPPSLVNMYKELATDIPGFERPSHGCLQSWAEQGVLLLNTVLTVEGGQAHSHAKLGWETFTDKVIAALNENREGVVF
LLWGAHAQKKGNFIDSNRHHVLKAPHPSPLSAHRGFLGCRHFSQANQLLVQQGLQPIDWLPQLPQS

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=59.5348837209302, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=59.5348837209302, Blast_Score=262, Evalue=2e-70,
Organism=Escherichia coli, GI1788934, Length=225, Percent_Identity=75.5555555555556, Blast_Score=361, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17556304, Length=219, Percent_Identity=48.4018264840183, Blast_Score=219, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6323620, Length=231, Percent_Identity=48.0519480519481, Blast_Score=192, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_SERP5 (A8GI39)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479907.1
- ProteinModelPortal:   A8GI39
- SMR:   A8GI39
- STRING:   A8GI39
- GeneID:   5606929
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3683
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   SPRO399741:SPRO_3683-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25164; Mature: 25033

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 64-64

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSLTWHDVIGKEKEQPYFHETLAFVAAERQAGKTIYPPQKDVFNAFRYTELADVKVVI
CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCEECCEEEEE
LGQDPYHGPNQAHGLSFSVLPGVPAPPSLVNMYKELATDIPGFERPSHGCLQSWAEQGVL
ECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEE
LLNTVLTVEGGQAHSHAKLGWETFTDKVIAALNENREGVVFLLWGAHAQKKGNFIDSNRH
EEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC
HVLKAPHPSPLSAHRGFLGCRHFSQANQLLVQQGLQPIDWLPQLPQS
EEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
>Mature Secondary Structure 
STSLTWHDVIGKEKEQPYFHETLAFVAAERQAGKTIYPPQKDVFNAFRYTELADVKVVI
CCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCEECCEEEEE
LGQDPYHGPNQAHGLSFSVLPGVPAPPSLVNMYKELATDIPGFERPSHGCLQSWAEQGVL
ECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEE
LLNTVLTVEGGQAHSHAKLGWETFTDKVIAALNENREGVVFLLWGAHAQKKGNFIDSNRH
EEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC
HVLKAPHPSPLSAHRGFLGCRHFSQANQLLVQQGLQPIDWLPQLPQS
EEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA