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The map label for this gene is dld [H]

Identifier: 157369607

GI number: 157369607

Start: 1492785

End: 1494485

Strand: Reverse

Name: dld [H]

Synonym: Spro_1364

Alternate gene names: 157369607

Gene position: 1494485-1492785 (Counterclockwise)

Preceding gene: 157369608

Following gene: 157369605

Centisome position: 27.43

GC content: 58.08

Gene sequence:

>1701_bases
ATGACGCAGTCCAACCAGGCATTCCTCAATCAGTTGAAAAGCATCGTCGGCGGCCCACAGTTGCTGACCGGCGAACGCAG
CACCGAACGCTACCGCAAAGGCTTCCGCTCCGGCGTTGGCCAGGCACTGGCGGTGGTGTTTCCGACCAGCCTGTTGCAGC
TCTGGCAACTGCTGGAGGCCTGCGTCGCTGCTGACAAAATTGTCATCATGCAGGCGGCCAACACCGGCCTGACCGAAGGC
TCAACCCCCAGCGGCAACGACTATGACCGCGATGTCGTCATTATCAGCACCCTGCGACTCAACCACGTGCAGGTGCTGGA
TAACGGTAAACAGGTGGTCGGTTTCCCCGGCAGCACCCTCAATCAGCTGGAAAAATTGCTCAAACCTTATGGCCGCGAGC
CGCATTCGGTAATCGGTTCCTCCTGTATCGGTGCGTCGGTGATCGGTGGCGTGTGTAATAACTCCGGCGGTTCGCTGGTC
AAGCGCGGCCCGGCCTACACCGAGATGGCACTGTACGCCCAGTTGGGGGAAGACGGCCAACTGCGGCTGGTAAACCATTT
GGGGATTAACCTCGGCGATACACCGGAGGAAATCCTCACTCGCTTAGAGAAAGGCGATTACCGGCCGGAGGATGTCGAGC
ACGGCGAACTGCGTGCTTCCGATAACGAATATGCCAGCCGGGTGCGCGACGTCGATGCCGATACGCCTTCCCGGTTTAAT
GCCGACAAGCGCCGCCTGTACGAGGCCTCCGGCTGTGCCGGCAAGCTGGCGGTGTTTGCGGTACGGTTGGACACCTTCGA
GAAAGAAGGCAAGGAACAGGTATTTTATATCGGTACCAACGATACCGCCGTGTTGACCGAACTGCGCCGCCATATGCTGA
GCCAGTTCGACAACCTGCCGGTGGCCGGTGAGTATATGCACCGGGATATTTTTGATATTGCCGAAGTGTACGGCAAAGAT
ACCTTTATGATGATCGACAAGCTCGGCACCGACCAGATGCCAAGCTTCTTCACCCTGAAAGGCCGTATGGATGCCAGCCT
TAACAAGCTGCCATTACTGCCGCACAACCTGACCGACCGGCTGATGCAAGGCCTGAGCCATCTGGCCCCCAGCCACCTGC
CGAAACGGATGAAAGACTACCGCGAACGCTTTGAACATCACCTGCTGCTGAAAATGGCCGGTCCGGGCGTTGAAGAAGCG
CAGCAGTACCTGAAACAGTACTTTGCCCAGGCCAACGGCGAGTTTTTCACCTGCACCCCGGACGAGGGCAAGAAAGCCTT
CCTGCACCGCTTTGCCGCCGCCGGTGCCGCCGTGCGTTACCATGCGGTGCATGCCGACAAGGTAGAAGATATTCTGGCGT
TGGATATCGCGTTGCGCCGTAACGACACCGACTGGTTCGAAACCCTGCCGCCAGAAATCGACAGCCAACTGGTGCACAAG
CTGTATTACGGCCACTTTATGTGCCACGTATTCCATCAGGATTATGTGGTGAAAAAAGGCGTCGACAGCCACGCATTGAA
AGAGAAAATGCTGGCGATCCTCGACCAGCGCGGCGCGGAGTACCCGGCGGAACATAACGTCGGCCACCTGTACCCGGCCA
AGCCCGATCTGCAGGCGTTCTACCGCAGCGCCGACCCGACCAACAGCTTTAATCCGGGCCTAGGTAAAACCAGCAAGCGG
AAAAACTGGGCCGACAATTAA

Upstream 100 bases:

>100_bases
CATCCCCAGGCGCTTACTCGAGTAAGTAACTGGGGTGAGCGAGTGCAGATAACAACGCTGCAGCTTGAAAGATGACGGGT
ATATTCGAAGGGAGATCGGC

Downstream 100 bases:

>100_bases
TTTCGTCAGGCCTAAAAAGCAAAAGCCCCCCACGCCAGAGCGGCGTGAGGGGCAATATCAAAACAGAGTTTAGAATAACC
AGGAACCATACCCCCACAGC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MTQSNQAFLNQLKSIVGGPQLLTGERSTERYRKGFRSGVGQALAVVFPTSLLQLWQLLEACVAADKIVIMQAANTGLTEG
STPSGNDYDRDVVIISTLRLNHVQVLDNGKQVVGFPGSTLNQLEKLLKPYGREPHSVIGSSCIGASVIGGVCNNSGGSLV
KRGPAYTEMALYAQLGEDGQLRLVNHLGINLGDTPEEILTRLEKGDYRPEDVEHGELRASDNEYASRVRDVDADTPSRFN
ADKRRLYEASGCAGKLAVFAVRLDTFEKEGKEQVFYIGTNDTAVLTELRRHMLSQFDNLPVAGEYMHRDIFDIAEVYGKD
TFMMIDKLGTDQMPSFFTLKGRMDASLNKLPLLPHNLTDRLMQGLSHLAPSHLPKRMKDYRERFEHHLLLKMAGPGVEEA
QQYLKQYFAQANGEFFTCTPDEGKKAFLHRFAAAGAAVRYHAVHADKVEDILALDIALRRNDTDWFETLPPEIDSQLVHK
LYYGHFMCHVFHQDYVVKKGVDSHALKEKMLAILDQRGAEYPAEHNVGHLYPAKPDLQAFYRSADPTNSFNPGLGKTSKR
KNWADN

Sequences:

>Translated_566_residues
MTQSNQAFLNQLKSIVGGPQLLTGERSTERYRKGFRSGVGQALAVVFPTSLLQLWQLLEACVAADKIVIMQAANTGLTEG
STPSGNDYDRDVVIISTLRLNHVQVLDNGKQVVGFPGSTLNQLEKLLKPYGREPHSVIGSSCIGASVIGGVCNNSGGSLV
KRGPAYTEMALYAQLGEDGQLRLVNHLGINLGDTPEEILTRLEKGDYRPEDVEHGELRASDNEYASRVRDVDADTPSRFN
ADKRRLYEASGCAGKLAVFAVRLDTFEKEGKEQVFYIGTNDTAVLTELRRHMLSQFDNLPVAGEYMHRDIFDIAEVYGKD
TFMMIDKLGTDQMPSFFTLKGRMDASLNKLPLLPHNLTDRLMQGLSHLAPSHLPKRMKDYRERFEHHLLLKMAGPGVEEA
QQYLKQYFAQANGEFFTCTPDEGKKAFLHRFAAAGAAVRYHAVHADKVEDILALDIALRRNDTDWFETLPPEIDSQLVHK
LYYGHFMCHVFHQDYVVKKGVDSHALKEKMLAILDQRGAEYPAEHNVGHLYPAKPDLQAFYRSADPTNSFNPGLGKTSKR
KNWADN
>Mature_565_residues
TQSNQAFLNQLKSIVGGPQLLTGERSTERYRKGFRSGVGQALAVVFPTSLLQLWQLLEACVAADKIVIMQAANTGLTEGS
TPSGNDYDRDVVIISTLRLNHVQVLDNGKQVVGFPGSTLNQLEKLLKPYGREPHSVIGSSCIGASVIGGVCNNSGGSLVK
RGPAYTEMALYAQLGEDGQLRLVNHLGINLGDTPEEILTRLEKGDYRPEDVEHGELRASDNEYASRVRDVDADTPSRFNA
DKRRLYEASGCAGKLAVFAVRLDTFEKEGKEQVFYIGTNDTAVLTELRRHMLSQFDNLPVAGEYMHRDIFDIAEVYGKDT
FMMIDKLGTDQMPSFFTLKGRMDASLNKLPLLPHNLTDRLMQGLSHLAPSHLPKRMKDYRERFEHHLLLKMAGPGVEEAQ
QYLKQYFAQANGEFFTCTPDEGKKAFLHRFAAAGAAVRYHAVHADKVEDILALDIALRRNDTDWFETLPPEIDSQLVHKL
YYGHFMCHVFHQDYVVKKGVDSHALKEKMLAILDQRGAEYPAEHNVGHLYPAKPDLQAFYRSADPTNSFNPGLGKTSKRK
NWADN

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=564, Percent_Identity=71.6312056737589, Blast_Score=855, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 63215; Mature: 63084

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSNQAFLNQLKSIVGGPQLLTGERSTERYRKGFRSGVGQALAVVFPTSLLQLWQLLEA
CCCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVAADKIVIMQAANTGLTEGSTPSGNDYDRDVVIISTLRLNHVQVLDNGKQVVGFPGSTL
HHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCCEEEECCCHHH
NQLEKLLKPYGREPHSVIGSSCIGASVIGGVCNNSGGSLVKRGPAYTEMALYAQLGEDGQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHCCCCCC
LRLVNHLGINLGDTPEEILTRLEKGDYRPEDVEHGELRASDNEYASRVRDVDADTPSRFN
EEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
ADKRRLYEASGCAGKLAVFAVRLDTFEKEGKEQVFYIGTNDTAVLTELRRHMLSQFDNLP
HHHHHHHHHCCCCCCHHHEEEHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCC
VAGEYMHRDIFDIAEVYGKDTFMMIDKLGTDQMPSFFTLKGRMDASLNKLPLLPHNLTDR
CCHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHH
LMQGLSHLAPSHLPKRMKDYRERFEHHLLLKMAGPGVEEAQQYLKQYFAQANGEFFTCTP
HHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCEEEECC
DEGKKAFLHRFAAAGAAVRYHAVHADKVEDILALDIALRRNDTDWFETLPPEIDSQLVHK
CCHHHHHHHHHHHHCHHHEEEEHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHH
LYYGHFMCHVFHQDYVVKKGVDSHALKEKMLAILDQRGAEYPAEHNVGHLYPAKPDLQAF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
YRSADPTNSFNPGLGKTSKRKNWADN
HHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQSNQAFLNQLKSIVGGPQLLTGERSTERYRKGFRSGVGQALAVVFPTSLLQLWQLLEA
CCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVAADKIVIMQAANTGLTEGSTPSGNDYDRDVVIISTLRLNHVQVLDNGKQVVGFPGSTL
HHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCCEEEECCCHHH
NQLEKLLKPYGREPHSVIGSSCIGASVIGGVCNNSGGSLVKRGPAYTEMALYAQLGEDGQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHCCCCCC
LRLVNHLGINLGDTPEEILTRLEKGDYRPEDVEHGELRASDNEYASRVRDVDADTPSRFN
EEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
ADKRRLYEASGCAGKLAVFAVRLDTFEKEGKEQVFYIGTNDTAVLTELRRHMLSQFDNLP
HHHHHHHHHCCCCCCHHHEEEHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCC
VAGEYMHRDIFDIAEVYGKDTFMMIDKLGTDQMPSFFTLKGRMDASLNKLPLLPHNLTDR
CCHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHH
LMQGLSHLAPSHLPKRMKDYRERFEHHLLLKMAGPGVEEAQQYLKQYFAQANGEFFTCTP
HHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCEEEECC
DEGKKAFLHRFAAAGAAVRYHAVHADKVEDILALDIALRRNDTDWFETLPPEIDSQLVHK
CCHHHHHHHHHHHHCHHHEEEEHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHH
LYYGHFMCHVFHQDYVVKKGVDSHALKEKMLAILDQRGAEYPAEHNVGHLYPAKPDLQAF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
YRSADPTNSFNPGLGKTSKRKNWADN
HHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]