Click here to switch to the map view.

The map label for this gene is wecC [H]

Identifier: 157368413

GI number: 157368413

Start: 185533

End: 186795

Strand: Direct

Name: wecC [H]

Synonym: Spro_0164

Alternate gene names: 157368413

Gene position: 185533-186795 (Clockwise)

Preceding gene: 157368412

Following gene: 157368414

Centisome position: 3.4

GC content: 56.61

Gene sequence:

>1263_bases
ATGAGTTTTAACACTATTTCGGTTATCGGCCTGGGTTACATCGGTCTGCCAACGGCGGCGGCGTTTGCCTCCCGCAAGAA
AAAAGTGGTGGGCGTAGATGTTAACCAACATGCGGTGGATACCATTAATCGCGGCGCGATCCACATCGTTGAACCCGATC
TGGATAAAGTGGTGAAAGACGCGGTCGACGGCGGCTACCTGCAGGCGGTGACCCAACCCCTGGCTGCGGACGCTTTCCTG
ATCGCGGTGCCAACGCCGTTTAAAGGTGACCATGAGCCGGATCTGGCCTATGTAGAAGCTGCGGCCAAATCTCTGGCACC
GGTGCTCAAAAAGGGCGATCTGGTTATCCTGGAATCCACCTCTCCGGTCGGCGCCACCGAGCAGATGGCGCAGTGGCTGG
CCGAGGCGCGCAGCGATCTCAGCTTCCCGCAGCAGGCGGGTGAAGCCGCTGATGTGAATATCGCTTATTGCCCAGAGCGC
GTTCTGCCAGGGCAGGTGATGGTTGAGCTGATTCAGAACGACCGCGTTATTGGCGGCATGACGCCAAAATGTTCGGAGCG
CGCCAGCGCGTTGTACAAGATTTTCCTCGAAGGCGAGTGCGTCATTACCAATTCACGTACTGCAGAGATGTGCAAACTCA
CCGAAAATAGCTTCCGCGACGTGAATATCGCCTTTGCCAACGAACTGTCGTTGATTTGCGCCGATCAGGGCATCAATGTC
TGGGAGCTTATTCGCTTGGCCAACCGCCATCCGCGGGTGAATATCCTGCAGCCAGGCCCTGGCGTTGGTGGCCACTGTAT
CGCGGTCGACCCTTGGTTTATCGTGTCGCAAAACCCGCAGCAGGCACGTTTGATTCATACTGCGCGTCTGGTGAATGACG
GAAAACCTTTGTGGGTAGTGGATCGCGTGAAAGCGGCCGTTGCCGACTGTCTGGCGGCGACCGACAAGCGCGCTTCAGAA
GTGAAAATTGCCTGTTTCGGCCTGGCCTTCAAGCCAAATATCGACGATCTGCGTGAAAGTCCGGCGGTGGAAGTGGCCCA
TCTGATTGCCGATTGGCACGTGGGAGAAACGCTGGTCGTTGAGCCGAACGTGGAACAGTTGCCGAAATCGTTGGTAGGCC
ACGTGACGCTGAAAGCGTTGCCAGAAGCGCTGCAGCAGGCGGATGTGATCGTGATGCTGGTCGATCATAAGCAATTCAAG
GCGATCAAGCCGGAAGAAATTACGCAGTCCTGGATCGTGGATACCAAAGGGGTTTGGCGTTGA

Upstream 100 bases:

>100_bases
AAGACGAATATCACGCCATGAGCCGGGCGCATAACCCTTACGGTGACGGGCATGCCTGCCAGCGTATTCTCGAAGCTTTG
AAGAATCATCAGGTGACACT

Downstream 100 bases:

>100_bases
AACGTATTTTAGTCACTGGAGGCGCCGGCTTTATTGGCTCCGCAGTCGTGAGGCATATTATCGAAGCCACGCAGGACAGT
GTCCTGGTGCTGGATAAGCT

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSFNTISVIGLGYIGLPTAAAFASRKKKVVGVDVNQHAVDTINRGAIHIVEPDLDKVVKDAVDGGYLQAVTQPLAADAFL
IAVPTPFKGDHEPDLAYVEAAAKSLAPVLKKGDLVILESTSPVGATEQMAQWLAEARSDLSFPQQAGEAADVNIAYCPER
VLPGQVMVELIQNDRVIGGMTPKCSERASALYKIFLEGECVITNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINV
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVSQNPQQARLIHTARLVNDGKPLWVVDRVKAAVADCLAATDKRASE
VKIACFGLAFKPNIDDLRESPAVEVAHLIADWHVGETLVVEPNVEQLPKSLVGHVTLKALPEALQQADVIVMLVDHKQFK
AIKPEEITQSWIVDTKGVWR

Sequences:

>Translated_420_residues
MSFNTISVIGLGYIGLPTAAAFASRKKKVVGVDVNQHAVDTINRGAIHIVEPDLDKVVKDAVDGGYLQAVTQPLAADAFL
IAVPTPFKGDHEPDLAYVEAAAKSLAPVLKKGDLVILESTSPVGATEQMAQWLAEARSDLSFPQQAGEAADVNIAYCPER
VLPGQVMVELIQNDRVIGGMTPKCSERASALYKIFLEGECVITNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINV
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVSQNPQQARLIHTARLVNDGKPLWVVDRVKAAVADCLAATDKRASE
VKIACFGLAFKPNIDDLRESPAVEVAHLIADWHVGETLVVEPNVEQLPKSLVGHVTLKALPEALQQADVIVMLVDHKQFK
AIKPEEITQSWIVDTKGVWR
>Mature_419_residues
SFNTISVIGLGYIGLPTAAAFASRKKKVVGVDVNQHAVDTINRGAIHIVEPDLDKVVKDAVDGGYLQAVTQPLAADAFLI
AVPTPFKGDHEPDLAYVEAAAKSLAPVLKKGDLVILESTSPVGATEQMAQWLAEARSDLSFPQQAGEAADVNIAYCPERV
LPGQVMVELIQNDRVIGGMTPKCSERASALYKIFLEGECVITNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINVW
ELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVSQNPQQARLIHTARLVNDGKPLWVVDRVKAAVADCLAATDKRASEV
KIACFGLAFKPNIDDLRESPAVEVAHLIADWHVGETLVVEPNVEQLPKSLVGHVTLKALPEALQQADVIVMLVDHKQFKA
IKPEEITQSWIVDTKGVWR

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=445, Percent_Identity=26.7415730337079, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI296040438, Length=347, Percent_Identity=25.9365994236311, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI48994968, Length=420, Percent_Identity=82.6190476190476, Blast_Score=725, Evalue=0.0,
Organism=Escherichia coli, GI1788340, Length=406, Percent_Identity=24.6305418719212, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560350, Length=381, Percent_Identity=29.9212598425197, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136908, Length=409, Percent_Identity=28.6063569682152, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45583; Mature: 45452

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFNTISVIGLGYIGLPTAAAFASRKKKVVGVDVNQHAVDTINRGAIHIVEPDLDKVVKD
CCCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCHHHHHHHCCCEEEEECCCHHHHHHH
AVDGGYLQAVTQPLAADAFLIAVPTPFKGDHEPDLAYVEAAAKSLAPVLKKGDLVILEST
HCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SPVGATEQMAQWLAEARSDLSFPQQAGEAADVNIAYCPERVLPGQVMVELIQNDRVIGGM
CCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEECC
TPKCSERASALYKIFLEGECVITNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINV
CCCHHHHHHHHEEEEECCEEEEECCCCHHHHHHHCCCCCEEEEEEECCEEEEEECCCCCH
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVSQNPQQARLIHTARLVNDGKPLWVV
HHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHHCCCCCEEEH
DRVKAAVADCLAATDKRASEVKIACFGLAFKPNIDDLRESPAVEVAHLIADWHVGETLVV
HHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEE
EPNVEQLPKSLVGHVTLKALPEALQQADVIVMLVDHKQFKAIKPEEITQSWIVDTKGVWR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
SFNTISVIGLGYIGLPTAAAFASRKKKVVGVDVNQHAVDTINRGAIHIVEPDLDKVVKD
CCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCHHHHHHHCCCEEEEECCCHHHHHHH
AVDGGYLQAVTQPLAADAFLIAVPTPFKGDHEPDLAYVEAAAKSLAPVLKKGDLVILEST
HCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SPVGATEQMAQWLAEARSDLSFPQQAGEAADVNIAYCPERVLPGQVMVELIQNDRVIGGM
CCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEECC
TPKCSERASALYKIFLEGECVITNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINV
CCCHHHHHHHHEEEEECCEEEEECCCCHHHHHHHCCCCCEEEEEEECCEEEEEECCCCCH
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVSQNPQQARLIHTARLVNDGKPLWVV
HHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHHCCCCCEEEH
DRVKAAVADCLAATDKRASEVKIACFGLAFKPNIDDLRESPAVEVAHLIADWHVGETLVV
HHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEE
EPNVEQLPKSLVGHVTLKALPEALQQADVIVMLVDHKQFKAIKPEEITQSWIVDTKGVWR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]