Click here to switch to the map view.

The map label for this gene is dinB

Identifier: 157369207

GI number: 157369207

Start: 1059466

End: 1060527

Strand: Direct

Name: dinB

Synonym: Spro_0962

Alternate gene names: 157369207

Gene position: 1059466-1060527 (Clockwise)

Preceding gene: 157369205

Following gene: 157369209

Centisome position: 19.44

GC content: 57.82

Gene sequence:

>1062_bases
ATGCGTAAAATCATTCATGTCGATATGGACTGCTTCTTCGCGGCGGTAGAAATGCGCGACGATCCCAGCCTGCGCGATAT
TCCGTTGGCGATCGGCGGCAGTGCCGACCGGCGTGGGGTGATCAGCACCGCCAACTATCCTGCACGCCGCTATGGTGTGC
ACAGTGCGATGTCGACGGCGATGGCGCTCAAGCTTTGCCCGCACCTTAAGCTGCTGCCTGGGCGCATGGCGGCGTATAAG
GAAGCTTCGCAGCATATCCGCGAAATCTTCGCCCGCTACACCCCACTGATTGAACCGCTGTCGCTGGATGAAGCCTATCT
GGACGTGACCGACTGCAGCCAGTGCAACGGCTCGGCGACGTTGATCGCCGAGCAAATTCGCCAGACTATCTCCGATGAAC
TCAACCTTACCGCTTCTGCCGGTATCGCGCCGATCAAGTTTCTCGCCAAAATTGCCTCAGAGTTGAATAAGCCGAACGGA
CAATACGTCATCACTCCGGCGCAGGTGCCGGCTTTTTTACAGCAGTTACCGCTGAGTAAAATCCCCGGCGTGGGCAAAGT
GACCGCCAAACGGCTGGAAGAAGTGGGGCTGATCACCTGCGCCGACGTACAGCAGTACGATCTGGCGGCGCTGTTAAAGC
GCTTCGGCAAATTTGGCCGGGTGTTGTGGGAGCGTTGTCAGGGGATCGATCTGCGTGAGGTTTCGCCAGAGCGGTTGCGC
AAGTCGGTGGGGGTGGAGCGAACCTTGGCGGAGGACATCCATGACTGGGAAGACTGCGAAGCGTTGATTGTCGACAAACT
CTATCCCGAGCTGGAACTGCGGTTGCGTAAGGTGAAACCGGATCTGCACATCGCCCGGCAGGGGGTAAAACTGAAGTTTC
AGGATTTCCAGCAAACGACGCAGGAACACGTTTGGCCGGTACTCAATAAAGACGATTTAATCAACGTGGCACGGCAGGTA
TGGCGTGAGCGGCGCGAAGGGCGCGGGGTGCGACTGGTTGGGTTACATGTGACGCTGCTGGATCCGCAACTGGAGCGGCA
ACTGCTGCTACCCTGGGAATAA

Upstream 100 bases:

>100_bases
TCGAAGATAATTGGGTGAAAGCCTGTTTTCTCCGAGTAGAGCCGAGGCTTGAGCTTTCCATTATTGCCTGTATATTTATA
CAGTATTATTGGGAGGAACG

Downstream 100 bases:

>100_bases
CAAGGGCGCAATGCAGTATTGCGCCCTTGGTTTAATCACTAAGTCATCTGTAATATTACGCGCGCTCTGGGATAGCCTTC
AGCAGTGCCGTCAGCAACTT

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MRKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRRGVISTANYPARRYGVHSAMSTAMALKLCPHLKLLPGRMAAYK
EASQHIREIFARYTPLIEPLSLDEAYLDVTDCSQCNGSATLIAEQIRQTISDELNLTASAGIAPIKFLAKIASELNKPNG
QYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAALLKRFGKFGRVLWERCQGIDLREVSPERLR
KSVGVERTLAEDIHDWEDCEALIVDKLYPELELRLRKVKPDLHIARQGVKLKFQDFQQTTQEHVWPVLNKDDLINVARQV
WRERREGRGVRLVGLHVTLLDPQLERQLLLPWE

Sequences:

>Translated_353_residues
MRKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRRGVISTANYPARRYGVHSAMSTAMALKLCPHLKLLPGRMAAYK
EASQHIREIFARYTPLIEPLSLDEAYLDVTDCSQCNGSATLIAEQIRQTISDELNLTASAGIAPIKFLAKIASELNKPNG
QYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAALLKRFGKFGRVLWERCQGIDLREVSPERLR
KSVGVERTLAEDIHDWEDCEALIVDKLYPELELRLRKVKPDLHIARQGVKLKFQDFQQTTQEHVWPVLNKDDLINVARQV
WRERREGRGVRLVGLHVTLLDPQLERQLLLPWE
>Mature_353_residues
MRKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRRGVISTANYPARRYGVHSAMSTAMALKLCPHLKLLPGRMAAYK
EASQHIREIFARYTPLIEPLSLDEAYLDVTDCSQCNGSATLIAEQIRQTISDELNLTASAGIAPIKFLAKIASELNKPNG
QYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAALLKRFGKFGRVLWERCQGIDLREVSPERLR
KSVGVERTLAEDIHDWEDCEALIVDKLYPELELRLRKVKPDLHIARQGVKLKFQDFQQTTQEHVWPVLNKDDLINVARQV
WRERREGRGVRLVGLHVTLLDPQLERQLLLPWE

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI84043967, Length=325, Percent_Identity=31.3846153846154, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI7706681, Length=326, Percent_Identity=31.2883435582822, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI7705344, Length=331, Percent_Identity=33.5347432024169, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI154350220, Length=251, Percent_Identity=32.2709163346614, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI5729982, Length=360, Percent_Identity=30, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786425, Length=350, Percent_Identity=79.1428571428572, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI1787432, Length=265, Percent_Identity=24.1509433962264, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193205700, Length=309, Percent_Identity=32.3624595469256, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17537959, Length=254, Percent_Identity=31.1023622047244, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193205702, Length=254, Percent_Identity=27.9527559055118, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324921, Length=209, Percent_Identity=31.5789473684211, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19923006, Length=328, Percent_Identity=30.1829268292683, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21355641, Length=283, Percent_Identity=32.5088339222615, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24644984, Length=283, Percent_Identity=32.5088339222615, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24668444, Length=118, Percent_Identity=37.2881355932203, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_SERP5 (A8GAC8)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477196.1
- ProteinModelPortal:   A8GAC8
- SMR:   A8GAC8
- STRING:   A8GAC8
- GeneID:   5605309
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0962
- eggNOG:   COG0389
- HOGENOM:   HBG734504
- OMA:   VICAASY
- ProtClustDB:   PRK02406
- BioCyc:   SPRO399741:SPRO_0962-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- InterPro:   IPR003583
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076
- SMART:   SM00278

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 39929; Mature: 39929

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 104-104

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRRGVISTANYPARRYGVHSAMSTA
CCCEEEECHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCEECCCCCHHHHHHHHHHHHH
MALKLCPHLKLLPGRMAAYKEASQHIREIFARYTPLIEPLSLDEAYLDVTDCSQCNGSAT
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHCCCCCCHH
LIAEQIRQTISDELNLTASAGIAPIKFLAKIASELNKPNGQYVITPAQVPAFLQQLPLSK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCHHH
IPGVGKVTAKRLEEVGLITCADVQQYDLAALLKRFGKFGRVLWERCQGIDLREVSPERLR
CCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KSVGVERTLAEDIHDWEDCEALIVDKLYPELELRLRKVKPDLHIARQGVKLKFQDFQQTT
HHHCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHCCCCEEHHHHHHHH
QEHVWPVLNKDDLINVARQVWRERREGRGVRLVGLHVTLLDPQLERQLLLPWE
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHCCCCCCCC
>Mature Secondary Structure
MRKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRRGVISTANYPARRYGVHSAMSTA
CCCEEEECHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCEECCCCCHHHHHHHHHHHHH
MALKLCPHLKLLPGRMAAYKEASQHIREIFARYTPLIEPLSLDEAYLDVTDCSQCNGSAT
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHCCCCCCHH
LIAEQIRQTISDELNLTASAGIAPIKFLAKIASELNKPNGQYVITPAQVPAFLQQLPLSK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCHHH
IPGVGKVTAKRLEEVGLITCADVQQYDLAALLKRFGKFGRVLWERCQGIDLREVSPERLR
CCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KSVGVERTLAEDIHDWEDCEALIVDKLYPELELRLRKVKPDLHIARQGVKLKFQDFQQTT
HHHCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHCCCCEEHHHHHHHH
QEHVWPVLNKDDLINVARQVWRERREGRGVRLVGLHVTLLDPQLERQLLLPWE
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA