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The map label for this gene is hemA [H]

Identifier: 157370072

GI number: 157370072

Start: 2012865

End: 2014076

Strand: Reverse

Name: hemA [H]

Synonym: Spro_1830

Alternate gene names: 157370072

Gene position: 2014076-2012865 (Counterclockwise)

Preceding gene: 157370073

Following gene: 157370071

Centisome position: 36.96

GC content: 57.67

Gene sequence:

>1212_bases
ATGAGCGTATTAAACATTCTTGAAGAAAAACTGGCCGAAACCAAAAGACAGGGCCGCTTCCGTGAGTTCCTCAATCTGGA
ACGCAGCGTGCTGGACAAACCCTGGGCCACCAGCCACGGTCAGAACGGTGAGCGCCGTCTGAACGTCTGGTGTTCCAATG
ACTATCTGGCGATGAGCCATCACCCTAAAGTCATTCTGGCCACCACCGAAGCGGTGAACCGCGTCGGGCTGGGCACCTGC
GGCGCACGCAGCATTTCCGGCACTTCTGTCTATCACAGTGAATTGGAAACCCTGTTGGCCAGCGCCTATGGCAAAGAGTC
GGCGCTGCTGTTTACCACCGGCTTCGGTGCCAATGACGCCACCTTGTCCACCCTGTGTGATGCCATTCCCGATCTGATTG
TGTTTTCCGATGAGCTGAACCACGCCTCGATGATTTACGGCATCCGTTACAGCAAGGCGGAGAAAAAGATCTTCCGCCAC
AATGACGTAGCCCATCTGGCCGAGCTGCTGCAGGCCGCCGACCCGCATCGGCCCAAACTGATCGCCTTCGAGTCGCTTTA
TTCAATGGACGGCGACTTTGCCCCACTGGCACAAATTGTGGAATTGGCTGAGAAATATCAGGCGCTGACCTATCTGGACG
AGATCCACTCTGCCGGCGTTTACGGTCATCGCGGGTTGGGCTATGCCGAACAACTTGGCCTGTTGGACAAAATCACCATT
ATCCAGGGCGGTTTTGGCAAATCTTACGGCGCTGCCGGTGGCTACATCGCCGCCCCGCGCGTGGTGGTTGAAGCGGTGCG
TAGCTGGTCGCCAGCGTTTGTCTTCAGCACCTCGTCCCCGGCTCCGGTGGTGGCGGCCGCGCTGGCCAGCTTCAAATACA
ACCTGGAGCATGACAATCAGCGCAAGCATCTGCTGGCGATCATCGACCACTTGAAGTCCGGCCTGCGCGACGCCGGCATT
CCGCTGGTTTCGGAGGACAGCCACATTCTGCCGGTGCTGGTCGGCGATCCACACCGCAACAAGCACATCAGCAAACAACT
GCTCGATGAGTACGATATTTACGTGCAGCCGGTGAACGCGCCAACGGTTCCGGCCGGTAGCGAGCGTTTGCGCGTTACGC
CGACCTCTGCCCATACTCATGAGGACGTGGAATATTTCCTGGCGGCGTTAAGCAAAGTCTGGGCTGCCAATCAGTTACGG
AGAGCAGGATGA

Upstream 100 bases:

>100_bases
GCATACCCGGCAATTAAACCATGCGCTGGTGACAATGTGTGTCGGTGTCGGCCAGGGTGTTTCATTGGTCATTAAAGCCC
TCTAATGCAAGGAATTCCGT

Downstream 100 bases:

>100_bases
AGTTGACGGACTATAACGGCCATTTTCTTACGCTGTGCCTGATGGCGACCGGCACCTTTGCCATCGGGACCGACGCGTTT
ATTGTCGCCGGTATCCTCGA

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSVLNILEEKLAETKRQGRFREFLNLERSVLDKPWATSHGQNGERRLNVWCSNDYLAMSHHPKVILATTEAVNRVGLGTC
GARSISGTSVYHSELETLLASAYGKESALLFTTGFGANDATLSTLCDAIPDLIVFSDELNHASMIYGIRYSKAEKKIFRH
NDVAHLAELLQAADPHRPKLIAFESLYSMDGDFAPLAQIVELAEKYQALTYLDEIHSAGVYGHRGLGYAEQLGLLDKITI
IQGGFGKSYGAAGGYIAAPRVVVEAVRSWSPAFVFSTSSPAPVVAAALASFKYNLEHDNQRKHLLAIIDHLKSGLRDAGI
PLVSEDSHILPVLVGDPHRNKHISKQLLDEYDIYVQPVNAPTVPAGSERLRVTPTSAHTHEDVEYFLAALSKVWAANQLR
RAG

Sequences:

>Translated_403_residues
MSVLNILEEKLAETKRQGRFREFLNLERSVLDKPWATSHGQNGERRLNVWCSNDYLAMSHHPKVILATTEAVNRVGLGTC
GARSISGTSVYHSELETLLASAYGKESALLFTTGFGANDATLSTLCDAIPDLIVFSDELNHASMIYGIRYSKAEKKIFRH
NDVAHLAELLQAADPHRPKLIAFESLYSMDGDFAPLAQIVELAEKYQALTYLDEIHSAGVYGHRGLGYAEQLGLLDKITI
IQGGFGKSYGAAGGYIAAPRVVVEAVRSWSPAFVFSTSSPAPVVAAALASFKYNLEHDNQRKHLLAIIDHLKSGLRDAGI
PLVSEDSHILPVLVGDPHRNKHISKQLLDEYDIYVQPVNAPTVPAGSERLRVTPTSAHTHEDVEYFLAALSKVWAANQLR
RAG
>Mature_402_residues
SVLNILEEKLAETKRQGRFREFLNLERSVLDKPWATSHGQNGERRLNVWCSNDYLAMSHHPKVILATTEAVNRVGLGTCG
ARSISGTSVYHSELETLLASAYGKESALLFTTGFGANDATLSTLCDAIPDLIVFSDELNHASMIYGIRYSKAEKKIFRHN
DVAHLAELLQAADPHRPKLIAFESLYSMDGDFAPLAQIVELAEKYQALTYLDEIHSAGVYGHRGLGYAEQLGLLDKITII
QGGFGKSYGAAGGYIAAPRVVVEAVRSWSPAFVFSTSSPAPVVAAALASFKYNLEHDNQRKHLLAIIDHLKSGLRDAGIP
LVSEDSHILPVLVGDPHRNKHISKQLLDEYDIYVQPVNAPTVPAGSERLRVTPTSAHTHEDVEYFLAALSKVWAANQLRR
AG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977444, Length=396, Percent_Identity=42.6767676767677, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI83977440, Length=396, Percent_Identity=42.6767676767677, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI83977442, Length=396, Percent_Identity=42.6767676767677, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI4502025, Length=393, Percent_Identity=42.4936386768448, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI40316939, Length=393, Percent_Identity=42.4936386768448, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI7657118, Length=345, Percent_Identity=36.231884057971, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=36.231884057971, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4758668, Length=393, Percent_Identity=30.0254452926209, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI119220554, Length=342, Percent_Identity=32.7485380116959, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI5454084, Length=255, Percent_Identity=30.9803921568627, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1790046, Length=390, Percent_Identity=34.1025641025641, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1786993, Length=342, Percent_Identity=34.7953216374269, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71994529, Length=390, Percent_Identity=32.8205128205128, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17560912, Length=341, Percent_Identity=33.1378299120235, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17560914, Length=341, Percent_Identity=33.1378299120235, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32566772, Length=385, Percent_Identity=27.7922077922078, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71982617, Length=262, Percent_Identity=28.2442748091603, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=262, Percent_Identity=28.2442748091603, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=39.8104265402844, Blast_Score=323, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6320267, Length=344, Percent_Identity=32.5581395348837, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6323954, Length=258, Percent_Identity=28.2945736434109, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137420, Length=398, Percent_Identity=42.2110552763819, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=33.6760925449871, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI17136286, Length=386, Percent_Identity=30.0518134715026, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653280, Length=267, Percent_Identity=28.8389513108614, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653276, Length=267, Percent_Identity=28.8389513108614, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653278, Length=267, Percent_Identity=28.8389513108614, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44210; Mature: 44078

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLNILEEKLAETKRQGRFREFLNLERSVLDKPWATSHGQNGERRLNVWCSNDYLAMSH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEECC
HPKVILATTEAVNRVGLGTCGARSISGTSVYHSELETLLASAYGKESALLFTTGFGANDA
CCEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCH
TLSTLCDAIPDLIVFSDELNHASMIYGIRYSKAEKKIFRHNDVAHLAELLQAADPHRPKL
HHHHHHHHHHHHEEECCCCCCCEEEEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCE
IAFESLYSMDGDFAPLAQIVELAEKYQALTYLDEIHSAGVYGHRGLGYAEQLGLLDKITI
EEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHEEEE
IQGGFGKSYGAAGGYIAAPRVVVEAVRSWSPAFVFSTSSPAPVVAAALASFKYNLEHDNQ
EECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHEECCCCCCC
RKHLLAIIDHLKSGLRDAGIPLVSEDSHILPVLVGDPHRNKHISKQLLDEYDIYVQPVNA
HHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEECCC
PTVPAGSERLRVTPTSAHTHEDVEYFLAALSKVWAANQLRRAG
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVLNILEEKLAETKRQGRFREFLNLERSVLDKPWATSHGQNGERRLNVWCSNDYLAMSH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEECC
HPKVILATTEAVNRVGLGTCGARSISGTSVYHSELETLLASAYGKESALLFTTGFGANDA
CCEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCH
TLSTLCDAIPDLIVFSDELNHASMIYGIRYSKAEKKIFRHNDVAHLAELLQAADPHRPKL
HHHHHHHHHHHHEEECCCCCCCEEEEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCE
IAFESLYSMDGDFAPLAQIVELAEKYQALTYLDEIHSAGVYGHRGLGYAEQLGLLDKITI
EEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHEEEE
IQGGFGKSYGAAGGYIAAPRVVVEAVRSWSPAFVFSTSSPAPVVAAALASFKYNLEHDNQ
EECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHEECCCCCCC
RKHLLAIIDHLKSGLRDAGIPLVSEDSHILPVLVGDPHRNKHISKQLLDEYDIYVQPVNA
HHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEECCC
PTVPAGSERLRVTPTSAHTHEDVEYFLAALSKVWAANQLRRAG
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]