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The map label for this gene is murQ

Identifier: 157371896

GI number: 157371896

Start: 4054545

End: 4055438

Strand: Reverse

Name: murQ

Synonym: Spro_3661

Alternate gene names: 157371896

Gene position: 4055438-4054545 (Counterclockwise)

Preceding gene: 157371900

Following gene: 157371895

Centisome position: 74.43

GC content: 61.41

Gene sequence:

>894_bases
ATGAACTTGGGCGCTTTAGTCTCTGAAACCCGCAATCCGGCCACCATGGGGCTCGACGAGATGTCGACGCTGGAGATGGT
GAGCTGTTTTAACCAGGAAGACCGCAAGGTACCGGAGGCGATTGAAAAAGTATTGCCGGCCATCGCACAAGCGGTGGATC
TGGCGGCCGCGGCGTTGAAGGCCGGTGGGCGGTTGATTTATCTGGGGGCCGGCACCAGCGGCCGCCTTGGGGTGTTGGAT
GCTTCCGAATGTCCGCCGACCTTCGGCGTGCCGCATGGCATGGTGATCGGGCTGATTGCCGGTGGCCCGGGCGCGCTGCT
CAAAGCGGTGGAAGGTGCGGAGGATGATGCGGCGCTGGGCGAGGCTGACCTTGTCGCGCTGGATTTGACCGCTACCGATA
TGGTGGTCGGGCTGGCAGCATCCGGGCGGACACCTTACGTGATTGGTGCACTGCGCTATGCACGCCAATTGGGCTGTCCG
ACGGCGGCGATCTCCTGTAACCCGGATTCGCCAATCGCCCATGAAGTGCAGGTGGCGATTTCACCGGTGGTGGGGCCGGA
AGCCCTGACCGGTTCGACGCGTTTGAAGTCTGGCACTGCGCAGAAACTGGTGCTGAACATGCTGTCGACCGGGGCGATGG
TCAAACTGGGTAAAGTCTATGAAAACCTGATGGTGGACGTGAAGGCAACCAACGTAAAACTGGTGGATCGCGCCTGCCGC
ATCGTGGTGGAAGCCACCGGTGCCGAGCGCAGTCAGGCCGAAGCGGCGCTGACGCAGACCGGTTTTGAAGTCAAACCGGC
AATCCTGATGATCCTGGCCGGTATCGACGCACAAGAGGCGCAGCAGCGCTTACAACAGCATGACGGCTATTTGCGCGCGG
CATTGACGCGCTAA

Upstream 100 bases:

>100_bases
TGTGAGCCAGTCTCTAAAATAGCAAAAAGCGCTCGCTTTGTTGAATAAAATATTCAAATAATGATTTCAGTTTGTGAATT
AAAAATTCAAAGGTGAAAAA

Downstream 100 bases:

>100_bases
ACCACACCTGGGGCGGGCGATGGACAAGACAACGGCACTGGCGACACAGATTCTGGCGGGCATTGGCGGCGAGGGGAATA
TCCTTCGGCTGGAGAACTGC

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNLGALVSETRNPATMGLDEMSTLEMVSCFNQEDRKVPEAIEKVLPAIAQAVDLAAAALKAGGRLIYLGAGTSGRLGVLD
ASECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDAALGEADLVALDLTATDMVVGLAASGRTPYVIGALRYARQLGCP
TAAISCNPDSPIAHEVQVAISPVVGPEALTGSTRLKSGTAQKLVLNMLSTGAMVKLGKVYENLMVDVKATNVKLVDRACR
IVVEATGAERSQAEAALTQTGFEVKPAILMILAGIDAQEAQQRLQQHDGYLRAALTR

Sequences:

>Translated_297_residues
MNLGALVSETRNPATMGLDEMSTLEMVSCFNQEDRKVPEAIEKVLPAIAQAVDLAAAALKAGGRLIYLGAGTSGRLGVLD
ASECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDAALGEADLVALDLTATDMVVGLAASGRTPYVIGALRYARQLGCP
TAAISCNPDSPIAHEVQVAISPVVGPEALTGSTRLKSGTAQKLVLNMLSTGAMVKLGKVYENLMVDVKATNVKLVDRACR
IVVEATGAERSQAEAALTQTGFEVKPAILMILAGIDAQEAQQRLQQHDGYLRAALTR
>Mature_297_residues
MNLGALVSETRNPATMGLDEMSTLEMVSCFNQEDRKVPEAIEKVLPAIAQAVDLAAAALKAGGRLIYLGAGTSGRLGVLD
ASECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDAALGEADLVALDLTATDMVVGLAASGRTPYVIGALRYARQLGCP
TAAISCNPDSPIAHEVQVAISPVVGPEALTGSTRLKSGTAQKLVLNMLSTGAMVKLGKVYENLMVDVKATNVKLVDRACR
IVVEATGAERSQAEAALTQTGFEVKPAILMILAGIDAQEAQQRLQQHDGYLRAALTR

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=297, Percent_Identity=57.9124579124579, Blast_Score=337, Evalue=8e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_SERP5 (A8GI17)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479885.1
- ProteinModelPortal:   A8GI17
- SMR:   A8GI17
- STRING:   A8GI17
- GeneID:   5606380
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3661
- eggNOG:   COG2103
- HOGENOM:   HBG703490
- OMA:   SMIGVGK
- ProtClustDB:   PRK05441
- BioCyc:   SPRO399741:SPRO_3661-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 30727; Mature: 30727

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 83-83 ACT_SITE 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLGALVSETRNPATMGLDEMSTLEMVSCFNQEDRKVPEAIEKVLPAIAQAVDLAAAALK
CCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGGRLIYLGAGTSGRLGVLDASECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDAALG
CCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCHHCC
EADLVALDLTATDMVVGLAASGRTPYVIGALRYARQLGCPTAAISCNPDSPIAHEVQVAI
CCCEEEEEEEHHHHHEEEECCCCCCEEHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEE
SPVVGPEALTGSTRLKSGTAQKLVLNMLSTGAMVKLGKVYENLMVDVKATNVKLVDRACR
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCCHHHHHHHE
IVVEATGAERSQAEAALTQTGFEVKPAILMILAGIDAQEAQQRLQQHDGYLRAALTR
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MNLGALVSETRNPATMGLDEMSTLEMVSCFNQEDRKVPEAIEKVLPAIAQAVDLAAAALK
CCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGGRLIYLGAGTSGRLGVLDASECPPTFGVPHGMVIGLIAGGPGALLKAVEGAEDDAALG
CCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCHHCC
EADLVALDLTATDMVVGLAASGRTPYVIGALRYARQLGCPTAAISCNPDSPIAHEVQVAI
CCCEEEEEEEHHHHHEEEECCCCCCEEHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEE
SPVVGPEALTGSTRLKSGTAQKLVLNMLSTGAMVKLGKVYENLMVDVKATNVKLVDRACR
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCCHHHHHHHE
IVVEATGAERSQAEAALTQTGFEVKPAILMILAGIDAQEAQQRLQQHDGYLRAALTR
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA