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The map label for this gene is pcaK [H]

Identifier: 157370339

GI number: 157370339

Start: 2291700

End: 2293079

Strand: Reverse

Name: pcaK [H]

Synonym: Spro_2097

Alternate gene names: 157370339

Gene position: 2293079-2291700 (Counterclockwise)

Preceding gene: 157370340

Following gene: 157370338

Centisome position: 42.08

GC content: 57.97

Gene sequence:

>1380_bases
ATGAGCAACCGCAACATTGTCGACGTCAAAGCGTGGATAGACTCCCGCCCGATTTCCCGCTATCAGTGGCTGGTATTAAT
TCTGTGTTTCGTGATCATCATGTTTGATGGTTATGACGCCGCGGTGATGGGTTTTATCGCCCCCGCACTGATTGAAGACT
GGGGTATTTCGCGCGCCGAAATGGGCCCGATCCTCGGTGCTGCAATGTTTGGCGTCGCTTTGGGAGCGCTGATCGCCGGC
CCCTATTCCGATCGTTTTGGCCGCAAGAAGGTGCTGCTGCTGTCCATTCTGTGCTTTGCGTTGTTCAGCCTGCTGAGCAC
CTTCGCCCGCACCCCGCTGGAAATGGCCTTGCTGCGTTTTCTTACCGGCCTGGGCTTGGGCGCGGTGATGCCCAACTGTG
TCACGCTGGTGTCAGAGTATATGCCCGAACGCCGCCGCGGCCTGATGATCACCCTGATGTACAGCGGCTTTAATATCGGT
TCCGGTGCCGGCGGGTTTATCGCCGCCGCCATGTTACCGCACTATGGCTGGAAGGCGGTGCTGTTCCTGGGCGGCATCAT
GCCGCTGCTGATGTTGCCGCTGCTGATTTGGATCCTGCCGGAATCGACGCTGTATATGGTGGTGCGCAACCATCACAAAG
AAAAAATTGCCCAAATCCTGCGCCGCGCCGGTGGCGTGTTCAGCGCCGGTACCACCTTCATACTGAAAACCCCGGTGATC
CCAAAGAAAGCCCGCGTGCTGCAACTGTTCAGTAATGGTTACGCCAGGGGCACCCTGGTGCTGTGGCTGACCTATTTTAT
GGGGCTGTTCGTGATTTACCTGCTCAACGGCTGGCTGCCGACCATCGTGCGCGGCGCCGGTTTCTCACTGGAGCGCGCCG
CGATAATCGCCGGTCTGTTCCAACTGGGCGGTACCCTGGGAGGCCTGCTGGTGGGTTACCTGATGGACCGCTTCGTCGCC
AAACGGGTGATCGGACTGTTTTATCTGATGGGCATGTTCTGCCTGCTGTCACAGGGTATCTGGGGCTTTGGTCCGACGCT
GCTGGCGGTGTTGGTCTTTGTTAGCGGCATGTGTATCAACGGGGCGCAGACCGGTCTGCAAGCATTCTCACCGGCATTCT
ACCCCACTGAAATGCGCGCGACCGGCGTCAGCTGGATGCACGGCATCGGCCGCAGCGGCGCCATTATCAGTTCGTCAATG
GGTGGCGTATTGCTGGGTATTTTCCCCGGCGCCACCAGCATTTTTATCATTCTGGCGATCCCGGCGTTGCTGGCGGCGAT
CACTATCATTAATCATCAAAAGGCACATCCGGCGGAAATGGTTAAGGGCATCGACATCACCGATCTGCCCGCGTTGTCAC
GCACCATGAATAACCGGTAA

Upstream 100 bases:

>100_bases
TTCTGACAATGCCCACTGACGCTCATTCAATACGTTTCCGGCCTGCAACCAAAGTTTTAATCCGATCACATATTAATAAA
AAAAACAGAGAGCGTACCCG

Downstream 100 bases:

>100_bases
TTCTTATTAATACAGAGGTAGACGATGGCTAAGATCATTGGCGGATTGGCGGTGTCACACACCCCAACCATCGGTTTTGC
AGTGGATCACAACAAGCAGA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSNRNIVDVKAWIDSRPISRYQWLVLILCFVIIMFDGYDAAVMGFIAPALIEDWGISRAEMGPILGAAMFGVALGALIAG
PYSDRFGRKKVLLLSILCFALFSLLSTFARTPLEMALLRFLTGLGLGAVMPNCVTLVSEYMPERRRGLMITLMYSGFNIG
SGAGGFIAAAMLPHYGWKAVLFLGGIMPLLMLPLLIWILPESTLYMVVRNHHKEKIAQILRRAGGVFSAGTTFILKTPVI
PKKARVLQLFSNGYARGTLVLWLTYFMGLFVIYLLNGWLPTIVRGAGFSLERAAIIAGLFQLGGTLGGLLVGYLMDRFVA
KRVIGLFYLMGMFCLLSQGIWGFGPTLLAVLVFVSGMCINGAQTGLQAFSPAFYPTEMRATGVSWMHGIGRSGAIISSSM
GGVLLGIFPGATSIFIILAIPALLAAITIINHQKAHPAEMVKGIDITDLPALSRTMNNR

Sequences:

>Translated_459_residues
MSNRNIVDVKAWIDSRPISRYQWLVLILCFVIIMFDGYDAAVMGFIAPALIEDWGISRAEMGPILGAAMFGVALGALIAG
PYSDRFGRKKVLLLSILCFALFSLLSTFARTPLEMALLRFLTGLGLGAVMPNCVTLVSEYMPERRRGLMITLMYSGFNIG
SGAGGFIAAAMLPHYGWKAVLFLGGIMPLLMLPLLIWILPESTLYMVVRNHHKEKIAQILRRAGGVFSAGTTFILKTPVI
PKKARVLQLFSNGYARGTLVLWLTYFMGLFVIYLLNGWLPTIVRGAGFSLERAAIIAGLFQLGGTLGGLLVGYLMDRFVA
KRVIGLFYLMGMFCLLSQGIWGFGPTLLAVLVFVSGMCINGAQTGLQAFSPAFYPTEMRATGVSWMHGIGRSGAIISSSM
GGVLLGIFPGATSIFIILAIPALLAAITIINHQKAHPAEMVKGIDITDLPALSRTMNNR
>Mature_458_residues
SNRNIVDVKAWIDSRPISRYQWLVLILCFVIIMFDGYDAAVMGFIAPALIEDWGISRAEMGPILGAAMFGVALGALIAGP
YSDRFGRKKVLLLSILCFALFSLLSTFARTPLEMALLRFLTGLGLGAVMPNCVTLVSEYMPERRRGLMITLMYSGFNIGS
GAGGFIAAAMLPHYGWKAVLFLGGIMPLLMLPLLIWILPESTLYMVVRNHHKEKIAQILRRAGGVFSAGTTFILKTPVIP
KKARVLQLFSNGYARGTLVLWLTYFMGLFVIYLLNGWLPTIVRGAGFSLERAAIIAGLFQLGGTLGGLLVGYLMDRFVAK
RVIGLFYLMGMFCLLSQGIWGFGPTLLAVLVFVSGMCINGAQTGLQAFSPAFYPTEMRATGVSWMHGIGRSGAIISSSMG
GVLLGIFPGATSIFIILAIPALLAAITIINHQKAHPAEMVKGIDITDLPALSRTMNNR

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=434, Percent_Identity=27.4193548387097, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI213021148, Length=442, Percent_Identity=23.0769230769231, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI7662270, Length=315, Percent_Identity=24.4444444444444, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI166064021, Length=362, Percent_Identity=26.5193370165746, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI216548223, Length=311, Percent_Identity=24.1157556270096, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI8923870, Length=349, Percent_Identity=25.5014326647564, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI262399383, Length=267, Percent_Identity=24.7191011235955, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI73695465, Length=207, Percent_Identity=25.1207729468599, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI87081723, Length=391, Percent_Identity=32.9923273657289, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87082159, Length=403, Percent_Identity=29.2803970223325, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082404, Length=408, Percent_Identity=23.5294117647059, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082231, Length=200, Percent_Identity=24.5, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786229, Length=383, Percent_Identity=24.0208877284595, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789152, Length=322, Percent_Identity=24.5341614906832, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788068, Length=453, Percent_Identity=20.5298013245033, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788074, Length=382, Percent_Identity=24.3455497382199, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI2367379, Length=327, Percent_Identity=22.9357798165138, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1789515, Length=318, Percent_Identity=22.9559748427673, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=424, Percent_Identity=24.5283018867925, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI32565921, Length=417, Percent_Identity=25.1798561151079, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19922874, Length=386, Percent_Identity=25.6476683937824, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640198, Length=223, Percent_Identity=25.5605381165919, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640196, Length=223, Percent_Identity=25.5605381165919, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640200, Length=223, Percent_Identity=25.5605381165919, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49806; Mature: 49675

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRNIVDVKAWIDSRPISRYQWLVLILCFVIIMFDGYDAAVMGFIAPALIEDWGISRAE
CCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHH
MGPILGAAMFGVALGALIAGPYSDRFGRKKVLLLSILCFALFSLLSTFARTPLEMALLRF
HHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
LTGLGLGAVMPNCVTLVSEYMPERRRGLMITLMYSGFNIGSGAGGFIAAAMLPHYGWKAV
HHHCCHHHHHHHHHHHHHHHCCHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHH
LFLGGIMPLLMLPLLIWILPESTLYMVVRNHHKEKIAQILRRAGGVFSAGTTFILKTPVI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEECCCC
PKKARVLQLFSNGYARGTLVLWLTYFMGLFVIYLLNGWLPTIVRGAGFSLERAAIIAGLF
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHH
QLGGTLGGLLVGYLMDRFVAKRVIGLFYLMGMFCLLSQGIWGFGPTLLAVLVFVSGMCIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
GAQTGLQAFSPAFYPTEMRATGVSWMHGIGRSGAIISSSMGGVLLGIFPGATSIFIILAI
CHHHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCCCHHCCCCCEEEEECCCHHHHHHHHHH
PALLAAITIINHQKAHPAEMVKGIDITDLPALSRTMNNR
HHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
SNRNIVDVKAWIDSRPISRYQWLVLILCFVIIMFDGYDAAVMGFIAPALIEDWGISRAE
CCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHH
MGPILGAAMFGVALGALIAGPYSDRFGRKKVLLLSILCFALFSLLSTFARTPLEMALLRF
HHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
LTGLGLGAVMPNCVTLVSEYMPERRRGLMITLMYSGFNIGSGAGGFIAAAMLPHYGWKAV
HHHCCHHHHHHHHHHHHHHHCCHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHH
LFLGGIMPLLMLPLLIWILPESTLYMVVRNHHKEKIAQILRRAGGVFSAGTTFILKTPVI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEECCCC
PKKARVLQLFSNGYARGTLVLWLTYFMGLFVIYLLNGWLPTIVRGAGFSLERAAIIAGLF
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHH
QLGGTLGGLLVGYLMDRFVAKRVIGLFYLMGMFCLLSQGIWGFGPTLLAVLVFVSGMCIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
GAQTGLQAFSPAFYPTEMRATGVSWMHGIGRSGAIISSSMGGVLLGIFPGATSIFIILAI
CHHHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCCCHHCCCCCEEEEECCCHHHHHHHHHH
PALLAAITIINHQKAHPAEMVKGIDITDLPALSRTMNNR
HHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]