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The map label for this gene is ahpC [C]

Identifier: 157369301

GI number: 157369301

Start: 1165239

End: 1165841

Strand: Reverse

Name: ahpC [C]

Synonym: Spro_1058

Alternate gene names: 157369301

Gene position: 1165841-1165239 (Counterclockwise)

Preceding gene: 157369302

Following gene: 157369300

Centisome position: 21.4

GC content: 52.24

Gene sequence:

>603_bases
ATGGTCCTGGTAACTCGTCAAGCCCCTGACTTCACTGCAGCTGCCGTACTTGGCAGTGGCGAAATCGTAGAAAACTTCAA
CTTCAAGAAGCACCTGAACGGCAAACCAGCCGTCCTGTTCTTCTGGCCGATGGACTTCACCTTCGTATGTCCTTCTGAGC
TGATCGCTTTCGATCACCGCTATGAAGAATTCCAGAAGCGTGGCGTTGAAGTGGTTGGCGTTTCATTCGACTCAGAATTT
GTCCACAACGCATGGCGTAAAACCCCTGTCGAGAATGGCGGCATCGGGGAAGTGAAATACGCAATGGTTGCTGACATTAA
GCGTGAAATTCAGAAAGCTTATGGCATCGAGCACCCAGAAGCAGGCGTTGCCCTGCGTGGTTCTTTCCTGATCGACAAAG
ACGGTGTGGTTCGCGCTCAGGTTGTTAACGACCTGCCAATCGGCCGTAACATCGACGAAATGATCCGTACCGTTGACGCG
CTGCAATTCCACGAGCAACACGGCGAAGTTTGCCCGGCTCAGTGGGAAAAAGGCAAAGCAGGTATGGGTGCATCTCCGGA
CGGCGTAGCTAAATACCTGTCTGAGAACGCTTCCAAGCTGTAA

Upstream 100 bases:

>100_bases
TCTCATTGATTGGTCTTTTACCCTTTCTTCACCAAGTCGTGGCCCCTATACTGGCCCTTGCTTTTACATCAACCCCTTAA
CACCTATTACAGGAGTAATT

Downstream 100 bases:

>100_bases
TTTCAGCCTGCAAGTGTATCAACCGGCCTCCGTGGCCGGTTTTTTTTGCTCTTTTTTAGGGCACATCGCCCCCATTGCGT
GCTTCATTTGCTTGTTTCCG

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MVLVTRQAPDFTAAAVLGSGEIVENFNFKKHLNGKPAVLFFWPMDFTFVCPSELIAFDHRYEEFQKRGVEVVGVSFDSEF
VHNAWRKTPVENGGIGEVKYAMVADIKREIQKAYGIEHPEAGVALRGSFLIDKDGVVRAQVVNDLPIGRNIDEMIRTVDA
LQFHEQHGEVCPAQWEKGKAGMGASPDGVAKYLSENASKL

Sequences:

>Translated_200_residues
MVLVTRQAPDFTAAAVLGSGEIVENFNFKKHLNGKPAVLFFWPMDFTFVCPSELIAFDHRYEEFQKRGVEVVGVSFDSEF
VHNAWRKTPVENGGIGEVKYAMVADIKREIQKAYGIEHPEAGVALRGSFLIDKDGVVRAQVVNDLPIGRNIDEMIRTVDA
LQFHEQHGEVCPAQWEKGKAGMGASPDGVAKYLSENASKL
>Mature_200_residues
MVLVTRQAPDFTAAAVLGSGEIVENFNFKKHLNGKPAVLFFWPMDFTFVCPSELIAFDHRYEEFQKRGVEVVGVSFDSEF
VHNAWRKTPVENGGIGEVKYAMVADIKREIQKAYGIEHPEAGVALRGSFLIDKDGVVRAQVVNDLPIGRNIDEMIRTVDA
LQFHEQHGEVCPAQWEKGKAGMGASPDGVAKYLSENASKL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=194, Percent_Identity=45.8762886597938, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI4505591, Length=189, Percent_Identity=43.9153439153439, Blast_Score=177, Evalue=4e-45,
Organism=Homo sapiens, GI32455266, Length=189, Percent_Identity=43.9153439153439, Blast_Score=177, Evalue=4e-45,
Organism=Homo sapiens, GI32455264, Length=189, Percent_Identity=43.9153439153439, Blast_Score=177, Evalue=4e-45,
Organism=Homo sapiens, GI5802974, Length=193, Percent_Identity=44.0414507772021, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI32483377, Length=192, Percent_Identity=43.75, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=42.7083333333333, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI33188454, Length=83, Percent_Identity=53.0120481927711, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4758638, Length=195, Percent_Identity=28.7179487179487, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI1786822, Length=192, Percent_Identity=36.9791666666667, Blast_Score=127, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17554494, Length=170, Percent_Identity=44.7058823529412, Blast_Score=167, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI193204376, Length=176, Percent_Identity=44.8863636363636, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32565831, Length=176, Percent_Identity=44.8863636363636, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25153706, Length=180, Percent_Identity=28.8888888888889, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=196, Percent_Identity=39.2857142857143, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320661, Length=184, Percent_Identity=38.5869565217391, Blast_Score=142, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319407, Length=181, Percent_Identity=29.2817679558011, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=46.3917525773196, Blast_Score=186, Evalue=9e-48,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=46.3917525773196, Blast_Score=186, Evalue=9e-48,
Organism=Drosophila melanogaster, GI17738015, Length=187, Percent_Identity=43.8502673796791, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21357347, Length=193, Percent_Identity=42.4870466321244, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17157991, Length=197, Percent_Identity=39.5939086294416, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24641739, Length=197, Percent_Identity=39.5939086294416, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24581278, Length=182, Percent_Identity=31.3186813186813, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17975518, Length=155, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652436, Length=155, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652434, Length=155, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22181; Mature: 22181

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLVTRQAPDFTAAAVLGSGEIVENFNFKKHLNGKPAVLFFWPMDFTFVCPSELIAFDHR
CEEEECCCCCCCCEEEECCCCHHHCCCCHHCCCCCCEEEEEECCCEEEECHHHHHHHHHH
YEEFQKRGVEVVGVSFDSEFVHNAWRKTPVENGGIGEVKYAMVADIKREIQKAYGIEHPE
HHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
AGVALRGSFLIDKDGVVRAQVVNDLPIGRNIDEMIRTVDALQFHEQHGEVCPAQWEKGKA
CCEEEECEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GMGASPDGVAKYLSENASKL
CCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLVTRQAPDFTAAAVLGSGEIVENFNFKKHLNGKPAVLFFWPMDFTFVCPSELIAFDHR
CEEEECCCCCCCCEEEECCCCHHHCCCCHHCCCCCCEEEEEECCCEEEECHHHHHHHHHH
YEEFQKRGVEVVGVSFDSEFVHNAWRKTPVENGGIGEVKYAMVADIKREIQKAYGIEHPE
HHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
AGVALRGSFLIDKDGVVRAQVVNDLPIGRNIDEMIRTVDALQFHEQHGEVCPAQWEKGKA
CCEEEECEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GMGASPDGVAKYLSENASKL
CCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]