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The map label for this gene is 157370627

Identifier: 157370627

GI number: 157370627

Start: 2607072

End: 2608544

Strand: Direct

Name: 157370627

Synonym: Spro_2387

Alternate gene names: NA

Gene position: 2607072-2608544 (Clockwise)

Preceding gene: 157370613

Following gene: 157370633

Centisome position: 47.85

GC content: 48.68

Gene sequence:

>1473_bases
ATGGACAATTCCCTAAATGGAAAGACCAGCGGTTGGGATGATGTTAATGATTTGCTGAATTATCATAATAGAGGAAATGG
TTTAACCCTCAATAATAAGCCTTCTTTTGGTGTGGAAGAGGCTGGCAAGCAAATAGCGCGTAGTGAGCAGACCTGGAATG
GCATTCATGTGACCGGCAAAGGTGCCACCGTCACTTATTCGTTCCCTGACTGGGATTATAATCAGAGTAATTTAAACTTC
CGATTTGGCTCCAATAATCAAGATACCGGCCTTAGCGCCTTTACCGCAGAGCAAAAGGCCCAGGCCAAGCTTTCGCTGCA
ATCCTGGGCTGATGTAGCTAACCTTACGTTTGTTGAAGTTGCCCCGGATCAAAAGTCCAATATTACCTTCGGAAATTATG
AGGGTTCCGGCCAGGCTTATGCAATTAAGCCATTCAGCGGGGCGGGTAACGACTATCGAGGGCATAATACCGATGGTCAA
AGCTGGTTCAACATCAATTACGATTACGCGGATCCCCGGGATGGGGTTTACGCCAATCTACACCCTGAGTTGGGCAACTA
TGGCCGTTTGAGTATCACCCATGAACTGGGGCATACGTTGGGGCTGGATCATCCAGGAAAATATAATGCTGATGAAAACA
ATCCACCCAACTACAGCATGGCGAATTACGCCGAGGATACGCGCCAATTCAGCGTAATGAGCTATTGGGATGAGTCCCTT
ACCGGTGGTGATAACGGCGGTCATTTTGCCGCCGCGCCGCTGGTTGACGATATTGCCGCTATTCAATATCTCTATGGCGC
CAATACCACTACGCGCACCGGGGATACGGTGTACGGGTTCAATTCTAATACCGGGCGGGATTTCTACACGCTGACGGACA
GTAACCAGAAGCTGGTGTTCTCCGTCTGGGATGCCGGCGGCAACGATACGCTTGATTTCTCGGGCTATACGCAAAACCAA
CGCATCAATTTGACGGAAGGCTCTTTCTCTGACGTCGGCGGGTTGAAGGGCAACGTTTCCATCGCCGTTGGTGCTGTGAT
TGAAAATGCCATTGGTGGTTCAGGTAATGATGTGATTGTCGGCAATGATGCGGCCAATATTATCCATGGTGGTGCGGGTA
ATGACGTTATCTACGGTGGCGGCGGGCAGGATCAGTTATTCGGTGGCAGCGGTAAAGATATCTTTGTTTTCTCTGCGGTG
AGTGATTCGTCGTTCAAATCACCGGATAAAATCCTGGACTTTGAAACCGGCATCGACAAAATCGATCTGTCCTTCTTTAA
TCATGGCGACAATGGCGCAGGATTTATTCATTTCGTCGACGCGTTTAGCGGGCAGGCGGGGGAGGCATTGCTAACCTATG
ACTCACAAAGTAATTTAAGTGAGTTGGCGCTAAATATAAATGGCCAGGCGGCTCCGGATTTTCTGGTTAATATTGTCGGG
CAAGCAAATACTGCCACTGACTTTATTGTTTAA

Upstream 100 bases:

>100_bases
ATACTAGCATTTAAATGCTGCGATATGATGTTGCGGTAATTCTATATATCGAAATTTTATTTCTATATAACGGAAATGAA
TTAACCTACTGGAGATGGAT

Downstream 100 bases:

>100_bases
ATCAGTCACGGTGGGTTATACCCACCGTTTTTAACGCTCTTTTATTATTCTGTACCACCTTGGTAAGTACAGAGGTAAAC
AAAGTCACCGCCTGCTCCAG

Product: serralysin

Products: NA

Alternate protein names: Extracellular metalloproteinase; Zinc proteinase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MDNSLNGKTSGWDDVNDLLNYHNRGNGLTLNNKPSFGVEEAGKQIARSEQTWNGIHVTGKGATVTYSFPDWDYNQSNLNF
RFGSNNQDTGLSAFTAEQKAQAKLSLQSWADVANLTFVEVAPDQKSNITFGNYEGSGQAYAIKPFSGAGNDYRGHNTDGQ
SWFNINYDYADPRDGVYANLHPELGNYGRLSITHELGHTLGLDHPGKYNADENNPPNYSMANYAEDTRQFSVMSYWDESL
TGGDNGGHFAAAPLVDDIAAIQYLYGANTTTRTGDTVYGFNSNTGRDFYTLTDSNQKLVFSVWDAGGNDTLDFSGYTQNQ
RINLTEGSFSDVGGLKGNVSIAVGAVIENAIGGSGNDVIVGNDAANIIHGGAGNDVIYGGGGQDQLFGGSGKDIFVFSAV
SDSSFKSPDKILDFETGIDKIDLSFFNHGDNGAGFIHFVDAFSGQAGEALLTYDSQSNLSELALNINGQAAPDFLVNIVG
QANTATDFIV

Sequences:

>Translated_490_residues
MDNSLNGKTSGWDDVNDLLNYHNRGNGLTLNNKPSFGVEEAGKQIARSEQTWNGIHVTGKGATVTYSFPDWDYNQSNLNF
RFGSNNQDTGLSAFTAEQKAQAKLSLQSWADVANLTFVEVAPDQKSNITFGNYEGSGQAYAIKPFSGAGNDYRGHNTDGQ
SWFNINYDYADPRDGVYANLHPELGNYGRLSITHELGHTLGLDHPGKYNADENNPPNYSMANYAEDTRQFSVMSYWDESL
TGGDNGGHFAAAPLVDDIAAIQYLYGANTTTRTGDTVYGFNSNTGRDFYTLTDSNQKLVFSVWDAGGNDTLDFSGYTQNQ
RINLTEGSFSDVGGLKGNVSIAVGAVIENAIGGSGNDVIVGNDAANIIHGGAGNDVIYGGGGQDQLFGGSGKDIFVFSAV
SDSSFKSPDKILDFETGIDKIDLSFFNHGDNGAGFIHFVDAFSGQAGEALLTYDSQSNLSELALNINGQAAPDFLVNIVG
QANTATDFIV
>Mature_490_residues
MDNSLNGKTSGWDDVNDLLNYHNRGNGLTLNNKPSFGVEEAGKQIARSEQTWNGIHVTGKGATVTYSFPDWDYNQSNLNF
RFGSNNQDTGLSAFTAEQKAQAKLSLQSWADVANLTFVEVAPDQKSNITFGNYEGSGQAYAIKPFSGAGNDYRGHNTDGQ
SWFNINYDYADPRDGVYANLHPELGNYGRLSITHELGHTLGLDHPGKYNADENNPPNYSMANYAEDTRQFSVMSYWDESL
TGGDNGGHFAAAPLVDDIAAIQYLYGANTTTRTGDTVYGFNSNTGRDFYTLTDSNQKLVFSVWDAGGNDTLDFSGYTQNQ
RINLTEGSFSDVGGLKGNVSIAVGAVIENAIGGSGNDVIVGNDAANIIHGGAGNDVIYGGGGQDQLFGGSGKDIFVFSAV
SDSSFKSPDKILDFETGIDKIDLSFFNHGDNGAGFIHFVDAFSGQAGEALLTYDSQSNLSELALNINGQAAPDFLVNIVG
QANTATDFIV

Specific function: Has insecticidal activity against the locust M.palpalis. When administered orally to locusts at a low dose it causes them to lie on their sides exhibiting sporadic limb movements and muscular twitching, followed by full recovery. When administered at high

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR001818
- InterPro:   IPR016294
- InterPro:   IPR013858
- InterPro:   IPR006026
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF00413 Peptidase_M10; PF08548 Peptidase_M10_C [H]

EC number: =3.4.24.40 [H]

Molecular weight: Translated: 52539; Mature: 52539

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS00142 ZINC_PROTEASE ; PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNSLNGKTSGWDDVNDLLNYHNRGNGLTLNNKPSFGVEEAGKQIARSEQTWNGIHVTGK
CCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEC
GATVTYSFPDWDYNQSNLNFRFGSNNQDTGLSAFTAEQKAQAKLSLQSWADVANLTFVEV
CCEEEEECCCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHEEEHHHHHHHHCEEEEEE
APDQKSNITFGNYEGSGQAYAIKPFSGAGNDYRGHNTDGQSWFNINYDYADPRDGVYANL
CCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEE
HPELGNYGRLSITHELGHTLGLDHPGKYNADENNPPNYSMANYAEDTRQFSVMSYWDESL
CCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEHHHHHC
TGGDNGGHFAAAPLVDDIAAIQYLYGANTTTRTGDTVYGFNSNTGRDFYTLTDSNQKLVF
CCCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEEECCCCEEEE
SVWDAGGNDTLDFSGYTQNQRINLTEGSFSDVGGLKGNVSIAVGAVIENAIGGSGNDVIV
EEECCCCCCEEEECCCCCCCEEEECCCCCHHCCCCCCCEEEEEEEHHHHHCCCCCCEEEE
GNDAANIIHGGAGNDVIYGGGGQDQLFGGSGKDIFVFSAVSDSSFKSPDKILDFETGIDK
CCCHHHEEECCCCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHEEECCCCCCE
IDLSFFNHGDNGAGFIHFVDAFSGQAGEALLTYDSQSNLSELALNINGQAAPDFLVNIVG
EEEEEEECCCCCCEEEEEEECCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCHHEEEC
QANTATDFIV
CCCCCCCCCC
>Mature Secondary Structure
MDNSLNGKTSGWDDVNDLLNYHNRGNGLTLNNKPSFGVEEAGKQIARSEQTWNGIHVTGK
CCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEC
GATVTYSFPDWDYNQSNLNFRFGSNNQDTGLSAFTAEQKAQAKLSLQSWADVANLTFVEV
CCEEEEECCCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHEEEHHHHHHHHCEEEEEE
APDQKSNITFGNYEGSGQAYAIKPFSGAGNDYRGHNTDGQSWFNINYDYADPRDGVYANL
CCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEE
HPELGNYGRLSITHELGHTLGLDHPGKYNADENNPPNYSMANYAEDTRQFSVMSYWDESL
CCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEHHHHHC
TGGDNGGHFAAAPLVDDIAAIQYLYGANTTTRTGDTVYGFNSNTGRDFYTLTDSNQKLVF
CCCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEEECCCCEEEE
SVWDAGGNDTLDFSGYTQNQRINLTEGSFSDVGGLKGNVSIAVGAVIENAIGGSGNDVIV
EEECCCCCCEEEECCCCCCCEEEECCCCCHHCCCCCCCEEEEEEEHHHHHCCCCCCEEEE
GNDAANIIHGGAGNDVIYGGGGQDQLFGGSGKDIFVFSAVSDSSFKSPDKILDFETGIDK
CCCHHHEEECCCCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHEEECCCCCCE
IDLSFFNHGDNGAGFIHFVDAFSGQAGEALLTYDSQSNLSELALNINGQAAPDFLVNIVG
EEEEEEECCCCCCEEEEEEECCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCHHEEEC
QANTATDFIV
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2274043; 8089845; 7752231 [H]