Click here to switch to the map view.

The map label for this gene is nat [H]

Identifier: 157369581

GI number: 157369581

Start: 1468841

End: 1469602

Strand: Reverse

Name: nat [H]

Synonym: Spro_1338

Alternate gene names: 157369581

Gene position: 1469602-1468841 (Counterclockwise)

Preceding gene: 157369582

Following gene: 157369576

Centisome position: 26.97

GC content: 55.51

Gene sequence:

>762_bases
GTGGACAGACAACGCTACCTGCAACATATTGGATTCGCAGGCATCCCCAAGCCCGACCTCCTGACGCTGCAACAGTTACA
CCGCTGCCATATGCTGAGCGTACCCTTTGAGAACCTGAGCATTATTTATCGCCAGGGGATTCATCTGGAGGAACCGGCGC
TGTTCAATAAAATTGTCGAACGCAACCGCGGCGGCTTTTGCTATGAGCTGAACCGGCTGTTTGCCGCGCTGTTGAAGGAC
ATCGGCTTTAACGTGCAGTTTATTTCCGGCGAGATCCGCGCACGCGACGGCAGCTTCGGCGCGCCCTTCGACCATATGGC
ACTGATGGTGGAGCTGGATCAGCCGTATCTGGTGGACGTGGGGTTTGGTGATTCGTTCCTGACGCCGCTGAAGATCACCA
CCACCGAGCAGCAACCGCAGACCAGCGGCACCTTCCATTTAGAGCAGGAAGGCGAGACCTATTACCTGGAACGCAGAAAC
GGCGATAATCGCTCGCATGCCAAAACCCTGTACCGCTTTACCCTGCAAGCCCGTGAGCCGAGTGAGTTCGACGGCATGTG
CCACTACCACAGTACCTCGCCGCAGTCGCATTTTACCCAGCGGCTGGTGTGTTCGCGGCCAACGGAAAATGGTCGGGTGA
CTATCAGCGAGAACAAACTGATTATCACCGAAGATCACCAACGCCATGAATCGACGCTGCATTCCGAAGACGAACGGCGT
GCTGCGCTGATGCGGTATTTTGGTATTGATCTGGAAAAATGA

Upstream 100 bases:

>100_bases
GGCAGACCAACCCCCAGCGTTCTGACGCAGCACGTATTGCGCCCACAGCAGTGAAAAATCCAACTATTTTATAATCAATT
TTTTTGCTGCGAGACACACC

Downstream 100 bases:

>100_bases
AACTCTCAGGTTGGCTAGCGTTTATCCCGATGGAGGCAGCCAACCCAGAGGGGCATGAGGAAACAAGATTAATCTAACCC
ACCCCAGGTGGGTTTATTAT

Product: N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MDRQRYLQHIGFAGIPKPDLLTLQQLHRCHMLSVPFENLSIIYRQGIHLEEPALFNKIVERNRGGFCYELNRLFAALLKD
IGFNVQFISGEIRARDGSFGAPFDHMALMVELDQPYLVDVGFGDSFLTPLKITTTEQQPQTSGTFHLEQEGETYYLERRN
GDNRSHAKTLYRFTLQAREPSEFDGMCHYHSTSPQSHFTQRLVCSRPTENGRVTISENKLIITEDHQRHESTLHSEDERR
AALMRYFGIDLEK

Sequences:

>Translated_253_residues
MDRQRYLQHIGFAGIPKPDLLTLQQLHRCHMLSVPFENLSIIYRQGIHLEEPALFNKIVERNRGGFCYELNRLFAALLKD
IGFNVQFISGEIRARDGSFGAPFDHMALMVELDQPYLVDVGFGDSFLTPLKITTTEQQPQTSGTFHLEQEGETYYLERRN
GDNRSHAKTLYRFTLQAREPSEFDGMCHYHSTSPQSHFTQRLVCSRPTENGRVTISENKLIITEDHQRHESTLHSEDERR
AALMRYFGIDLEK
>Mature_253_residues
MDRQRYLQHIGFAGIPKPDLLTLQQLHRCHMLSVPFENLSIIYRQGIHLEEPALFNKIVERNRGGFCYELNRLFAALLKD
IGFNVQFISGEIRARDGSFGAPFDHMALMVELDQPYLVDVGFGDSFLTPLKITTTEQQPQTSGTFHLEQEGETYYLERRN
GDNRSHAKTLYRFTLQAREPSEFDGMCHYHSTSPQSHFTQRLVCSRPTENGRVTISENKLIITEDHQRHESTLHSEDERR
AALMRYFGIDLEK

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI237649126, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI237649124, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI237649122, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI237649119, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI42741671, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI237649009, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI237649132, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI237649130, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI116295260, Length=231, Percent_Identity=32.034632034632, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1787736, Length=257, Percent_Identity=28.0155642023346, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 29335; Mature: 29335

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRQRYLQHIGFAGIPKPDLLTLQQLHRCHMLSVPFENLSIIYRQGIHLEEPALFNKIVE
CCHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCHHHHHHHHHCCCCCCCHHHHHHHHH
RNRGGFCYELNRLFAALLKDIGFNVQFISGEIRARDGSFGAPFDHMALMVELDQPYLVDV
CCCCCEEEHHHHHHHHHHHHHCCCEEEEECEEEECCCCCCCCHHHEEEEEECCCCEEEEE
GFGDSFLTPLKITTTEQQPQTSGTFHLEQEGETYYLERRNGDNRSHAKTLYRFTLQAREP
CCCCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHEEEEECCCC
SEFDGMCHYHSTSPQSHFTQRLVCSRPTENGRVTISENKLIITEDHQRHESTLHSEDERR
CCCCCEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCHHHHHHHCCCHHHH
AALMRYFGIDLEK
HHHHHHHCCCCCC
>Mature Secondary Structure
MDRQRYLQHIGFAGIPKPDLLTLQQLHRCHMLSVPFENLSIIYRQGIHLEEPALFNKIVE
CCHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCHHHHHHHHHCCCCCCCHHHHHHHHH
RNRGGFCYELNRLFAALLKDIGFNVQFISGEIRARDGSFGAPFDHMALMVELDQPYLVDV
CCCCCEEEHHHHHHHHHHHHHCCCEEEEECEEEECCCCCCCCHHHEEEEEECCCCEEEEE
GFGDSFLTPLKITTTEQQPQTSGTFHLEQEGETYYLERRNGDNRSHAKTLYRFTLQAREP
CCCCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHEEEEECCCC
SEFDGMCHYHSTSPQSHFTQRLVCSRPTENGRVTISENKLIITEDHQRHESTLHSEDERR
CCCCCEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCHHHHHHHCCCHHHH
AALMRYFGIDLEK
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]