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The map label for this gene is licC [H]

Identifier: 157370100

GI number: 157370100

Start: 2040405

End: 2041766

Strand: Direct

Name: licC [H]

Synonym: Spro_1858

Alternate gene names: 157370100

Gene position: 2040405-2041766 (Clockwise)

Preceding gene: 157370099

Following gene: 157370101

Centisome position: 37.45

GC content: 53.23

Gene sequence:

>1362_bases
ATGGCGGGTTTAAATAGCATTCTGGAACGTTACGTGTTGCCGACGGCGTTAAAAATTGCCGGGCAAAAACATATTCTGTC
GGTGCGGGACGGCATAATTCTCAACATGCCGTTTATGTTAATCGGGTCATTTTTCCTGATCTTCGCTTACTTACCGATCC
CCAGCTACGCCAATCTGATGGGCGAGGTGTTTGGTGCGGCGTGGCGGGATAAATTGTTGTACCCGGTCAAGGCGACCTAC
GACATCATGGCGATAATCTCCAGCTTTGGCATTGCCTACCGGCTGGCGGAGAAATACCGTGGAATGGATCCGCTCAGTAC
CGGTGCGGTTTCGCTGGTGGCATTTATCATGACCATTCCCCAACATACGCTGTTTACACCGGTGAAAGGGGCTGCAGAGC
AAATTGTTAAAGGCGTGCTGCCGATGAATTTTATCGGCAGTCAGGGGTTGTTTGTGGCGATTGTAGTGGCGCTGTTATCG
ACGGAAATCTACCGTTTCGTGCATAACCGCAATCTGGTGATCAACATGCCGGAAGGGGTGCCGCCGGCGGTAGCCAAATC
CTTCCTGGCCCTGATCCCGGGGTTCTGCGTGCTGGCAGTGATTTTGCTGCTGCGTTTGATTGTTGAGGCTACGCCGTTTG
GCGATATCAACACCATGATCGCTACGCTTATCGGTATCCCGATGCATCACGTGGGTGGGACACTTCCGGGGATGATTTTC
TCGGTGATCCTGATCGGCTTGCTGTGGACGCTGGGGCTGCATGGCGACGCCATCGTACTGGTGTTTATTCAACCGGTGTG
GCTGGCGAATATGTCAGAAAACCTGGTGGCGTTTCAGAGTAATCAGCCGATCCCGCACATTATCACCCAGCAATTTTACG
ATTTGTGGATTGCGCCCGGTGGAACTGGCGCCCTGCTGGGGCTGGTGATCTTTATGCTGTTGCGCAGCCGTAGCGCCCAG
ATGAAACAGTTGGGGAAAATCGCCGCGCCGGGTTGCCTGTTTAACATTAGCGAACCCATGGTGTTCGGCATCCCGTTGGT
GATGAATCCGTACTTCTTCCTGCCGTTTATTCTGACTCCGGTGGTGCTGGTGATTGTGACCTACAGCGCGATGGCTACCG
GGTTGGTGACGCCTCCGGTTGGCATTGCCTTGCCGTTCACCACGCCGATTTTCATTAGTGGCTATCTGGCAACCGGCGGC
CATATTTCAGGAACGGTGATCCAGGTGGTCAATTTGCTGATTTCAATGGCGATTTACTATCCGTTCTTCCGCGCCTGGGA
TAAGCAAAAATACCGCGAAGAAAATCAGGCGGCGATGCCAGTACAAAATGCCGTGACTGATGAGCAACCGCAGACACCAT
AA

Upstream 100 bases:

>100_bases
GAGGTACTGAGCCTGAACCAGGCCTATCTGCCGCAGTTTAATTAAGTCGATATTCCATAATAACAATCACGACGGCCGGC
TTTGCCGGGCAGGGGGGATG

Downstream 100 bases:

>100_bases
ATGTGCATTTTCTGCGGCGGTGTTGAGTTATTGCCGCCGCAGAAAGGGAGTGAAAAAGGTCTCGCACATGAATTGTTACA
TTATAACAAAGTTAAATTTC

Product: PTS system lactose/cellobiose family transporter subunit IIC

Products: pyruvate; diacetylchitobiose-6-phosphate [Cytoplasm]; cellobiose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EIIC-Lic; PTS system lichenan-specific EIIC component [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MAGLNSILERYVLPTALKIAGQKHILSVRDGIILNMPFMLIGSFFLIFAYLPIPSYANLMGEVFGAAWRDKLLYPVKATY
DIMAIISSFGIAYRLAEKYRGMDPLSTGAVSLVAFIMTIPQHTLFTPVKGAAEQIVKGVLPMNFIGSQGLFVAIVVALLS
TEIYRFVHNRNLVINMPEGVPPAVAKSFLALIPGFCVLAVILLLRLIVEATPFGDINTMIATLIGIPMHHVGGTLPGMIF
SVILIGLLWTLGLHGDAIVLVFIQPVWLANMSENLVAFQSNQPIPHIITQQFYDLWIAPGGTGALLGLVIFMLLRSRSAQ
MKQLGKIAAPGCLFNISEPMVFGIPLVMNPYFFLPFILTPVVLVIVTYSAMATGLVTPPVGIALPFTTPIFISGYLATGG
HISGTVIQVVNLLISMAIYYPFFRAWDKQKYREENQAAMPVQNAVTDEQPQTP

Sequences:

>Translated_453_residues
MAGLNSILERYVLPTALKIAGQKHILSVRDGIILNMPFMLIGSFFLIFAYLPIPSYANLMGEVFGAAWRDKLLYPVKATY
DIMAIISSFGIAYRLAEKYRGMDPLSTGAVSLVAFIMTIPQHTLFTPVKGAAEQIVKGVLPMNFIGSQGLFVAIVVALLS
TEIYRFVHNRNLVINMPEGVPPAVAKSFLALIPGFCVLAVILLLRLIVEATPFGDINTMIATLIGIPMHHVGGTLPGMIF
SVILIGLLWTLGLHGDAIVLVFIQPVWLANMSENLVAFQSNQPIPHIITQQFYDLWIAPGGTGALLGLVIFMLLRSRSAQ
MKQLGKIAAPGCLFNISEPMVFGIPLVMNPYFFLPFILTPVVLVIVTYSAMATGLVTPPVGIALPFTTPIFISGYLATGG
HISGTVIQVVNLLISMAIYYPFFRAWDKQKYREENQAAMPVQNAVTDEQPQTP
>Mature_452_residues
AGLNSILERYVLPTALKIAGQKHILSVRDGIILNMPFMLIGSFFLIFAYLPIPSYANLMGEVFGAAWRDKLLYPVKATYD
IMAIISSFGIAYRLAEKYRGMDPLSTGAVSLVAFIMTIPQHTLFTPVKGAAEQIVKGVLPMNFIGSQGLFVAIVVALLST
EIYRFVHNRNLVINMPEGVPPAVAKSFLALIPGFCVLAVILLLRLIVEATPFGDINTMIATLIGIPMHHVGGTLPGMIFS
VILIGLLWTLGLHGDAIVLVFIQPVWLANMSENLVAFQSNQPIPHIITQQFYDLWIAPGGTGALLGLVIFMLLRSRSAQM
KQLGKIAAPGCLFNISEPMVFGIPLVMNPYFFLPFILTPVVLVIVTYSAMATGLVTPPVGIALPFTTPIFISGYLATGGH
ISGTVIQVVNLLISMAIYYPFFRAWDKQKYREENQAAMPVQNAVTDEQPQTP

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG1455

COG function: function code G; Phosphotransferase system cellobiose-specific component IIC

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-3 domain [H]

Homologues:

Organism=Escherichia coli, GI1788032, Length=470, Percent_Identity=30, Blast_Score=186, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003352
- InterPro:   IPR004796
- InterPro:   IPR004501 [H]

Pfam domain/function: PF02378 PTS_EIIC [H]

EC number: NA

Molecular weight: Translated: 49423; Mature: 49292

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS51105 PTS_EIIC_TYPE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLNSILERYVLPTALKIAGQKHILSVRDGIILNMPFMLIGSFFLIFAYLPIPSYANLM
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCCHHHHHH
GEVFGAAWRDKLLYPVKATYDIMAIISSFGIAYRLAEKYRGMDPLSTGAVSLVAFIMTIP
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
QHTLFTPVKGAAEQIVKGVLPMNFIGSQGLFVAIVVALLSTEIYRFVHNRNLVINMPEGV
CHHHCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PPAVAKSFLALIPGFCVLAVILLLRLIVEATPFGDINTMIATLIGIPMHHVGGTLPGMIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCHHHHH
SVILIGLLWTLGLHGDAIVLVFIQPVWLANMSENLVAFQSNQPIPHIITQQFYDLWIAPG
HHHHHHHHHHHCCCCCEEEEEEECHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHEECCC
GTGALLGLVIFMLLRSRSAQMKQLGKIAAPGCLFNISEPMVFGIPLVMNPYFFLPFILTP
CHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCHHCCCHHHHCHHHHHHHHHHH
VVLVIVTYSAMATGLVTPPVGIALPFTTPIFISGYLATGGHISGTVIQVVNLLISMAIYY
HHHHHHHHHHHHHCCCCCCCCEEECCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHH
PFFRAWDKQKYREENQAAMPVQNAVTDEQPQTP
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
AGLNSILERYVLPTALKIAGQKHILSVRDGIILNMPFMLIGSFFLIFAYLPIPSYANLM
CCHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCCHHHHHH
GEVFGAAWRDKLLYPVKATYDIMAIISSFGIAYRLAEKYRGMDPLSTGAVSLVAFIMTIP
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
QHTLFTPVKGAAEQIVKGVLPMNFIGSQGLFVAIVVALLSTEIYRFVHNRNLVINMPEGV
CHHHCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PPAVAKSFLALIPGFCVLAVILLLRLIVEATPFGDINTMIATLIGIPMHHVGGTLPGMIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCHHHHH
SVILIGLLWTLGLHGDAIVLVFIQPVWLANMSENLVAFQSNQPIPHIITQQFYDLWIAPG
HHHHHHHHHHHCCCCCEEEEEEECHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHEECCC
GTGALLGLVIFMLLRSRSAQMKQLGKIAAPGCLFNISEPMVFGIPLVMNPYFFLPFILTP
CHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCHHCCCHHHHCHHHHHHHHHHH
VVLVIVTYSAMATGLVTPPVGIALPFTTPIFISGYLATGGHISGTVIQVVNLLISMAIYY
HHHHHHHHHHHHHCCCCCCCCEEECCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHH
PFFRAWDKQKYREENQAAMPVQNAVTDEQPQTP
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: diacetylchitobiose [Periplasm]; phosphoenolpyruvate; cellobiose [Periplasm] [C]

Specific reaction: phosphoenolpyruvate + diacetylchitobiose [Periplasm] = pyruvate + diacetylchitobiose-6-phosphate [Cytoplasm] phosphoenolpyruvate + cellobiose [Periplasm] = cellobiose-6-phosphate [Cytoplasm] + pyruvate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8990303; 8969509; 9384377 [H]