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The map label for this gene is mtlA [H]

Identifier: 157368321

GI number: 157368321

Start: 75110

End: 77029

Strand: Direct

Name: mtlA [H]

Synonym: Spro_0072

Alternate gene names: 157368321

Gene position: 75110-77029 (Clockwise)

Preceding gene: 157368320

Following gene: 157368322

Centisome position: 1.38

GC content: 57.76

Gene sequence:

>1920_bases
ATGTTTTCACCAGACATCAAAGTCAAAGTTCAGAACTTTGGCCGCTTCTTAAGCAACATGGTGATGCCCAACATTGGCGC
ATTTATCGCCTGGGGTATCATCACCGCGTTATTCATTCCTACCGGTTGGCTGCCGAACGAAACCTTAGCCAAGTTGGTTG
GTCCGATGATCACTTACCTGCTGCCGCTGCTGATCGGTTTCACCGGTGGCCGCCTGGTGGGGGGCGATCGCGGCGGCGTG
GTCGGTGCCATCACCACCATGGGTGTGATTGTCGGTGCAGACATGCCGATGTTCCTCGGTGCGATGATTGCCGGCCCGCT
GGGTGGCTGGGCGATCAAGCATTTTGACCGCTGGGTCGACGGCAAAATCAAAAGCGGTTTTGAGATGTTGGTGAACAACT
TCTCCGCCGGCATTATCGGTATGCTGCTGGCTATCCTGTCGTTTATGGCGATTGGTCCGCTGGTCGAAGGGTTGTCGCAT
ATCCTGGCTACCGGCGTGAACATCATGGTGACCAACAACCTGTTGCCGTTGGCGTCAATCTTCGTGGAACCGGCGAAAAT
CCTGTTCCTCAACAACGCGATTAACCACGGTATCTTCTCACCGCTGGGCATCCAGCAGGCGACCGAAACCGGCAAATCCA
TCTTCTTCCTGATCGAAGCCAACCCAGGCCCGGGTTTGGGCGTGCTGATGGCCTACATGTTCTTTGGTCGCGGCAGTGCC
AAGCAGTCTGCCGGTGGTGCTGCGATCATTCACTTCTTCGGTGGTATCCACGAAATCTACTTCCCGTACGTGCTGATGAA
CCCACGTCTGCTGTTGGCGGTGATCCTGGGTGGCATGACCGGCGTATTCACCCTGACCATGTTGAACGGCGGTCTGGTCT
CTCCGGCTTCACCGGGTTCGATTCTGGCGGTGCTGGCGATGACGCCGAAGGGCGCTTATTTCGCTAACCTGGCGGCTATC
GGTGCGGCCTTTGTGGTGTCGTTTGTGGTCGCGGGCTTCCTGCTGAAAACCTCAAAAGTGAAAGAAGAGGACGATCTGGA
AGAGGCAACTCGCCGTATGCAAGAAATGAAGTCGCAGTCTAAAGGCGGCGCGGCGGCTCATGCAGCGGTCGATGGCGATC
TGACCACGGTACGTAAAATCATCGTTGCCTGCGATGCCGGTATGGGCTCCAGCGCGATGGGGGCCGGGGTGCTGCGCAAA
AAAGTGGCGGATGCCGGGCTGAAAAATATCTCGGTGACCAATAGCGCCATCAATAGCCTGCCGGACGATGTGGATCTGGT
GATCACTCACCGCGACCTGACCGAGCGAGCGATGCGGCACGCGCCTCAGGCCCAGCATATCTCGCTGACCAACTTCCTCG
ACAGCAAGCTGTACAGCGATCTGACCGAGCGTCTGGTGGCGGCCAACAAAACCACCGATAACCAACAGAAAGTCATCAGC
ACGCTGGACGACAGCTTTGAAGCGAGCGAGCAAAACCTGTTCCGCCTCAGCGAAAGCAACGTGTTCCTTAACCTGCAGGC
CAGCGACAAGGAACAGGCGATCCGCTTTGCCGGTGAGCAACTGGTCAAGGGGGGCTACGTCGAGCCGGAATACGTTCCTG
CGATGCTGGAGCGCGAGAAACTGACCTCCACCTATCTGGGCGAGTCGATCGCCGTGCCGCACGGCACCATCGAAGCCAAA
GACCGGGTACTGCGCACCGGCGTGGTGTTCTGCCAATACCCGCAGGGCGTGCGTTTCGGTGATGAAGAGGACGAGGTGGC
GCGGCTGGTCATCGGTATTGCCGCACGCAATAACGAACATATCCAGGTGATCACCAGCCTGACCAATGCGTTGGATGACG
ACGGCGTCATCGAGCGGCTGGCGAATACCAGCAGCGTGCAGGAAGTGCTGGATCTGCTGGGCGGCAAAAAACGCGGATAA

Upstream 100 bases:

>100_bases
CGTGATAGAGTCCATTTCGCATACAGCCACAACACAGCTGGATCGTAACAACAATAATCACGCGCTCTATTGTCAGCGCG
TAACAATAGGGGTGTGTTTT

Downstream 100 bases:

>100_bases
CAGAATCATTTTAAGGGGTGCAGCTTGCTGCACCCTTCGACATTAGAAAGGTAGAAATATGAAAGCATTACATTTCGGTG
CGGGAAATATTGGCCGTGGT

Product: PTS system mannitol-specific transporter subunit IIC

Products: NA

Alternate protein names: EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component [H]

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MFSPDIKVKVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGFTGGRLVGGDRGGV
VGAITTMGVIVGADMPMFLGAMIAGPLGGWAIKHFDRWVDGKIKSGFEMLVNNFSAGIIGMLLAILSFMAIGPLVEGLSH
ILATGVNIMVTNNLLPLASIFVEPAKILFLNNAINHGIFSPLGIQQATETGKSIFFLIEANPGPGLGVLMAYMFFGRGSA
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTMLNGGLVSPASPGSILAVLAMTPKGAYFANLAAI
GAAFVVSFVVAGFLLKTSKVKEEDDLEEATRRMQEMKSQSKGGAAAHAAVDGDLTTVRKIIVACDAGMGSSAMGAGVLRK
KVADAGLKNISVTNSAINSLPDDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSKLYSDLTERLVAANKTTDNQQKVIS
TLDDSFEASEQNLFRLSESNVFLNLQASDKEQAIRFAGEQLVKGGYVEPEYVPAMLEREKLTSTYLGESIAVPHGTIEAK
DRVLRTGVVFCQYPQGVRFGDEEDEVARLVIGIAARNNEHIQVITSLTNALDDDGVIERLANTSSVQEVLDLLGGKKRG

Sequences:

>Translated_639_residues
MFSPDIKVKVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGFTGGRLVGGDRGGV
VGAITTMGVIVGADMPMFLGAMIAGPLGGWAIKHFDRWVDGKIKSGFEMLVNNFSAGIIGMLLAILSFMAIGPLVEGLSH
ILATGVNIMVTNNLLPLASIFVEPAKILFLNNAINHGIFSPLGIQQATETGKSIFFLIEANPGPGLGVLMAYMFFGRGSA
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTMLNGGLVSPASPGSILAVLAMTPKGAYFANLAAI
GAAFVVSFVVAGFLLKTSKVKEEDDLEEATRRMQEMKSQSKGGAAAHAAVDGDLTTVRKIIVACDAGMGSSAMGAGVLRK
KVADAGLKNISVTNSAINSLPDDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSKLYSDLTERLVAANKTTDNQQKVIS
TLDDSFEASEQNLFRLSESNVFLNLQASDKEQAIRFAGEQLVKGGYVEPEYVPAMLEREKLTSTYLGESIAVPHGTIEAK
DRVLRTGVVFCQYPQGVRFGDEEDEVARLVIGIAARNNEHIQVITSLTNALDDDGVIERLANTSSVQEVLDLLGGKKRG
>Mature_639_residues
MFSPDIKVKVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGFTGGRLVGGDRGGV
VGAITTMGVIVGADMPMFLGAMIAGPLGGWAIKHFDRWVDGKIKSGFEMLVNNFSAGIIGMLLAILSFMAIGPLVEGLSH
ILATGVNIMVTNNLLPLASIFVEPAKILFLNNAINHGIFSPLGIQQATETGKSIFFLIEANPGPGLGVLMAYMFFGRGSA
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTMLNGGLVSPASPGSILAVLAMTPKGAYFANLAAI
GAAFVVSFVVAGFLLKTSKVKEEDDLEEATRRMQEMKSQSKGGAAAHAAVDGDLTTVRKIIVACDAGMGSSAMGAGVLRK
KVADAGLKNISVTNSAINSLPDDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSKLYSDLTERLVAANKTTDNQQKVIS
TLDDSFEASEQNLFRLSESNVFLNLQASDKEQAIRFAGEQLVKGGYVEPEYVPAMLEREKLTSTYLGESIAVPHGTIEAK
DRVLRTGVVFCQYPQGVRFGDEEDEVARLVIGIAARNNEHIQVITSLTNALDDDGVIERLANTSSVQEVLDLLGGKKRG

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=636, Percent_Identity=82.8616352201258, Blast_Score=1060, Evalue=0.0,
Organism=Escherichia coli, GI1789301, Length=464, Percent_Identity=51.7241379310345, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1788494, Length=146, Percent_Identity=44.5205479452055, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 68218; Mature: 68218

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSPDIKVKVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYL
CCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LPLLIGFTGGRLVGGDRGGVVGAITTMGVIVGADMPMFLGAMIAGPLGGWAIKHFDRWVD
HHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHC
GKIKSGFEMLVNNFSAGIIGMLLAILSFMAIGPLVEGLSHILATGVNIMVTNNLLPLASI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHH
FVEPAKILFLNNAINHGIFSPLGIQQATETGKSIFFLIEANPGPGLGVLMAYMFFGRGSA
HHCCHHEEEECCHHHCCCCCCCCCHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTMLNGGLVSPASPGS
CCCCCCEEHHHHHCCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCC
ILAVLAMTPKGAYFANLAAIGAAFVVSFVVAGFLLKTSKVKEEDDLEEATRRMQEMKSQS
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
KGGAAAHAAVDGDLTTVRKIIVACDAGMGSSAMGAGVLRKKVADAGLKNISVTNSAINSL
CCCCEEEHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHCC
PDDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSKLYSDLTERLVAANKTTDNQQKVIS
CCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TLDDSFEASEQNLFRLSESNVFLNLQASDKEQAIRFAGEQLVKGGYVEPEYVPAMLEREK
HHHHHHHHCHHHHHEEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LTSTYLGESIAVPHGTIEAKDRVLRTGVVFCQYPQGVRFGDEEDEVARLVIGIAARNNEH
HHHHHCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHEECCCCH
IQVITSLTNALDDDGVIERLANTSSVQEVLDLLGGKKRG
HHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSPDIKVKVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYL
CCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LPLLIGFTGGRLVGGDRGGVVGAITTMGVIVGADMPMFLGAMIAGPLGGWAIKHFDRWVD
HHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHC
GKIKSGFEMLVNNFSAGIIGMLLAILSFMAIGPLVEGLSHILATGVNIMVTNNLLPLASI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHH
FVEPAKILFLNNAINHGIFSPLGIQQATETGKSIFFLIEANPGPGLGVLMAYMFFGRGSA
HHCCHHEEEECCHHHCCCCCCCCCHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTMLNGGLVSPASPGS
CCCCCCEEHHHHHCCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCC
ILAVLAMTPKGAYFANLAAIGAAFVVSFVVAGFLLKTSKVKEEDDLEEATRRMQEMKSQS
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
KGGAAAHAAVDGDLTTVRKIIVACDAGMGSSAMGAGVLRKKVADAGLKNISVTNSAINSL
CCCCEEEHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHCC
PDDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSKLYSDLTERLVAANKTTDNQQKVIS
CCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TLDDSFEASEQNLFRLSESNVFLNLQASDKEQAIRFAGEQLVKGGYVEPEYVPAMLEREK
HHHHHHHHCHHHHHEEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LTSTYLGESIAVPHGTIEAKDRVLRTGVVFCQYPQGVRFGDEEDEVARLVIGIAARNNEH
HHHHHCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHEECCCCH
IQVITSLTNALDDDGVIERLANTSSVQEVLDLLGGKKRG
HHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6309813; 8041620; 9278503; 3135464; 3142516; 1946374; 9551558 [H]