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The map label for this gene is ggt [H]

Identifier: 157369300

GI number: 157369300

Start: 1163245

End: 1165008

Strand: Reverse

Name: ggt [H]

Synonym: Spro_1057

Alternate gene names: 157369300

Gene position: 1165008-1163245 (Counterclockwise)

Preceding gene: 157369301

Following gene: 157369299

Centisome position: 21.38

GC content: 59.86

Gene sequence:

>1764_bases
ATGTTTTTACAAAAATGGAGCAAGCCGCTGACCATGGCGGCGCTGCTGGTCAGCAGCAGCCTGTATGCCGCCTCCAATCC
GGCGGTCGAAGCCAAAAACGGCATGGTGGTGACATCGCAACATCTGGCCTCGCAGGTCGGCGTGGATATCCTGAAACTGG
GCGGCAACGCCGTCGATGCGGCCGTCGCCGTGGGTTATGCGCAGGCGGTGGTCAACCCGTGCTGCGGTAATATCGGCGGT
GGCGGCTTTATGACGGTGCACCTGGCCGATGGCACCGACACCTTTATCAACTTCCGCGAAACCGCGCCGGCAGCGGCCAG
CGCCAACATGTATCTGGATGCCGCCGGCAACGTGAAGAAAGGCGCCAGTCTGTACGGCTATCTGGCCGCAGGCGTGCCGG
GCACCGTGCTGGGCATGGAAACCGCGCGCAAAAAATACGGCAAACTGAGCCGCGAGCAGGTCATGGAGCCGGCAATCAAA
CTGGCGCGCGAGGGCTTTGTGCTGACCCGCGCCGATACCGATATCCTTGATACCACCATCGCACGCTTTAAACAGGATGC
GGAATCTGCCCGAATCTTCCTGCGCCCGGACGGCACGCCGTTGCAACCGGGCGATCGCCTGGTGCAGAGCGACCTGGCCA
ATACGCTGGCGGCCATCGCCAAAGAAGGCCCGGACGCCTTCTATAAAGGCAAAATACCCCAGGCGGTAGAGGCGGCAGCC
AAACAGGGCGGCGGCATTCTGACGGCAGCCGATTTCGCCAATTACCAAGTCACCGAAACCCCGCCGATTACCTGCAGCTA
TCGCGGCTATAAGTTTGTTTCGGCTCCCCCGCCAAGCTCTGGCGGCGTGACGCTGTGCGAAATCCTCAACGTGGTTGAAG
GTTACGATCTCAAGAGCATGGGCTTTAATTCGGCGGCGGCCATCCATACCATGACCGAAGCGATGCGCCACGCCTATATG
GACCGTAACACTTACCTCGGCGACCCGGAGTTCATCAAGAACCCGATCGACAGGCTGGTCAGCAAGAGCTATGCCGAAGA
GATCCGCAAGAAAATCGTCGCGGACAAAGCCACGCCGTCAGAGAACGTGCAGCCGGGCATGGAACCCCACGAGAAGCCGG
AAACCACCCACTACTCGATTGTCGATCATCAGGGTAACGCCGTCTCCACCACCTATACCGTCAACGGTCGCTTTGGTGCC
GTGGTGATAGCCCCGGGTACCGGCTTCTTCCTCAACGATGAGATGGACGATTTCACCGTCAAAGTCGGCGAGAAAAATCT
TTATGGGCTGGTGCAGGGAACCGCCAACAGCATAGCCCCCGGTAAGCGCCCACTATCGTCGATGAGCCCGACGCTGGTGA
CCAAGGACAATAAAATCTTTATGGTTCTCGGCTCGCCGGGCGGATCGCGCATCATCACCATCACTCTGCAAACCGCCTTA
AACGTGATCGACCACGGTATGGCGCCGCAGGAGGCCGTAGATGCACCGCGTATCCACCATCAGTGGTTACCGGATGAGGT
TTACTACGAACAGCGCGGAGTTTCTGCCGATACGCTGAAAATTCTCGGCGGCATGGGTTACAAGATGGTTGAGCAAACGC
CATGGGGCGCCGCCGAACTGATTCTGGTCGGCCTGCCAGGCGCCGCAGGCGTCAGCCCGGCCAACTCCGGCAATGACTCC
GCAGTTTCCGGCAGAGTGCGCGAAGGCTACCTGTACGGCGCCAATGACGTTCGTCGCCCGGCCGGATCTGCCGTAGGTTA
TTGA

Upstream 100 bases:

>100_bases
TCCCTTAACTCTGGCTAGTATCAATAACGCTGGCCCGCTCTTTGCACGTCAGGAGGGGCAAGCCAAACACAATAAGAAAA
CTGACAGGGTAGGAATAACT

Downstream 100 bases:

>100_bases
TGATCCCTGCGTTGGCTCGGTATTGCGTGCCAGCGTTAGGCTATACTCCTCCCACTCTGTCTGTGACAGACCACGGTCGG
CACCCGCCGGCCGTTTCTTT

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MFLQKWSKPLTMAALLVSSSLYAASNPAVEAKNGMVVTSQHLASQVGVDILKLGGNAVDAAVAVGYAQAVVNPCCGNIGG
GGFMTVHLADGTDTFINFRETAPAAASANMYLDAAGNVKKGASLYGYLAAGVPGTVLGMETARKKYGKLSREQVMEPAIK
LAREGFVLTRADTDILDTTIARFKQDAESARIFLRPDGTPLQPGDRLVQSDLANTLAAIAKEGPDAFYKGKIPQAVEAAA
KQGGGILTAADFANYQVTETPPITCSYRGYKFVSAPPPSSGGVTLCEILNVVEGYDLKSMGFNSAAAIHTMTEAMRHAYM
DRNTYLGDPEFIKNPIDRLVSKSYAEEIRKKIVADKATPSENVQPGMEPHEKPETTHYSIVDHQGNAVSTTYTVNGRFGA
VVIAPGTGFFLNDEMDDFTVKVGEKNLYGLVQGTANSIAPGKRPLSSMSPTLVTKDNKIFMVLGSPGGSRIITITLQTAL
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADTLKILGGMGYKMVEQTPWGAAELILVGLPGAAGVSPANSGNDS
AVSGRVREGYLYGANDVRRPAGSAVGY

Sequences:

>Translated_587_residues
MFLQKWSKPLTMAALLVSSSLYAASNPAVEAKNGMVVTSQHLASQVGVDILKLGGNAVDAAVAVGYAQAVVNPCCGNIGG
GGFMTVHLADGTDTFINFRETAPAAASANMYLDAAGNVKKGASLYGYLAAGVPGTVLGMETARKKYGKLSREQVMEPAIK
LAREGFVLTRADTDILDTTIARFKQDAESARIFLRPDGTPLQPGDRLVQSDLANTLAAIAKEGPDAFYKGKIPQAVEAAA
KQGGGILTAADFANYQVTETPPITCSYRGYKFVSAPPPSSGGVTLCEILNVVEGYDLKSMGFNSAAAIHTMTEAMRHAYM
DRNTYLGDPEFIKNPIDRLVSKSYAEEIRKKIVADKATPSENVQPGMEPHEKPETTHYSIVDHQGNAVSTTYTVNGRFGA
VVIAPGTGFFLNDEMDDFTVKVGEKNLYGLVQGTANSIAPGKRPLSSMSPTLVTKDNKIFMVLGSPGGSRIITITLQTAL
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADTLKILGGMGYKMVEQTPWGAAELILVGLPGAAGVSPANSGNDS
AVSGRVREGYLYGANDVRRPAGSAVGY
>Mature_587_residues
MFLQKWSKPLTMAALLVSSSLYAASNPAVEAKNGMVVTSQHLASQVGVDILKLGGNAVDAAVAVGYAQAVVNPCCGNIGG
GGFMTVHLADGTDTFINFRETAPAAASANMYLDAAGNVKKGASLYGYLAAGVPGTVLGMETARKKYGKLSREQVMEPAIK
LAREGFVLTRADTDILDTTIARFKQDAESARIFLRPDGTPLQPGDRLVQSDLANTLAAIAKEGPDAFYKGKIPQAVEAAA
KQGGGILTAADFANYQVTETPPITCSYRGYKFVSAPPPSSGGVTLCEILNVVEGYDLKSMGFNSAAAIHTMTEAMRHAYM
DRNTYLGDPEFIKNPIDRLVSKSYAEEIRKKIVADKATPSENVQPGMEPHEKPETTHYSIVDHQGNAVSTTYTVNGRFGA
VVIAPGTGFFLNDEMDDFTVKVGEKNLYGLVQGTANSIAPGKRPLSSMSPTLVTKDNKIFMVLGSPGGSRIITITLQTAL
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADTLKILGGMGYKMVEQTPWGAAELILVGLPGAAGVSPANSGNDS
AVSGRVREGYLYGANDVRRPAGSAVGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=528, Percent_Identity=32.5757575757576, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI73915090, Length=528, Percent_Identity=32.5757575757576, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI73915096, Length=528, Percent_Identity=32.5757575757576, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI73915094, Length=528, Percent_Identity=32.5757575757576, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI113429324, Length=526, Percent_Identity=30.6083650190114, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI113429326, Length=531, Percent_Identity=30.1318267419962, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI153266885, Length=478, Percent_Identity=30.1255230125523, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI153266901, Length=479, Percent_Identity=30.062630480167, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI109148539, Length=481, Percent_Identity=32.016632016632, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI153266907, Length=477, Percent_Identity=28.7211740041929, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI30581157, Length=177, Percent_Identity=37.8531073446328, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI30581155, Length=177, Percent_Identity=37.8531073446328, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI218505805, Length=223, Percent_Identity=30.0448430493274, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI310124095, Length=223, Percent_Identity=26.457399103139, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1789856, Length=560, Percent_Identity=47.8571428571429, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17506189, Length=492, Percent_Identity=34.5528455284553, Blast_Score=245, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI72000294, Length=518, Percent_Identity=34.3629343629344, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI212646519, Length=518, Percent_Identity=34.3629343629344, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI193208247, Length=501, Percent_Identity=34.9301397205589, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI193208245, Length=501, Percent_Identity=34.9301397205589, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17542894, Length=494, Percent_Identity=33.4008097165992, Blast_Score=219, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17564448, Length=431, Percent_Identity=27.8422273781903, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI72001497, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI72001495, Length=250, Percent_Identity=24.8, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323330, Length=536, Percent_Identity=30.0373134328358, Blast_Score=177, Evalue=3e-45,
Organism=Drosophila melanogaster, GI45551474, Length=515, Percent_Identity=30.873786407767, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161077880, Length=515, Percent_Identity=30.873786407767, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161077878, Length=515, Percent_Identity=30.873786407767, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24642670, Length=515, Percent_Identity=30.873786407767, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24642666, Length=515, Percent_Identity=30.873786407767, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161077496, Length=496, Percent_Identity=31.8548387096774, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI18859893, Length=516, Percent_Identity=33.1395348837209, Blast_Score=220, Evalue=3e-57,
Organism=Drosophila melanogaster, GI18859741, Length=501, Percent_Identity=28.7425149700599, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62224; Mature: 62224

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLQKWSKPLTMAALLVSSSLYAASNPAVEAKNGMVVTSQHLASQVGVDILKLGGNAVDA
CCCHHHCCHHHHHHHHHHHHHHCCCCCCEECCCCEEEEHHHHHHHHCCCEEECCCCHHHH
AVAVGYAQAVVNPCCGNIGGGGFMTVHLADGTDTFINFRETAPAAASANMYLDAAGNVKK
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEECCCCCCC
GASLYGYLAAGVPGTVLGMETARKKYGKLSREQVMEPAIKLAREGFVLTRADTDILDTTI
CCCEEEEEECCCCCCEECHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHH
ARFKQDAESARIFLRPDGTPLQPGDRLVQSDLANTLAAIAKEGPDAFYKGKIPQAVEAAA
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KQGGGILTAADFANYQVTETPPITCSYRGYKFVSAPPPSSGGVTLCEILNVVEGYDLKSM
HCCCCEEEEECCCCEEEECCCCEEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCCCHHC
GFNSAAAIHTMTEAMRHAYMDRNTYLGDPEFIKNPIDRLVSKSYAEEIRKKIVADKATPS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ENVQPGMEPHEKPETTHYSIVDHQGNAVSTTYTVNGRFGAVVIAPGTGFFLNDEMDDFTV
CCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCCEEECCCCCCEEE
KVGEKNLYGLVQGTANSIAPGKRPLSSMSPTLVTKDNKIFMVLGSPGGSRIITITLQTAL
EECCCCEEEEEECCCCCCCCCCCCHHHCCCEEEECCCEEEEEEECCCCCEEEEEEHHHHH
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADTLKILGGMGYKMVEQTPWGAAEL
HHHHCCCCCHHHCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHCCCCHHHHHCCCCCCEEE
ILVGLPGAAGVSPANSGNDSAVSGRVREGYLYGANDVRRPAGSAVGY
EEEECCCCCCCCCCCCCCCCHHCCEEECCEEECCCHHCCCCCCCCCC
>Mature Secondary Structure
MFLQKWSKPLTMAALLVSSSLYAASNPAVEAKNGMVVTSQHLASQVGVDILKLGGNAVDA
CCCHHHCCHHHHHHHHHHHHHHCCCCCCEECCCCEEEEHHHHHHHHCCCEEECCCCHHHH
AVAVGYAQAVVNPCCGNIGGGGFMTVHLADGTDTFINFRETAPAAASANMYLDAAGNVKK
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEECCCCCCC
GASLYGYLAAGVPGTVLGMETARKKYGKLSREQVMEPAIKLAREGFVLTRADTDILDTTI
CCCEEEEEECCCCCCEECHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHH
ARFKQDAESARIFLRPDGTPLQPGDRLVQSDLANTLAAIAKEGPDAFYKGKIPQAVEAAA
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KQGGGILTAADFANYQVTETPPITCSYRGYKFVSAPPPSSGGVTLCEILNVVEGYDLKSM
HCCCCEEEEECCCCEEEECCCCEEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCCCHHC
GFNSAAAIHTMTEAMRHAYMDRNTYLGDPEFIKNPIDRLVSKSYAEEIRKKIVADKATPS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ENVQPGMEPHEKPETTHYSIVDHQGNAVSTTYTVNGRFGAVVIAPGTGFFLNDEMDDFTV
CCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCCEEECCCCCCEEE
KVGEKNLYGLVQGTANSIAPGKRPLSSMSPTLVTKDNKIFMVLGSPGGSRIITITLQTAL
EECCCCEEEEEECCCCCCCCCCCCHHHCCCEEEECCCEEEEEEECCCCCEEEEEEHHHHH
NVIDHGMAPQEAVDAPRIHHQWLPDEVYYEQRGVSADTLKILGGMGYKMVEQTPWGAAEL
HHHHCCCCCHHHCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHCCCCHHHHHCCCCCCEEE
ILVGLPGAAGVSPANSGNDSAVSGRVREGYLYGANDVRRPAGSAVGY
EEEECCCCCCCCCCCCCCCCHHCCEEECCEEECCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]