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The map label for this gene is fimE [H]

Identifier: 157369299

GI number: 157369299

Start: 1162537

End: 1163130

Strand: Reverse

Name: fimE [H]

Synonym: Spro_1056

Alternate gene names: 157369299

Gene position: 1163130-1162537 (Counterclockwise)

Preceding gene: 157369300

Following gene: 157369298

Centisome position: 21.35

GC content: 59.93

Gene sequence:

>594_bases
TTGATAAAATTACCACAGCACCGCAAGCACCTCACCCGGGGGGAAGTCGGGCGTCTGCTGCTGCAAGCCGCCGCCGGCCG
GGCGCCCGAGCGTGACACCTGCCTGATCTGGATGGGTTTCATTCATGGCTGTCGCGTCAGCGAACTCACCGGCTTGCGCC
TCGCCGACCTCGACATGGACGACGGCTGCCTTTACATCAGCCGCCTTAAAAACGGCCTGTCCACCACCCACCCGCTGGAA
ACCACCGAGAAACGCCTGTTGCAGCGCTGGCTGGAAAAACGCCAATTCTGCCGCAACCTGGACGACCAGGACTGGCTGTT
TCTGTCACAAAAGGGCTATCGCCTGTCGCGCCAGCGTATCTTTCGTATGTTGCGTGAGTATGGCCGTCGGGCCGGGCTGG
AGGTCGAGGCGCACCCGCACATGCTGCGTCATGCCTGTGGCTATGCGCTGGCGGATAACGGCGCCGATACGCGGGTGATT
CAGGATTATCTGGGGCATCGCAACATTCAACACACGGTGCTGTACACCGCCGCCAATGCCGGACGATTCAGGGACTTATG
GGAGGAAAAACGCCGAAAAAATGTAACACTTTGA

Upstream 100 bases:

>100_bases
GCTCGGTATTGCGTGCCAGCGTTAGGCTATACTCCTCCCACTCTGTCTGTGACAGACCACGGTCGGCACCCGCCGGCCGT
TTCTTTTCGAGGAAAATACT

Downstream 100 bases:

>100_bases
GCCAAACTGACACATAAACTAAGAATTACCCGAAAAGAAGTCAATACCGCCGTCGTATTTTTTTCATCCCTCCAATAAAC
ATCACATTATCAGTAAGATA

Product: integrase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMDDGCLYISRLKNGLSTTHPLE
TTEKRLLQRWLEKRQFCRNLDDQDWLFLSQKGYRLSRQRIFRMLREYGRRAGLEVEAHPHMLRHACGYALADNGADTRVI
QDYLGHRNIQHTVLYTAANAGRFRDLWEEKRRKNVTL

Sequences:

>Translated_197_residues
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMDDGCLYISRLKNGLSTTHPLE
TTEKRLLQRWLEKRQFCRNLDDQDWLFLSQKGYRLSRQRIFRMLREYGRRAGLEVEAHPHMLRHACGYALADNGADTRVI
QDYLGHRNIQHTVLYTAANAGRFRDLWEEKRRKNVTL
>Mature_197_residues
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMDDGCLYISRLKNGLSTTHPLE
TTEKRLLQRWLEKRQFCRNLDDQDWLFLSQKGYRLSRQRIFRMLREYGRRAGLEVEAHPHMLRHACGYALADNGADTRVI
QDYLGHRNIQHTVLYTAANAGRFRDLWEEKRRKNVTL

Specific function: FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790768, Length=181, Percent_Identity=51.3812154696133, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI1790767, Length=184, Percent_Identity=51.0869565217391, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI1789261, Length=191, Percent_Identity=33.5078534031414, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1790244, Length=175, Percent_Identity=30.2857142857143, Blast_Score=80, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 23065; Mature: 23065

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCHHHHCCCEEECCCCC
DGCLYISRLKNGLSTTHPLETTEKRLLQRWLEKRQFCRNLDDQDWLFLSQKGYRLSRQRI
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHH
FRMLREYGRRAGLEVEAHPHMLRHACGYALADNGADTRVIQDYLGHRNIQHTVLYTAANA
HHHHHHHHHHCCCCCCCCHHHHHHHHCHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCC
GRFRDLWEEKRRKNVTL
CHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCHHHHCCCEEECCCCC
DGCLYISRLKNGLSTTHPLETTEKRLLQRWLEKRQFCRNLDDQDWLFLSQKGYRLSRQRI
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHH
FRMLREYGRRAGLEVEAHPHMLRHACGYALADNGADTRVIQDYLGHRNIQHTVLYTAANA
HHHHHHHHHHCCCCCCCCHHHHHHHHCHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCC
GRFRDLWEEKRRKNVTL
CHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]