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The map label for this gene is wecB [H]

Identifier: 157368412

GI number: 157368412

Start: 184406

End: 185536

Strand: Direct

Name: wecB [H]

Synonym: Spro_0163

Alternate gene names: 157368412

Gene position: 184406-185536 (Clockwise)

Preceding gene: 157368411

Following gene: 157368413

Centisome position: 3.38

GC content: 54.91

Gene sequence:

>1131_bases
GTGAAAGTGTTGACTGTTTTCGGCACCAGACCTGAAGCCATCAAAATGGCCCCGCTGGTACATGCCCTGGCTCAGGATGA
AGCCTTTGAATCAAGAGTCTGCGTTACGGCACAGCATCGTGAGATGTTGGATCAGGTATTGCGGTTATTTGAGATAGTGC
CTGATTACGACCTGAACATCATGAAGCCCGGCCAGGGATTGAGTGAGATCACCTGCCGTATTCTGGAAGGCCTGAAAGGC
GTTCTTGAAGAATTCAAACCGGACGTGGTGCTGGTTCATGGTGATACCACCACCACGCTGGCGACCAGTTTGGCGGCGTT
TTACCAGCGTATCCCGGTTGGGCACGTAGAGGCGGGTCTGCGCACCGGCGACCTTTACTCCCCATGGCCGGAAGAGGCTA
ACCGCAAGCTGACCGGCCATCTGGCGATGTATCATTTTGCCCCGACGGAAAACTCGCGTCAGAACCTGTTGCGTGAATTG
TTACCGGACGATCATATCTTCGTCACCGGCAACACGGTGATTGATGCATTGTTCTGGGTACGCGATCGGGTGATGGGTGA
TGCGGCATTGCATGACAGCCTGGCACAGCGTTATCCGTTCCTGGATGCCGACAAAAAAATGATCCTGGTGACCGGCCACC
GTCGTGAAAGTTTTGGCGGCGGATTTGAGCGGATTTGCAGTGCGCTGGCAGAAATTGCCCGCACTCATCCCGATGTGCAG
GTGGTGTACCCGGTACATCTCAATCCCAACGTTAGCGAGCCGGTCAACCGCATTCTGAAAGGGATCGATAACATCATCCT
GATCGACCCGCAGGATTACTTGCCCTTTGTGTACCTGATGGCCAACGCTTATATGATCCTGACCGACTCTGGCGGCATTC
AGGAAGAGGCGCCGTCATTGGGCAAACCGGTGCTGGTGATGCGCGATACCACCGAACGGCCGGAAGCGGTCGATTCGGGT
ACGGTGCGTCTGGTGGGAACCGACGTAGCCAAAATTGTTGATGCGGTTACCCAGTTGCTGACGGACGAAGACGAATATCA
CGCCATGAGCCGGGCGCATAACCCTTACGGTGACGGGCATGCCTGCCAGCGTATTCTCGAAGCTTTGAAGAATCATCAGG
TGACACTATGA

Upstream 100 bases:

>100_bases
TCGGCCGCGTAATTAAAAATAATATAATAATTCGCTGAAGGGCGCATAAGCGCCCAATTCGCAGGTACGCCTGCGGTTAA
CCGACAATAAGAGATTCGCT

Downstream 100 bases:

>100_bases
GTTTTAACACTATTTCGGTTATCGGCCTGGGTTACATCGGTCTGCCAACGGCGGCGGCGTTTGCCTCCCGCAAGAAAAAA
GTGGTGGGCGTAGATGTTAA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKVLTVFGTRPEAIKMAPLVHALAQDEAFESRVCVTAQHREMLDQVLRLFEIVPDYDLNIMKPGQGLSEITCRILEGLKG
VLEEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGLRTGDLYSPWPEEANRKLTGHLAMYHFAPTENSRQNLLREL
LPDDHIFVTGNTVIDALFWVRDRVMGDAALHDSLAQRYPFLDADKKMILVTGHRRESFGGGFERICSALAEIARTHPDVQ
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMANAYMILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSG
TVRLVGTDVAKIVDAVTQLLTDEDEYHAMSRAHNPYGDGHACQRILEALKNHQVTL

Sequences:

>Translated_376_residues
MKVLTVFGTRPEAIKMAPLVHALAQDEAFESRVCVTAQHREMLDQVLRLFEIVPDYDLNIMKPGQGLSEITCRILEGLKG
VLEEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGLRTGDLYSPWPEEANRKLTGHLAMYHFAPTENSRQNLLREL
LPDDHIFVTGNTVIDALFWVRDRVMGDAALHDSLAQRYPFLDADKKMILVTGHRRESFGGGFERICSALAEIARTHPDVQ
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMANAYMILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSG
TVRLVGTDVAKIVDAVTQLLTDEDEYHAMSRAHNPYGDGHACQRILEALKNHQVTL
>Mature_376_residues
MKVLTVFGTRPEAIKMAPLVHALAQDEAFESRVCVTAQHREMLDQVLRLFEIVPDYDLNIMKPGQGLSEITCRILEGLKG
VLEEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGLRTGDLYSPWPEEANRKLTGHLAMYHFAPTENSRQNLLREL
LPDDHIFVTGNTVIDALFWVRDRVMGDAALHDSLAQRYPFLDADKKMILVTGHRRESFGGGFERICSALAEIARTHPDVQ
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMANAYMILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSG
TVRLVGTDVAKIVDAVTQLLTDEDEYHAMSRAHNPYGDGHACQRILEALKNHQVTL

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=376, Percent_Identity=81.1170212765958, Blast_Score=619, Evalue=1e-178,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 41923; Mature: 41923

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALAQDEAFESRVCVTAQHREMLDQVLRLFEIVPDYDLNI
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCEE
MKPGQGLSEITCRILEGLKGVLEEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCC
RTGDLYSPWPEEANRKLTGHLAMYHFAPTENSRQNLLRELLPDDHIFVTGNTVIDALFWV
CCCCCCCCCCHHHCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHH
RDRVMGDAALHDSLAQRYPFLDADKKMILVTGHRRESFGGGFERICSALAEIARTHPDVQ
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEE
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMANAYMILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCEEEEECCCCCCCCCCCC
GKPVLVMRDTTERPEAVDSGTVRLVGTDVAKIVDAVTQLLTDEDEYHAMSRAHNPYGDGH
CCCEEEEECCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCH
ACQRILEALKNHQVTL
HHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALAQDEAFESRVCVTAQHREMLDQVLRLFEIVPDYDLNI
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCEE
MKPGQGLSEITCRILEGLKGVLEEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCC
RTGDLYSPWPEEANRKLTGHLAMYHFAPTENSRQNLLRELLPDDHIFVTGNTVIDALFWV
CCCCCCCCCCHHHCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHH
RDRVMGDAALHDSLAQRYPFLDADKKMILVTGHRRESFGGGFERICSALAEIARTHPDVQ
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEE
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMANAYMILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCEEEEECCCCCCCCCCCC
GKPVLVMRDTTERPEAVDSGTVRLVGTDVAKIVDAVTQLLTDEDEYHAMSRAHNPYGDGH
CCCEEEEECCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCH
ACQRILEALKNHQVTL
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]