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The map label for this gene is ugd [H]

Identifier: 157161532

GI number: 157161532

Start: 2156840

End: 2158006

Strand: Reverse

Name: ugd [H]

Synonym: EcHS_A2178

Alternate gene names: 157161532

Gene position: 2158006-2156840 (Counterclockwise)

Preceding gene: 157161533

Following gene: 157161531

Centisome position: 46.47

GC content: 50.56

Gene sequence:

>1167_bases
ATGAAAATTACTATTTCCGGTACAGGTTATGTTGGTTTATCGAACGGTGTCCTGATTGCGCAAAACCACGAAGTGGTTGC
TCTGGATATCGTACAGGCCAAAGTGGATATGCTTAACCAGAAGATCTCTCCGATTGTGGATAAAGAGATTCAGGAATATC
TGGCAGAAAAACCGTTAAATTTCCGTGCCACCACGGACAAGCACGACGCCTATCGTAATGCCGACTACGTGATCATTGCG
ACGCCGACCGATTACGATCCCAAAACCAACTACTTCAACACCTCTACAGTGGAAGCGGTTATTCGCGATGTCACAGAGAT
CAACCCGAACGCGGTGATGATCATTAAATCGACCATCCCGGTGGGGTTCACCCGCGACATCAAAGAACGTTTAGGGATTG
ATAATGTTATTTTCTCTCCTGAGTTCCTGCGTGAAGGCCGTGCGCTGTACGACAACCTGCACCCATCGCGCATTGTTATT
GGTGAGCGCTCTGCGCGTGCCGAGCGTTTCGCAGACCTGCTGAAAGAAGGCGCGATTAAGCAGGATATCCCGACCCTGTT
TACCGACTCCACTGAAGCGGAAGCGATCAAACTGTTCGCGAACACCTATCTGGCGCTGCGTGTTGCCTATTTCAATGAGC
TCGACAGCTATGCTGAAAGCCAGGGGCTGAACAGCAAGCAGATTATCGAAGGGGTATGCCTGGATCCGCGTATCGGCAAC
CACTACAACAACCCGTCCTTTGGCTATGGCGGCTACTGCCTGCCGAAAGATACCAAGCAGCTGCTGGCGAACTACGAATC
GGTCCCGAACAATATCATCGCGGCTATCGTGGATGCTAACCGTACCCGTAAAGACTTTATCGCGGATTCTATTCTCGCCC
GTAAGCCGAAAGTGGTGGGTGTGTATCGCCTGATCATGAAGAGTGGTTCGGACAACTTCCGTGCTTCTTCTATTCAGGGC
ATTATGAAGCGCATCAAGGCGAAAGGTATTCCGGTTATTATCTATGAACCGGTGATGCAGGAAGATGAGTTCTTTAACTC
CCGCGTCGTGCGCGACCTGGATACCTTCAAACAAGAGGCGGATGTGATCATCTCTAACCGTATGGCGGAAGAGCTGGCGG
ATGTGGCGGACAAGGTATACACCCGCGATCTGTTTGGTAACGATTAA

Upstream 100 bases:

>100_bases
GACTTGACTTACCTTCCTTCTCAGCGTAAAACCGCCAACAGCATTATTTAAATTCGTGGCTATCCGCCATTACCCAGTTA
ACTGATTAAAGTGTAATCGA

Downstream 100 bases:

>100_bases
TCGGTAATGCTGCCAACTTACTGATTTAGTGTATGATGGTGATTTTAAGGTGCTTGCGTGGCTTCCATTTCCATCAGATG
TCCTTCCTGCTCCGCTACTG

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKITISGTGYVGLSNGVLIAQNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLNFRATTDKHDAYRNADYVIIA
TPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIPVGFTRDIKERLGIDNVIFSPEFLREGRALYDNLHPSRIVI
GERSARAERFADLLKEGAIKQDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIAAIVDANRTRKDFIADSILARKPKVVGVYRLIMKSGSDNFRASSIQG
IMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDTFKQEADVIISNRMAEELADVADKVYTRDLFGND

Sequences:

>Translated_388_residues
MKITISGTGYVGLSNGVLIAQNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLNFRATTDKHDAYRNADYVIIA
TPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIPVGFTRDIKERLGIDNVIFSPEFLREGRALYDNLHPSRIVI
GERSARAERFADLLKEGAIKQDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIAAIVDANRTRKDFIADSILARKPKVVGVYRLIMKSGSDNFRASSIQG
IMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDTFKQEADVIISNRMAEELADVADKVYTRDLFGND
>Mature_388_residues
MKITISGTGYVGLSNGVLIAQNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLNFRATTDKHDAYRNADYVIIA
TPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIPVGFTRDIKERLGIDNVIFSPEFLREGRALYDNLHPSRIVI
GERSARAERFADLLKEGAIKQDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIAAIVDANRTRKDFIADSILARKPKVVGVYRLIMKSGSDNFRASSIQG
IMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDTFKQEADVIISNRMAEELADVADKVYTRDLFGND

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=375, Percent_Identity=28.5333333333333, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI296040438, Length=264, Percent_Identity=28.7878787878788, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI296040443, Length=216, Percent_Identity=28.7037037037037, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=83.2474226804124, Blast_Score=677, Evalue=0.0,
Organism=Escherichia coli, GI48994968, Length=289, Percent_Identity=27.3356401384083, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560350, Length=393, Percent_Identity=25.9541984732824, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136908, Length=380, Percent_Identity=26.5789473684211, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 43537; Mature: 43537

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITISGTGYVGLSNGVLIAQNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLN
CEEEEECCCEEECCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FRATTDKHDAYRNADYVIIATPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIP
CEECCCHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCC
VGFTRDIKERLGIDNVIFSPEFLREGRALYDNLHPSRIVIGERSARAERFADLLKEGAIK
CCCHHHHHHHCCCCCEEECHHHHHCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHH
QDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPRIGN
HCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEECCCCCCC
HYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIAAIVDANRTRKDFIADSILARKPKVVG
CCCCCCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHH
VYRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDTFKQEA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
DVIISNRMAEELADVADKVYTRDLFGND
HHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKITISGTGYVGLSNGVLIAQNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLN
CEEEEECCCEEECCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FRATTDKHDAYRNADYVIIATPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIP
CEECCCHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCC
VGFTRDIKERLGIDNVIFSPEFLREGRALYDNLHPSRIVIGERSARAERFADLLKEGAIK
CCCHHHHHHHCCCCCEEECHHHHHCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHH
QDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPRIGN
HCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEECCCCCCC
HYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIAAIVDANRTRKDFIADSILARKPKVVG
CCCCCCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHH
VYRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDTFKQEA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
DVIISNRMAEELADVADKVYTRDLFGND
HHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383197 [H]