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The map label for this gene is rfbC [H]

Identifier: 157161533

GI number: 157161533

Start: 2158187

End: 2158741

Strand: Reverse

Name: rfbC [H]

Synonym: EcHS_A2179

Alternate gene names: 157161533

Gene position: 2158741-2158187 (Counterclockwise)

Preceding gene: 157161534

Following gene: 157161532

Centisome position: 46.49

GC content: 55.5

Gene sequence:

>555_bases
ATGAACATTATTAAAACAGATATTCCTGAGGTGCTGATTTTTGAACCGCGCGTGTTTGGTGATGCGCGGGGCTTCTTCTT
CGAGAGCTTCAGCAGCAAGGTGTTTAATGAAGCGGTGGGCCGCCAGGTGGATTTTGTTCAGGACAACCACTCCCAGTCCC
AGAAAGGCGTACTGCGCGGGCTGCACTATCAGCTGGCTCCGCACGCCCAGGGCAAACTGGTCCGCTGTGTGGAAGGTGAG
GTGTTTGATGTGGCGGTGGATATCCGTCGTTCATCGCCCACCTTTGGCAAATGGGTGGGCGCGGTACTCAGCGCAGAGAA
TAAACGTCAGCTGTGGATCCCGGAAGGGTTCGCCCACGGGTTTATGGCGCTGAGCGACACGGTGCAGTTTGTCTACAAGG
CGACGAACTACTACGCGCCGCAGTCAGAACGGAGCATCATCTGGAACGATCCGGAGATCGGGATTGACTGGCCGGCGCTG
AGCGATTGCGCGCTCTCGCTGTCGGAGAAAGATCTGCAGGCACATACTCTTGCCACTGCAGAAGTATATAAATAA

Upstream 100 bases:

>100_bases
AAAAATTCCAGCAGGCATTTGGGGTGACTCTCCCGGACTGGCGTCAGGGTGTGGCTCGCGTGGTAACAGAAGTCCTGGGC
AAATAAACGGGTGGCAAACG

Downstream 100 bases:

>100_bases
TTAGGTTGTTTTTTCCTAAAATGGCGGGTTCCAGATGGAACTCGTCATGTTTCTTCGTTAACAAGCCGGGTCAACCGACC
GACTTGACTTACCTTCCTTC

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MNIIKTDIPEVLIFEPRVFGDARGFFFESFSSKVFNEAVGRQVDFVQDNHSQSQKGVLRGLHYQLAPHAQGKLVRCVEGE
VFDVAVDIRRSSPTFGKWVGAVLSAENKRQLWIPEGFAHGFMALSDTVQFVYKATNYYAPQSERSIIWNDPEIGIDWPAL
SDCALSLSEKDLQAHTLATAEVYK

Sequences:

>Translated_184_residues
MNIIKTDIPEVLIFEPRVFGDARGFFFESFSSKVFNEAVGRQVDFVQDNHSQSQKGVLRGLHYQLAPHAQGKLVRCVEGE
VFDVAVDIRRSSPTFGKWVGAVLSAENKRQLWIPEGFAHGFMALSDTVQFVYKATNYYAPQSERSIIWNDPEIGIDWPAL
SDCALSLSEKDLQAHTLATAEVYK
>Mature_184_residues
MNIIKTDIPEVLIFEPRVFGDARGFFFESFSSKVFNEAVGRQVDFVQDNHSQSQKGVLRGLHYQLAPHAQGKLVRCVEGE
VFDVAVDIRRSSPTFGKWVGAVLSAENKRQLWIPEGFAHGFMALSDTVQFVYKATNYYAPQSERSIIWNDPEIGIDWPAL
SDCALSLSEKDLQAHTLATAEVYK

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=177, Percent_Identity=62.1468926553672, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17550412, Length=167, Percent_Identity=49.7005988023952, Blast_Score=162, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 20700; Mature: 20700

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIKTDIPEVLIFEPRVFGDARGFFFESFSSKVFNEAVGRQVDFVQDNHSQSQKGVLRG
CCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEECEECCCCCCHHHHHHHH
LHYQLAPHAQGKLVRCVEGEVFDVAVDIRRSSPTFGKWVGAVLSAENKRQLWIPEGFAHG
HHHEECCCCCCCEEEEECCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCHHHH
FMALSDTVQFVYKATNYYAPQSERSIIWNDPEIGIDWPALSDCALSLSEKDLQAHTLATA
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHH
EVYK
HHCC
>Mature Secondary Structure
MNIIKTDIPEVLIFEPRVFGDARGFFFESFSSKVFNEAVGRQVDFVQDNHSQSQKGVLRG
CCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEECEECCCCCCHHHHHHHH
LHYQLAPHAQGKLVRCVEGEVFDVAVDIRRSSPTFGKWVGAVLSAENKRQLWIPEGFAHG
HHHEECCCCCCCEEEEECCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCHHHH
FMALSDTVQFVYKATNYYAPQSERSIIWNDPEIGIDWPALSDCALSLSEKDLQAHTLATA
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHH
EVYK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170390; 8157605; 12384590; 12704152 [H]