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The map label for this gene is mdtL [H]

Identifier: 156976040

GI number: 156976040

Start: 71413

End: 72597

Strand: Reverse

Name: mdtL [H]

Synonym: VIBHAR_04810

Alternate gene names: 156976040

Gene position: 72597-71413 (Counterclockwise)

Preceding gene: 156976041

Following gene: 156976037

Centisome position: 3.29

GC content: 49.96

Gene sequence:

>1185_bases
ATGAGTCGACCGATTGAATTTAAAACCATCTTGCTGGCGTGTCTTATCATCAGTGTTGGTCAACTCAGCATGGGCTTGGT
GTTTCCATCTCTTCCTTGGATCGCGAAAGATTTCGATATTTCCCTCGACCAAGCTCAGCTGTTAGTCAGTGTTTACTTGC
TAGGTTTTGGGCCTTCACAGTTTATCTATGGCCCGGTATCCGATGCATTGGGCCGAAAAAAGGTGCTGTTGGCTGGCTTG
TTGATTGCCATGCTCGGCCTATTGATGATCATCTTCCTAAGCCACACTTTCACTGGCATGGTGGCGGGACGTTTTCTGCA
AGGTTTAGGAACTGGCTGTTGCGCGGTGTTAGCCCGAGCGTCTACTCGCGACCGCTTCAATGGCCCTGAGCTCCCTGTCG
CTTTGTCCTACATTGCTATGGCAGCTTCTATTACACCGTTAGTTGCTCCTGTTATTGGTGGTTTCATCAACGCCCACTTC
GGCTGGACCATGGTGTTTATCTCGCTGTTGGGTTACGTATTGTTGGCTTGGACTGTGATCGTATTTCGCTTCCAAGAGAC
CATCACACAAACCTCAGCCTTGCCATCACCGAAAAAGATGCTGCTGCAATATCGTGACCTTTTGACTTCTCGTTACTTTA
TGAGCTTTGCCAGTATTGGTTGGCTTAACTTCAGCTTGATGATCACCACTGTTTCGGTGATGCCTTTCATCATGCAAAAC
CAAACCGGCATGACATCCGATCAATACGCGATGTGGGCACTGATTCCGGCGTTCGGCATGATCTGCGGCACCAGTATCTG
TAACCGTGTGCGACCAATCATCGGCACGAAGAAGATGCTACTGGTCACGCCAATCCTGCACGTCAGTTCCGCAGCGTGGC
TGTTCTTCTGCCCTGTTGAGCCGCTGTACTTAATGCTAGGCCAACTGCTGATGATTTTAGGCAATGCTATCGCTCTACCT
TGTGCTCAAGCCATGGTAATGCAACCCTATAAGAAACAAGCGGGGGCAACTGCGGCGATGTCGGGCGGCGGCCAAATGGT
GGTGTCATCGATTGTGAGTATGGCATTGGTGCAGCTCGGATTAAGCCAAGCGTGGCATCTGTCATTAGTAATCGTGGTCT
TCGCGCTCATTACACTGACCAATGTTTTGCGAGGCTTCACCACAGAGCAACCTTCAGAGCAATAA

Upstream 100 bases:

>100_bases
AATGTGAAGTCAGCCTATCGACGGTCAAACGTGTGAAAGCCAAACTGAATGATTTTGACGAAGAAGGCAGCTTACGTCGC
CGTGGTGATGGTGAAAAATC

Downstream 100 bases:

>100_bases
AAACAAAAAGGCGACACCGAAGTCGCCTTTTTATTATGAAGAAATCCTTCGAGATTGATGCCTGTGAATCACGCTTATTG
CTGAGCTACCTTCACTGATG

Product: Xaa-His dipeptidase

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSRPIEFKTILLACLIISVGQLSMGLVFPSLPWIAKDFDISLDQAQLLVSVYLLGFGPSQFIYGPVSDALGRKKVLLAGL
LIAMLGLLMIIFLSHTFTGMVAGRFLQGLGTGCCAVLARASTRDRFNGPELPVALSYIAMAASITPLVAPVIGGFINAHF
GWTMVFISLLGYVLLAWTVIVFRFQETITQTSALPSPKKMLLQYRDLLTSRYFMSFASIGWLNFSLMITTVSVMPFIMQN
QTGMTSDQYAMWALIPAFGMICGTSICNRVRPIIGTKKMLLVTPILHVSSAAWLFFCPVEPLYLMLGQLLMILGNAIALP
CAQAMVMQPYKKQAGATAAMSGGGQMVVSSIVSMALVQLGLSQAWHLSLVIVVFALITLTNVLRGFTTEQPSEQ

Sequences:

>Translated_394_residues
MSRPIEFKTILLACLIISVGQLSMGLVFPSLPWIAKDFDISLDQAQLLVSVYLLGFGPSQFIYGPVSDALGRKKVLLAGL
LIAMLGLLMIIFLSHTFTGMVAGRFLQGLGTGCCAVLARASTRDRFNGPELPVALSYIAMAASITPLVAPVIGGFINAHF
GWTMVFISLLGYVLLAWTVIVFRFQETITQTSALPSPKKMLLQYRDLLTSRYFMSFASIGWLNFSLMITTVSVMPFIMQN
QTGMTSDQYAMWALIPAFGMICGTSICNRVRPIIGTKKMLLVTPILHVSSAAWLFFCPVEPLYLMLGQLLMILGNAIALP
CAQAMVMQPYKKQAGATAAMSGGGQMVVSSIVSMALVQLGLSQAWHLSLVIVVFALITLTNVLRGFTTEQPSEQ
>Mature_393_residues
SRPIEFKTILLACLIISVGQLSMGLVFPSLPWIAKDFDISLDQAQLLVSVYLLGFGPSQFIYGPVSDALGRKKVLLAGLL
IAMLGLLMIIFLSHTFTGMVAGRFLQGLGTGCCAVLARASTRDRFNGPELPVALSYIAMAASITPLVAPVIGGFINAHFG
WTMVFISLLGYVLLAWTVIVFRFQETITQTSALPSPKKMLLQYRDLLTSRYFMSFASIGWLNFSLMITTVSVMPFIMQNQ
TGMTSDQYAMWALIPAFGMICGTSICNRVRPIIGTKKMLLVTPILHVSSAAWLFFCPVEPLYLMLGQLLMILGNAIALPC
AQAMVMQPYKKQAGATAAMSGGGQMVVSSIVSMALVQLGLSQAWHLSLVIVVFALITLTNVLRGFTTEQPSEQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=326, Percent_Identity=29.1411042944785, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788509, Length=368, Percent_Identity=24.1847826086957, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082312, Length=337, Percent_Identity=26.1127596439169, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790794, Length=251, Percent_Identity=26.2948207171315, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI48994889, Length=195, Percent_Identity=28.2051282051282, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42818; Mature: 42687

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SRPIEFKTILLACLIISVGQLSMGLVFPSLPWIAKDFDISLDQAQLLVSVYLLGFGPSQ
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHHCCCCC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HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]