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The map label for this gene is gpt

Identifier: 157369209

GI number: 157369209

Start: 1062368

End: 1062826

Strand: Direct

Name: gpt

Synonym: Spro_0964

Alternate gene names: 157369209

Gene position: 1062368-1062826 (Clockwise)

Preceding gene: 157369207

Following gene: 157369210

Centisome position: 19.5

GC content: 55.99

Gene sequence:

>459_bases
ATGAGCGAAAAATACGTTGTTACCTGGGACATGCTGCAAATGCAAGCGCGCAAACTGGCTCATCGCCTGCTGCCTGCTGA
CCAATGGACGGGCATTATTGCCGTAAGCCGTGGCGGGCTGGTACCGGCTGCCTTACTGGCGCGTGAGCTGGGTATTCGCC
ACGTGGATACCGTCTGCATTTCCAGCTATGACCATGACAATCAACGTGAAATGAAAGTGCTCAAGCGCGCTGAAGGCGAC
GGTGAAGGCTTTATCGTTATCGACGATCTGGTGGATACCGGCGGCACCGCGAAAGCGATCCGTGAAATGTACCCGAAAGC
GCACTTCGTCACTATCTTCGCCAAGCCGGCAGGTCGCCCGTTGGTAGACGATTATGTGGTTGATATCCCACAGGATACCT
GGATCGAGCAGCCATGGGACATGGCGGTGACCTTCGTGCCACCGATCGGCGGTCGTTAA

Upstream 100 bases:

>100_bases
ACAACTGGCATTTGATGCGGTCAGTCTTTATAATCTCGCGCAACCTTTTTTCCCCTGATTACTGAGTAAGCCGCACCACT
GCTGGCTGGGACACCATTCT

Downstream 100 bases:

>100_bases
GTTCGCCACGCCGATTTGCCAAAACGCCCGGTTCCACCGGGCGTTTGCATTTCTGATTTCCGCCCCACAGATCCGCTTCA
AGTATGACGGGTTTATCGCG

Product: xanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: Xanthine-guanine phosphoribosyltransferase; XGPRT

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MSEKYVVTWDMLQMQARKLAHRLLPADQWTGIIAVSRGGLVPAALLARELGIRHVDTVCISSYDHDNQREMKVLKRAEGD
GEGFIVIDDLVDTGGTAKAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMAVTFVPPIGGR

Sequences:

>Translated_152_residues
MSEKYVVTWDMLQMQARKLAHRLLPADQWTGIIAVSRGGLVPAALLARELGIRHVDTVCISSYDHDNQREMKVLKRAEGD
GEGFIVIDDLVDTGGTAKAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMAVTFVPPIGGR
>Mature_151_residues
SEKYVVTWDMLQMQARKLAHRLLPADQWTGIIAVSRGGLVPAALLARELGIRHVDTVCISSYDHDNQREMKVLKRAEGDG
EGFIVIDDLVDTGGTAKAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMAVTFVPPIGGR

Specific function: Acts on guanine, xanthine and to a lesser extent hypoxanthine

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily

Homologues:

Organism=Escherichia coli, GI1786433, Length=152, Percent_Identity=90.7894736842105, Blast_Score=288, Evalue=8e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XGPT_SERP5 (A8GAD0)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477198.1
- ProteinModelPortal:   A8GAD0
- SMR:   A8GAD0
- STRING:   A8GAD0
- GeneID:   5603113
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0964
- eggNOG:   COG0503
- HOGENOM:   HBG503428
- OMA:   LVDTFIT
- ProtClustDB:   PRK09177
- BioCyc:   SPRO399741:SPRO_0964-MONOMER
- HAMAP:   MF_01903
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 16988; Mature: 16857

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 69-69 BINDING 92-92 BINDING 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKYVVTWDMLQMQARKLAHRLLPADQWTGIIAVSRGGLVPAALLARELGIRHVDTVCI
CCCCEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHEE
SSYDHDNQREMKVLKRAEGDGEGFIVIDDLVDTGGTAKAIREMYPKAHFVTIFAKPAGRP
CCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCC
LVDDYVVDIPQDTWIEQPWDMAVTFVPPIGGR
CCCHHEEECCCCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SEKYVVTWDMLQMQARKLAHRLLPADQWTGIIAVSRGGLVPAALLARELGIRHVDTVCI
CCCEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHEE
SSYDHDNQREMKVLKRAEGDGEGFIVIDDLVDTGGTAKAIREMYPKAHFVTIFAKPAGRP
CCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCC
LVDDYVVDIPQDTWIEQPWDMAVTFVPPIGGR
CCCHHEEECCCCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA