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The map label for this gene is trpR

Identifier: 157368921

GI number: 157368921

Start: 745031

End: 745360

Strand: Direct

Name: trpR

Synonym: Spro_0676

Alternate gene names: 157368921

Gene position: 745031-745360 (Clockwise)

Preceding gene: 157368920

Following gene: 157368923

Centisome position: 13.67

GC content: 56.06

Gene sequence:

>330_bases
ATGACGCAATTATCGCTTAACGACCCGGCTCTTTCAGAACAAGGTAATGAGGATTGGCTGCGCTTTGTTGCGCTGCTGCA
GAATTCGTTTGCCCAGGATCTGCATCAACCGCTGATGCAACTGCTGCTGACGCCGGACGAACGCACGGCTTTAGGCACAA
GGGTACGGATTATCCAGGAATTGATGCGCGGTGAGATGAGCCAACGTGAGCTGAAAAATGAACTGGGGGCGGGGATTGCC
ACCATCACTCGCGGTTCGAACAGCCTGAAGGCGGCGACGCCTGCGCTGAAACAGTGGCTGGAACAGCAGTTGCTGGGCGA
TGCGCAGTAG

Upstream 100 bases:

>100_bases
CCGGCTAAAGTGCTGACCGACGCCGAGTGGCAGAGGCGTTATTGATTTTGACGTCGCTATGGTATGCTGCTGTACTAGTT
AAATAGTATGGTGGCTTGCC

Downstream 100 bases:

>100_bases
CGCCGCGCCCACCGAAGGTTATTTCTGTGCCGCGTTGTTATGGTTCTGGTAGATCGGGTTGTGGAAAGGCACCAGCGCCA
GCAGCAGAGCCTGATGGTAA

Product: Trp operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MTQLSLNDPALSEQGNEDWLRFVALLQNSFAQDLHQPLMQLLLTPDERTALGTRVRIIQELMRGEMSQRELKNELGAGIA
TITRGSNSLKAATPALKQWLEQQLLGDAQ

Sequences:

>Translated_109_residues
MTQLSLNDPALSEQGNEDWLRFVALLQNSFAQDLHQPLMQLLLTPDERTALGTRVRIIQELMRGEMSQRELKNELGAGIA
TITRGSNSLKAATPALKQWLEQQLLGDAQ
>Mature_108_residues
TQLSLNDPALSEQGNEDWLRFVALLQNSFAQDLHQPLMQLLLTPDERTALGTRVRIIQELMRGEMSQRELKNELGAGIAT
ITRGSNSLKAATPALKQWLEQQLLGDAQ

Specific function: This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regula

COG id: COG2973

COG function: function code K; Trp operon repressor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpR family

Homologues:

Organism=Escherichia coli, GI1790854, Length=105, Percent_Identity=69.5238095238095, Blast_Score=132, Evalue=5e-33,

Paralogues:

None

Copy number: 250-750 50-300 [C]

Swissprot (AC and ID): TRPR_SERP5 (A8G9J2)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476910.1
- ProteinModelPortal:   A8G9J2
- SMR:   A8G9J2
- STRING:   A8G9J2
- GeneID:   5605631
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0676
- eggNOG:   COG2973
- HOGENOM:   HBG677773
- OMA:   ELMRGEM
- ProtClustDB:   PRK01381
- BioCyc:   SPRO399741:SPRO_0676-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00475
- InterPro:   IPR000831
- InterPro:   IPR013335
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1270.10
- PIRSF:   PIRSF003196
- ProDom:   PD012582
- TIGRFAMs:   TIGR01321

Pfam domain/function: PF01371 Trp_repressor; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 12184; Mature: 12053

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLSLNDPALSEQGNEDWLRFVALLQNSFAQDLHQPLMQLLLTPDERTALGTRVRIIQE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LMRGEMSQRELKNELGAGIATITRGSNSLKAATPALKQWLEQQLLGDAQ
HHHCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TQLSLNDPALSEQGNEDWLRFVALLQNSFAQDLHQPLMQLLLTPDERTALGTRVRIIQE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LMRGEMSQRELKNELGAGIATITRGSNSLKAATPALKQWLEQQLLGDAQ
HHHCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA