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The map label for this gene is ydgK [H]

Identifier: 157369433

GI number: 157369433

Start: 1307476

End: 1308666

Strand: Reverse

Name: ydgK [H]

Synonym: Spro_1190

Alternate gene names: 157369433

Gene position: 1308666-1307476 (Counterclockwise)

Preceding gene: 157369434

Following gene: 157369431

Centisome position: 24.02

GC content: 60.62

Gene sequence:

>1191_bases
ATGACCAGACAACTTGCCAGACAACGTCTGGTATACGCGCTCGTGCTTGGCCTGCTAGCCTCACTGGGGCCGCTGTGCAT
CGACCTCTACCTGCCCGCCCTGCCGGAAATGGCCGGCGATCTGAACACCTCTACCGCTACGGCGCAGCTCAGCCTGACCG
CCGGCCTGCTCGGTTTGGGCGTCGGCCAGCTGATTTTTGGCCCCTACAGCGACAAGCTCGGCCGTATGCGCCCGCTGTTA
CTGTCGCTGACGCTGCTGCTGGCCGCCTCGCTGTGGTGCGCCCTGGCCCCCAATATCGATCAGTTGCTGATTGCCCGTCT
GTTGCAAGGGCTGGCCGGTGCCGGCGGTGCCGTCATTTCTCGCGCCATCGCCCGTGACCTTTATTCCGGGCACGAACTGA
CGCGTTTCTTTGCCCTGCTGATGTTGGTCAACGGCCTGGCACCGATCATTGCGCCGGTGTTGGGGGGCGCCTTGCTGCAG
TTTATGGACTGGCGCGGGATTTTCGGCGTACTGGCGGCCATTGCCGTGCTGCTGTTCACGCTCGCCAGCCTGAAGTTAGA
TGAGTCATTGCCTGCCGAACGCCGCAGCCAGGGCGGTATTTTTGCCATGTTGCGGTCACTGGGCGGATTGCTGACCCAGC
GTCAGTTTATGGGCCTGTGTCTGACGCAAGGTTTTGTGATGGCCGGGATGTTCGCCTATATCGGCGCCTCGCCTTTCGTG
CTGCAGCAGATTTATGGCCTCAGCCCGCAGATGTTCAGCCTGTGCTTCGCCATCAACGGCGTCGGACTGATTATTTCCGC
GCAGATTGCCAGCCGCCTGAGCATACATTTTGGTGAAAGAAAGGTATTGAAAGGCGGATTGACCCTGGCAGCGGTTTCTT
CGCTGCTGTTACTGTTGGCAGCCAGCCTGCACGCGCCGCTGGCACTGTTGATGGTGCCGCTATTCTTCTCGGTGGCCGTG
ATCGGTATTGTCGGCCCGACGGCATCATCATTGGCGATGCAAAGCCAGGGCGACAAGGCGGGCAGCGCCTCTGCGCTGAT
TGGCGTGAGCATGTTCGCACTCGGTGCCTGTAGCGTGCCCTTGACGGGGCTGGGTGGCACTTCCAGCGTATCAATGGCAC
TGACCATCGTCGGCTGTTACGCCGTCGCCATCACGCTGTTTAAACTGCTGGTACGCAAAGCTCAGGTATAA

Upstream 100 bases:

>100_bases
CCGGTTACCGCATACTGACCACACAAAAAGCCGACGTCAGCCTGCTGAACGGCCTATACCAACAAGCTATCTCTCACCTG
TTCAGGAAACCTTAATCCCT

Downstream 100 bases:

>100_bases
AGCGACGGAAAAAAGGCAATAAAAAACCCGCTCAGTGAGCGGGTTTTAAGAATTTCGGCTGTAGCATTAGATAGCGATAA
CGTTAGCAGCAGATGGGCCT

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTRQLARQRLVYALVLGLLASLGPLCIDLYLPALPEMAGDLNTSTATAQLSLTAGLLGLGVGQLIFGPYSDKLGRMRPLL
LSLTLLLAASLWCALAPNIDQLLIARLLQGLAGAGGAVISRAIARDLYSGHELTRFFALLMLVNGLAPIIAPVLGGALLQ
FMDWRGIFGVLAAIAVLLFTLASLKLDESLPAERRSQGGIFAMLRSLGGLLTQRQFMGLCLTQGFVMAGMFAYIGASPFV
LQQIYGLSPQMFSLCFAINGVGLIISAQIASRLSIHFGERKVLKGGLTLAAVSSLLLLLAASLHAPLALLMVPLFFSVAV
IGIVGPTASSLAMQSQGDKAGSASALIGVSMFALGACSVPLTGLGGTSSVSMALTIVGCYAVAITLFKLLVRKAQV

Sequences:

>Translated_396_residues
MTRQLARQRLVYALVLGLLASLGPLCIDLYLPALPEMAGDLNTSTATAQLSLTAGLLGLGVGQLIFGPYSDKLGRMRPLL
LSLTLLLAASLWCALAPNIDQLLIARLLQGLAGAGGAVISRAIARDLYSGHELTRFFALLMLVNGLAPIIAPVLGGALLQ
FMDWRGIFGVLAAIAVLLFTLASLKLDESLPAERRSQGGIFAMLRSLGGLLTQRQFMGLCLTQGFVMAGMFAYIGASPFV
LQQIYGLSPQMFSLCFAINGVGLIISAQIASRLSIHFGERKVLKGGLTLAAVSSLLLLLAASLHAPLALLMVPLFFSVAV
IGIVGPTASSLAMQSQGDKAGSASALIGVSMFALGACSVPLTGLGGTSSVSMALTIVGCYAVAITLFKLLVRKAQV
>Mature_395_residues
TRQLARQRLVYALVLGLLASLGPLCIDLYLPALPEMAGDLNTSTATAQLSLTAGLLGLGVGQLIFGPYSDKLGRMRPLLL
SLTLLLAASLWCALAPNIDQLLIARLLQGLAGAGGAVISRAIARDLYSGHELTRFFALLMLVNGLAPIIAPVLGGALLQF
MDWRGIFGVLAAIAVLLFTLASLKLDESLPAERRSQGGIFAMLRSLGGLLTQRQFMGLCLTQGFVMAGMFAYIGASPFVL
QQIYGLSPQMFSLCFAINGVGLIISAQIASRLSIHFGERKVLKGGLTLAAVSSLLLLLAASLHAPLALLMVPLFFSVAVI
GIVGPTASSLAMQSQGDKAGSASALIGVSMFALGACSVPLTGLGGTSSVSMALTIVGCYAVAITLFKLLVRKAQV

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=396, Percent_Identity=33.0808080808081, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI48994889, Length=329, Percent_Identity=30.6990881458967, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790146, Length=256, Percent_Identity=27.734375, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082312, Length=340, Percent_Identity=27.0588235294118, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790794, Length=371, Percent_Identity=24.5283018867925, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787065, Length=243, Percent_Identity=27.5720164609054, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790195, Length=163, Percent_Identity=28.8343558282209, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319517, Length=188, Percent_Identity=28.1914893617021, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41202; Mature: 41071

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQLARQRLVYALVLGLLASLGPLCIDLYLPALPEMAGDLNTSTATAQLSLTAGLLGLG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VGQLIFGPYSDKLGRMRPLLLSLTLLLAASLWCALAPNIDQLLIARLLQGLAGAGGAVIS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHH
RAIARDLYSGHELTRFFALLMLVNGLAPIIAPVLGGALLQFMDWRGIFGVLAAIAVLLFT
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASLKLDESLPAERRSQGGIFAMLRSLGGLLTQRQFMGLCLTQGFVMAGMFAYIGASPFV
HHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LQQIYGLSPQMFSLCFAINGVGLIISAQIASRLSIHFGERKVLKGGLTLAAVSSLLLLLA
HHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHH
ASLHAPLALLMVPLFFSVAVIGIVGPTASSLAMQSQGDKAGSASALIGVSMFALGACSVP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
LTGLGGTSSVSMALTIVGCYAVAITLFKLLVRKAQV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRQLARQRLVYALVLGLLASLGPLCIDLYLPALPEMAGDLNTSTATAQLSLTAGLLGLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VGQLIFGPYSDKLGRMRPLLLSLTLLLAASLWCALAPNIDQLLIARLLQGLAGAGGAVIS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHH
RAIARDLYSGHELTRFFALLMLVNGLAPIIAPVLGGALLQFMDWRGIFGVLAAIAVLLFT
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASLKLDESLPAERRSQGGIFAMLRSLGGLLTQRQFMGLCLTQGFVMAGMFAYIGASPFV
HHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LQQIYGLSPQMFSLCFAINGVGLIISAQIASRLSIHFGERKVLKGGLTLAAVSSLLLLLA
HHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHH
ASLHAPLALLMVPLFFSVAVIGIVGPTASSLAMQSQGDKAGSASALIGVSMFALGACSVP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
LTGLGGTSSVSMALTIVGCYAVAITLFKLLVRKAQV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]