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The map label for this gene is emrY [H]

Identifier: 157369576

GI number: 157369576

Start: 1463735

End: 1465342

Strand: Reverse

Name: emrY [H]

Synonym: Spro_1333

Alternate gene names: 157369576

Gene position: 1465342-1463735 (Counterclockwise)

Preceding gene: 157369581

Following gene: 157369575

Centisome position: 26.89

GC content: 58.02

Gene sequence:

>1608_bases
ATGAATGCTCAGCCTGCGCCTGCCGTCGCTGCGCCGCATCCTTTTACCCTGCGTCTGGCTGTGGGGTTGGTGGGTGTGCT
GATTGCCGCCCTGACCTCAGGACTCAATGATCGCATCAGCGATTTGGCGCTGGCGGATATCCGCGCGGCTATCGGTATCG
GTTTCGACCAGGGGAGCTGGATCACCTCGGCCTATCAGGCCGCGGAAGTGTCGGCCATGATGGTGGCCCCCTGGTTTGCC
GTGACCTTTTCGCTACGCCGTTTCGCCCTGGTGATGATCGGCGGTTTTGCCGCCGTCGGCGTACTCCAGCCGTTAACTGC
TGATCCCACGCTGTTTATTGCTCTGCGGGTGGTGCAAGGCCTGTTTGGCGGGGCATTGCCGCCGTTGCTGATGACGGTGG
CGCTGCGTTTTCTGCCCCCGACCATCAAACTTTACGGGCTGGCCGCCTATGCGCTCACCGCCACCTTTGGCCCCAATGTC
GCGGCACCGCTGGCGGCGCTGTGGACCGACAGTCTGGGTTGGCAGTTTGTCTTTTGGCAGGCGATCCCGCTGTGTCTGAT
AGCCTCCTTACTGATCGGCTGGGGGTTGCCGCAGGATCCCTTGCGGCTGGAGCGTTTCCGCCAGATTGATCTGTTCGGCA
TGCTGACCGGTTGTAGCGGTATTGCGCTGTTGATTCTCTCGCTGACTCAGGGTGAGCGGCTAGACTGGTTCAATTCACCC
TTAATTAGCCTGATGCTGCCGGTTTCCATTGCGTTGTTGGTGACGTTTTTAATCAACGAATGGTTCCATCCGTTGCCGCT
GTTAAAACTGCAATTACTGCGGCGCATCAATCTTTCTTATAGCCTGCTGACGCTGGCTGGCGTGCTGTTGCTGGCGTTGT
CAGGCTCAATGCTGCCGTCGTTTTACTTTTCGCAGGTGGAGGGTTTTCGCACCGTACAATTTGCGCCGCTGGCGTTAGCC
GTCGGCCTGCCGCAGTTGGTGATAGCCCCTTTAATCGCCGCCCTGTTGAACCTGCGCTGGATAGACGCCCGTTGGGTGCT
GACTATCGGTGCCGCGCTAATCGCCGTCTCCTGCCTGCTGGGAATGCAATTGACCGACGATTGGGCACGAGAAAACTTCT
GGCTGATCCAAGGCCTGCAGGCATTTGGCCAGCCGATGATGATTTTACCGGTGTTAATGACCTCTACCAGCGTGATCCTG
CCACCGGAAGGGCCTTTTGCCTCGGCCATGTTTAACACCGTGCGCGGTTTTTCCGCCGTGGCGGCGGGCAGCCTGGTCGA
GAATTTTATTAGCTACCGAGAGCAATTTCACTCTCATGTGCTGGTTGACCGCCTGGGCAATCGCCCGTGGCTGATGACGG
CAGAGAGCTCAGAACACGCCAGCGGGGCTATGCCGCTGTTACCGGACGGCTCGGTCAGTTCAGCGGAAAATCTCGGGCAT
TTTTCGACGTTGGTAAAGCATCAGGCGGTGATCCTCAGTATCAGTGACGCCTACCTGCTGATTATTGGCTGTGCGCTGCT
TTTGGTGTTGCTGACCGCCTGGTTGCCGAAGCGTGTCTATCCGCCGCAAACGCTCTTACCTCTAGTTCCAAAAACATCAG
GATCATAA

Upstream 100 bases:

>100_bases
ATGTACCACATTGCAATACAGTGCATCACAATGTAGCATGCGTCACAATGTATCGCTATGCAATACAGTGCATCGTAAGT
TTCGTTTCTGGAGTCATACT

Downstream 100 bases:

>100_bases
CCATGAGCTTCACCCCTGCAAAACGAACCTTAACCCTGGCGTTGCTGCTGTTAATCCTGCTGGCGATTGCTTTTTTTGTC
CGCTCATCGCTCAATCGCCA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MNAQPAPAVAAPHPFTLRLAVGLVGVLIAALTSGLNDRISDLALADIRAAIGIGFDQGSWITSAYQAAEVSAMMVAPWFA
VTFSLRRFALVMIGGFAAVGVLQPLTADPTLFIALRVVQGLFGGALPPLLMTVALRFLPPTIKLYGLAAYALTATFGPNV
AAPLAALWTDSLGWQFVFWQAIPLCLIASLLIGWGLPQDPLRLERFRQIDLFGMLTGCSGIALLILSLTQGERLDWFNSP
LISLMLPVSIALLVTFLINEWFHPLPLLKLQLLRRINLSYSLLTLAGVLLLALSGSMLPSFYFSQVEGFRTVQFAPLALA
VGLPQLVIAPLIAALLNLRWIDARWVLTIGAALIAVSCLLGMQLTDDWARENFWLIQGLQAFGQPMMILPVLMTSTSVIL
PPEGPFASAMFNTVRGFSAVAAGSLVENFISYREQFHSHVLVDRLGNRPWLMTAESSEHASGAMPLLPDGSVSSAENLGH
FSTLVKHQAVILSISDAYLLIIGCALLLVLLTAWLPKRVYPPQTLLPLVPKTSGS

Sequences:

>Translated_535_residues
MNAQPAPAVAAPHPFTLRLAVGLVGVLIAALTSGLNDRISDLALADIRAAIGIGFDQGSWITSAYQAAEVSAMMVAPWFA
VTFSLRRFALVMIGGFAAVGVLQPLTADPTLFIALRVVQGLFGGALPPLLMTVALRFLPPTIKLYGLAAYALTATFGPNV
AAPLAALWTDSLGWQFVFWQAIPLCLIASLLIGWGLPQDPLRLERFRQIDLFGMLTGCSGIALLILSLTQGERLDWFNSP
LISLMLPVSIALLVTFLINEWFHPLPLLKLQLLRRINLSYSLLTLAGVLLLALSGSMLPSFYFSQVEGFRTVQFAPLALA
VGLPQLVIAPLIAALLNLRWIDARWVLTIGAALIAVSCLLGMQLTDDWARENFWLIQGLQAFGQPMMILPVLMTSTSVIL
PPEGPFASAMFNTVRGFSAVAAGSLVENFISYREQFHSHVLVDRLGNRPWLMTAESSEHASGAMPLLPDGSVSSAENLGH
FSTLVKHQAVILSISDAYLLIIGCALLLVLLTAWLPKRVYPPQTLLPLVPKTSGS
>Mature_535_residues
MNAQPAPAVAAPHPFTLRLAVGLVGVLIAALTSGLNDRISDLALADIRAAIGIGFDQGSWITSAYQAAEVSAMMVAPWFA
VTFSLRRFALVMIGGFAAVGVLQPLTADPTLFIALRVVQGLFGGALPPLLMTVALRFLPPTIKLYGLAAYALTATFGPNV
AAPLAALWTDSLGWQFVFWQAIPLCLIASLLIGWGLPQDPLRLERFRQIDLFGMLTGCSGIALLILSLTQGERLDWFNSP
LISLMLPVSIALLVTFLINEWFHPLPLLKLQLLRRINLSYSLLTLAGVLLLALSGSMLPSFYFSQVEGFRTVQFAPLALA
VGLPQLVIAPLIAALLNLRWIDARWVLTIGAALIAVSCLLGMQLTDDWARENFWLIQGLQAFGQPMMILPVLMTSTSVIL
PPEGPFASAMFNTVRGFSAVAAGSLVENFISYREQFHSHVLVDRLGNRPWLMTAESSEHASGAMPLLPDGSVSSAENLGH
FSTLVKHQAVILSISDAYLLIIGCALLLVLLTAWLPKRVYPPQTLLPLVPKTSGS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=424, Percent_Identity=26.8867924528302, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1789042, Length=510, Percent_Identity=22.9411764705882, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 57692; Mature: 57692

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQPAPAVAAPHPFTLRLAVGLVGVLIAALTSGLNDRISDLALADIRAAIGIGFDQGSW
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCH
ITSAYQAAEVSAMMVAPWFAVTFSLRRFALVMIGGFAAVGVLQPLTADPTLFIALRVVQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LFGGALPPLLMTVALRFLPPTIKLYGLAAYALTATFGPNVAAPLAALWTDSLGWQFVFWQ
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHH
AIPLCLIASLLIGWGLPQDPLRLERFRQIDLFGMLTGCSGIALLILSLTQGERLDWFNSP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCH
LISLMLPVSIALLVTFLINEWFHPLPLLKLQLLRRINLSYSLLTLAGVLLLALSGSMLPS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHH
FYFSQVEGFRTVQFAPLALAVGLPQLVIAPLIAALLNLRWIDARWVLTIGAALIAVSCLL
HHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GMQLTDDWARENFWLIQGLQAFGQPMMILPVLMTSTSVILPPEGPFASAMFNTVRGFSAV
CCHHCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHH
AAGSLVENFISYREQFHSHVLVDRLGNRPWLMTAESSEHASGAMPLLPDGSVSSAENLGH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHH
FSTLVKHQAVILSISDAYLLIIGCALLLVLLTAWLPKRVYPPQTLLPLVPKTSGS
HHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MNAQPAPAVAAPHPFTLRLAVGLVGVLIAALTSGLNDRISDLALADIRAAIGIGFDQGSW
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCH
ITSAYQAAEVSAMMVAPWFAVTFSLRRFALVMIGGFAAVGVLQPLTADPTLFIALRVVQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LFGGALPPLLMTVALRFLPPTIKLYGLAAYALTATFGPNVAAPLAALWTDSLGWQFVFWQ
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHH
AIPLCLIASLLIGWGLPQDPLRLERFRQIDLFGMLTGCSGIALLILSLTQGERLDWFNSP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCH
LISLMLPVSIALLVTFLINEWFHPLPLLKLQLLRRINLSYSLLTLAGVLLLALSGSMLPS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHH
FYFSQVEGFRTVQFAPLALAVGLPQLVIAPLIAALLNLRWIDARWVLTIGAALIAVSCLL
HHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GMQLTDDWARENFWLIQGLQAFGQPMMILPVLMTSTSVILPPEGPFASAMFNTVRGFSAV
CCHHCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHH
AAGSLVENFISYREQFHSHVLVDRLGNRPWLMTAESSEHASGAMPLLPDGSVSSAENLGH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHH
FSTLVKHQAVILSISDAYLLIIGCALLLVLLTAWLPKRVYPPQTLLPLVPKTSGS
HHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]