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The map label for this gene is aqpZ [H]

Identifier: 157369252

GI number: 157369252

Start: 1109619

End: 1110314

Strand: Reverse

Name: aqpZ [H]

Synonym: Spro_1009

Alternate gene names: 157369252

Gene position: 1110314-1109619 (Counterclockwise)

Preceding gene: 157369254

Following gene: 157369250

Centisome position: 20.38

GC content: 52.87

Gene sequence:

>696_bases
ATGTCAAAGCGACTTTTTGCCGAATTTTTTGGCACATTTTGGTTGGTGTTCGGTGGTTGTGGTAGCGCAGTATTAGCAGC
AGCATTTCCACAGCTGGGTATTGGTTTTCTTGGTGTCGCGCTCGCTTTTGGTTTGACCGTGGTCACCATGGCTTATGCCG
TTGGCCATATTTCTGGCGGGCACTTTAACCCGGCGATTACCGTGGGGTTGTTTGCCGGCGGCCGTTTCGCCGCTAAAGAC
GTGATCCCCTATGTGATTGCTCAGGTTATTGGCGGGATTGCTGCAGCGGCGGTGTTGTATTTGATCGCCAGCGGCAAGGC
AGGTTTTGACGCTACCGGCGGCGGCTTTGCCTCCAACGGTTACGGTGAACACTCACCGGGCGGCTATTCTCTGCAGTCCG
CAATCGTAATCGAATTGGTCCTGACCGCATTCTTCCTGATCGTTATTCATGGTGTCACAGATAAACGTGCGCCTGCGGGC
TTTGCTCCATTGGCCATTGGTTTGACGTTAACCCTGATTCACCTGATCAGTATTCCGGTTACCAATACTTCCGTTAACCC
GGCGCGTAGTACCGGCGTAGCAATATTCCAGGGAACCTGGGCATTGCAACAACTATGGGTATTCTGGCTGGTGCCATTAG
TGGGCGGTGTTATCGGCGGCCTGATTTATCGCTGCCTGCTGGAAGACAAGAAGTAA

Upstream 100 bases:

>100_bases
TCATTAAGAATAATCCTGATAGAAACCTGCATTAATTGAAAAAGGTGTTCTATAGTTTTTAGTGCTAACGCCCGTTAGTA
TTTTCCGTAGGATGGAGTCT

Downstream 100 bases:

>100_bases
TTTCTTTCCTGGCAGTATTCTGTCAGGGCAGCCGCTATATCCCGCGTGTTTCCGCTTGCCATCGGGAAAATGAAGGGTAT
ATCGGCTGCCCTGAATTATT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSKRLFAEFFGTFWLVFGGCGSAVLAAAFPQLGIGFLGVALAFGLTVVTMAYAVGHISGGHFNPAITVGLFAGGRFAAKD
VIPYVIAQVIGGIAAAAVLYLIASGKAGFDATGGGFASNGYGEHSPGGYSLQSAIVIELVLTAFFLIVIHGVTDKRAPAG
FAPLAIGLTLTLIHLISIPVTNTSVNPARSTGVAIFQGTWALQQLWVFWLVPLVGGVIGGLIYRCLLEDKK

Sequences:

>Translated_231_residues
MSKRLFAEFFGTFWLVFGGCGSAVLAAAFPQLGIGFLGVALAFGLTVVTMAYAVGHISGGHFNPAITVGLFAGGRFAAKD
VIPYVIAQVIGGIAAAAVLYLIASGKAGFDATGGGFASNGYGEHSPGGYSLQSAIVIELVLTAFFLIVIHGVTDKRAPAG
FAPLAIGLTLTLIHLISIPVTNTSVNPARSTGVAIFQGTWALQQLWVFWLVPLVGGVIGGLIYRCLLEDKK
>Mature_230_residues
SKRLFAEFFGTFWLVFGGCGSAVLAAAFPQLGIGFLGVALAFGLTVVTMAYAVGHISGGHFNPAITVGLFAGGRFAAKDV
IPYVIAQVIGGIAAAAVLYLIASGKAGFDATGGGFASNGYGEHSPGGYSLQSAIVIELVLTAFFLIVIHGVTDKRAPAGF
APLAIGLTLTLIHLISIPVTNTSVNPARSTGVAIFQGTWALQQLWVFWLVPLVGGVIGGLIYRCLLEDKK

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=227, Percent_Identity=40.0881057268723, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4502179, Length=228, Percent_Identity=37.719298245614, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI37694062, Length=242, Percent_Identity=36.7768595041322, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI6912506, Length=227, Percent_Identity=37.0044052863436, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4755125, Length=225, Percent_Identity=31.1111111111111, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI4502181, Length=225, Percent_Identity=31.1111111111111, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI86792455, Length=232, Percent_Identity=33.6206896551724, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI157266307, Length=252, Percent_Identity=32.1428571428571, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI45446752, Length=225, Percent_Identity=31.1111111111111, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4502187, Length=246, Percent_Identity=29.6747967479675, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI22538420, Length=251, Percent_Identity=25.0996015936255, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1787101, Length=231, Percent_Identity=80.0865800865801, Blast_Score=343, Evalue=5e-96,
Organism=Escherichia coli, GI1790362, Length=267, Percent_Identity=27.7153558052434, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71993722, Length=235, Percent_Identity=31.9148936170213, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71992966, Length=235, Percent_Identity=29.3617021276596, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994009, Length=242, Percent_Identity=28.5123966942149, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558372, Length=229, Percent_Identity=28.3842794759825, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531431, Length=239, Percent_Identity=28.0334728033473, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531429, Length=239, Percent_Identity=28.0334728033473, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652747, Length=231, Percent_Identity=36.7965367965368, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45551084, Length=231, Percent_Identity=36.7965367965368, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24652751, Length=230, Percent_Identity=36.5217391304348, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI19922038, Length=232, Percent_Identity=36.2068965517241, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17136672, Length=235, Percent_Identity=28.936170212766, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24762342, Length=227, Percent_Identity=29.9559471365639, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550503, Length=231, Percent_Identity=25.5411255411255, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24762344, Length=225, Percent_Identity=28, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24762346, Length=225, Percent_Identity=28, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24762348, Length=225, Percent_Identity=28, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130305, Length=225, Percent_Identity=28, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23860; Mature: 23729

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRLFAEFFGTFWLVFGGCGSAVLAAAFPQLGIGFLGVALAFGLTVVTMAYAVGHISGG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HFNPAITVGLFAGGRFAAKDVIPYVIAQVIGGIAAAAVLYLIASGKAGFDATGGGFASNG
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
YGEHSPGGYSLQSAIVIELVLTAFFLIVIHGVTDKRAPAGFAPLAIGLTLTLIHLISIPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
TNTSVNPARSTGVAIFQGTWALQQLWVFWLVPLVGGVIGGLIYRCLLEDKK
CCCCCCCCHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKRLFAEFFGTFWLVFGGCGSAVLAAAFPQLGIGFLGVALAFGLTVVTMAYAVGHISGG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HFNPAITVGLFAGGRFAAKDVIPYVIAQVIGGIAAAAVLYLIASGKAGFDATGGGFASNG
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
YGEHSPGGYSLQSAIVIELVLTAFFLIVIHGVTDKRAPAGFAPLAIGLTLTLIHLISIPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
TNTSVNPARSTGVAIFQGTWALQQLWVFWLVPLVGGVIGGLIYRCLLEDKK
CCCCCCCCHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]