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The map label for this gene is mtlD

Identifier: 157368322

GI number: 157368322

Start: 77088

End: 78239

Strand: Direct

Name: mtlD

Synonym: Spro_0073

Alternate gene names: 157368322

Gene position: 77088-78239 (Clockwise)

Preceding gene: 157368321

Following gene: 157368323

Centisome position: 1.41

GC content: 58.94

Gene sequence:

>1152_bases
ATGAAAGCATTACATTTCGGTGCGGGAAATATTGGCCGTGGTTTTATCGGCAAGCTGCTGGCGGACGCGCAGGCCGAACT
GACCTTTGCCGACGTCAACCAGACGGTGCTGGACCTGCTGAACAGCCGCAAAAGTTATCAGGTGCACGTGGTCGGCGAAC
AGGCCAGGGTCGAACAGGTCAACAACGTCAGCGCAGTGAACAGCGGCAGTGAAGAGGCGGTTGCGCTGATCGCCGAAGCG
GATATCGTGACCACCGCAGTGGGGCCGCAGATCCTGGCTAAAATTGCCGGAACTATCGCCAAAGGGCTGAGCAAGCGTCA
CCAGCAGGGCAATAGCCAACCGCTGAACATCATCGCCTGTGAGAACATGGTGCGGGGCACCAGCCAGTTAAAACAGCACG
TGTTTGATGTCCTGCCGCAGGAAGATCAGGCATGGGCCCTACAGCATGTAGGCTTCGTTGATTCGGCAGTTGACCGCATT
GTACCGCCGGCGGAAGCGGGCAGCAGCGATCCGCTGGAAGTGACGGTAGAAACCTTCAGCGAGTGGATTGTCGATCAAAC
CCAGTTCAAGGGCCAGCCACCGGCGATTGCCGGTATGGAACTGACCGACAACCTGATGGCGTTTGTTGAGCGCAAGTTGT
TCACGCTCAATACCGGCCATGCGATTACCGCCTATCTTGGGCAACAGGCCGGCCTGCAGACCATTCGCGATGCCATTCTT
GACCCGAAAATCCGCCAGGTGGTGAAAGGCGCGATGGAAGAGAGCGGTGCGGTGCTGATCAAACGCTACGGTTTTGACGC
CGCCAAGCATGCCGCTTACATCGACAAAATCCTCAGCCGCTTTGAAAACCCCTATCTGCACGACGACGTGGAGCGCGTGG
GCCGTCAGCCGCTGCGCAAACTGAGCGCCGGCGATCGCCTGATCAAGCCGCTGCTCGGCACGCTGGAGTACGGTCTGCCG
CACGCCAACCTGATCCAGGGTATTGCCGCCGCCATGAGCTACCGCAGCGAGCAGGATCCGCAGGCCAAAGAGCTGGTGGA
ACTGCTGGCCAAACTGGGGCCAAAAGCGGCGCTGGCGCAAATTTCCGGCCTGCCGGCGGAAAGTGAGGTTGTAGAACAGG
CGGTTGCTGTGTATAACGCCATGCAAAAGTAG

Upstream 100 bases:

>100_bases
CAGGAAGTGCTGGATCTGCTGGGCGGCAAAAAACGCGGATAACAGAATCATTTTAAGGGGTGCAGCTTGCTGCACCCTTC
GACATTAGAAAGGTAGAAAT

Downstream 100 bases:

>100_bases
ATTCAATATGATGAATCTTCGGGCGCAGCAAGTTGCGCCCCTACACCCCGACTTCGGCATTGACGGCGCCACCCAGGCCA
TTCGAAAAGCGACGATGGAA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKALHFGAGNIGRGFIGKLLADAQAELTFADVNQTVLDLLNSRKSYQVHVVGEQARVEQVNNVSAVNSGSEEAVALIAEA
DIVTTAVGPQILAKIAGTIAKGLSKRHQQGNSQPLNIIACENMVRGTSQLKQHVFDVLPQEDQAWALQHVGFVDSAVDRI
VPPAEAGSSDPLEVTVETFSEWIVDQTQFKGQPPAIAGMELTDNLMAFVERKLFTLNTGHAITAYLGQQAGLQTIRDAIL
DPKIRQVVKGAMEESGAVLIKRYGFDAAKHAAYIDKILSRFENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLP
HANLIQGIAAAMSYRSEQDPQAKELVELLAKLGPKAALAQISGLPAESEVVEQAVAVYNAMQK

Sequences:

>Translated_383_residues
MKALHFGAGNIGRGFIGKLLADAQAELTFADVNQTVLDLLNSRKSYQVHVVGEQARVEQVNNVSAVNSGSEEAVALIAEA
DIVTTAVGPQILAKIAGTIAKGLSKRHQQGNSQPLNIIACENMVRGTSQLKQHVFDVLPQEDQAWALQHVGFVDSAVDRI
VPPAEAGSSDPLEVTVETFSEWIVDQTQFKGQPPAIAGMELTDNLMAFVERKLFTLNTGHAITAYLGQQAGLQTIRDAIL
DPKIRQVVKGAMEESGAVLIKRYGFDAAKHAAYIDKILSRFENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLP
HANLIQGIAAAMSYRSEQDPQAKELVELLAKLGPKAALAQISGLPAESEVVEQAVAVYNAMQK
>Mature_383_residues
MKALHFGAGNIGRGFIGKLLADAQAELTFADVNQTVLDLLNSRKSYQVHVVGEQARVEQVNNVSAVNSGSEEAVALIAEA
DIVTTAVGPQILAKIAGTIAKGLSKRHQQGNSQPLNIIACENMVRGTSQLKQHVFDVLPQEDQAWALQHVGFVDSAVDRI
VPPAEAGSSDPLEVTVETFSEWIVDQTQFKGQPPAIAGMELTDNLMAFVERKLFTLNTGHAITAYLGQQAGLQTIRDAIL
DPKIRQVVKGAMEESGAVLIKRYGFDAAKHAAYIDKILSRFENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLP
HANLIQGIAAAMSYRSEQDPQAKELVELLAKLGPKAALAQISGLPAESEVVEQAVAVYNAMQK

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=382, Percent_Identity=76.9633507853403, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1788497, Length=282, Percent_Identity=26.9503546099291, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787823, Length=271, Percent_Identity=26.9372693726937, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790779, Length=264, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324401, Length=264, Percent_Identity=28.030303030303, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320765, Length=264, Percent_Identity=28.030303030303, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_SERP5 (A8G7U3)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476311.1
- ProteinModelPortal:   A8G7U3
- STRING:   A8G7U3
- GeneID:   5606298
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0073
- eggNOG:   COG0246
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- BioCyc:   SPRO399741:SPRO_0073-MONOMER
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 41383; Mature: 41383

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALHFGAGNIGRGFIGKLLADAQAELTFADVNQTVLDLLNSRKSYQVHVVGEQARVEQV
CCCEECCCCCCCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
NNVSAVNSGSEEAVALIAEADIVTTAVGPQILAKIAGTIAKGLSKRHQQGNSQPLNIIAC
HCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEH
ENMVRGTSQLKQHVFDVLPQEDQAWALQHVGFVDSAVDRIVPPAEAGSSDPLEVTVETFS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHH
EWIVDQTQFKGQPPAIAGMELTDNLMAFVERKLFTLNTGHAITAYLGQQAGLQTIRDAIL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHC
DPKIRQVVKGAMEESGAVLIKRYGFDAAKHAAYIDKILSRFENPYLHDDVERVGRQPLRK
CHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYGLPHANLIQGIAAAMSYRSEQDPQAKELVELLAKLGPKAALAQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHH
ISGLPAESEVVEQAVAVYNAMQK
HCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKALHFGAGNIGRGFIGKLLADAQAELTFADVNQTVLDLLNSRKSYQVHVVGEQARVEQV
CCCEECCCCCCCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
NNVSAVNSGSEEAVALIAEADIVTTAVGPQILAKIAGTIAKGLSKRHQQGNSQPLNIIAC
HCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEH
ENMVRGTSQLKQHVFDVLPQEDQAWALQHVGFVDSAVDRIVPPAEAGSSDPLEVTVETFS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHH
EWIVDQTQFKGQPPAIAGMELTDNLMAFVERKLFTLNTGHAITAYLGQQAGLQTIRDAIL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHC
DPKIRQVVKGAMEESGAVLIKRYGFDAAKHAAYIDKILSRFENPYLHDDVERVGRQPLRK
CHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYGLPHANLIQGIAAAMSYRSEQDPQAKELVELLAKLGPKAALAQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHH
ISGLPAESEVVEQAVAVYNAMQK
HCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA